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Calpol SixPlus Fastmelts - 12 Pack

Calpol SixPlus Fastmelts - 12 Pack

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  • ✔️ Relieves mild to moderate pain in children aged 6 to 12
  • ✔️ Reduces fever quickly with 250mg paracetamol per tablet
  • ✔️ Dissolves on the tongue — no water or spoon needed
  • ✔️ Sugar-free formula suitable for children with dental concerns
  • ✔️ Convenient 12-pack ideal for home medicine cabinets

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What Are Calpol SixPlus Fastmelts and How Do They Help?

 

When your child is unwell with a fever or aching from a cold, getting medicine into them quickly can feel like a battle. Calpol SixPlus Fastmelts offer a genuinely practical solution — a strawberry-flavoured dissolving tablet that melts on the tongue without needing water or the usual struggle with spoons of liquid. Each pack contains 12 tablets, making it a handy option to keep in the medicine cabinet at home or to take out with you. Available from our baby and toddler range, these tablets are designed specifically for children aged 6 years and over.

Each tablet contains 250mg of paracetamol, a well-established analgesic and antipyretic used widely in children's medicine across the UK. Paracetamol has a long safety record when used at the correct dose, and the NHS recommends it as a first-line option for managing mild to moderate pain and fever in children.

 

How Does Paracetamol in Calpol SixPlus Fastmelts Work?

 

Paracetamol works primarily in the central nervous system. It inhibits the synthesis of prostaglandins — chemical messengers that sensitise pain receptors and contribute to the rise in body temperature during illness. By reducing prostaglandin activity in the brain, paracetamol both lowers fever and dulls the perception of pain.

  • Blocks prostaglandin production in the brain and spinal cord
  • Reduces elevated body temperature (antipyretic effect)
  • Decreases the sensation of mild to moderate pain (analgesic effect)
  • Dissolving format allows rapid absorption via the oral mucosa and gastrointestinal tract

The fastmelt format is not just about convenience. Because the tablet dissolves quickly on the tongue, it may be absorbed slightly faster than a standard swallowed tablet, which can be helpful when your child is distressed and you need relief to begin promptly.

 

Who Is Calpol SixPlus Fastmelts Suitable For?

 

These tablets are intended for children aged 6 to 12 years. They are particularly useful for children who find it difficult to swallow tablets or who refuse liquid medicines. That said, they are not appropriate for every child — always check the full list of contraindications before use.

  • Children aged 6 to 12 years with mild to moderate pain (e.g. headache, toothache, sore throat)
  • Children with a fever caused by cold, flu, or post-vaccination reactions
  • Children who struggle to swallow conventional tablets or capsules
  • Children who dislike the taste or texture of liquid paracetamol suspensions

They are not suitable for children under 6 years, children with phenylketonuria (due to aspartame content), or those with known hypersensitivity to paracetamol. If your child has liver or kidney problems, speak to your GP or pharmacist before use.

 

How Do Calpol SixPlus Fastmelts Compare to Calpol Six Plus Suspension?

 

Feature Calpol SixPlus Fastmelts Calpol Six Plus Suspension
Active ingredient Paracetamol 250mg per tablet Paracetamol 250mg per 5ml
Format Dissolving oral tablet Oral liquid suspension
Water needed? No No (but measuring spoon required)
Suitable for phenylketonuria? No (contains aspartame) Check individual product label
Age range 6–12 years 6–12 years

 

How Should Calpol SixPlus Fastmelts Be Stored?

 

Store Calpol SixPlus Fastmelts below 25°C in a dry place, away from direct sunlight and moisture. Keep the pack tightly closed when not in use. As with all medicines, store out of the sight and reach of children — even though these tablets are flavoured and child-friendly in format, accidental ingestion of multiple tablets can cause serious harm.

Check the expiry date printed on the packaging before each use. Do not use the tablets if the packaging is damaged or if the tablets appear discoloured or broken. If you need to browse further options for managing your child's symptoms, our cold and flu collection includes a range of suitable products.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Calpol SixPlus Fastmelts 12 Pack specifications
Treatment category Children's pain relief and fever management
Active ingredient Paracetamol 250mg per tablet
Mechanism of action Prostaglandin synthesis inhibitor (central)
Suitable for Children aged 6 to 12 years
Pack size 12 tablets
Strength 250mg paracetamol per tablet
UK classification General Sale List (GSL)
Drug class Analgesic / Antipyretic
Preparation Orodispersible tablet (fastmelt)
Route of administration Oral

Specifications of Calpol SixPlus Fastmelts 12 Pack

 

What Is Calpol SixPlus Fastmelts and What Is It Used For?

