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Anadin Extra

Anadin Extra

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  • ✔️ Combines aspirin, paracetamol and caffeine for triple-action relief
  • ✔️ Targets headaches, migraine, dental pain and period pain
  • ✔️ Caffeine enhances analgesic absorption for faster pain relief
  • ✔️ Suitable for adults and young people aged 16 and over
  • ✔️ General Sale Medicine — no prescription required

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What Are Anadin Extra Tablets and How Do They Relieve Pain?

 

If you've ever reached for something stronger than a standard paracetamol tablet during a particularly stubborn headache, you'll understand the appeal of a triple-action formula. Anadin Extra tablets combine three active ingredients — aspirin 300 mg, paracetamol 200 mg, and caffeine 45 mg — to tackle mild to moderate pain from multiple angles at once. Available over the counter without a prescription, they're one of the most recognised analgesic options in UK pharmacies. You can find them alongside a wide range of other options in our pain relief collection.

Each tablet is a general sale medicine (GSL) in the UK, meaning it can be purchased without a pharmacist's supervision, though it's always worth reading the label carefully before you start. The combination of ingredients has been used for decades and is well established in clinical practice for short-term pain management.

 

How Does Anadin Extra Work to Relieve Pain?

 

The three-ingredient approach is what sets this product apart from single-ingredient analgesics. Each component plays a distinct role:

  • Aspirin (300 mg): A non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclo-oxygenase (COX) enzymes, reducing the production of prostaglandins — the chemicals responsible for pain, inflammation, and fever.
  • Paracetamol (200 mg): Works centrally in the brain to raise the pain threshold, complementing aspirin's peripheral anti-inflammatory action.
  • Caffeine (45 mg): Acts as an adjuvant analgesic. Research suggests caffeine enhances the absorption and efficacy of co-administered analgesics, meaning you may need a lower dose of each active ingredient to achieve the same effect.

The result is a synergistic effect — each ingredient supports the others, rather than simply adding up their individual actions.

 

Who Is Anadin Extra Suitable For?

 

Anadin Extra tablets are intended for adults and young people aged 16 and over. They're particularly useful when standard single-ingredient analgesics haven't provided adequate relief. Typical indications include:

  • Tension headaches and migraines
  • Dental pain and toothache
  • Muscular aches and rheumatic pain
  • Period pain (dysmenorrhoea)
  • Cold and flu symptoms accompanied by pain or fever

They are not suitable for children under 16, due to the aspirin content and the associated risk of Reye's syndrome — a rare but serious condition affecting the brain and liver. People with a known aspirin allergy, active peptic ulcer disease, or haemophilia should also avoid this product.

 

How Does Anadin Extra Compare to Standard Paracetamol Tablets?

 

Feature Anadin Extra Standard Paracetamol (500 mg)
Active ingredients Aspirin, paracetamol, caffeine Paracetamol only
Anti-inflammatory action Yes (aspirin) No
Suitable for under 16s No Yes (age-appropriate dose)
Suitable with warfarin No Generally yes (with caution)

 

How Should You Store Anadin Extra Tablets?

 

Store Anadin Extra tablets below 25°C in a dry place, away from direct sunlight. Keep them in their original packaging and out of the reach and sight of children. Do not use after the expiry date printed on the pack. If you're unsure whether a medicine is still safe to use, your local pharmacist can advise — or you can browse our first aid collection for additional health essentials.

Anadin Extra tablets should not be stored in a bathroom cabinet or near a sink, as moisture can degrade the active ingredients over time. A cool, dry cupboard away from heat sources is ideal.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Anadin Extra specifications
Treatment category Analgesic / Pain relief
Mechanism of action COX enzyme inhibition (aspirin), central pain threshold elevation (paracetamol), adjuvant analgesic (caffeine)
Effective for Headache, migraine, dental pain, muscular aches, period pain, cold and flu symptoms
Suitable for Adults and young people aged 16 and over
Active ingredients Aspirin 300 mg, Paracetamol 200 mg, Caffeine 45 mg
Pack sizes 12 tablets, 24 tablets
UK classification General Sale Medicine (GSL)
Drug class NSAID + analgesic combination
Preparation Tablet
Route of administration Oral

Specifications of Anadin Extra

 

What Is Anadin Extra and What Is It Used For?

 

Anadin Extra is an over-the-counter analgesic tablet used for the short-term relief of mild to moderate pain. It contains three active ingredients: aspirin 300 mg, paracetamol 200 mg, and caffeine 45 mg per tablet. The combination is indicated for headaches, migraine, toothache, period pain, muscular aches, and the aches and fever associated with colds and flu. It is classified as a General Sale Medicine (GSL) in the UK, meaning it can be purchased without a prescription from pharmacies, supermarkets, and registered online pharmacies.

 

What Do You Need to Know Before Using Anadin Extra?

 

Before taking Anadin Extra tablets, it's important to check whether this medicine is right for you. Do not take this product if any of the following apply:

  • You are allergic to aspirin, paracetamol, caffeine, or any other NSAID
  • You have or have had a peptic ulcer or stomach bleeding
  • You have haemophilia or another bleeding disorder
  • You are under 16 years of age (risk of Reye's syndrome with aspirin)
  • You are in the last trimester of pregnancy
  • You have severe kidney or liver impairment
  • You have asthma triggered by aspirin or NSAIDs

The following medicines may interact with Anadin Extra. Always tell your pharmacist or doctor what you are taking:

  • Anticoagulants such as warfarin — aspirin increases bleeding risk
  • Other NSAIDs (e.g. ibuprofen, naproxen) — increased risk of gastrointestinal side effects
  • Methotrexate — aspirin can increase methotrexate toxicity
  • