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Calpol Six Plus Sugar Free Suspension - 200ml

Calpol Six Plus Sugar Free Suspension - 200ml

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  • ✔️ Relieves fever and mild to moderate pain in children aged 6–12
  • ✔️ Sugar free formula suitable for children managing sugar intake
  • ✔️ Contains paracetamol 250mg per 5ml for age-appropriate dosing
  • ✔️ Starts working within approximately 30 minutes of correct dose
  • ✔️ Trusted paracetamol suspension for post-vaccination fever relief

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What Is Calpol Six Plus Sugar Free Suspension?

 

Calpol Six Plus Sugar Free Suspension is a paracetamol-based oral liquid designed specifically for children aged 6 to 12 years. Each 5ml dose contains 250mg of paracetamol, giving you a straightforward way to manage your child's fever or mild to moderate pain without the added sugar found in some other formulations. It's one of the most recognised children's medicines in the UK — and for good reason. Whether your child is struggling with a high temperature after a vaccination, dealing with a headache, or suffering from the aches that come with a cold, this suspension offers targeted, age-appropriate relief. You can browse our full range of baby and toddler health products alongside this one.

The sugar free formula is particularly useful if your child has diabetes, is prone to tooth decay, or simply doesn't tolerate sweetened medicines well. It still has a pleasant taste, so most children take it without a fuss. At £7.69 for a 200ml bottle, it represents solid value for a trusted, clinically established product.

 

How Does Calpol Six Plus Sugar Free Suspension Work?

 

Paracetamol — the active ingredient here — works primarily by inhibiting the synthesis of prostaglandins in the central nervous system. Prostaglandins are chemical messengers that signal pain and trigger the hypothalamus to raise body temperature. By reducing their production, paracetamol lowers fever and dulls the perception of pain. It's worth noting that paracetamol doesn't have significant anti-inflammatory effects at standard doses, which distinguishes it from ibuprofen.

  • Paracetamol is absorbed rapidly from the gastrointestinal tract after oral administration.
  • Peak plasma concentration is typically reached within 30 to 60 minutes.
  • It is metabolised primarily in the liver and excreted via the kidneys.
  • Fever reduction and pain relief usually begin within 30 minutes of the correct dose.

 

Who Should Use Calpol Six Plus Sugar Free Suspension?

 

This suspension is intended for children aged 6 to 12 years. It's not suitable for younger children — there are other Calpol formulations designed for infants and toddlers. If your child falls within the right age range and is experiencing any of the following, this product may be appropriate:

  • Fever (high temperature above 38°C)
  • Mild to moderate pain, including headache, toothache, or sore throat
  • Post-vaccination fever or discomfort
  • Aches and pains associated with cold or flu

Children with known liver or kidney problems, or those already taking other paracetamol-containing medicines, should not use this product without first speaking to a doctor or pharmacist. If your child has a known allergy to paracetamol or any of the excipients, do not use this suspension.

 

How Does Calpol Six Plus Compare to Calpol Infant Suspension?

 

Feature Calpol Six Plus Sugar Free Suspension Calpol Infant Suspension
Age range 6–12 years 2 months–6 years
Paracetamol strength 250mg per 5ml 120mg per 5ml
Sugar free Yes No (standard version contains sugar)
Typical dose volume 5ml–10ml per dose 2.5ml–5ml per dose

 

How Should You Store Calpol Six Plus Sugar Free Suspension?

 

Store the bottle below 25°C in a dry place, away from direct sunlight. Do not refrigerate — chilling can affect the consistency of the suspension. Always keep the bottle tightly closed and well out of reach of children. Once opened, use within the period stated on the packaging (typically 28 days). Check the expiry date before each use, and never use a product that has passed its expiry date or looks discoloured.

