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Canesten Pessary 100mg - 6 Pessaries With Applicator

Canesten Pessary 100mg - 6 Pessaries With Applicator

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  • ✔️ Treats vaginal thrush caused by Candida albicans effectively
  • ✔️ Six-night course targets infection at the source intravaginally
  • ✔️ Clotrimazole 100mg relieves itching, soreness, and discharge
  • ✔️ Includes reusable applicator for easy, comfortable insertion
  • ✔️ Suitable for women aged 16 and over without a prescription

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What Is Canesten Pessary 100mg and How Does It Treat Thrush?

 

Vaginal thrush is one of the most common fungal infections affecting women in the UK. It is caused by an overgrowth of a yeast called Candida albicans, which naturally lives in the vagina in small amounts. When conditions change — due to antibiotics, hormonal shifts, or a weakened immune system — it can multiply and cause uncomfortable symptoms. Canesten pessary 100mg is a clinically established intravaginal treatment containing clotrimazole, an antifungal medicine that targets the source of the infection directly. Each pack contains six pessaries and a reusable applicator, making it straightforward to use at home. If you are looking for a broader range of treatments for fungal conditions, you can also browse our athletes foot and fungal infections collection for related products.

Thrush affects up to three quarters of women at some point in their lives, according to the NHS. Symptoms typically include itching, soreness, a thick white discharge (often described as cottage cheese-like), and redness around the vaginal area. The six-pessary course is particularly suited to women who prefer a gradual, locally acting treatment rather than a single high-dose option.

 

How Does Canesten Pessary 100mg Work Inside the Body?

 

Clotrimazole, the active ingredient in this product, belongs to a class of medicines called azole antifungals. It works by interfering with the production of ergosterol — a key component of the fungal cell membrane. Without ergosterol, the cell membrane becomes leaky and unstable, ultimately causing the Candida cells to die. Because it acts locally within the vagina, very little of the medicine is absorbed into the bloodstream, which is why it is considered safe for most women to use without a prescription.

  • Clotrimazole binds to fungal enzymes responsible for ergosterol synthesis
  • The fungal cell membrane loses structural integrity
  • Candida cells are unable to replicate and begin to die off
  • Symptoms such as itching and discharge gradually resolve over the treatment course

 

Who Should Use Canesten Pessary 100mg?

 

This product is suitable for women aged 16 and over who have previously had vaginal thrush diagnosed by a doctor and recognise the same symptoms returning. It is not appropriate for first-time sufferers who have not yet had a confirmed diagnosis, as other conditions — such as bacterial vaginosis or sexually transmitted infections — can cause similar symptoms and require different treatment.

  • Women aged 16 and over with a confirmed history of vaginal thrush
  • Those who prefer a multi-day intravaginal treatment over a single-dose pessary or oral capsule
  • Women who cannot take oral antifungal medicines (e.g. due to liver conditions or drug interactions)
  • Those experiencing mild to moderate thrush symptoms without signs of a more serious infection

 

How Does Canesten Pessary 100mg Compare to Other Thrush Treatments?

 

Feature Canesten Pessary 100mg (6-pack) Canesten Pessary 500mg (Single Dose)
Active ingredient Clotrimazole 100mg Clotrimazole 500mg
Treatment duration 6 nights 1 night
Route of administration Intravaginal Intravaginal
Suitable for pregnancy (2nd/3rd trimester) Under medical supervision Under medical supervision

 

Is Canesten Pessary 100mg Suitable During Pregnancy or Breastfeeding?

 

If you are pregnant, you should not use canesten pessary 100mg during the first trimester. In the second and third trimesters, it may be used under the guidance of a doctor or midwife. The applicator should be used with care during pregnancy to avoid any risk of injury. If you are breastfeeding, the medicine is considered unlikely to cause harm due to its minimal systemic absorption, but always check with your GP or pharmacist first. For other women's health products and treatments, visit our women's health collection.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Canesten Pessary 100mg - 6 Pessaries With Applicator specifications
Treatment category Antifungal / Vaginal thrush
Active ingredient Clotrimazole 100mg
Mechanism of action Inhibits ergosterol synthesis in fungal cell membranes
Effective against Candida albicans (vaginal thrush)
Suitable for Women aged 16 and over
Pack size 6 pessaries with applicator
Strength 100mg per pessary
UK classification Pharmacy (P) medicine
Drug class Azole antifungal
Preparation Pessary
Route of administration Intravaginal

Specifications of Canesten Pessary 100mg - 6 Pessaries With Applicator

 

What Is Canesten Pessary 100mg and What Is It Used For?

