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Calpol Six Plus Sugar Free Suspension - 100ml

Calpol Six Plus Sugar Free Suspension - 100ml

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  • ✔️ Relieves mild to moderate pain in children aged 6 and over
  • ✔️ Reduces fever quickly with paracetamol 250mg per 5ml
  • ✔️ Sugar free formula suitable for children with diabetes
  • ✔️ Strawberry flavour makes dosing easier for reluctant children
  • ✔️ Trusted paracetamol liquid recommended by NHS for childhood fever

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What Is Calpol Six Plus Sugar Free Suspension?

 

When your child is running a temperature or complaining of a headache, you want something that works — and that you can trust. Calpol Six Plus sugar free suspension is a well-established oral paracetamol liquid designed specifically for children aged 6 years and over. Each 5ml dose contains 250mg of paracetamol, providing reliable relief from mild to moderate pain and helping to bring down a fever. It's sugar free, which makes it a practical choice for children who need to limit their sugar intake. You can find it alongside other trusted options in our baby and toddler range.

Paracetamol has been used safely in children for decades and remains one of the most widely recommended medicines for childhood fever and pain by the NHS. This suspension is strawberry flavoured, making it easier to give to children who might otherwise resist taking medicine. It's available over the counter without a prescription, so you can order it quickly and conveniently when you need it most.

 

How Does Calpol Six Plus Sugar Free Suspension Work?

 

Paracetamol works primarily in the central nervous system. It reduces fever and relieves pain through a well-understood mechanism, though researchers continue to refine their understanding of the exact pathways involved. Here's a simplified breakdown:

  • Paracetamol inhibits the enzyme cyclooxygenase (COX) in the brain, reducing the production of prostaglandins — chemicals that trigger pain and raise body temperature.
  • By lowering prostaglandin levels in the hypothalamus (the brain's temperature-regulating centre), it helps bring a fever down.
  • It also raises the pain threshold, meaning your child feels less discomfort from headaches, sore throats, toothache, or aches associated with colds and flu.
  • Unlike ibuprofen, paracetamol does not have significant anti-inflammatory properties, but it is gentler on the stomach.

The liquid formulation means it's absorbed relatively quickly, with effects typically beginning within 30 to 60 minutes of taking the correct dose.

 

Who Should Use Calpol Six Plus Sugar Free Suspension?

 

This suspension is intended for children aged 6 years and over. It's particularly useful when a child needs pain or fever relief but cannot swallow tablets. It's also a sensible option for children who need to avoid sugar in their diet. That said, it's not suitable for everyone — always read the label carefully before use.

This product is well suited for children who:

  • Are aged 6 years or older and need relief from mild to moderate pain (e.g. headache, toothache, sore throat, earache)
  • Have a fever associated with a cold, flu, or post-vaccination reaction
  • Have diabetes or are on a sugar-restricted diet and need a sugar free paracetamol option
  • Struggle to swallow tablets or capsules and require a liquid formulation

 

How Does Calpol Six Plus Compare to Calpol Infant Suspension?

 

Feature Calpol Six Plus Sugar Free Suspension Calpol Infant Suspension
Age range 6 years and over 2 months to 6 years
Paracetamol strength 250mg per 5ml 120mg per 5ml
Sugar free Yes Available in sugar free variant
Flavour Strawberry Strawberry

 

Is Calpol Six Plus Suitable for Children With Allergies or Specific Health Conditions?

 

If your child has a known allergy to paracetamol or any of the other ingredients listed in the product leaflet, do not use this suspension. Children with liver or kidney problems should only use Calpol Six Plus sugar free suspension under medical supervision, as paracetamol is processed by the liver. Similarly, if your child is already taking any other medicine containing paracetamol — including some cold and flu remedies — do not give this product at the same time, as this can lead to accidental overdose. If you're unsure, our cold and flu section has further guidance on managing symptoms safely.