If you're looking for broader children's health support, our cold and flu range includes additional products that may help manage your child's symptoms alongside this suspension.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Calpol Six Plus Sugar Free Suspension 200ml specifications
Treatment category Fever and mild to moderate pain relief
Mechanism of action Prostaglandin synthesis inhibition (central)
Effective for Fever, headache, toothache, sore throat, post-vaccination discomfort
Suitable for Children aged 6 to 12 years
Active ingredient Paracetamol 250mg per 5ml
Pack size 200ml
UK classification General Sale List (GSL)
Drug class Analgesic / Antipyretic
Preparation Oral suspension
Route of administration Oral

Specifications of Calpol Six Plus Sugar Free Suspension 200ml

 

What Is Calpol Six Plus Sugar Free Suspension and What Is It Used For?

 

Calpol Six Plus Sugar Free Suspension contains paracetamol 250mg per 5ml as its active ingredient. It is used to relieve mild to moderate pain and to reduce fever (high temperature) in children aged 6 to 12 years. Common reasons parents reach for this suspension include fever following childhood illnesses or vaccinations, headaches, toothache, sore throats, and the general aches associated with colds. The sugar free formulation means it does not contain sucrose, making it a more appropriate choice for children who need to manage their sugar intake.

 

What Do You Need to Know Before Using Calpol Six Plus Sugar Free Suspension?

 

Before giving this suspension to your child, read the following carefully. There are situations where it should not be used, and others where extra caution is needed.

Do not use if your child:

  • Is under 6 years of age
  • Has a known allergy to paracetamol or any other ingredient in the suspension
  • Is already taking another medicine containing paracetamol
  • Has severe liver disease

Speak to your doctor or pharmacist first if your child:

  • Has liver or kidney problems
  • Is underweight or malnourished
  • Has phenylketonuria (this product contains aspartame)
  • Is taking any regular prescription medicines

Known drug interactions to be aware of:

  • Warfarin and other anticoagulants — regular paracetamol use may enhance anticoagulant effect
  • Other paracetamol-containing products — concurrent use risks overdose
  • Metoclopramide or domperidone — may increase the rate of paracetamol absorption
  • Cholestyramine — may reduce paracetamol absorption if taken within one hour

 

How Should You Use Calpol Six Plus Sugar Free Suspension?

 

Always use the measuring device provided with the bottle — never use a kitchen spoon, as this can lead to inaccurate dosing. Shake the bottle well before each use to ensure the suspension is evenly mixed.

  1. Check your child's weight and age to confirm the correct dose.
  2. Shake the bottle thoroughly before opening.
  3. Use the supplied measuring syringe or spoon to draw up the correct volume.
  4. Give the dose orally, directly into your child's mouth.
  5. Replace the cap securely after use.
  6. Note the time of the dose so you can track the next safe administration time.
Age Group Dose Volume Frequency
6–8 years 250mg paracetamol 5ml Every 4–6 hours (max 4 doses in 24 hours)
8–10 years 375mg paracetamol 7.5ml Every 4–6 hours (max 4 doses in 24 hours)
10–12 years 500mg paracetamol 10ml Every 4–6 hours (max 4 doses in 24 hours)

Never give more than 4 doses in any 24-hour period. Leave at least 4 hours between doses. If your child's symptoms do not improve within 24 hours of starting treatment, or if fever persists beyond 3 days, seek medical advice. You can also explore our pain relief collection for additional options suitable for older children and adults.

 

What Are the Possible Side Effects of Calpol Six Plus Sugar Free Suspension?

 

Paracetamol is generally well tolerated at recommended doses. Serious side effects are rare when the medicine is used correctly. However, it's important to know what to watch for.

Common side effects (may affect up to 1 in 10 children):

  • Nausea
  • Stomach discomfort

Less common or rare side effects:

  • Allergic skin reactions, including rash or urticaria
  • Swelling of the face, lips, or throat (angioedema) — seek emergency help immediately
  • Blood disorders such as thrombocytopenia (very rare)
  • Liver damage — only if the recommended dose is exceeded

If you notice any signs of an allergic reaction, stop giving the medicine and seek urgent medical attention. Overdose with paracetamol is a medical emergency — if you suspect your child has taken too much, go to A&E immediately, even if they seem well.

