What is the difference between clotrimazole cream and miconazole cream?

Both are azole antifungals used to treat similar fungal infections. Clotrimazole is typically applied 2–3 times daily, while miconazole is often applied twice daily and also has some antibacterial activity.

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Clotrimazole Cream 1% 20g

✔️ Treats athlete's foot, ringworm, and fungal skin infections
✔️ Clinically proven antifungal active ingredient: clotrimazole 1%
✔️ Visible improvement often seen within a few days of use
✔️ Suitable for adults and children with fungal skin conditions
✔️ Compact 20g tube — easy to apply and carry anywhere

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What Is Clotrimazole Cream and How Does It Treat Fungal Infections?

Fungal skin infections are more common than you might think. Athlete's foot alone affects roughly 15–25% of people at some point in their lives, according to the NHS. Clotrimazole cream is a well-established, over-the-counter antifungal treatment that tackles a range of fungal skin conditions — from the itchy, flaking skin between your toes to ringworm and sweat rash. At just £2.49 for a 20g tube, it's an accessible and clinically proven option you can order directly from our athletes foot and fungal infections range.

The active ingredient, clotrimazole 1%, has been used in the UK for decades and is listed in the British National Formulary as a first-line topical antifungal. It's suitable for adults and children alike, and because it's available without a prescription, you don't need to wait for a GP appointment to start treatment.

How Does Clotrimazole Cream Work Against Fungal Infections?

Clotrimazole belongs to the azole class of antifungals. It works by targeting a substance called ergosterol, which is a key component of fungal cell membranes — a bit like the mortar holding bricks together. Without it, the membrane becomes leaky and the fungal cell can no longer survive.

Clotrimazole inhibits the enzyme lanosterol 14α-demethylase, which fungi need to produce ergosterol.
Without ergosterol, the fungal cell membrane loses its structural integrity.
The fungal cells leak their contents and die — a process called fungicidal activity at higher concentrations.
At lower concentrations, it slows fungal growth (fungistatic), allowing your immune system to clear the infection.

This mechanism is highly targeted to fungal cells, which is why clotrimazole cream has a good safety profile when applied to the skin.

Who Should Use Clotrimazole Cream 1%?

This cream is suitable for anyone experiencing a superficial fungal skin infection. It's particularly useful if you've been diagnosed with — or strongly suspect — one of the following conditions:

Athlete's foot (tinea pedis) — itching, scaling, or cracking between the toes or on the soles
Ringworm (tinea corporis) — circular, scaly patches on the body or scalp
Jock itch (tinea cruris) — a fungal rash in the groin area
Pityriasis versicolor — patches of discoloured skin caused by an overgrowth of skin yeast

It's also used for candidal skin infections (caused by Candida yeast), including intertrigo — the sore, red rash that can develop in skin folds. If you're unsure whether your symptoms are fungal in origin, speak to a pharmacist before starting treatment.

How Does Clotrimazole Cream Compare to Other Antifungal Creams?

Feature	Clotrimazole Cream 1%	Miconazole Cream 2%
Drug class	Azole antifungal	Azole antifungal
Application frequency	2–3 times daily	Twice daily
Antibacterial activity	No	Yes (some gram-positive bacteria)
Available OTC in UK	Yes	Yes

Is Clotrimazole Cream Safe to Store and Use Long Term?

Clotrimazole cream should be stored below 25°C, away from direct heat and sunlight. Keep the tube tightly closed when not in use, and always check the expiry date before applying. You can browse our full range of creams and ointments if you need additional topical treatments alongside this one.

Most fungal skin infections respond well within 2–4 weeks of consistent use. However, if your symptoms haven't improved after four weeks, or if they worsen at any point, stop using the cream and consult your GP. Prolonged use without medical supervision is not recommended.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Clotrimazole Cream 1% 20g specifications

Treatment category	Antifungal / Fungal skin infections
Mechanism of action	Inhibits ergosterol synthesis in fungal cell membranes
Effective against	Dermatophytes, Candida species, Malassezia furfur
Suitable for	Adults and children (seek pharmacist advice for infants)
Active ingredient	Clotrimazole 1% w/w
Pack size	20g
Strength	1%
UK classification	Pharmacy (P)
Drug class	Azole antifungal
Preparation	Topical cream
Route of administration	Topical (skin)

Specifications of Clotrimazole Cream 1% 20g

What Is Clotrimazole Cream 1% and What Is It Used For?