 

Calpol SixPlus Fastmelts are orodispersible paracetamol tablets containing 250mg of paracetamol each. They are used to relieve mild to moderate pain in children aged 6 to 12 years — including headaches, toothache, sore throats, and the aches associated with colds and flu. They are also used to reduce fever, including fever following childhood vaccinations. The NHS recommends paracetamol as a first-line treatment for pain and fever in children when used at the correct dose.

 

What Do You Need to Know Before Using Calpol SixPlus Fastmelts?

 

Do not give these tablets to your child if any of the following apply:

  • Your child is under 6 years of age
  • Your child has a known allergy or hypersensitivity to paracetamol or any other ingredient in the tablet
  • Your child has been diagnosed with phenylketonuria — the tablets contain aspartame, a source of phenylalanine
  • Your child has severe liver or kidney disease

Speak to your pharmacist or GP before use if your child has liver problems, kidney problems, or is malnourished, as these conditions can affect how paracetamol is processed in the body.

Be aware of the following potential drug interactions:

  • Do not use alongside other paracetamol-containing products (e.g. cold and flu remedies, other pain relief syrups) — this risks paracetamol overdose
  • Paracetamol may enhance the anticoagulant effect of warfarin with regular use — seek medical advice if your child takes warfarin
  • Medicines that speed up or slow down stomach emptying (e.g. metoclopramide) may affect how quickly paracetamol is absorbed

 

How Should You Use Calpol SixPlus Fastmelts?

 

Always follow the dosage instructions on the packaging or as directed by your pharmacist. The tablets are designed to dissolve on the tongue — no water is required. If you are also managing other symptoms such as a runny nose or congestion, you may find our ear, nose and throat collection helpful for complementary products.

  1. Check the child's age and weight to confirm the correct dose
  2. Place the tablet on the child's tongue
  3. Allow the tablet to dissolve fully — do not chew or swallow whole
  4. No water is needed, but a small sip can be offered if preferred
  5. Note the time of the dose and do not repeat within 4 hours
  6. Do not give more than 4 doses in any 24-hour period
Age Group Number of Tablets per Dose Paracetamol per Dose Maximum Doses per 24 Hours
6–9 years 2 tablets 500mg 4
10–12 years 2–4 tablets 500mg–1000mg 4

 

What Are the Possible Side Effects of Calpol SixPlus Fastmelts?

 

Paracetamol is generally very well tolerated in children when used at the recommended dose. Side effects are uncommon, but you should be aware of the following:

Common side effects (may affect up to 1 in 10 children):

  • Nausea
  • Stomach discomfort

Less common or rare side effects:

  • Skin rash or itching — stop use immediately if this occurs
  • Low blood pressure (hypotension) — particularly with intravenous paracetamol, but rarely reported with oral use
  • Blood disorders such as thrombocytopenia (low platelet count) — very rare
  • Serious liver damage — only in cases of overdose; seek emergency help immediately if overdose is suspected

If your child develops any unexpected symptoms after taking these tablets, stop use and contact your GP or pharmacist. In the event of a suspected overdose, go to your nearest A&E immediately, even if your child appears well — paracetamol overdose symptoms can be delayed.

 

How Should You Store Calpol SixPlus Fastmelts?

 

  • Store below 25°C in a dry place
  • Keep away from direct sunlight and moisture
  • Keep the blister pack sealed until use
  • Store out of the sight and reach of children
  • Do not use after the expiry date printed on the packaging
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

If you are looking for additional support products for your child's health, our vitamins and supplements collection includes options to support immune health in children.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Calpol SixPlus Fastmelts online in the UK?

You can buy Calpol SixPlus Fastmelts directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £5.99 per 12-pack. No prescription is needed as they are a General Sale List medicine. Simply add to your basket and choose your preferred delivery option at checkout.

How do Calpol SixPlus Fastmelts work in the body?