Store the bottle below 25°C and keep it out of reach of children. Do not refrigerate. Once opened, use within the period stated on the packaging.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Calpol Six Plus Sugar Free Suspension 100ml specifications
Treatment category Children's pain relief and fever reduction
Mechanism of action COX enzyme inhibition reducing prostaglandin synthesis
Effective for Mild to moderate pain, fever
Suitable for Children aged 6 years and over
Active ingredient Paracetamol 250mg per 5ml
Pack size 100ml
UK classification General Sale List (GSL)
Drug class Analgesic / Antipyretic
Preparation Oral suspension
Route of administration Oral

Specifications of Calpol Six Plus Sugar Free Suspension 100ml

 

What Is Calpol Six Plus Sugar Free Suspension and What Is It Used For?

 

Calpol Six Plus Sugar Free Suspension is an oral liquid medicine containing paracetamol 250mg per 5ml. It is used to relieve mild to moderate pain in children aged 6 and over — including headaches, toothache, sore throats, and earache — and to reduce fever. The NHS recommends paracetamol as a first-line option for managing fever and pain in children when used at the correct dose. This formulation is sugar free, making it appropriate for children who need to avoid sucrose.

 

What Do You Need to Know Before Using Calpol Six Plus Sugar Free Suspension?

 

Before giving this medicine to your child, read the following carefully. Do not use Calpol Six Plus Sugar Free Suspension if any of the contraindications below apply:

  • Your child is under 6 years of age
  • Your child is allergic to paracetamol or any other ingredient in the suspension
  • Your child has severe liver or kidney disease
  • Your child is already taking another medicine containing paracetamol

Speak to your pharmacist or GP before use if your child has liver problems, kidney problems, or is malnourished, as these conditions can affect how paracetamol is processed in the body.

Be aware of the following potential drug interactions:

  • Other paracetamol-containing products (risk of overdose)
  • Warfarin — regular use of paracetamol may enhance the anticoagulant effect
  • Some medicines used to treat epilepsy (e.g. carbamazepine, phenytoin) may affect how paracetamol works
  • Metoclopramide and domperidone may increase the rate of paracetamol absorption

 

How Should You Use Calpol Six Plus Sugar Free Suspension?

 

Always use the measuring device provided with the pack to ensure an accurate dose. Never use a kitchen spoon, as this can lead to under- or over-dosing. Follow these steps:

  1. Shake the bottle well before each use.
  2. Use the syringe or measuring cup provided to draw up the correct dose for your child's age or weight.
  3. Give the suspension orally — it can be swallowed directly or mixed with a small amount of water if needed.
  4. Leave at least 4 hours between doses.
  5. Do not give more than 4 doses in any 24-hour period.
Age Group Dose Frequency Max doses per 24 hours
6–8 years 5ml (250mg) Every 4–6 hours 4 doses
8–10 years 7.5ml (375mg) Every 4–6 hours 4 doses
10–12 years 10ml (500mg) Every 4–6 hours 4 doses
12–16 years 10–15ml (500–750mg) Every 4–6 hours 4 doses

If your child's symptoms do not improve after 3 days (for fever) or 5 days (for pain), stop use and consult a doctor. You can also browse our pain relief collection for additional options suitable for older children and adults.

 

What Are the Possible Side Effects of Calpol Six Plus Sugar Free Suspension?

 

Paracetamol is generally very well tolerated at recommended doses. Serious side effects are rare but can occur, particularly if the medicine is used incorrectly or in excessive amounts. Always follow the dosing instructions carefully.

Common side effects (may affect up to 1 in 10 children):

  • Nausea
  • Stomach discomfort

Less common side effects (may affect up to 1 in 100 children):

  • Skin rash or itching
  • Allergic reactions including urticaria (hives)
  • Blood disorders (e.g. thrombocytopenia — low platelet count) — very rare
  • Liver damage — only in cases of overdose or prolonged excessive use

If your child develops a rash, swelling of the face or throat, or difficulty breathing after taking this medicine, stop use immediately and seek emergency medical help. These may be signs of a serious allergic reaction (anaphylaxis), which is very rare but requires urgent attention.

