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Calpol Six Plus Sugar Free Suspension Sachets

Calpol Six Plus Sugar Free Suspension Sachets

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  • ✔️ Relieves mild to moderate pain in children aged 6 to 12
  • ✔️ Reduces fever quickly with paracetamol 250mg per 5ml
  • ✔️ Sugar free formula suitable for children with diabetes
  • ✔️ Pre-measured sachets — no spoon or measuring required
  • ✔️ Portable single-dose sachets ideal for school or travel

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What Are Calpol Six Plus Sugar Free Sachets?

 

When your child is running a temperature or complaining of a headache, you want something that works — and that you can trust. Calpol Six Plus sugar free sachets are a well-established, over-the-counter paracetamol suspension designed specifically for children aged 6 years and over. Each sachet contains paracetamol 250mg/5ml in a convenient, pre-measured format that makes dosing straightforward, even when you're tired and stressed at 2am. You can find this product and other children's essentials in our baby and toddler collection.

The sachets are sugar free, which matters if your child has diabetes or if you're simply trying to reduce their sugar intake. They're also alcohol free and gluten free, making them a practical choice for families with specific dietary needs. Paracetamol is one of the most widely used and well-studied medicines for children in the UK, recommended by the NHS for the relief of mild to moderate pain and fever.

 

How Do Calpol Six Plus Sachets Work in the Body?

 

Paracetamol — the active ingredient in these sachets — works by inhibiting the synthesis of prostaglandins in the central nervous system. Prostaglandins are chemical messengers that play a key role in triggering pain and raising body temperature. By reducing their production, paracetamol helps to lower fever and ease discomfort. Here's a simple breakdown of the mechanism:

  • Paracetamol is absorbed through the gut wall into the bloodstream after swallowing.
  • It crosses into the central nervous system, where it acts on pain-processing pathways.
  • It inhibits prostaglandin synthesis, reducing the sensation of pain and the hypothalamic set-point for body temperature.
  • Effects typically begin within 30 to 60 minutes of taking a dose.
  • The duration of action is usually 4 to 6 hours.

Unlike ibuprofen, paracetamol does not have significant anti-inflammatory properties, but it is generally better tolerated in children with stomach sensitivities or asthma.

 

Who Should Use Calpol Six Plus Sachets?

 

These sachets are intended for children aged 6 to 12 years. They're particularly useful for children who struggle to swallow tablets, or for parents who want a pre-measured, portable option rather than carrying a bottle of liquid suspension. The sugar-free formulation also makes them a sensible choice for children with diabetes or those prone to tooth decay.

  • Children aged 6 to 12 years with mild to moderate pain (e.g. headache, toothache, sore throat, earache)
  • Children with a fever, including post-vaccination fever
  • Children who need to avoid sugar in their medicines
  • Families who want a convenient, portable dosing format for school bags or travel

Do not give these sachets to children under 6 years old. If your child is under 6, speak to your pharmacist about age-appropriate alternatives.

 

How Do Calpol Six Plus Sachets Compare to Calpol Six Plus Liquid?

 

Feature Calpol Six Plus Sachets Calpol Six Plus Liquid (Bottle)
Formulation Pre-measured sachets Bottle with measuring spoon/syringe
Sugar free Yes Sugar-free version available
Portability Highly portable — no spoon needed Less portable; requires measuring
Active ingredient Paracetamol 250mg/5ml Paracetamol 250mg/5ml

 

Is Calpol Six Plus Suitable for Children With Allergies or Specific Health Conditions?

 

Most children tolerate Calpol Six Plus sugar free sachets well. However, you should check the full ingredients list if your child has known allergies, particularly to any of the excipients. Children with severe liver or kidney problems should not use paracetamol without medical supervision. If your child is already taking other medicines — including any that contain paracetamol — speak to your pharmacist before giving these sachets, as combining paracetamol products can lead to accidental overdose. For broader children's health support, including vitamins and supplements to support immunity, browse our vitamins and supplements collection.

Store sachets below 25°C, away from direct sunlight, and keep them out of the reach and sight of children. Do not use after the expiry date printed on the packaging.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Calpol Six Plus Sugar Free Suspension Sachets specifications
Treatment category Children's pain relief and fever reduction
Mechanism of action Inhibits prostaglandin synthesis in the central nervous system
Effective for Mild to moderate pain, fever
Suitable for Children aged 6 to 12 years
Active ingredient Paracetamol 250mg/5ml
UK classification General Sale List (GSL)
Drug class Analgesic / Antipyretic
Preparation Oral suspension in sachet
Route of administration Oral

Specifications of Calpol Six Plus Sugar Free Suspension Sachets

 

What Is Calpol Six Plus Sugar Free Suspension and What Is It Used For?