 

How Should You Store Calpol Six Plus Sugar Free Suspension?

 

  • Store below 25°C in a dry place, away from direct sunlight and heat.
  • Do not refrigerate or freeze.
  • Keep the bottle tightly closed when not in use.
  • Keep out of the sight and reach of children at all times.
  • Once opened, use within 28 days.
  • Do not use after the expiry date printed on the label.
  • Do not dispose of medicines via wastewater or household waste — return unused medicine to your pharmacist.

For general health support alongside fever management, our vitamins and supplements range includes products that may support your child's immune health during recovery.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Calpol Six Plus Sugar Free Suspension online in the UK?

You can buy Calpol Six Plus Sugar Free Suspension 200ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for £7.69. It is available without a prescription as a General Sale List medicine. Simply add it to your basket and it will be dispatched to your door.

How does Calpol Six Plus Sugar Free Suspension work in the body?

The active ingredient, paracetamol 250mg per 5ml, works by inhibiting prostaglandin synthesis in the central nervous system, which reduces the brain's fever response and lowers the perception of pain. It is absorbed quickly from the gut, with effects typically beginning within 30 minutes of the correct dose. It does not have significant anti-inflammatory properties at standard doses.

What age is Calpol Six Plus Sugar Free Suspension suitable for?

This suspension is specifically formulated for children aged 6 to 12 years. It should not be given to children under 6 years old — for younger children, the Calpol Infant Suspension (120mg/5ml) is the appropriate choice. Always check the age range on the packaging before administering.

How do I give Calpol Six Plus Sugar Free Suspension step by step?

Shake the bottle well before use, then use the measuring syringe or spoon provided to draw up the correct dose for your child's age. Give the suspension orally, directly into your child's mouth, and note the time so you can track when the next dose is due. Never use a kitchen spoon, as this can result in inaccurate dosing.

What is the correct dose of Calpol Six Plus Sugar Free for my child?

The dose depends on your child's age: 5ml (250mg) for children aged 6–8 years, 7.5ml (375mg) for 8–10 years, and 10ml (500mg) for 10–12 years. Each dose can be repeated every 4 to 6 hours, but no more than 4 doses should be given in any 24-hour period. Always follow the instructions on the packaging.

Can I give Calpol Six Plus Sugar Free alongside other medicines?

Do not give this suspension alongside any other medicine containing paracetamol, as this significantly increases the risk of overdose. If your child is taking warfarin, metoclopramide, or any other regular prescription medicine, speak to your pharmacist before use. Our cold and flu range lists products that can be used safely alongside paracetamol.

What are the side effects of Calpol Six Plus Sugar Free Suspension?

Side effects are uncommon when the medicine is used at the recommended dose. Possible side effects include nausea, stomach discomfort, and rarely, allergic skin reactions such as rash or urticaria. If your child develops swelling of the face, lips, or throat, stop the medicine immediately and seek emergency medical help.

Is Calpol Six Plus Sugar Free Suspension suitable for children with diabetes?

The sugar free formulation does not contain sucrose, making it more appropriate for children with diabetes or those who need to limit their sugar intake. However, it does contain aspartame, which is a source of phenylalanine — so it should not be given to children with phenylketonuria. Always consult your child's doctor or pharmacist if you are unsure.

What happens if I miss a dose of Calpol Six Plus Sugar Free Suspension?

If you miss a dose, give it as soon as you remember — provided at least 4 hours have passed since the last dose. Never give a double dose to make up for a missed one. If your child's symptoms are improving, you may not need to give the next dose at all.

How long can my child take Calpol Six Plus Sugar Free Suspension?