 

Canesten Pessary 100mg is an intravaginal antifungal medicine used to treat vaginal thrush (also known as vulvovaginal candidiasis). Each pessary contains 100mg of clotrimazole, which works locally inside the vagina to eliminate the Candida yeast responsible for the infection. The six-pessary course is designed to be used once nightly for six consecutive nights. It is available over the counter from pharmacies in the UK for women aged 16 and over who have previously had thrush confirmed by a doctor. You can find this product and related treatments in our dedicated thrush collection.

 

What Do You Need to Know Before Using Canesten Pessary 100mg?

 

Before using this product, read the following carefully. Do not use Canesten Pessary 100mg if any of the following apply to you:

  • You are under 16 years of age
  • You have never had vaginal thrush diagnosed by a doctor before
  • You are in the first trimester of pregnancy
  • You are allergic to clotrimazole or any other ingredient in the pessary
  • You have irregular vaginal bleeding or a blood-stained discharge not related to your period
  • You have vulval or vaginal sores, ulcers, or blisters
  • You have had more than two episodes of thrush in the last six months
  • Your partner has penile symptoms such as redness, irritation, or discharge

Speak to your doctor before use if you have a sexually transmitted infection, are immunocompromised, or have diabetes, as these conditions can increase the risk of recurrent thrush and may require a different treatment approach.

Drug interactions to be aware of:

  • Latex condoms and diaphragms — clotrimazole can weaken rubber and reduce contraceptive effectiveness; use an alternative method during treatment and for at least five days after
  • Tacrolimus — there is a potential interaction; seek medical advice before use
  • Warfarin — although systemic absorption is minimal, inform your doctor if you are taking anticoagulants

 

How Should You Use Canesten Pessary 100mg?

 

Always follow the instructions in the patient information leaflet supplied with your pack. The pessaries are for intravaginal use only — do not swallow them.

  1. Wash your hands thoroughly before handling the pessary and applicator
  2. Remove one pessary from the foil blister strip
  3. Place the pessary into the open end of the applicator
  4. Lie on your back with your knees bent and legs apart
  5. Gently insert the applicator as high as comfortably possible into the vagina
  6. Press the plunger slowly to release the pessary
  7. Withdraw the applicator carefully
  8. Wash the applicator with warm soapy water and allow to dry before reuse
  9. Wash your hands again after use
Indication Age Group Dose Frequency
Vaginal thrush Women aged 16 and over 1 pessary (100mg) Once nightly for 6 consecutive nights
Vaginal thrush Under 16 years Not suitable Not suitable — seek medical advice

 

What Are the Possible Side Effects of Canesten Pessary 100mg?

 

Like all medicines, canesten pessary 100mg can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the vaginal area.

Common side effects (may affect up to 1 in 10 people):

  • Vaginal burning or stinging shortly after insertion
  • Local itching or irritation in the vaginal area
  • Mild redness around the vagina

Less common side effects (may affect up to 1 in 100 people):

  • Abdominal discomfort or cramping
  • Vaginal discharge that differs from usual
  • Skin rash or peeling in the vaginal area

Stop using the pessaries and seek medical advice immediately if you experience signs of a serious allergic reaction, such as swelling of the face, lips, or throat, difficulty breathing, or a widespread skin rash. These reactions are rare but require prompt attention.

 

How Should You Store Canesten Pessary 100mg?

 

Correct storage helps maintain the effectiveness of the pessaries throughout the treatment course. For other intimate health and hygiene products, browse our condoms and sexual health collection.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and moisture
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the packaging
  • Do not store in the bathroom or near a heat source
  • Do not freeze

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Canesten Pessary 100mg online in the UK?

You can buy Canesten Pessary 100mg online from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £7.99. It is available without a prescription for women aged 16 and over who have previously had vaginal thrush diagnosed by a doctor. Browse our full thrush treatment range for additional options.

How does Canesten Pessary 100mg work in the body?

Canesten Pessary 100mg contains clotrimazole, an azole antifungal that disrupts the production of ergosterol — a vital component of the Candida fungal cell membrane. Without ergosterol, the cell membrane breaks down and the yeast cells die, clearing the infection. Because it acts locally inside the vagina, very little of the medicine enters the bloodstream.

