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Calpol SixPlus Sugar Free 5ml - 12 Sachets

Calpol SixPlus Sugar Free 5ml - 12 Sachets

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  • ✔️ Relieves fever and mild to moderate pain in children aged 6+
  • ✔️ Paracetamol 250mg/5ml starts working within 30 minutes
  • ✔️ Sugar-free formula suitable for children managing sugar intake
  • ✔️ Pre-measured 5ml sachets — no spoon or syringe needed
  • ✔️ Each pack contains 12 individual sachets for convenient dosing

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What Are Calpol SixPlus Sugar Free Sachets?

 

When your child has a fever or is in pain, you want something that works quickly and that you can trust. Calpol SixPlus sugar free sachets are a convenient, pre-measured oral suspension of paracetamol 250mg per 5ml, designed specifically for children aged 6 years and over. Each sachet contains exactly 5ml — no measuring required, which makes dosing straightforward whether you're at home or on the go. At just £4.39 for 12 sachets, it's an accessible option for parents managing everyday childhood illnesses. You can find this product alongside other trusted remedies in our baby and toddler collection.

Paracetamol has been used safely in children for decades and remains one of the most widely recommended medicines for childhood fever and mild to moderate pain. The sugar-free formulation is particularly useful for children who need to limit their sugar intake, or for those who simply prefer a less sweet taste. Each sachet is individually sealed, making it hygienic and easy to carry in a school bag or changing bag.

 

How Does Calpol SixPlus Work to Relieve Fever and Pain?

 

Paracetamol — the active ingredient in Calpol SixPlus — works centrally in the brain and nervous system. It is thought to inhibit the synthesis of prostaglandins, which are chemical messengers involved in triggering both pain signals and the rise in body temperature associated with fever. The result is a reduction in temperature and a lessening of pain perception, without the anti-inflammatory action you'd find in ibuprofen.

  • Paracetamol is absorbed through the gastrointestinal tract after swallowing.
  • It reaches peak plasma concentration within 30 to 60 minutes in most children.
  • It acts on the hypothalamus to help regulate and reduce elevated body temperature.
  • Pain relief typically begins within 30 minutes and can last up to 6 hours.

 

Who Is Calpol SixPlus Suitable For?

 

This product is intended for children aged 6 years and over. It is not suitable for children under 6 — for younger children, Calpol Infant Suspension (120mg/5ml) is the appropriate choice. Calpol SixPlus is suitable for managing a range of common childhood complaints, including:

  • Fever, including fever following vaccinations
  • Headache and mild to moderate pain
  • Sore throat and cold symptoms
  • Toothache and earache
  • Aches and pains associated with cold and flu

Children with known hypersensitivity to paracetamol or any of the excipients should not use this product. It should also be used with caution in children with liver or kidney problems. If your child has a long-term health condition, always check with your pharmacist or GP before use. For broader cold and flu support, you may also want to browse our cold and flu range.

 

How Does Calpol SixPlus Compare to Calpol Infant Suspension?

 

Feature Calpol SixPlus Sugar Free Sachets Calpol Infant Suspension
Active ingredient strength Paracetamol 250mg/5ml Paracetamol 120mg/5ml
Suitable age range 6 years and over 2 months to 6 years
Sugar free Yes Available in sugar-free version
Format Pre-measured 5ml sachets Bottle with measuring syringe

 

How Should You Store Calpol SixPlus Sachets?

 

Store Calpol SixPlus sugar free sachets below 25°C in a dry place, away from direct sunlight and moisture. Do not refrigerate. Always keep medicines out of the reach and sight of children — ideally in a locked medicine cabinet. Check the expiry date printed on each sachet before use, and do not use any sachet that appears damaged or has been previously opened.

Once a sachet is opened, the contents should be used immediately and any unused portion discarded. Do not store an opened sachet for later use. If you are unsure whether this product is right for your child, speak to your pharmacist before administering.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Calpol SixPlus Sugar Free 5ml - 12 Sachets specifications
Treatment category Analgesic / Antipyretic
Mechanism of action Inhibits prostaglandin synthesis; reduces fever and pain centrally
Effective for Fever, headache, sore throat, toothache, cold and flu symptoms
Suitable for Children aged 6 years and over
Active ingredient Paracetamol 250mg per 5ml
Pack size 12 sachets × 5ml
Strength 250mg/5ml
UK classification General Sale List (GSL)
Drug class Paracetamol (analgesic/antipyretic)
Preparation Oral suspension (sachet)
Route of administration Oral

Specifications of Calpol SixPlus Sugar Free 5ml - 12 Sachets

 

What Is Calpol SixPlus Sugar Free and What Is It Used For?