 

Calpol Six Plus Sugar Free Suspension Sachets contain paracetamol 250mg/5ml as the active ingredient. They are used to relieve mild to moderate pain in children aged 6 to 12 years, including headache, toothache, sore throat, and earache. They are also used to reduce fever, including fever that can occur after childhood vaccinations. Paracetamol is one of the first-line medicines recommended by the NHS for managing pain and high temperature in children.

 

What Do You Need to Know Before Using Calpol Six Plus Sachets?

 

Before giving these sachets to your child, read the following carefully. There are situations where this medicine should not be used, or where extra caution is needed.

Do not use if your child:

  • Is under 6 years of age
  • Is allergic to paracetamol or any other ingredient in the sachets
  • Has severe liver disease
  • Is already taking another medicine containing paracetamol

Use with caution and speak to a pharmacist or doctor if your child:

  • Has kidney or liver problems
  • Is underweight or malnourished
  • Has phenylketonuria (PKU) — check the excipient list, as some formulations contain aspartame
  • Has a known allergy to any medicine

Known drug interactions to be aware of:

  • Warfarin — regular use of paracetamol may enhance the anticoagulant effect
  • Other paracetamol-containing products — concurrent use risks overdose
  • Metoclopramide or domperidone — may increase the rate of paracetamol absorption
  • Cholestyramine — may reduce paracetamol absorption if taken within one hour

 

How Should You Give Calpol Six Plus Sachets to Your Child?

 

Always follow the dosage instructions on the packaging or as directed by your pharmacist. The sachets are pre-measured, which removes the guesswork of measuring liquid with a spoon. Here's how to use them correctly:

  1. Check your child's age and weight to confirm the correct dose.
  2. Tear open one sachet along the perforated edge.
  3. Pour the contents directly into your child's mouth, or mix with a small amount of water if preferred.
  4. Ensure your child swallows the full contents of the sachet.
  5. Note the time of the dose and do not repeat within 4 hours.
  6. Do not give more than 4 doses in any 24-hour period.
Age Group Dose per Administration Maximum Frequency Maximum in 24 Hours
6 to 9 years 5ml (1 sachet) Every 4–6 hours 4 doses
10 to 12 years 5ml–10ml (1–2 sachets) Every 4–6 hours 4 doses

If your child's symptoms do not improve after 3 days of fever treatment or 5 days of pain treatment, stop use and consult a doctor. If you're also managing cold and flu symptoms alongside pain and fever, you may find our cold and flu collection helpful for additional support options.

 

What Are the Possible Side Effects of Calpol Six Plus Sachets?

 

Paracetamol is generally very well tolerated when used at the recommended dose. Serious side effects are rare, but it's important to know what to look out for.

Common side effects (may affect up to 1 in 10 children):

  • Nausea
  • Stomach discomfort

Less common side effects (may affect up to 1 in 100 children):

  • Skin rash or itching
  • Flushing
  • Low blood pressure (hypotension) — very rare
  • Blood disorders such as thrombocytopenia or agranulocytosis — extremely rare

Stop giving the medicine and seek immediate medical attention if your child develops a severe skin reaction, difficulty breathing, or swelling of the face, lips, or throat. These may be signs of a serious allergic reaction (anaphylaxis), which is very rare but requires urgent treatment.

 

How Should You Store Calpol Six Plus Sachets?

 

Correct storage helps to maintain the medicine's effectiveness and safety. Follow these guidelines:

  • Store below 25°C in a dry place.
  • Keep away from direct sunlight and heat sources.
  • Keep all medicines out of the reach and sight of children.
  • Do not use after the expiry date printed on the outer carton.
  • Do not dispose of medicines via wastewater or household waste — return unused sachets to your local pharmacy for safe disposal.

For children who experience discomfort alongside their illness, such as ear or throat pain, our ear, nose and throat collection includes additional products that may help manage associated symptoms.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Calpol Six Plus sugar free sachets online in the UK?

You can buy Calpol Six Plus sugar free sachets online from Cured Pharmacy, a GPhC-registered UK online pharmacy. They are available without a prescription as an over-the-counter medicine. Simply add them to your basket and choose your preferred delivery option at checkout.

How do Calpol Six Plus sugar free sachets work in the body?

Each sachet contains paracetamol 250mg/5ml, which works by inhibiting the production of prostaglandins — chemical messengers that trigger pain and raise body temperature. This reduces your child's perception of pain and helps bring a fever down. Effects typically begin within 30 to 60 minutes of taking a dose.

What age is Calpol Six Plus suitable for?

Calpol Six Plus sachets are suitable for children aged 6 to 12 years. They should not be given to children under 6 years old. If your child is under 6, speak to your pharmacist about an age-appropriate paracetamol product.

How many Calpol Six Plus sachets can my child have in 24 hours?

