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Calpol Six Plus Suspension Orange Flavour – 200ml

Calpol Six Plus Suspension Orange Flavour – 200ml

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  • ✔️ Relieves mild to moderate pain in children aged 6–12 years
  • ✔️ Reduces fever quickly with paracetamol 250mg per 5ml
  • ✔️ Orange flavour makes dosing easier for older children
  • ✔️ Suitable for headache, sore throat, earache and cold symptoms
  • ✔️ Trusted paracetamol liquid available without a prescription

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What Is Calpol Six Plus Suspension and How Does It Help?

 

When your child is unwell with a fever, headache, or the aches that come with a cold, you want something that works quickly and that you can trust. Calpol Six Plus suspension is one of the most recognised children's medicines in the UK, and for good reason. It contains paracetamol 250mg per 5ml — a well-established active ingredient used to relieve mild to moderate pain and reduce high temperature in children aged 6 to 12 years. The orange flavour makes it easier to give to children who might otherwise resist taking medicine, and the 200ml bottle gives you enough for multiple doses when you need it most. You can find it alongside other trusted options in our baby and toddler range.

Paracetamol has been used safely in children for decades. It is recommended by the NHS as a first-line option for managing fever and pain in children, and Calpol Six Plus is a well-known formulation designed specifically for older children who have moved beyond the infant suspension strength.

 

How Does Calpol Six Plus Suspension Work?

 

Paracetamol works centrally — meaning it acts on the brain and central nervous system rather than at the site of pain or inflammation. Here is how it works step by step:

  • Paracetamol inhibits the enzyme cyclooxygenase (COX) in the central nervous system, reducing the production of prostaglandins — chemical messengers that signal pain and raise body temperature.
  • By lowering prostaglandin levels in the hypothalamus (the brain's temperature-regulating centre), it helps bring a fever down.
  • It raises the pain threshold, meaning your child's brain perceives less pain from the same stimulus.
  • Unlike ibuprofen, paracetamol does not have significant anti-inflammatory effects at standard doses, so it is gentler on the stomach.

The liquid formulation means it is absorbed relatively quickly through the gastrointestinal tract, with effects typically beginning within 30 to 60 minutes of taking a dose.

 

Who Should Use Calpol Six Plus Suspension?

 

This product is specifically formulated for children aged 6 to 12 years. It is not suitable for younger children — for those under 6, a lower-strength paracetamol suspension is required. It is appropriate for children experiencing:

  • Fever (high temperature above 38°C)
  • Headache or toothache
  • Sore throat or earache
  • Aches and pains associated with cold and flu
  • Post-vaccination discomfort

Children who are allergic to paracetamol or any of the other ingredients should not use this product. It should also be used with caution in children with liver or kidney problems — always speak to your pharmacist or GP first if you are unsure.

 

How Does Calpol Six Plus Compare to Calpol Infant Suspension?

 

Feature Calpol Six Plus Suspension Calpol Infant Suspension
Age range 6–12 years 2 months–6 years
Paracetamol strength 250mg per 5ml 120mg per 5ml
Flavour Orange Strawberry
Sugar-free option Yes (separate variant) Yes (separate variant)

 

Is Calpol Six Plus Suspension Safe to Store at Home?

 

Yes — but there are a few important storage points to keep in mind. Store the bottle below 25°C and do not refrigerate it, as cold temperatures can affect the consistency of the suspension. Always keep the bottle tightly closed and out of reach of children. Once opened, check the expiry date on the packaging and do not use the product beyond that date. If you are building a home medicine cabinet for your family, you might also want to explore our pain relief collection for other useful products to keep on hand.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Calpol Six Plus Suspension Orange Flavour 200ml specifications
Treatment category Analgesic / Antipyretic
Mechanism of action Central COX inhibition reducing prostaglandin synthesis
Effective for Mild to moderate pain and fever in children
Suitable for Children aged 6 to 12 years
Active ingredient Paracetamol 250mg per 5ml
Pack size 200ml
Strength 250mg/5ml
UK classification General Sale List (GSL)
Drug class Non-opioid analgesic
Preparation Oral suspension
Route of administration Oral

Specifications of Calpol Six Plus Suspension Orange Flavour 200ml

 

What Is Calpol Six Plus Suspension and What Is It Used For?