 

How Should You Store Calpol Six Plus Sugar Free Suspension?

 

Correct storage helps maintain the medicine's effectiveness and safety. Follow these guidelines:

  • Store below 25°C in a dry place
  • Do not refrigerate or freeze
  • Keep the bottle tightly closed when not in use
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the label
  • Do not dispose of medicines via wastewater or household waste — return unused medicine to your pharmacist

If you're managing your child's health during cold and flu season, it's worth keeping a well-stocked medicine cabinet. Our first aid collection includes a range of essentials to help you stay prepared.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Calpol Six Plus Sugar Free Suspension online in the UK?

You can buy Calpol Six Plus Sugar Free Suspension 100ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is available without a prescription as a General Sale List (GSL) medicine. Simply add it to your basket and it will be dispatched to your door.

How does Calpol Six Plus Sugar Free Suspension work in the body?

It contains paracetamol 250mg per 5ml, which inhibits the COX enzyme in the brain, reducing the production of prostaglandins — chemicals responsible for pain and fever. This lowers your child's temperature and raises their pain threshold. Effects typically begin within 30 to 60 minutes of taking the correct dose.

What age is Calpol Six Plus Sugar Free Suspension suitable for?

This suspension is suitable for children aged 6 years and over only. It must not be given to children under 6 years old, as the paracetamol concentration (250mg per 5ml) is higher than that found in infant formulations. For younger children, Calpol Infant Suspension (120mg per 5ml) is the appropriate choice.

How do I give Calpol Six Plus step by step?

Shake the bottle well before use, then use the measuring syringe or cup provided to draw up the correct dose for your child's age. Give the suspension orally and leave at least 4 hours before giving another dose. Never exceed 4 doses in any 24-hour period.

What is the correct dose of Calpol Six Plus for a 7-year-old?

For a child aged 6 to 8 years, the recommended dose is 5ml (250mg of paracetamol), given every 4 to 6 hours as needed. No more than 4 doses should be given in any 24-hour period. Always check the packaging or ask your pharmacist if you are unsure.

How often can I give Calpol Six Plus to my child?

You can give Calpol Six Plus every 4 to 6 hours, but you must leave at least 4 hours between each dose. The maximum is 4 doses in any 24-hour period. If your child still has a fever or pain after 3 days, consult your GP.

Is Calpol Six Plus Sugar Free Suspension safe for children with diabetes?

Yes, this formulation is sugar free (sucrose free), making it more suitable for children with diabetes or those on a sugar-restricted diet compared to sugar-containing alternatives. However, it does contain other excipients such as maltitol liquid — always check the full ingredients list and consult your child's doctor or pharmacist if you have concerns.

What are the side effects of Calpol Six Plus Sugar Free Suspension?

Side effects are uncommon when the medicine is used at the recommended dose. Possible side effects include nausea, stomach discomfort, and rarely, skin rashes or allergic reactions. If your child develops swelling of the face, difficulty breathing, or a severe rash, stop use immediately and seek emergency medical help.

Can I give Calpol Six Plus alongside other medicines?

Do not give Calpol Six Plus at the same time as any other medicine containing paracetamol, including many cold and flu remedies, as this can cause accidental overdose. It may also interact with warfarin and certain epilepsy medicines. Always check with a pharmacist before combining medicines — you can browse our cold and flu range for guidance on suitable combination products.

What happens if I accidentally give my child too much Calpol Six Plus?

If you think your child has taken too much paracetamol, go to your nearest A&E or call 999 immediately — even if your child seems well, as overdose symptoms can be delayed. Do not wait for symptoms to appear before seeking help. Take the medicine packaging with you so medical staff can see exactly what was taken.

