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Calpol Six Plus Sugar Free Suspension - 200ml

Calpol Six Plus Sugar Free Suspension - 200ml

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  • ✔️ Relieves mild to moderate pain in children aged 6–12 years
  • ✔️ Reduces fever quickly, including post-vaccination temperature
  • ✔️ Sugar-free formula suitable for children with diabetes
  • ✔️ Contains paracetamol 250mg/5ml for accurate age-appropriate dosing
  • ✔️ Oral suspension ideal for children unable to swallow tablets

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What Is Calpol Six Plus Sugar Free Suspension?

 

When your child is running a temperature or complaining of a headache, you want something that works — and that you can trust. Calpol Six Plus sugar free suspension is one of the most widely recognised paracetamol liquids for children aged 6 and over in the UK. Each 5ml dose contains 250mg of paracetamol, making it straightforward to give the right amount without the guesswork. It's sugar free, which makes it a practical choice for children who need to avoid sucrose — including those with diabetes or tooth sensitivity concerns. You can browse our full range of baby and toddler products if you're looking for options for younger children too.

This suspension is available over the counter without a prescription. At £8.59 for a 200ml bottle, it offers a reliable supply for managing short-term pain and fever at home.

 

How Does Calpol Six Plus Sugar Free Suspension Work?

 

Paracetamol — the active ingredient here — has been used safely in children for decades. It works by inhibiting the synthesis of prostaglandins in the central nervous system, which are chemical messengers involved in transmitting pain signals and regulating body temperature. By reducing prostaglandin activity, paracetamol helps bring down a fever and eases mild to moderate pain.

  • Paracetamol is absorbed through the gastrointestinal tract after swallowing.
  • It acts centrally in the brain to reduce the perception of pain.
  • It lowers elevated body temperature by acting on the hypothalamus — the brain's temperature-regulating centre.
  • It does not have significant anti-inflammatory properties, unlike ibuprofen.

Effects are typically felt within 30 to 60 minutes of taking a dose, and relief can last for up to 4 to 6 hours.

 

Who Should Use Calpol Six Plus Sugar Free Suspension?

 

This suspension is specifically formulated for children aged 6 years and over, up to 12 years. It's particularly useful when a child needs paracetamol but cannot or should not have sugar — for example, children with type 1 or type 2 diabetes. It's also a sensible option for children who dislike the taste of standard formulations, as the sugar-free version uses alternative sweeteners.

  • Children aged 6 to 12 years with mild to moderate pain (e.g. headache, toothache, sore throat, earache).
  • Children with a fever, including post-vaccination fever.
  • Children who need to avoid sucrose for medical or dietary reasons.
  • Children who struggle to swallow tablets and require a liquid formulation.

It is not suitable for children under 6 years old. For younger children, Calpol Infant Suspension (120mg/5ml) is the appropriate formulation.

 

How Does Calpol Six Plus Compare to Calpol Infant Suspension?

 

Feature Calpol Six Plus Sugar Free Calpol Infant Suspension
Active ingredient strength Paracetamol 250mg/5ml Paracetamol 120mg/5ml
Suitable age range 6–12 years 2 months–6 years
Sugar free option Yes (this product) Yes (separate SKU available)
Available OTC Yes Yes

 

How Should You Store Calpol Six Plus Sugar Free Suspension?

 

Store this suspension below 25°C in a dry place, away from direct sunlight. Do not refrigerate — chilling can affect the consistency of the liquid. Always keep the bottle tightly closed and out of the reach and sight of children. Once opened, use within the period stated on the packaging (typically 3 months). If you're also managing other health conditions in the family, our pain relief collection includes a range of options for adults and older teenagers.

Check the expiry date printed on the bottle before each use. Never use a medicine that has passed its expiry date, even if it looks and smells unchanged.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Calpol Six Plus Sugar Free Suspension 200ml specifications
Treatment category Children's pain relief and fever reduction
Active ingredient Paracetamol 250mg per 5ml
Mechanism of action Prostaglandin synthesis inhibitor (central)
Suitable for Children aged 6 to 12 years
Pack size 200ml
Strengths 250mg/5ml
UK classification General Sale List (GSL)
Drug class Analgesic / Antipyretic
Preparation Oral suspension
Route of administration Oral

Specifications of Calpol Six Plus Sugar Free Suspension 200ml

 

What Is Calpol Six Plus Sugar Free Suspension and What Is It Used For?

 

Calpol Six Plus Sugar Free Suspension is an oral liquid medicine containing paracetamol 250mg per 5ml. It is used to relieve mild to moderate pain in children aged 6 to 12 years — including headaches, toothache, sore throats, earache, and aches associated with colds and flu. It also reduces fever, including fever that can follow childhood vaccinations. Because it contains no sucrose, it is suitable for children who need to limit their sugar intake.