 

Calpol SixPlus Sugar Free 5ml sachets contain paracetamol 250mg per 5ml as the active ingredient. Paracetamol is a well-established analgesic (painkiller) and antipyretic (fever reducer) that has been used in children for many years. This product is used to relieve mild to moderate pain and to reduce fever in children aged 6 years and over. Common conditions it is used for include headache, sore throat, toothache, earache, and the aches and pains associated with colds and flu. It may also be used to manage fever following childhood vaccinations, under appropriate guidance.

 

What Do You Need to Know Before Using Calpol SixPlus?

 

Before giving this medicine to your child, read the following carefully. There are situations where Calpol SixPlus should not be used, and others where extra care is needed.

Do not use Calpol SixPlus if your child:

  • Is under 6 years of age
  • Is allergic to paracetamol or any other ingredient in the product
  • Is already taking another medicine containing paracetamol
  • Has severe liver disease

Use with caution and speak to a pharmacist or GP if your child:

  • Has liver or kidney problems
  • Is underweight or malnourished
  • Has phenylketonuria (this product contains aspartame)
  • Is taking regular prescribed medicines

Known drug interactions to be aware of:

  • Warfarin and other anticoagulants — regular paracetamol use may enhance anticoagulant effect
  • Other paracetamol-containing products — concurrent use risks overdose
  • Metoclopramide and domperidone — may increase the rate of paracetamol absorption
  • Cholestyramine — may reduce paracetamol absorption if taken within one hour

 

How Should You Use Calpol SixPlus Correctly?

 

Always use Calpol SixPlus exactly as described in the patient information leaflet or as directed by your pharmacist. The oral suspension is ready to use — simply tear open the sachet and administer the contents directly into your child's mouth or mix with a small amount of water if preferred.

  1. Check the expiry date on the sachet before use.
  2. Tear open the sachet along the perforated edge.
  3. Administer the full 5ml contents directly into your child's mouth.
  4. Alternatively, mix with a small amount of cool water or soft food.
  5. Discard any unused portion — do not save an opened sachet.
  6. Note the time of the dose and do not repeat for at least 4 hours.
  7. Do not give more than 4 doses in any 24-hour period.
Age Group Dose Frequency Max in 24 hours
6–9 years 5ml (1 sachet) Every 4–6 hours 4 doses
10–12 years 5ml–10ml (1–2 sachets) Every 4–6 hours 4 doses
Under 6 years Not suitable

If your child's symptoms do not improve within 3 days, or if they worsen at any point, stop use and consult a GP. For children managing pain alongside other symptoms, our pain relief collection includes a range of additional options suitable for different ages and needs.

 

What Are the Possible Side Effects of Calpol SixPlus?

 

Paracetamol is generally very well tolerated in children when used at the correct dose. However, as with all medicines, side effects are possible. If your child experiences any serious reaction, stop use immediately and seek medical advice.

Common side effects:

  • Nausea
  • Stomach discomfort

Less common side effects:

  • Skin rash or itching
  • Flushing
  • Low blood pressure (hypotension) — rare, associated with intravenous use, not oral
  • Blood disorders — extremely rare with short-term oral use

Serious allergic reactions (anaphylaxis) are very rare but require immediate emergency medical attention. Signs include swelling of the face, lips, or throat, difficulty breathing, or a sudden rash. If you suspect an overdose — even if your child appears well — go to A&E immediately, as paracetamol overdose can cause delayed liver damage.

 

How Should You Store Calpol SixPlus Sachets Safely?

 

  • Store below 25°C in a dry place away from direct sunlight.
  • Do not refrigerate or freeze.
  • Keep all medicines out of the reach and sight of children.
  • Do not use after the expiry date printed on the sachet.
  • Once opened, use immediately and discard any remaining contents.
  • Do not dispose of medicines via wastewater or household waste — return unused sachets to your pharmacy.

If you need further guidance on managing your child's health at home, our first aid collection has a range of useful products to keep on hand for everyday family health needs.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Calpol SixPlus Sugar Free sachets online in the UK?

You can buy Calpol SixPlus Sugar Free 5ml sachets directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for £4.39 per pack of 12. They are also available from most high street pharmacies and supermarkets without a prescription. Buying online is convenient and means you can have them delivered before you need them, rather than waiting until your child is already unwell.

How does Calpol SixPlus work in the body?