How do I use Canesten Pessary 100mg step by step?

Wash your hands, place one pessary into the applicator, and lie on your back with knees bent. Insert the applicator as high as comfortably possible into the vagina and press the plunger to release the pessary, then withdraw the applicator and wash it with warm soapy water. Repeat this process once every night at bedtime for six consecutive nights.

What is the correct dose of Canesten Pessary 100mg?

The recommended dose is one 100mg pessary inserted into the vagina each night for six consecutive nights. Do not use more than one pessary per night or extend the course beyond six nights without speaking to a doctor. If symptoms have not resolved after completing the course, seek medical advice.

How long does Canesten Pessary 100mg take to work?

Many women notice an improvement in symptoms such as itching and soreness within one to three days of starting the six-night course. However, it is important to complete all six pessaries even if you feel better sooner, as stopping early can allow the infection to return. If there is no improvement after the full course, consult your GP.

What are the side effects of Canesten Pessary 100mg and how do I manage them?

The most common side effects are mild local irritation, burning, or itching in the vaginal area shortly after inserting the pessary — these usually settle quickly on their own. Less commonly, you may experience abdominal discomfort or a change in vaginal discharge. If you develop signs of a serious allergic reaction such as facial swelling or difficulty breathing, stop use immediately and seek emergency medical help.

Who is eligible to use Canesten Pessary 100mg without a prescription?

This product is suitable for women aged 16 and over who have previously had vaginal thrush diagnosed by a doctor and recognise the same symptoms returning. It is not suitable for girls under 16, women who have never had thrush confirmed by a doctor, or those who are in the first trimester of pregnancy. Women with recurrent thrush (more than two episodes in six months) should see their GP before self-treating.

Can I use Canesten Pessary 100mg during my period?

It is generally recommended to avoid starting treatment during your period, as menstrual flow may wash the pessary out of the vagina before it has time to work effectively. If your period starts during the course, you can continue using the pessaries but use a sanitary towel rather than a tampon. Speak to your pharmacist if you are unsure about timing.

Does Canesten Pessary 100mg affect condoms or contraception?

Yes — clotrimazole can damage latex and rubber contraceptives, including condoms, diaphragms, and cervical caps, making them less reliable. You should use an alternative method of contraception during the six-night treatment course and for at least five days after completing it. Non-latex condoms are not guaranteed to be unaffected, so barrier methods should be avoided during this period.

Can I use Canesten Pessary 100mg during pregnancy?

Canesten Pessary 100mg should not be used during the first trimester of pregnancy. In the second and third trimesters, it may be used under the supervision of a doctor or midwife, and the applicator should be inserted gently to avoid any risk of injury. Always consult your GP or midwife before using any medicine during pregnancy.

What happens if I miss a dose of Canesten Pessary 100mg?

If you forget to insert a pessary on one night, use it as soon as you remember — ideally the following night — and then continue the remaining pessaries on consecutive nights as normal. Do not insert two pessaries on the same night to make up for a missed dose. Completing the full six-night course is important for effective treatment.

What are the alternatives to Canesten Pessary 100mg for thrush?

Alternatives include a single-dose Canesten 500mg pessary, an oral fluconazole 150mg capsule (such as Canesten Oral), or a combination pack containing both a pessary and external cream for symptom relief. The best option depends on your symptoms, preferences, and medical history. You can explore related treatments in our women's health collection.

How long can I keep using Canesten Pessary 100mg if thrush keeps coming back?

If you experience more than two episodes of thrush within six months, you should see your GP rather than continuing to self-treat. Recurrent thrush may indicate an underlying condition such as diabetes or a weakened immune system that requires investigation. Your doctor can recommend a longer-term antifungal treatment plan if appropriate.

Is Canesten Pessary 100mg the same as Canesten cream?

No — Canesten Pessary 100mg is an intravaginal pessary designed to treat the internal fungal infection, while Canesten cream is applied externally to relieve itching and soreness around the vulva. Both contain clotrimazole but are formulated differently for different purposes. Many women use both together for complete symptom relief, and combination packs are available.

What is the latest guidance on treating vaginal thrush in the UK?

Current NHS guidance recommends intravaginal clotrimazole or oral fluconazole as first-line treatments for uncomplicated vaginal thrush in non-pregnant women. The NHS advises that women who have had thrush before and recognise the symptoms can self-treat with an over-the-counter product such as canesten pessary 100mg without needing to see a GP. Women with recurrent, severe, or atypical symptoms should always seek medical assessment.