 

What Do You Need to Know Before Using Calpol Six Plus Sugar Free Suspension?

 

Before giving this medicine to your child, read the following carefully. There are situations where it should not be used, or where extra caution is needed.

Do not use if your child:

  • Is under 6 years of age.
  • Is allergic to paracetamol or any other ingredient in the suspension.
  • Is already taking another medicine containing paracetamol — this includes many cold and flu remedies.
  • Has severe liver or kidney disease.

Speak to a pharmacist or doctor first if your child:

  • Has liver or kidney problems.
  • Is underweight or malnourished.
  • Has phenylketonuria (PKU) — this product contains saccharin sodium.
  • Has a rare hereditary condition involving fructose intolerance, as the product contains maltitol liquid.

Known drug interactions:

  • Warfarin — regular use of paracetamol may enhance the anticoagulant effect; occasional doses are generally acceptable but seek advice.
  • Other paracetamol-containing products — concurrent use risks overdose.
  • Metoclopramide or domperidone — may increase the rate of paracetamol absorption.
  • Cholestyramine — may reduce paracetamol absorption if taken within one hour.

 

How Should You Use Calpol Six Plus Sugar Free Suspension?

 

Always use the measuring syringe or spoon provided with the pack to ensure an accurate dose. Do not estimate using a household teaspoon, as these vary in size and can lead to under- or over-dosing.

  1. Shake the bottle well before each use.
  2. Use the oral syringe or measuring device provided to draw up the correct dose.
  3. Give the suspension directly into your child's mouth, or mix with a small amount of water if preferred.
  4. Replace the cap securely after use.
  5. Wait at least 4 hours before giving another dose.
  6. Do not give more than 4 doses in any 24-hour period.
Age Group Dose Frequency Max doses per 24 hours
6–9 years 5ml (250mg) Every 4–6 hours 4 doses
10–12 years 10ml (500mg) Every 4–6 hours 4 doses

If your child's symptoms do not improve within 3 days (fever) or 5 days (pain), stop use and consult a doctor. For children managing cold and flu symptoms alongside pain, you may also find our cold and flu range helpful for additional symptom relief options.

 

What Are the Possible Side Effects of Calpol Six Plus Sugar Free Suspension?

 

Paracetamol is generally well tolerated at recommended doses. Serious side effects are rare, but it's important to know what to look out for.

Common side effects (may affect up to 1 in 10 children):

  • Nausea
  • Stomach discomfort

Less common side effects (may affect up to 1 in 100 children):

  • Skin rash or itching
  • Flushing
  • Low blood pressure (hypotension) — very rare, associated with intravenous use, not oral

Serious reactions — stop use immediately and seek urgent medical help if your child develops:

  • Swelling of the face, lips, tongue, or throat (signs of a severe allergic reaction / anaphylaxis)
  • Difficulty breathing or swallowing
  • Signs of liver damage — yellowing of the skin or eyes, dark urine, severe abdominal pain (typically only with overdose)

If you suspect your child has taken too much paracetamol — even if they seem well — go to A&E immediately or call 999. Paracetamol overdose can cause serious liver damage that may not be apparent for several days.

 

How Should You Store Calpol Six Plus Sugar Free Suspension?

 

  • Store below 25°C in a dry place, away from direct sunlight.
  • Do not refrigerate or freeze.
  • Keep the bottle tightly closed when not in use.
  • Keep out of the sight and reach of children.
  • Do not use after the expiry date printed on the label.
  • Once opened, use within 3 months (check packaging for exact guidance).
  • Do not dispose of medicines via wastewater or household waste — return unused medicine to your pharmacist for safe disposal.

If you're looking for other products to support your child's health, our vitamins and supplements collection includes children's multivitamins and immune support options.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Calpol Six Plus Sugar Free Suspension online in the UK?

You can buy Calpol Six Plus Sugar Free Suspension 200ml directly from Cured Pharmacy, a GPhC-registered online pharmacy. It is available without a prescription as a General Sale List medicine. Simply add it to your basket and it will be dispatched to your door.

How does Calpol Six Plus Sugar Free Suspension work in the body?

It contains paracetamol 250mg per 5ml, which works by inhibiting prostaglandin synthesis in the central nervous system. This reduces the transmission of pain signals and lowers an elevated body temperature by acting on the hypothalamus. It does not have anti-inflammatory properties in the way ibuprofen does.

What age is Calpol Six Plus Sugar Free Suspension suitable for?

This suspension is suitable for children aged 6 to 12 years only. It should not be given to children under 6 years old — for younger children, Calpol Infant Suspension (120mg/5ml) is the appropriate product. Always check the age guidance on the packaging before use.