Clotrimazole cream 1% is a topical antifungal medicine used to treat infections of the skin caused by fungi and yeasts. It is licensed in the UK for the treatment of athlete's foot, ringworm, jock itch, pityriasis versicolor, and candidal skin infections. The NHS recommends clotrimazole as a first-line treatment for many of these conditions, and it is available over the counter without a prescription. You can find it alongside other treatments in our foot care collection.

What Do You Need to Know Before Using Clotrimazole Cream?

Before applying this cream, read the following carefully. There are certain situations where you should not use it, or where you should seek advice first.

Do not use clotrimazole cream if you:

Are allergic to clotrimazole or any other ingredient in the cream
Have a known hypersensitivity to other azole antifungals
Have broken, infected, or severely inflamed skin (seek GP advice first)

Speak to your pharmacist or GP before use if you:

Are pregnant or breastfeeding — topical use is generally considered low risk, but always seek advice
Are treating a child under 12 — parental supervision is recommended
Have diabetes — fungal infections can be more persistent and may need medical review
Have a weakened immune system, for example due to HIV or immunosuppressant medicines

Drug interactions:

Topical clotrimazole has no clinically significant interactions when used on the skin
If you are using latex condoms or diaphragms in the vaginal area, note that clotrimazole can weaken latex — this is more relevant to vaginal preparations, but worth noting

How Should You Use Clotrimazole Cream 1%?

Always follow the instructions in the patient information leaflet supplied with your product. The general guidance from the NHS is as follows:

Wash and thoroughly dry the affected area before applying the cream.
Squeeze a small amount of cream onto your fingertip — a thin layer is sufficient.
Gently rub the cream into the affected skin and the surrounding area.
Wash your hands after application, unless your hands are the area being treated.
Apply 2–3 times daily, or as directed by your pharmacist.
Continue treatment for the full recommended course, even if symptoms improve.

Indication	Age Group	Dose	Duration
Athlete's foot	Adults & children	Thin layer, 2–3 times daily	4 weeks
Ringworm / jock itch	Adults & children	Thin layer, 2–3 times daily	2–4 weeks
Candidal skin infection	Adults & children	Thin layer, 2–3 times daily	2–4 weeks
Pityriasis versicolor	Adults	Thin layer, 2–3 times daily	2–4 weeks

What Are the Possible Side Effects of Clotrimazole Cream?

Like all medicines, clotrimazole cream can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the area of application.

Common side effects:

Mild burning or stinging sensation after application
Itching at the application site
Skin redness or irritation

Less common side effects:

Blistering or peeling of the skin
Swelling or rash beyond the treated area
Skin dryness or flaking

Stop using the cream and seek medical advice immediately if you develop signs of a serious allergic reaction — this includes widespread rash, swelling of the face or throat, or difficulty breathing. These reactions are rare but require urgent attention. You can also explore our skin care range for complementary products to support skin recovery.

How Should You Store Clotrimazole Cream 1%?

Store below 25°C in a cool, dry place
Keep away from direct sunlight and heat sources
Keep the tube tightly closed when not in use
Keep out of the reach and sight of children
Do not use after the expiry date printed on the tube
Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacy

References

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Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy clotrimazole cream online in the UK?

You can buy clotrimazole cream 1% 20g directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £2.49. It is available without a prescription and can be ordered from our athletes foot and fungal infections collection. It is also stocked in most high street pharmacies across the UK.

How does clotrimazole cream work in the body?

Clotrimazole works by blocking an enzyme that fungi need to produce ergosterol, a vital component of their cell membranes. Without ergosterol, the fungal cell membrane breaks down and the organism can no longer survive or replicate. This targeted mechanism means it is effective against a wide range of fungi and yeasts without significantly affecting human cells.

How do I use clotrimazole cream step by step?