Each tablet contains 250mg of paracetamol, which works by inhibiting prostaglandin synthesis in the central nervous system. This reduces the brain's response to pain signals and lowers elevated body temperature. The dissolving format means the tablet begins to break down on the tongue immediately, allowing absorption to start quickly.

How do I give Calpol SixPlus Fastmelts to my child step by step?

Place the correct number of tablets on your child's tongue and ask them to let the tablets dissolve — no water is needed, though a small sip is fine if preferred. Check the age-appropriate dose on the packaging before each use, and record the time of each dose to avoid giving it too soon. Do not give more than 4 doses in any 24-hour period.

What is the correct dose of Calpol SixPlus Fastmelts for a 7-year-old?

For children aged 6 to 9 years, the recommended dose is 2 tablets (500mg paracetamol) per dose. This can be repeated every 4 to 6 hours as needed, but no more than 4 times in 24 hours. Always confirm the dose with the packaging instructions or ask your pharmacist if you are unsure.

Can I give Calpol SixPlus Fastmelts with Nurofen for Children?

Paracetamol and ibuprofen (the active ingredient in Nurofen for Children) can sometimes be used together or alternated under medical guidance, as they work via different mechanisms. However, you should always consult your pharmacist or GP before combining medicines in children. Never give two paracetamol-containing products at the same time.

What are the side effects of Calpol SixPlus Fastmelts?

Side effects are uncommon at the recommended dose. Occasionally, children may experience mild nausea or stomach discomfort. Rarely, a skin rash may occur — if this happens, stop use immediately and seek medical advice. Paracetamol overdose can cause serious liver damage, so always keep medicines out of children's reach.

Are Calpol SixPlus Fastmelts suitable for children with phenylketonuria?

No — Calpol SixPlus Fastmelts contain aspartame, which is a source of phenylalanine and is therefore not suitable for children with phenylketonuria (PKU). If your child has PKU, speak to your GP or pharmacist about a suitable alternative paracetamol product. There are aspartame-free paracetamol suspensions available for children.

Can I give Calpol SixPlus Fastmelts alongside cold and flu remedies?

You should check the ingredients of any cold and flu remedy carefully before combining it with Calpol SixPlus Fastmelts, as many contain paracetamol. Giving two paracetamol-containing products together risks exceeding the safe daily dose. Browse our cold and flu collection for products that can be used safely alongside paracetamol.

How long can my child take Calpol SixPlus Fastmelts for?

Calpol SixPlus Fastmelts should not be used for more than 3 consecutive days without consulting a doctor or pharmacist. If your child's fever persists beyond 3 days, or their pain does not improve, seek medical advice promptly. Prolonged use without medical supervision is not recommended.

What happens if my child accidentally takes too many Calpol SixPlus Fastmelts?

If you suspect your child has taken more than the recommended dose, go to your nearest A&E immediately — do not wait for symptoms to appear, as paracetamol overdose can cause serious liver damage that may not be obvious straight away. Take the packaging with you so medical staff can see exactly what was taken. Early treatment is essential.

Are Calpol SixPlus Fastmelts suitable for children with asthma?

Paracetamol is generally considered safer than ibuprofen for children with asthma, as ibuprofen (an NSAID) can trigger bronchospasm in some asthmatic children. However, if your child has asthma or any other respiratory condition, it is always wise to check with your GP or pharmacist before starting any new medicine.

What are the alternatives to Calpol SixPlus Fastmelts?

Alternatives include Calpol Six Plus Suspension (liquid paracetamol), Medinol paracetamol oral suspension, or ibuprofen-based products such as Nurofen for Children (for children without contraindications to ibuprofen). You can explore a range of options in our pain relief collection. Always choose the format most appropriate for your child's age and medical history.

Do Calpol SixPlus Fastmelts contain sugar or artificial colours?

Calpol SixPlus Fastmelts are sugar-free, which makes them suitable for children who need to limit sugar intake or who have dental concerns. They do contain aspartame as a sweetener, so they are not suitable for children with phenylketonuria. Always check the full ingredients list on the packaging if your child has known food sensitivities.

Can Calpol SixPlus Fastmelts be used after vaccinations?

Yes — paracetamol is commonly used to manage fever and discomfort following childhood vaccinations, and the NHS acknowledges its use in this context. Give the dose appropriate for your child's age as soon as symptoms appear, and repeat as needed following the dosage instructions. If you have any concerns about your child's reaction to a vaccine, contact your GP or call NHS 111.