 

Calpol Six Plus Suspension Orange Flavour is an oral paracetamol liquid medicine containing 250mg of paracetamol per 5ml. It is used to relieve mild to moderate pain — including headache, toothache, sore throat, and earache — and to reduce fever (high temperature) in children aged 6 to 12 years. It is a General Sale List (GSL) medicine, meaning it can be purchased without a prescription from pharmacies and supermarkets across the UK. The NHS recommends paracetamol as a first-line treatment for managing pain and fever in children when used at the correct dose.

 

What Do You Need to Know Before Using Calpol Six Plus Suspension?

 

Before giving this medicine to your child, read the following carefully. Do not use Calpol Six Plus Suspension if your child:

  • Is under 6 years of age
  • Is allergic to paracetamol or any other ingredient in the product
  • Has severe liver or kidney disease
  • Is already taking another medicine containing paracetamol — this includes many cold and flu remedies

Use with caution and speak to your pharmacist or GP first if your child has:

  • Liver problems (including those caused by alcohol or hepatitis)
  • Kidney problems
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • Low body weight or is malnourished

Drug interactions to be aware of:

  • Warfarin — regular use of paracetamol may increase the anticoagulant effect
  • Other paracetamol-containing products — risk of accidental overdose
  • Metoclopramide or domperidone — may speed up paracetamol absorption
  • Cholestyramine — may reduce paracetamol absorption if taken within one hour

 

How Should You Use Calpol Six Plus Suspension?

 

Always use the measuring syringe or spoon provided with the pack to ensure an accurate dose. Shake the bottle well before each use. Follow these steps:

  1. Check your child's age and weight to confirm the correct dose (see table below).
  2. Shake the bottle well before opening.
  3. Use the measuring device provided — never use a kitchen spoon.
  4. Give the dose orally, either directly or mixed with a small amount of water if needed.
  5. Note the time of the dose and do not repeat for at least 4 hours.
  6. Do not give more than 4 doses in any 24-hour period.
Age Group Dose Frequency Max doses per 24 hours
6–8 years 5ml Every 4–6 hours 4 doses
8–10 years 7.5ml Every 4–6 hours 4 doses
10–12 years 10ml Every 4–6 hours 4 doses

If your child's fever or pain does not improve after 3 days (fever) or 5 days (pain), stop use and consult a doctor. You can also browse our cold and flu range for additional supportive products during illness.

 

What Are the Possible Side Effects of Calpol Six Plus Suspension?

 

Paracetamol is generally very well tolerated at recommended doses. However, side effects can occur. Stop use and seek medical advice if your child develops any unusual symptoms.

Common side effects:

  • Nausea
  • Stomach discomfort

Less common side effects:

  • Skin rash or itching
  • Flushing
  • Low blood pressure (hypotension) — rare, associated with intravenous use, not oral
  • Blood disorders (thrombocytopenia, leucopenia) — very rare
  • Serious allergic reaction (anaphylaxis) — very rare; symptoms include swelling of the face, lips, or throat, difficulty breathing, or collapse

If your child shows signs of a serious allergic reaction, stop the medicine immediately and call 999 or go to your nearest A&E. Overdose with paracetamol is a medical emergency — even if your child appears well, seek immediate help if you suspect they have taken too much. For families managing multiple health needs, our first aid collection has useful products to keep at home.

 

How Should You Store Calpol Six Plus Suspension?

 

  • Store below 25°C in a dry place.
  • Do not refrigerate — cold temperatures can affect the suspension.
  • Keep the bottle tightly closed when not in use.
  • Keep out of the sight and reach of children.
  • Do not use after the expiry date printed on the label.
  • Do not dispose of medicines via wastewater or household waste — return unused medicine to your pharmacy.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Calpol Six Plus Suspension online in the UK?

You can buy Calpol Six Plus Suspension Orange Flavour 200ml online from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £5.99. It is a General Sale List medicine, so no prescription is needed. It is also available from most UK supermarkets and high street pharmacies.

How does Calpol Six Plus work in the body?