Start by washing and thoroughly drying the affected area. Apply a thin layer of cream to the infected skin and the surrounding area, rubbing it in gently 2–3 times a day. Always wash your hands after application unless your hands are the area being treated, and continue for the full recommended course.

How long does clotrimazole cream take to work?

Many people notice an improvement in symptoms — such as reduced itching and redness — within a few days of starting treatment. However, it is important to continue using the cream for the full 2–4 week course to ensure the infection is fully cleared. Stopping early can allow the fungus to return.

What is the correct dose of clotrimazole cream for athlete's foot?

For athlete's foot, apply a thin layer of clotrimazole cream 1% to the affected area 2–3 times daily. Treatment should continue for at least 4 weeks, even if symptoms resolve sooner. If there is no improvement after 4 weeks, consult your GP or pharmacist.

What are the side effects of clotrimazole cream?

The most common side effects are mild and include burning, stinging, or itching at the site of application. Less commonly, you may experience skin redness, blistering, or peeling. If you develop signs of a serious allergic reaction — such as widespread rash, facial swelling, or breathing difficulties — stop using the cream and seek urgent medical attention.

Can I use clotrimazole cream during pregnancy?

Topical clotrimazole cream is generally considered low risk during pregnancy when used on the skin, as very little is absorbed into the bloodstream. That said, you should always speak to your GP or pharmacist before using any medicine during pregnancy. They can confirm it is appropriate for your specific situation.

Is clotrimazole cream suitable for children?

Yes, clotrimazole cream can be used in children for fungal skin infections, but parental supervision is recommended. For infants and very young children, always seek advice from a pharmacist or GP before applying. The cream should be kept out of reach of children and never applied near the eyes or mouth.

What happens if I miss an application of clotrimazole cream?

If you forget to apply the cream at your usual time, apply it as soon as you remember and then continue with your regular schedule. Do not apply a double amount to make up for a missed application. Consistency is important — missing doses can slow your recovery and increase the risk of the infection returning.

How long can I use clotrimazole cream for?

Most fungal skin infections require 2–4 weeks of treatment with clotrimazole cream. You should not use it for longer than 4 weeks without seeking medical advice. If your symptoms persist or worsen after the recommended course, speak to your GP as you may need a different treatment or investigation for an underlying cause.

What are the alternatives to clotrimazole cream?

Other topical antifungal creams available over the counter in the UK include miconazole, terbinafine, and ketoconazole. Terbinafine is often preferred for athlete's foot as it may require a shorter treatment course. Your pharmacist can help you choose the most appropriate option based on your specific infection and medical history.

Can clotrimazole cream be used for thrush?

Clotrimazole is used to treat candidal (thrush) infections of the skin, such as intertrigo in skin folds. For vaginal thrush, there are specific clotrimazole vaginal preparations (pessaries and vaginal cream) that are more appropriate. You can browse dedicated treatments in our thrush collection for vaginal thrush options.

Who is eligible to buy clotrimazole cream without a prescription?

Clotrimazole cream 1% is classified as a Pharmacy (P) medicine in the UK, meaning most adults can purchase it without a prescription. It is suitable for adults and children, though a pharmacist should be consulted for use in infants or people with complex medical histories. It is not suitable for people with known hypersensitivity to clotrimazole or other azole antifungals.

What are the latest studies on clotrimazole cream for athlete's foot?

Clotrimazole has been extensively studied since the 1970s and remains a recommended first-line treatment for tinea pedis (athlete's foot) in current NHS and BNF guidance. Clinical evidence consistently supports its efficacy against dermatophyte fungi, with cure rates comparable to other azole antifungals. No major new safety concerns have emerged from recent literature reviews.

Can I use clotrimazole cream on my face?

Clotrimazole cream can be used on facial fungal infections such as ringworm, but you should avoid contact with the eyes, mouth, and mucous membranes. If you are treating a facial infection, it is advisable to speak to a pharmacist or GP first to confirm the diagnosis and ensure this is the most appropriate treatment. Apply carefully and use only a thin layer.

How Should You Use Clotrimazole Cream 1% 20g?