Children aged 6 to 9 years should receive one 5ml sachet per dose, up to four times in 24 hours. Children aged 10 to 12 years may receive one to two sachets per dose, up to four times in 24 hours. Always leave at least 4 hours between doses and never exceed four doses in one day.

Are Calpol Six Plus sachets really sugar free?

Yes, Calpol Six Plus Suspension Sachets are formulated without sugar, making them suitable for children who need to limit their sugar intake. They are also a practical option for children with diabetes. Always check the full ingredients list if your child has specific dietary requirements or allergies.

What conditions can Calpol Six Plus sachets treat?

Calpol Six Plus sachets can be used to relieve mild to moderate pain in children, including headache, toothache, sore throat, and earache. They are also effective at reducing fever, including post-vaccination fever. They are not suitable for treating inflammation or conditions that require an anti-inflammatory medicine.

How do I give Calpol Six Plus sachets to my child step by step?

Tear open the sachet along the perforated edge and pour the contents directly into your child's mouth, or mix with a small amount of water if they prefer. Make sure your child swallows the full contents of the sachet. Note the time of the dose and do not repeat within 4 hours.

What are the side effects of Calpol Six Plus sachets?

Side effects are uncommon at recommended doses but may include nausea, stomach discomfort, or skin rash. Serious allergic reactions are very rare but require immediate medical attention — signs include swelling of the face, difficulty breathing, or a severe skin reaction. Stop use and contact a doctor if you notice any unusual symptoms in your child.

Can I give Calpol Six Plus sachets alongside other medicines?

Do not give Calpol Six Plus sachets at the same time as any other medicine containing paracetamol, as this can lead to accidental overdose. If your child is taking warfarin or any other regular medication, speak to your pharmacist before use. For children with cold and flu symptoms, check our cold and flu collection for compatible products.

What happens if I accidentally give my child too much Calpol?

If you think your child has taken too much paracetamol, seek medical attention immediately — even if they seem well — because overdose can cause serious liver damage that may not be apparent straight away. Go to your nearest A&E or call 999. Do not wait for symptoms to appear before seeking help.

What should I do if I miss a dose of Calpol Six Plus?

If you miss a dose, give it as soon as you remember — provided at least 4 hours have passed since the last dose. Never give a double dose to make up for a missed one. If your child's symptoms persist or worsen, consult your pharmacist or GP.

How long can my child take Calpol Six Plus sachets for?

For fever, do not use for more than 3 days without consulting a doctor. For pain relief, do not use for more than 5 days without medical advice. If symptoms do not improve within these timeframes, your child should be assessed by a healthcare professional to rule out an underlying cause.

Are Calpol Six Plus sachets suitable for children with diabetes?

Yes, because these sachets are sugar free, they are generally considered suitable for children with diabetes. However, always check the full list of excipients on the packaging and consult your child's doctor or pharmacist if you have any concerns about specific ingredients. Managing your child's overall health is important, and our vitamins and supplements collection may also support their wellbeing.

What are the alternatives to Calpol Six Plus sachets for children?

Alternatives include Calpol Six Plus liquid suspension in a bottle, ibuprofen suspension (for children aged 3 months and over who are not contraindicated), or other branded paracetamol suspensions. Ibuprofen has anti-inflammatory properties that paracetamol does not, but it is not suitable for all children — speak to your pharmacist for personalised advice.

What is the latest guidance on using paracetamol for children's fever?

Current NHS guidance recommends paracetamol as a first-line option for relieving discomfort and reducing fever in children. The NHS advises that alternating paracetamol and ibuprofen is not routinely recommended unless advised by a healthcare professional. Always use the lowest effective dose for the shortest time necessary.

How Should You Use Calpol Six Plus Sugar Free Sachets?

Using these sachets correctly ensures your child gets the right amount of medicine safely. Always read the packaging before giving any dose, and check that you have the right product for your child's age group.

Follow these steps each time you give a dose:

What Is the Correct Dose of Calpol Six Plus Sachets?

The dose depends on your child's age. Never exceed the maximum number of doses in a 24-hour period, and always leave at least 4 hours between doses. If you are unsure about the correct dose for your child, ask your pharmacist before giving the medicine.

When Is the Best Time to Use Calpol Six Plus Sachets?

Give a dose as soon as your child begins to show signs of pain or a rising temperature — there is no need to wait until symptoms become severe. The sachets can be given with or without food, so timing around meals is flexible. If your child wakes in the night with a fever or discomfort, it is appropriate to give a dose provided at least 4 hours have passed since the last one.

Try to space doses evenly throughout the day where possible, rather than clustering them together. This helps maintain a more consistent level of paracetamol in your child's system and provides more sustained relief.

How Long Can You Use Calpol Six Plus Sachets For?