Calpol SixPlus contains paracetamol, which works by inhibiting the production of prostaglandins — chemical messengers in the brain that trigger pain and raise body temperature. It acts on the central nervous system rather than at the site of inflammation, which is why it reduces fever and pain but does not have anti-inflammatory properties like ibuprofen. Effects typically begin within 30 minutes of taking the dose.

What age is Calpol SixPlus suitable for?

Calpol SixPlus is suitable for children aged 6 years and over only. It should never be given to children under 6, as the paracetamol concentration (250mg/5ml) is higher than that found in infant formulations. For children aged 2 months to 6 years, Calpol Infant Suspension at 120mg/5ml is the appropriate product.

How often can I give my child Calpol SixPlus sachets?

You can give Calpol SixPlus every 4 to 6 hours as needed, but you must leave at least 4 hours between doses. No more than 4 doses should be given in any 24-hour period. If your child still has a fever or pain after 3 days of use, stop and consult a GP or pharmacist.

Is Calpol SixPlus really sugar free and why does it matter?

Yes, Calpol SixPlus Sugar Free sachets contain no sucrose or glucose and are sweetened with alternative sweeteners including aspartame. This matters for children who need to manage their sugar intake, such as those with diabetes or dental concerns. However, because it contains aspartame, it is not suitable for children with phenylketonuria (PKU).

Can I give Calpol SixPlus alongside other medicines?

You must not give Calpol SixPlus at the same time as any other product containing paracetamol, including many cold and flu remedies, as this can lead to accidental overdose. If your child is taking warfarin or any other regular prescribed medicine, speak to a pharmacist before use. Always check the ingredients of any other medicine you are giving your child at the same time.

What should I do if my child accidentally takes too much Calpol SixPlus?

If you think your child has taken more than the recommended dose, go to your nearest A&E or call 999 immediately — even if they appear well. Paracetamol overdose can cause serious and potentially fatal liver damage that may not show symptoms for 24 to 72 hours. Do not wait for symptoms to appear before seeking help.

How do I use Calpol SixPlus sachets step by step?

Tear open the sachet along the perforated edge and administer the full 5ml contents directly into your child's mouth. If your child prefers, you can mix the contents with a small amount of cool water or soft food. Always use the full sachet and discard any opened sachet that has not been used immediately — do not save it for later.

What are the side effects of Calpol SixPlus I should watch for?

Calpol SixPlus is generally well tolerated, but possible side effects include nausea, stomach discomfort, and occasionally a skin rash or itching. Serious allergic reactions are very rare but require immediate medical attention — signs include facial swelling, difficulty breathing, or a sudden widespread rash. If you notice any unusual reaction after giving this medicine, stop use and seek advice from a pharmacist or GP.

Can Calpol SixPlus be used for fever after vaccinations?

Yes, paracetamol can be used to manage fever and discomfort following childhood vaccinations in children aged 6 and over. The NHS advises that paracetamol is appropriate for post-vaccination fever when given at the correct dose. Always follow the dosage instructions on the pack and consult your GP or practice nurse if you have any concerns about your child's reaction to a vaccine.

What are the alternatives to Calpol SixPlus for children?

The main alternative to paracetamol-based products for children aged 6 and over is ibuprofen suspension, which also reduces fever and relieves pain but additionally has anti-inflammatory properties. Ibuprofen is not suitable for all children, particularly those with asthma, kidney problems, or stomach issues. You can explore further options in our baby and toddler collection, or speak to your pharmacist for personalised advice.

How long can my child keep taking Calpol SixPlus?

Calpol SixPlus is intended for short-term use only. For pain relief, it should not be used for more than 3 days without consulting a GP. For fever, if symptoms have not improved within 3 days, medical advice should be sought. Long-term or regular use of paracetamol in children should only be undertaken under medical supervision.

Is Calpol SixPlus suitable for children with asthma?

Paracetamol is generally considered safer than ibuprofen for children with asthma, as ibuprofen can trigger bronchospasm in some asthmatic children. However, a small number of children with asthma may be sensitive to paracetamol too. If your child has asthma or any other respiratory condition, speak to your GP or pharmacist before use.

What is the latest guidance on using paracetamol in children?

Current NHS and NICE guidance supports the use of paracetamol as a first-line treatment for mild to moderate pain and fever in children, at the lowest effective dose for the shortest necessary duration. Routine use of paracetamol solely to prevent post-vaccination fever is no longer recommended by the NHS, though it remains appropriate to treat fever once it occurs. Always follow up-to-date guidance from your GP or pharmacist. You can also browse our ear, nose and throat range for products that support related childhood symptoms.