How Should You Use Canesten Pessary 100mg?

Using Canesten Pessary 100mg correctly is important to ensure the clotrimazole reaches the site of infection and works as intended. Always read the patient information leaflet included in your pack before starting treatment, and wash your hands thoroughly before and after each use.

It is normal for a small amount of the pessary to leak from the vagina overnight. Wearing a panty liner can help protect your underwear during the treatment course.

What Is the Correct Dose of Canesten Pessary 100mg?

The standard recommended dose for adults and girls aged 16 and over is one pessary per night for six consecutive nights. Do not use more than one pessary in a single night, and do not extend the course beyond six nights without speaking to a doctor or pharmacist first.

When Is the Best Time to Use Canesten Pessary 100mg?

The pessaries should be inserted at bedtime each night. Using them just before you go to sleep means you will be lying down for several hours, which allows the pessary to dissolve fully and the clotrimazole to remain in contact with the vaginal walls for as long as possible. Inserting the pessary while upright or active may cause it to slide out before it has dissolved properly.

Try to use the pessary at roughly the same time each evening to maintain a consistent treatment routine across the six-night course.

How Long Can You Use Canesten Pessary 100mg For?

The full course is six nights. Most women find their symptoms begin to improve within the first two to three days, but it is essential to complete all six pessaries to ensure the infection is fully cleared and to reduce the risk of it returning. Do not stop early just because you feel better.

If your symptoms have not resolved after completing the full six-night course, or if they return within a short period, do not repeat the treatment without first speaking to your GP. Recurrent thrush — defined as two or more episodes within six months — requires medical assessment to rule out underlying causes.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Canesten Pessary 100mg?

Most women tolerate Canesten Pessary 100mg well, and side effects are generally mild and short-lived. The most frequently reported effects are localised to the vaginal area and tend to occur shortly after inserting the pessary.

  • Vaginal burning or stinging immediately after insertion
  • Itching or irritation inside the vagina or around the vulva
  • Mild redness or soreness in the vaginal area
  • Slight increase in vaginal discharge during the treatment course

These effects are usually temporary and settle on their own within a short time. They do not typically require you to stop treatment.

What Are the Less Common Side Effects of Canesten Pessary 100mg?

A smaller number of women may experience side effects that are less common but still worth being aware of. If any of the following persist or become bothersome, speak to your pharmacist or GP.

  • Abdominal discomfort or mild cramping
  • Pelvic pain or pressure
  • Skin peeling or flaking around the vaginal opening
  • Unusual vaginal discharge that differs from your normal pattern

These effects are not dangerous in most cases, but they can sometimes indicate that the product is not the right treatment for your symptoms — particularly if the discharge changes significantly in colour or smell.

What Are the Serious Side Effects of Canesten Pessary 100mg?

Serious side effects are rare with clotrimazole pessaries due to the minimal amount of medicine absorbed into the bloodstream. However, a small number of people may experience a hypersensitivity or allergic reaction. Stop using the pessaries immediately and seek urgent medical attention if you notice any of the following:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • A widespread skin rash, hives, or blistering
  • Dizziness or feeling faint

These symptoms may indicate anaphylaxis, which is a medical emergency requiring immediate treatment.

What Should You Do If You Experience Side Effects?

For mild local irritation, you may find it helpful to apply a small amount of Canesten external cream around the vulva to soothe discomfort — this is separate from the pessary and is applied to the skin only. If side effects are moderate or worsening, stop the course and speak to your pharmacist before continuing. Never ignore symptoms that feel unusual or significantly different from what you would expect from a thrush infection.

You should also see your GP if your symptoms do not improve after completing the full six-night course, or if they return quickly after treatment ends.

Can Canesten Pessary 100mg Interact With Other Medicines?

Because clotrimazole is absorbed in very small amounts from the vagina, systemic drug interactions are uncommon. However, there are a few important interactions to be aware of. Clotrimazole can degrade latex and rubber, meaning it may reduce the effectiveness of condoms, diaphragms, and cervical caps — use an alternative contraceptive method during treatment and for at least five days afterwards. There is also a potential interaction with tacrolimus (an immunosuppressant), and women taking warfarin should inform their doctor before using any antifungal treatment. Always tell your pharmacist about all medicines you are currently taking, including herbal remedies and supplements.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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