How do I give Calpol Six Plus Sugar Free Suspension step by step?

Shake the bottle well, then use the oral syringe or measuring device provided to draw up the correct dose for your child's age. Give the suspension directly into your child's mouth or mix with a small amount of water. Wait at least 4 hours before giving another dose, and never exceed 4 doses in 24 hours.

What is the correct dose of Calpol Six Plus for my child?

Children aged 6 to 9 years should receive 5ml (250mg) per dose. Children aged 10 to 12 years should receive 10ml (500mg) per dose. Both age groups can have doses every 4 to 6 hours, up to a maximum of 4 doses in any 24-hour period.

Can I give Calpol Six Plus alongside other medicines?

Do not give Calpol Six Plus at the same time as any other product containing paracetamol, as this significantly increases the risk of overdose. Many children's cold and flu remedies already contain paracetamol, so always check the ingredients. If your child takes regular prescribed medicines, speak to a pharmacist before use.

What are the side effects of Calpol Six Plus Sugar Free Suspension?

Side effects are uncommon when the correct dose is used. Occasionally, children may experience nausea or stomach discomfort. Rarely, allergic reactions such as skin rash or swelling can occur — if this happens, stop use immediately and seek medical advice.

Is Calpol Six Plus Sugar Free suitable for children with diabetes?

Yes — this formulation contains no sucrose, making it suitable for children with diabetes or those who need to reduce their sugar intake. It is sweetened with maltitol liquid and saccharin sodium instead. However, children with rare hereditary fructose intolerance should avoid maltitol-containing products, so check with a doctor first.

How long can I give my child Calpol Six Plus Sugar Free Suspension?

For fever, do not use for more than 3 days without consulting a doctor. For pain relief, do not use for more than 5 days without seeking medical advice. If symptoms persist or worsen at any point, stop use and speak to your GP or pharmacist promptly.

What happens if my child accidentally takes too much Calpol Six Plus?

If you think your child has taken more than the recommended dose — even if they appear well — go to your nearest A&E department immediately or call 999. Paracetamol overdose can cause serious liver damage that may not show symptoms for several days. Do not wait for symptoms to appear before seeking help.

What is Calpol Six Plus Sugar Free used to treat?

It is used to relieve mild to moderate pain in children aged 6 to 12 years, including headaches, toothache, sore throats, earache, and muscular aches. It also reduces fever, including post-vaccination fever. For broader children's health products, visit our baby and toddler collection.

How is Calpol Six Plus different from regular Calpol Six Plus (with sugar)?

Both versions contain the same active ingredient — paracetamol 250mg per 5ml — and work in exactly the same way. The sugar-free version replaces sucrose with maltitol liquid and saccharin sodium, making it suitable for children who need to avoid sugar. The clinical effectiveness is identical.

Can Calpol Six Plus be used for a child's cold or flu symptoms?

Yes — it can help relieve the fever, headache, sore throat, and general aches associated with colds and flu in children aged 6 and over. It does not treat the underlying viral infection itself. You can also explore our cold and flu range for additional symptom relief options.

What are the alternatives to Calpol Six Plus Sugar Free Suspension?

Alternatives for children aged 6 and over include ibuprofen oral suspension (e.g. Nurofen for Children 6+), which also reduces inflammation. Paracetamol and ibuprofen can sometimes be alternated under pharmacist guidance for persistent fever. Always check age suitability and contraindications before switching products.

What does the latest guidance say about paracetamol use in children?

NHS guidance confirms that paracetamol remains a first-line option for managing mild to moderate pain and fever in children, provided the correct age-appropriate dose is used. It should not be given solely to prevent post-vaccination fever unless a child is distressed. Always follow current NHS and manufacturer dosing instructions.

How Should You Use Calpol Six Plus Sugar Free Suspension?

Always shake the bottle well before measuring each dose. Use only the oral syringe or measuring device supplied with the pack — never a household teaspoon, as these are not accurate enough for medicine. Give the suspension directly into your child's mouth, or mix with a small amount of water if your child prefers.

Follow these steps each time you give a dose:

What Is the Correct Dose of Calpol Six Plus Sugar Free Suspension?

The dose depends on your child's age. Do not give more than the recommended amount, and always leave at least 4 hours between doses. Never give more than 4 doses in any 24-hour period.

When Is the Best Time to Use Calpol Six Plus Sugar Free Suspension?

Give a dose as soon as your child begins to show signs of pain or a rising temperature — there is no need to wait until symptoms become severe. If your child wakes in the night with a fever or discomfort, it is appropriate to give a dose at that time, provided at least 4 hours have passed since the last dose.