Does Calpol SixPlus contain any allergens or artificial colours?

Calpol SixPlus Sugar Free sachets do not contain sucrose, glucose, or artificial colours such as tartrazine. They do contain aspartame (a source of phenylalanine), which means they are not suitable for children with phenylketonuria. If your child has known food allergies or intolerances, check the full list of excipients on the product packaging or patient information leaflet before use.

How Should You Use Calpol SixPlus Sugar Free Sachets?

Calpol SixPlus Sugar Free sachets are designed to be simple to use, with no measuring required. Each sachet contains exactly 5ml of oral suspension, ready to administer. Always read the patient information leaflet before use and follow the steps below carefully.

Using the product correctly ensures your child receives the right dose at the right time, reducing the risk of under- or over-dosing.

What Is the Correct Dose of Calpol SixPlus?

The correct dose depends on your child's age. Always use the lowest effective dose for the shortest time needed. Do not give more than 4 doses in any 24-hour period, and always leave at least 4 hours between doses.

When Is the Best Time to Use Calpol SixPlus?

Give Calpol SixPlus as soon as your child develops a fever or begins to experience pain, rather than waiting for symptoms to worsen. There is no specific time of day that is better than another — the key is to space doses at least 4 hours apart and not to exceed 4 doses in 24 hours.

If your child wakes in the night with a fever, it is appropriate to give a dose at that time, provided the required interval since the last dose has passed. Keeping a note of dose times can help you avoid accidental double-dosing, particularly if more than one carer is involved.

How Long Can You Use Calpol SixPlus For?

Calpol SixPlus is intended for short-term use only. For pain relief, do not use for more than 3 consecutive days without seeking medical advice. For fever, if your child's temperature has not improved within 3 days, or if symptoms worsen at any point, stop use and consult a GP.

Prolonged or regular use of paracetamol in children should only take place under medical supervision. If your child frequently requires pain relief or fever management, speak to your GP to identify any underlying cause that may need treatment.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Calpol SixPlus?

Paracetamol is one of the most widely used medicines for children and is generally very well tolerated when taken at the correct dose. Serious side effects are uncommon, but as with any medicine, some children may experience unwanted effects.

  • Nausea or feeling sick
  • Stomach discomfort or abdominal pain
  • Diarrhoea (uncommon)

What Are the Less Common Side Effects of Calpol SixPlus?

Less common side effects are rare but worth being aware of. If your child develops any of the following, stop use and speak to a pharmacist or GP.

  • Skin rash or hives (urticaria)
  • Itching (pruritus)
  • Flushing of the skin
  • Headache (paradoxical, with overuse)
  • Malaise or general feeling of being unwell

What Are the Serious Side Effects of Calpol SixPlus?

Serious side effects from paracetamol at therapeutic doses are very rare. However, they can occur and require immediate medical attention. The most significant risk is liver damage, which is associated with overdose rather than correct use — but it is important to be aware of the signs.

A severe allergic reaction (anaphylaxis) is extremely rare but constitutes a medical emergency. Signs include sudden swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing, a rapid heartbeat, dizziness, or a widespread skin rash. If any of these occur, call 999 immediately. Blood disorders such as thrombocytopenia (low platelet count) have been reported in very rare cases with long-term use.

What Should You Do If Your Child Experiences Side Effects?

For mild side effects such as nausea or stomach discomfort, try giving the dose with a small amount of food or water. If the side effect persists or your child seems distressed, stop use and consult a pharmacist. Do not give a further dose until you have sought advice.

For any sign of an allergic reaction — however mild — stop use immediately and seek medical advice. If the reaction appears severe or is progressing rapidly, call 999 without delay. Always report suspected side effects to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Calpol SixPlus Interact With Other Medicines?

Yes, paracetamol can interact with certain other medicines. The most important interaction to be aware of is with other products containing paracetamol — giving two paracetamol-containing products at the same time can lead to accidental overdose, even if each product is within its own recommended dose. Always check the ingredients of any other medicine your child is taking.

Warfarin and other anticoagulants may be affected by regular paracetamol use, potentially increasing the risk of bleeding. Metoclopramide and domperidone can increase the speed at which paracetamol is absorbed. Cholestyramine may reduce absorption if taken within one hour of paracetamol. If your child is taking any prescribed medicines, always check with your pharmacist before giving Calpol SixPlus.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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