What should I do if I miss a dose of Calpol Six Plus?

If you miss a dose and your child is still in pain or has a fever, give the next dose as soon as you remember — provided at least 4 hours have passed since the last dose. Never give a double dose to make up for a missed one. If you are unsure, speak to your pharmacist.

How long can my child take Calpol Six Plus for?

For fever, do not use for more than 3 days without consulting a doctor. For pain relief, do not use for more than 5 days without medical advice. If symptoms persist, worsen, or new symptoms develop, always seek professional guidance rather than continuing to self-treat.

What are the alternatives to Calpol Six Plus Sugar Free Suspension?

Alternatives for children aged 6 and over include ibuprofen suspension (e.g. Nurofen for Children), which also reduces inflammation, or paracetamol tablets for older children who can swallow them. Ibuprofen should be avoided in children with asthma, kidney problems, or stomach ulcers. You can explore further options in our pain relief collection.

Is Calpol Six Plus Sugar Free Suspension suitable for children with asthma?

Paracetamol is generally considered safer than ibuprofen for children with asthma, as ibuprofen can trigger bronchospasm in some asthmatic children. However, a small number of children with aspirin-sensitive asthma may also react to paracetamol. Always consult your child's GP or asthma nurse before use if your child has asthma.

What are the latest NHS recommendations on using paracetamol for children's fever?

The NHS advises that paracetamol can be used to relieve discomfort and reduce fever in children, but that treating a fever is not always necessary if the child is otherwise well. The focus should be on keeping the child comfortable, ensuring they drink plenty of fluids, and monitoring for signs of serious illness. Alternating paracetamol and ibuprofen is not routinely recommended by the NHS unless advised by a healthcare professional.

How Should You Use Calpol Six Plus Sugar Free Suspension?

Always read the label before giving this medicine to your child. Use only the measuring syringe or cup provided with the pack — never a kitchen spoon, as this can result in an inaccurate dose. Follow these steps each time you give a dose:

If your child spits out the dose or vomits immediately after taking it, do not give another dose straight away. Wait and observe, and if symptoms continue, contact your pharmacist for advice.

What Is the Correct Dose of Calpol Six Plus Sugar Free Suspension?

The dose depends on your child's age. Always use the lowest effective dose for the shortest time necessary. Do not give more than 4 doses in any 24-hour period, and always leave at least 4 hours between doses.

When Is the Best Time to Use Calpol Six Plus Sugar Free Suspension?

Give a dose when your child is clearly uncomfortable — for example, when they have a raised temperature, are in pain, or are distressed due to a cold or flu. There is no fixed time of day; the medicine can be given at any point, day or night, as long as the 4-hour gap between doses is observed. If your child wakes in the night with a fever, it is appropriate to give a dose at that time provided the previous dose was at least 4 hours ago.

You do not need to give the medicine with food, though doing so may help if your child has a sensitive stomach.

How Long Can You Use Calpol Six Plus Sugar Free Suspension For?

For fever, do not use this medicine for more than 3 consecutive days without consulting a doctor. For pain relief, the maximum recommended duration without medical advice is 5 days. If your child's symptoms have not improved within these timeframes, or if they worsen at any point, stop use and seek medical advice promptly. Prolonged or excessive use of paracetamol can cause liver damage, so it is important to stick to the recommended duration and dose.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use Calpol Six Plus Sugar Free Suspension?

Always read the label before giving this medicine to your child. Use only the measuring syringe or cup provided with the pack — never a kitchen spoon, as this can result in an inaccurate dose. Follow these steps each time you give a dose:

If your child spits out the dose or vomits immediately after taking it, do not give another dose straight away. Wait and observe, and if symptoms continue, contact your pharmacist for advice.

What Is the Correct Dose of Calpol Six Plus Sugar Free Suspension?