For fever, do not use for more than 3 days without seeking medical advice. For pain relief, do not use for more than 5 days without consulting a doctor. If symptoms persist or worsen, stop use and speak to your GP. Prolonged use without medical supervision is not recommended.

What are the alternatives to Calpol Six Plus Sugar Free Suspension?

Alternatives for children aged 6 to 12 years include ibuprofen-based suspensions (such as Nurofen for Children), which also reduce fever and have anti-inflammatory properties. Paracetamol and ibuprofen can sometimes be alternated under medical guidance, but should not be given simultaneously without a doctor's advice. You can explore our pain relief collection for further options.

Who is not eligible to use Calpol Six Plus Sugar Free Suspension?

This product should not be given to children under 6 years old, children with a known allergy to paracetamol, or those already taking another paracetamol-containing medicine. Children with severe liver disease or phenylketonuria should also not use this suspension. Always read the full list of ingredients before use.

Can Calpol Six Plus Sugar Free Suspension be used for teething pain?

This suspension is only suitable for children aged 6 years and over, so it is not appropriate for teething pain in infants or toddlers. For children aged 6 and above who experience dental pain or discomfort, it can be used as directed. For younger children, speak to your pharmacist about age-appropriate options.

What should I do if my child takes too much Calpol Six Plus Sugar Free Suspension?

Paracetamol overdose is a medical emergency. If you think your child has taken more than the recommended dose — even if they appear well — go to your nearest A&E department immediately or call 999. Do not wait for symptoms to appear, as liver damage from paracetamol overdose can develop hours after ingestion.

What are the latest guidelines on using paracetamol for children's fever?

Current NHS guidance recommends paracetamol as a first-line option for managing fever and discomfort in children, provided the correct age-appropriate dose is used. The NHS advises that fever itself is not always harmful and that medicines should be used to improve comfort rather than simply to normalise temperature. Always follow the dosage instructions and seek medical advice if fever lasts more than 3 days or your child seems very unwell.

How Should You Use Calpol Six Plus Sugar Free Suspension?

Always shake the bottle well before measuring each dose. Use only the measuring syringe or spoon supplied with the bottle — kitchen spoons vary in size and can lead to under- or over-dosing. Give the suspension orally, directly into your child's mouth. Do not mix it into food or drink, as this may affect how much your child actually receives.

Follow these steps each time you give a dose:

What Is the Correct Dose of Calpol Six Plus Sugar Free Suspension?

The dose is determined by your child's age. Do not exceed the stated dose for your child's age group, and never give more than 4 doses in any 24-hour period. Leave at least 4 hours between each dose.

When Is the Best Time to Use Calpol Six Plus Sugar Free Suspension?

Give the suspension as soon as your child's symptoms begin — there is no need to wait until fever reaches a specific temperature before treating discomfort. It can be given with or without food, though giving it after a small amount of food may help if your child has a sensitive stomach. Space doses evenly throughout the day where possible, and avoid giving a dose late at night unless your child is clearly distressed or feverish.

If your child wakes in the night with a high temperature, it is appropriate to give a dose at that time, provided at least 4 hours have passed since the previous dose.

How Long Can You Use Calpol Six Plus Sugar Free Suspension For?

For fever, do not use this suspension for more than 3 consecutive days without seeking medical advice. For pain relief, the limit is 5 days. If your child's symptoms have not improved within these timeframes, or if they worsen at any point, stop use and consult your GP. Prolonged or frequent use of paracetamol without medical supervision is not recommended.

If your child regularly needs pain relief or fever management over an extended period, this should be investigated by a healthcare professional rather than managed solely with over-the-counter medicines.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use Calpol Six Plus Sugar Free Suspension?

Always shake the bottle well before measuring each dose. Use only the measuring syringe or spoon supplied with the bottle — kitchen spoons vary in size and can lead to under- or over-dosing. Give the suspension orally, directly into your child's mouth. Do not mix it into food or drink, as this may affect how much your child actually receives.