For post-vaccination fever, the NHS advises that paracetamol should only be given if your child is distressed or unwell — not routinely as a preventive measure. Always follow the advice of your GP or practice nurse after vaccinations.

How Long Can You Use Calpol Six Plus Sugar Free Suspension For?

This suspension is intended for short-term use only. For fever, do not use for more than 3 consecutive days without seeking medical advice. For pain relief, do not continue for more than 5 days without consulting a doctor or pharmacist.

If your child's symptoms do not improve within these timeframes, or if they worsen at any point, stop use and contact your GP. Prolonged or repeated use of paracetamol without medical supervision is not recommended.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use Calpol Six Plus Sugar Free Suspension?

Always shake the bottle well before measuring each dose. Use only the oral syringe or measuring device supplied with the pack — never a household teaspoon, as these are not accurate enough for medicine. Give the suspension directly into your child's mouth, or mix with a small amount of water if your child prefers.

Follow these steps each time you give a dose:

What Is the Correct Dose of Calpol Six Plus Sugar Free Suspension?

The dose depends on your child's age. Do not give more than the recommended amount, and always leave at least 4 hours between doses. Never give more than 4 doses in any 24-hour period.

When Is the Best Time to Use Calpol Six Plus Sugar Free Suspension?

Give a dose as soon as your child begins to show signs of pain or a rising temperature — there is no need to wait until symptoms become severe. If your child wakes in the night with a fever or discomfort, it is appropriate to give a dose at that time, provided at least 4 hours have passed since the last dose.

For post-vaccination fever, the NHS advises that paracetamol should only be given if your child is distressed or unwell — not routinely as a preventive measure. Always follow the advice of your GP or practice nurse after vaccinations.

How Long Can You Use Calpol Six Plus Sugar Free Suspension For?

This suspension is intended for short-term use only. For fever, do not use for more than 3 consecutive days without seeking medical advice. For pain relief, do not continue for more than 5 days without consulting a doctor or pharmacist.

If your child's symptoms do not improve within these timeframes, or if they worsen at any point, stop use and contact your GP. Prolonged or repeated use of paracetamol without medical supervision is not recommended.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Calpol Six Plus Sugar Free Suspension?

When used at the recommended dose, paracetamol is one of the most well-tolerated medicines available for children. Serious side effects are rare. That said, some children may experience mild digestive discomfort, particularly if the suspension is taken on an empty stomach.

  • Nausea
  • Stomach discomfort or abdominal pain
  • Feeling generally unwell (malaise)

What Are the Less Common Side Effects of Calpol Six Plus Sugar Free Suspension?

Less common reactions are uncommon but can occur. If your child develops any of the following, stop use and speak to a pharmacist or GP.

  • Skin rash or hives (urticaria)
  • Itching (pruritus)
  • Flushing of the skin
  • Headache (unrelated to the condition being treated)

What Are the Serious Side Effects of Calpol Six Plus Sugar Free Suspension?

Serious side effects from paracetamol at recommended doses are very rare. However, they can occur and require immediate medical attention. The most significant risk is associated with overdose rather than therapeutic use.

  • Severe allergic reaction (anaphylaxis) — signs include swelling of the face, lips, tongue, or throat, difficulty breathing, or a sudden drop in blood pressure.
  • Liver damage — this is associated with overdose and may not produce symptoms for 24 to 72 hours. Signs include yellowing of the skin or eyes (jaundice), dark urine, and severe upper abdominal pain.
  • Blood disorders — very rarely, paracetamol has been associated with thrombocytopenia (low platelet count) or agranulocytosis.

If you suspect your child has taken too much paracetamol, go to A&E immediately — do not wait for symptoms to develop.

What Should You Do If Your Child Experiences Side Effects?

For mild side effects such as nausea, try giving the next dose with a small amount of food or water. If a skin rash or any allergic reaction develops, stop the medicine immediately and seek medical advice. For any sign of a severe allergic reaction — swelling, breathing difficulty, or collapse — call 999 without delay.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve medicine safety for everyone.

Can Calpol Six Plus Sugar Free Suspension Interact With Other Medicines?

Yes, interactions are possible. The most important one to be aware of is the risk of paracetamol overdose if this suspension is given alongside any other paracetamol-containing product — including many children's cold and flu remedies. Always check the ingredients of any other medicine your child is taking before giving Calpol Six Plus.

Warfarin — used to prevent blood clots — may be affected by regular paracetamol use, potentially increasing bleeding risk. Occasional doses are generally considered acceptable, but if your child takes warfarin regularly, seek pharmacist advice first. Medicines that affect stomach emptying, such as metoclopramide or domperidone, may alter how quickly paracetamol is absorbed.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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