Calpol Six Plus contains paracetamol 250mg per 5ml, which works by inhibiting cyclooxygenase (COX) enzymes in the central nervous system, reducing the production of prostaglandins that signal pain and raise body temperature. This lowers fever and raises the pain threshold so your child feels more comfortable. It does not have significant anti-inflammatory effects at standard doses.

What age is Calpol Six Plus Suspension suitable for?

Calpol Six Plus Suspension is suitable for children aged 6 to 12 years only. It should not be given to children under 6 years — for younger children, Calpol Infant Suspension (120mg/5ml) is the appropriate formulation. Always check the age guidance on the packaging before use.

What is the correct dose of Calpol Six Plus for my child?

The dose depends on your child's age: children aged 6–8 years take 5ml, those aged 8–10 years take 7.5ml, and children aged 10–12 years take 10ml. Each dose can be repeated every 4 to 6 hours, but no more than 4 doses should be given in any 24-hour period. Always use the measuring device provided in the pack.

Can I give Calpol Six Plus at the same time as ibuprofen?

Paracetamol and ibuprofen can sometimes be used together or alternated in children, but you should always speak to your pharmacist or GP before doing so. Never give two paracetamol-containing products simultaneously, as this risks accidental overdose. If your child's symptoms are not controlled with one medicine, seek professional advice.

What are the side effects of Calpol Six Plus Suspension?

Side effects are uncommon at recommended doses but may include nausea, stomach discomfort, or skin rash. Very rarely, a serious allergic reaction (anaphylaxis) can occur — symptoms include facial swelling, difficulty breathing, or collapse. If any serious reaction occurs, stop the medicine and call 999 immediately.

How long can my child take Calpol Six Plus?

Calpol Six Plus should not be used for more than 3 days for fever or more than 5 days for pain without consulting a doctor or pharmacist. If your child's symptoms persist, worsen, or new symptoms develop, seek medical advice promptly. Prolonged use without medical supervision is not recommended.

What happens if my child is given too much Calpol Six Plus?

Paracetamol overdose can cause serious liver damage, even if your child appears well at first — symptoms of overdose may not appear for 24 hours or more. If you suspect your child has taken too much, go to your nearest A&E or call 999 immediately. Do not wait for symptoms to develop before seeking help.

Is Calpol Six Plus Suspension sugar-free?

The standard Calpol Six Plus Suspension Orange Flavour does contain some excipients — check the patient information leaflet for the full list of ingredients including any sugars or sweeteners. A sugar-free variant of Calpol Six Plus is available separately if your child needs to avoid sugar. Ask your pharmacist if you are unsure which version is right for your child.

Can Calpol Six Plus be used for toothache in children?

Yes — Calpol Six Plus Suspension can be used to relieve toothache in children aged 6 to 12 years as part of short-term pain management. However, toothache in children should always be assessed by a dentist to identify and treat the underlying cause. You can find additional oral health products in our oral health collection.

What are the alternatives to Calpol Six Plus Suspension?

Alternatives for children aged 6 to 12 years include ibuprofen oral suspension (e.g. Nurofen for Children), which also reduces inflammation, or other branded paracetamol suspensions. The right choice depends on your child's medical history and the nature of their symptoms — speak to your pharmacist for personalised advice. You can also browse our pain relief range for more options.

How quickly does Calpol Six Plus start working?

Calpol Six Plus Suspension is typically absorbed through the gastrointestinal tract and begins to take effect within 30 to 60 minutes of being given. Peak plasma concentrations of paracetamol are usually reached within 30 to 90 minutes after an oral dose. The duration of effect is generally 4 to 6 hours.

Can Calpol Six Plus be used for cold and flu symptoms in children?

Yes — Calpol Six Plus Suspension is suitable for relieving the aches, pains, sore throat, and fever associated with cold and flu in children aged 6 to 12 years. It does not treat the underlying viral infection itself, but it helps manage symptoms and keep your child more comfortable. For a wider range of cold and flu support products, visit our cold and flu collection.

Does Calpol Six Plus interact with any other medicines?

The most important interaction to be aware of is with warfarin — regular use of paracetamol can enhance its anticoagulant effect and increase bleeding risk. You should also never give Calpol Six Plus alongside any other paracetamol-containing product, including many cold and flu remedies. Always check with your pharmacist if your child is taking any other medicines.

What are the latest guidelines on using paracetamol for children's fever?