What is the latest guidance on using paracetamol in children?

Current NHS and MHRA guidance continues to support paracetamol as a safe and effective first-line option for mild to moderate pain and fever in children when used at the correct dose. Clinicians advise against routine use purely to prevent post-vaccination fever, as some research suggests this may slightly reduce the immune response to certain vaccines. Always follow current NHS guidance and consult your pharmacist if you are unsure.

How Should You Use Calpol SixPlus Fastmelts?

Calpol SixPlus Fastmelts are designed to be placed directly on your child's tongue, where they dissolve quickly without the need for water. Always read the packaging carefully before use and confirm your child's age to ensure you are giving the correct dose.

Follow these steps each time you give a dose:

What Is the Correct Dose of Calpol SixPlus Fastmelts?

The dose depends on your child's age. Never exceed the maximum number of doses in a 24-hour period, and do not give doses closer together than every 4 hours. If you are unsure which dose is right for your child, ask your pharmacist before use.

When Is the Best Time to Use Calpol SixPlus Fastmelts?

Give Calpol SixPlus Fastmelts as soon as your child begins to show signs of pain or a rising temperature — there is no need to wait until symptoms become severe. The tablets can be given with or without food, so you do not need to time doses around mealtimes.

If your child wakes in the night with a fever or discomfort, it is appropriate to give a dose at that time, provided at least 4 hours have passed since the last dose and the maximum daily limit has not been reached.

How Long Can You Use Calpol SixPlus Fastmelts For?

Do not use Calpol SixPlus Fastmelts for more than 3 consecutive days without seeking advice from a doctor or pharmacist. Short-term use for acute pain or fever is appropriate, but ongoing symptoms always warrant a medical review to identify the underlying cause.

If your child's condition does not improve within 3 days, or if symptoms worsen at any point, stop use and contact your GP or call NHS 111 for guidance.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Calpol SixPlus Fastmelts?

Paracetamol is one of the most widely used medicines in children and is generally very well tolerated at the recommended dose. Serious side effects are rare when the product is used correctly. That said, as with any medicine, some children may experience unwanted effects.

  • Nausea or feeling sick
  • Mild stomach discomfort or abdominal pain

What Are the Less Common Side Effects of Calpol SixPlus Fastmelts?

Less common reactions are infrequent but worth knowing about. If your child develops any of the following, stop use and seek medical advice promptly.

  • Skin rash, itching, or hives (urticaria)
  • Swelling of the face, lips, or throat — this may indicate an allergic reaction and requires immediate medical attention
  • Unusual bruising or bleeding — may suggest a rare effect on blood platelets (thrombocytopenia)
  • Unexplained fatigue or pallor

What Are the Serious Side Effects of Calpol SixPlus Fastmelts?

Serious side effects from paracetamol at recommended doses are extremely rare. However, paracetamol overdose — whether accidental or otherwise — can cause severe and potentially fatal liver damage. Symptoms of overdose may not appear for 24 hours or more after ingestion, which is why immediate action is critical even if your child appears well.

If you suspect your child has taken more than the recommended dose, go to your nearest A&E immediately. Take the packaging with you. Do not induce vomiting unless specifically instructed to do so by a medical professional.

What Should You Do If Your Child Experiences Side Effects?

For mild side effects such as nausea, try giving the next dose after a small amount of food. If a skin rash or any sign of an allergic reaction develops, stop the medicine immediately and seek medical advice. For any serious or unexpected reaction, contact your GP, call NHS 111, or attend A&E depending on the severity.

Always report suspected side effects to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk — this helps improve medicine safety for all patients.

Can Calpol SixPlus Fastmelts Interact With Other Medicines?

The most important interaction to be aware of is with other paracetamol-containing products. Many over-the-counter cold and flu remedies, cough syrups, and combination pain relief products contain paracetamol. Giving these alongside Calpol SixPlus Fastmelts can easily lead to exceeding the safe daily dose without realising it.

Paracetamol can also interact with warfarin — regular use may enhance its anticoagulant effect, increasing the risk of bleeding. If your child takes any regular prescribed medicines, always check with your pharmacist before adding paracetamol. Medicines that affect stomach emptying, such as metoclopramide, may alter how quickly paracetamol is absorbed.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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