Follow these steps each time you give a dose:

What Is the Correct Dose of Calpol Six Plus Sugar Free Suspension?

The dose is determined by your child's age. Do not exceed the stated dose for your child's age group, and never give more than 4 doses in any 24-hour period. Leave at least 4 hours between each dose.

When Is the Best Time to Use Calpol Six Plus Sugar Free Suspension?

Give the suspension as soon as your child's symptoms begin — there is no need to wait until fever reaches a specific temperature before treating discomfort. It can be given with or without food, though giving it after a small amount of food may help if your child has a sensitive stomach. Space doses evenly throughout the day where possible, and avoid giving a dose late at night unless your child is clearly distressed or feverish.

If your child wakes in the night with a high temperature, it is appropriate to give a dose at that time, provided at least 4 hours have passed since the previous dose.

How Long Can You Use Calpol Six Plus Sugar Free Suspension For?

For fever, do not use this suspension for more than 3 consecutive days without seeking medical advice. For pain relief, the limit is 5 days. If your child's symptoms have not improved within these timeframes, or if they worsen at any point, stop use and consult your GP. Prolonged or frequent use of paracetamol without medical supervision is not recommended.

If your child regularly needs pain relief or fever management over an extended period, this should be investigated by a healthcare professional rather than managed solely with over-the-counter medicines.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Calpol Six Plus Sugar Free Suspension?

Paracetamol is one of the most widely used medicines for children in the UK and is generally well tolerated when used at the correct dose. Serious side effects are rare. That said, it's important to know what to look out for so you can act quickly if something doesn't seem right.

  • Nausea
  • Stomach discomfort or abdominal pain

What Are the Less Common Side Effects of Calpol Six Plus Sugar Free Suspension?

Less common reactions can occur, particularly in children who are sensitive to paracetamol or any of the other ingredients in the suspension. These are not frequently reported but should be taken seriously if they appear.

  • Skin rash or itching (urticaria)
  • Redness or flushing of the skin
  • Headache
  • Dizziness
  • Malaise (general feeling of being unwell)

What Are the Serious Side Effects of Calpol Six Plus Sugar Free Suspension?

Serious side effects are very rare when the medicine is used correctly and at the recommended dose. However, they can occur and require immediate medical attention.

  • Angioedema — swelling of the face, lips, tongue, or throat. This is a medical emergency. Call 999 immediately.
  • Severe allergic reaction (anaphylaxis) — symptoms include difficulty breathing, rapid heartbeat, and collapse.
  • Blood disorders such as thrombocytopenia (low platelet count) or agranulocytosis — extremely rare.
  • Liver damage — this occurs only in cases of overdose, not at recommended doses. If overdose is suspected, go to A&E immediately.

If your child has taken more than the recommended dose — even if they appear well — seek emergency medical help without delay. Paracetamol overdose can cause severe liver damage that may not become apparent for 24 to 72 hours after ingestion.

What Should You Do If Your Child Experiences Side Effects?

For mild side effects such as nausea or stomach discomfort, try giving the next dose after a small amount of food. If the side effect is persistent or troubling, stop the medicine and speak to your pharmacist or GP. For any sign of an allergic reaction — rash, swelling, difficulty breathing — stop the medicine immediately and seek urgent medical attention. You can report suspected side effects to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Calpol Six Plus Sugar Free Suspension Interact With Other Medicines?

Yes. The most important interaction to be aware of is with other paracetamol-containing products. Giving two paracetamol-containing medicines at the same time can easily lead to overdose, even if each individual product seems to contain a small amount. Always check the ingredients of any other medicine your child is taking — many cold and flu remedies contain paracetamol. Other interactions include warfarin (paracetamol may enhance its anticoagulant effect with regular use), metoclopramide and domperidone (which can increase the speed of paracetamol absorption), and cholestyramine (which may reduce absorption if taken within one hour of paracetamol). Always tell your pharmacist about all medicines your child is currently taking before starting this suspension.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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