Before applying clotrimazole cream, always wash the affected area with mild soap and water, then pat it completely dry. Fungi thrive in warm, moist environments, so keeping the skin dry is just as important as the treatment itself.

Avoid getting the cream in your eyes, mouth, or on mucous membranes. If accidental contact occurs, rinse thoroughly with water.

What Is the Correct Dose of Clotrimazole Cream 1% 20g?

The dose does not vary significantly by age for topical use, but the duration of treatment may differ depending on the type of infection being treated. Always use the smallest amount needed to cover the affected area — more cream does not mean faster results.

When Is the Best Time to Use Clotrimazole Cream?

There is no single "best" time of day, but spacing your applications evenly helps maintain consistent antifungal activity on the skin. A practical routine is to apply the cream in the morning, at midday or after work, and again before bed. Applying it after bathing — once the skin is fully dry — is particularly effective, as the cream can penetrate the skin more easily when pores are clean and open.

If you are treating athlete's foot, applying the cream after removing socks and shoes and drying between your toes thoroughly is especially important. Wearing breathable, moisture-wicking socks can also help speed up recovery.

How Long Can You Use Clotrimazole Cream For?

Treatment duration depends on the type and severity of the infection. Athlete's foot typically requires a full 4-week course, while other fungal skin infections may clear within 2–3 weeks. It is essential to complete the full course even if your symptoms disappear earlier — stopping too soon is one of the most common reasons fungal infections return.

Do not use clotrimazole cream for longer than 4 weeks without seeking medical advice. If your symptoms have not improved after the recommended course, consult your GP, as you may need a different treatment or further investigation.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Clotrimazole Cream?

Most people tolerate clotrimazole cream well, and side effects are generally mild and short-lived. They tend to occur at the site of application rather than affecting the whole body, since very little of the active ingredient is absorbed through the skin into the bloodstream.

Mild burning or stinging sensation immediately after application
Itching at the treated area
Skin redness or irritation
Slight warmth or tingling on the skin

These reactions are usually temporary and settle within a few minutes of applying the cream. If they persist or worsen, stop using the product and speak to your pharmacist.

What Are the Less Common Side Effects of Clotrimazole Cream?

Less frequently, some people experience more noticeable skin reactions. These are still generally localised to the application area and are not usually a sign of a serious problem, but they do warrant attention.

Blistering or peeling of the skin
Skin dryness or flaking beyond the infected area
Swelling or rash at or near the application site
Skin discolouration in the treated area

If any of these occur, discontinue use and consult a pharmacist or GP. They can advise whether you should switch to an alternative antifungal or whether the reaction needs further assessment.

What Are the Serious Side Effects of Clotrimazole Cream?

Serious side effects from topical clotrimazole are rare, but they can occur. The most significant concern is a hypersensitivity or allergic reaction. This is more likely in people who have a known allergy to clotrimazole or other azole antifungals, though it can occasionally occur in people with no prior history of allergy.

Signs of a serious allergic reaction include widespread skin rash or hives, swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing, and dizziness or feeling faint. If you experience any of these symptoms, stop using the cream immediately and call 999 or go to your nearest A&E department.

What Should You Do If You Experience Side Effects?

For mild side effects such as temporary stinging or redness, you can usually continue treatment and monitor whether the reaction settles. Applying the cream to clean, dry skin and using only a thin layer can help minimise irritation. If the side effect is persistent, worsening, or causing significant discomfort, stop using the cream and seek advice from a pharmacist.

You can report suspected side effects of any medicine in the UK through the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk. This helps regulators monitor the safety of medicines in real-world use.

Can Clotrimazole Cream Interact With Other Medicines?

Topical clotrimazole cream has no clinically significant interactions with other medicines when used on the skin, as systemic absorption is minimal. However, if you are using other topical products on the same area — such as steroid creams or emollients — speak to your pharmacist about the correct order of application and whether combining them is appropriate.

It is worth noting that clotrimazole can degrade latex. While this is primarily relevant to vaginal preparations, it is good practice to be aware of this if you are using the cream near areas where latex products may be used. Always inform your pharmacist of all medicines and topical products you are currently using.

If you are concerned about any side effects, contact your pharmacist or GP immediately.