The dose depends on your child's age. Always use the lowest effective dose for the shortest time necessary. Do not give more than 4 doses in any 24-hour period, and always leave at least 4 hours between doses.

When Is the Best Time to Use Calpol Six Plus Sugar Free Suspension?

Give a dose when your child is clearly uncomfortable — for example, when they have a raised temperature, are in pain, or are distressed due to a cold or flu. There is no fixed time of day; the medicine can be given at any point, day or night, as long as the 4-hour gap between doses is observed. If your child wakes in the night with a fever, it is appropriate to give a dose at that time provided the previous dose was at least 4 hours ago.

You do not need to give the medicine with food, though doing so may help if your child has a sensitive stomach.

How Long Can You Use Calpol Six Plus Sugar Free Suspension For?

For fever, do not use this medicine for more than 3 consecutive days without consulting a doctor. For pain relief, the maximum recommended duration without medical advice is 5 days. If your child's symptoms have not improved within these timeframes, or if they worsen at any point, stop use and seek medical advice promptly. Prolonged or excessive use of paracetamol can cause liver damage, so it is important to stick to the recommended duration and dose.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Calpol Six Plus Sugar Free Suspension?

When used at the correct dose, Calpol Six Plus Sugar Free Suspension is generally very well tolerated by most children. Serious side effects are rare. The most commonly reported side effects include:

  • Nausea or feeling sick
  • Stomach discomfort or abdominal pain

These effects are usually mild and short-lived. If your child feels sick after taking the suspension, try giving it with a small amount of food or water next time.

What Are the Less Common Side Effects of Calpol Six Plus Sugar Free Suspension?

Less common side effects occur in a small number of children and may include:

  • Skin rash or itching (urticaria / hives)
  • Flushing or redness of the skin
  • Swelling of the face, lips, or throat (angioedema) — rare
  • Low blood platelet count (thrombocytopenia) — very rare
  • Low white blood cell count (leucopenia or agranulocytosis) — very rare

If your child develops a skin rash or any swelling after taking this medicine, stop use immediately and seek medical advice. These reactions, while uncommon, should always be taken seriously.

What Are the Serious Side Effects of Calpol Six Plus Sugar Free Suspension?

Serious side effects are almost exclusively associated with overdose or prolonged excessive use rather than correct therapeutic use. Paracetamol overdose can cause severe liver damage, which may not be immediately apparent. Symptoms of overdose can include nausea, vomiting, and abdominal pain in the first 24 hours, followed by signs of liver failure if untreated.

If you suspect your child has taken too much paracetamol — even if they appear well — go to your nearest A&E immediately or call 999. Do not wait for symptoms to develop. Take the medicine packaging with you.

What Should You Do If Your Child Experiences Side Effects?

For mild side effects such as nausea or stomach discomfort, try giving the next dose with a small amount of food. If the side effect is persistent or troubling, stop use and speak to your pharmacist or GP. For any signs of an allergic reaction — including rash, swelling, or difficulty breathing — stop use immediately and seek emergency medical help by calling 999 or going to A&E.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve medicine safety for everyone.

Can Calpol Six Plus Sugar Free Suspension Interact With Other Medicines?

Yes. The most important interaction to be aware of is with other medicines containing paracetamol. Many over-the-counter cold and flu remedies contain paracetamol, so giving them alongside Calpol Six Plus can easily lead to accidental overdose. Always check the ingredients of any other medicine your child is taking before giving this suspension.

Other notable interactions include:

  • Warfarin — regular paracetamol use may increase the anticoagulant effect
  • Carbamazepine, phenytoin, and phenobarbital — may reduce the effectiveness of paracetamol or increase the risk of liver toxicity
  • Metoclopramide and domperidone — may speed up paracetamol absorption
  • Cholestyramine — may reduce paracetamol absorption if taken at the same time

If your child takes any regular medicines, always check with your pharmacist before giving Calpol Six Plus Sugar Free Suspension.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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