Current NHS guidance recommends paracetamol as a first-line option for managing fever and pain in children, used at the lowest effective dose for the shortest time necessary. The NHS advises that alternating paracetamol and ibuprofen is not routinely recommended unless advised by a healthcare professional. Always follow the dosage instructions on the packaging and consult your pharmacist or GP if you have concerns.

How Should You Use Calpol Six Plus Suspension?

Always shake the bottle well before measuring each dose, as the suspension can settle between uses. Use only the measuring syringe or spoon provided in the pack — never a household teaspoon, as this can lead to inaccurate dosing.

What Is the Correct Dose of Calpol Six Plus Suspension?

The dose is determined by your child's age. Do not give more than 4 doses in any 24-hour period, and leave at least 4 hours between each dose. If you are unsure about the correct dose for your child, ask your pharmacist before use.

When Is the Best Time to Use Calpol Six Plus Suspension?

Calpol Six Plus can be given at any time of day, with or without food. If your child is unwell overnight with a fever or pain, it is appropriate to give a dose during the night provided at least 4 hours have passed since the previous dose. Try to space doses as evenly as possible throughout the day to maintain consistent symptom relief.

For fever, the NHS advises that you do not routinely give paracetamol solely to prevent fever after vaccination — only use it if your child is clearly uncomfortable or distressed. Always follow the guidance of your healthcare professional in post-vaccination situations.

How Long Can You Use Calpol Six Plus Suspension For?

Do not use Calpol Six Plus for more than 3 consecutive days for fever, or more than 5 consecutive days for pain, without seeking medical advice. If your child's symptoms do not improve within these timeframes, or if they worsen at any point, consult your GP or pharmacist promptly.

Prolonged or frequent use of paracetamol without medical supervision is not recommended. If your child regularly needs pain relief, this should be discussed with a doctor to identify any underlying cause.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Calpol Six Plus Suspension?

Calpol Six Plus Suspension is generally very well tolerated when used at the recommended dose for the recommended duration. Most children experience no side effects at all. However, as with all medicines, some children may notice mild reactions.

  • Nausea or feeling sick
  • Stomach discomfort or abdominal pain

What Are the Less Common Side Effects of Calpol Six Plus Suspension?

Less common side effects occur in a small number of children and are usually mild. If any of the following persist or concern you, stop use and speak to your pharmacist or GP.

  • Skin rash or itching (urticaria)
  • Flushing or redness of the skin
  • Headache
  • Dizziness

What Are the Serious Side Effects of Calpol Six Plus Suspension?

Serious side effects are very rare when paracetamol is used correctly, but they can occur. The most important serious risk is liver damage, which can result from taking too much paracetamol — even accidentally. Symptoms of liver damage may not appear for 24 to 72 hours after an overdose, so do not wait for symptoms before seeking help if you suspect your child has taken too much.

Very rarely, a serious allergic reaction (anaphylaxis) can occur. Signs include:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Sudden drop in blood pressure or collapse
  • Severe skin rash or hives spreading rapidly

If any of these occur, stop the medicine immediately and call 999 or go to your nearest A&E without delay.

What Should You Do If Your Child Experiences Side Effects?

For mild side effects such as nausea or a skin rash, stop giving the medicine and speak to your pharmacist. They can advise whether it is safe to continue or whether an alternative is more appropriate for your child. Keep a note of when the side effect started and what dose was given — this information will help your pharmacist or GP.

In the event of a suspected overdose — even if your child seems well — go immediately to your nearest A&E or call 999. Paracetamol overdose is a medical emergency and early treatment is essential to prevent serious liver damage. You can also call the NHS 111 service for urgent advice.

Can Calpol Six Plus Interact With Other Medicines?

Yes. The most clinically significant interaction is with warfarin — regular use of paracetamol can increase the anticoagulant effect of warfarin, raising the risk of bleeding. If your child is taking warfarin (which is uncommon but possible in certain conditions), seek medical advice before using paracetamol. Additionally, never give Calpol Six Plus alongside any other product containing paracetamol, including many branded cold and flu remedies, as this significantly increases the risk of accidental overdose. Medicines that affect stomach emptying, such as metoclopramide or domperidone, may alter the rate at which paracetamol is absorbed.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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