For fever, do not use these sachets for more than 3 consecutive days without seeking medical advice. For pain relief, the maximum recommended duration without consulting a doctor or pharmacist is 5 days. If your child's symptoms persist beyond these timeframes, or if they worsen at any point, stop use and seek professional guidance promptly.

Prolonged use of paracetamol beyond the recommended duration without medical supervision is not advised. If your child frequently needs pain relief or has recurring fevers, this should be investigated by a GP rather than managed long-term with over-the-counter medicines.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use Calpol Six Plus Sugar Free Sachets?

Using these sachets correctly ensures your child gets the right amount of medicine safely. Always read the packaging before giving any dose, and check that you have the right product for your child's age group.

Follow these steps each time you give a dose:

What Is the Correct Dose of Calpol Six Plus Sachets?

The dose depends on your child's age. Never exceed the maximum number of doses in a 24-hour period, and always leave at least 4 hours between doses. If you are unsure about the correct dose for your child, ask your pharmacist before giving the medicine.

When Is the Best Time to Use Calpol Six Plus Sachets?

Give a dose as soon as your child begins to show signs of pain or a rising temperature — there is no need to wait until symptoms become severe. The sachets can be given with or without food, so timing around meals is flexible. If your child wakes in the night with a fever or discomfort, it is appropriate to give a dose provided at least 4 hours have passed since the last one.

Try to space doses evenly throughout the day where possible, rather than clustering them together. This helps maintain a more consistent level of paracetamol in your child's system and provides more sustained relief.

How Long Can You Use Calpol Six Plus Sachets For?

For fever, do not use these sachets for more than 3 consecutive days without seeking medical advice. For pain relief, the maximum recommended duration without consulting a doctor or pharmacist is 5 days. If your child's symptoms persist beyond these timeframes, or if they worsen at any point, stop use and seek professional guidance promptly.

Prolonged use of paracetamol beyond the recommended duration without medical supervision is not advised. If your child frequently needs pain relief or has recurring fevers, this should be investigated by a GP rather than managed long-term with over-the-counter medicines.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Calpol Six Plus Sachets?

Paracetamol is one of the most widely used medicines for children in the UK and is generally very well tolerated when used at the correct dose. Serious side effects are rare. That said, it's important to be aware of what can occasionally occur so you can respond appropriately.

  • Nausea
  • Stomach discomfort or abdominal pain
  • Feeling generally unwell

What Are the Less Common Side Effects of Calpol Six Plus Sachets?

Less common side effects occur in a small number of children and are usually mild. If any of the following persist or concern you, stop use and speak to your pharmacist or GP.

  • Skin rash or itching
  • Flushing of the skin
  • Urticaria (hives)
  • Low blood pressure (hypotension) — very rare

What Are the Serious Side Effects of Calpol Six Plus Sachets?

Serious side effects from paracetamol at recommended doses are extremely rare. However, they can occur and require immediate medical attention. Liver damage is the most significant risk associated with paracetamol — this is almost always the result of taking too much, either in a single dose or by using multiple paracetamol-containing products at the same time. Signs of liver problems include yellowing of the skin or eyes (jaundice), dark urine, and severe abdominal pain.

Blood disorders such as thrombocytopenia (low platelet count) and agranulocytosis (low white blood cell count) have been reported in very rare cases. A severe allergic reaction (anaphylaxis) is also possible, though extremely uncommon. Signs include sudden swelling of the face, lips, tongue or throat, difficulty breathing, and a rapid drop in blood pressure. This is a medical emergency — call 999 immediately.

What Should You Do If Your Child Experiences Side Effects?

For mild side effects such as nausea or a skin rash, stop giving the medicine and monitor your child closely. If the side effect resolves quickly and was mild, you may wish to speak to your pharmacist before giving any further doses. For any serious or unexpected reaction — particularly difficulty breathing, swelling, or signs of liver problems — seek emergency medical help immediately. Do not wait to see if symptoms improve on their own.

If you suspect your child has taken too much paracetamol, go to A&E straight away or call 999, even if your child appears well. Paracetamol overdose can cause severe liver damage that may not become apparent for several days.

Can Calpol Six Plus Sachets Interact With Other Medicines?

Yes, paracetamol can interact with certain other medicines. The most important interaction to be aware of is with other products containing paracetamol — using them together can lead to accidental overdose. Always check the ingredients of any other medicine your child is taking, including cold and flu remedies, before giving Calpol Six Plus sachets. Warfarin (a blood-thinning medicine) may be affected by regular paracetamol use, increasing the risk of bleeding. Medicines that affect stomach emptying, such as metoclopramide or domperidone, can alter how quickly paracetamol is absorbed. Cholestyramine may reduce absorption if taken within one hour of paracetamol. Always tell your pharmacist about all medicines your child is currently taking before starting a new one.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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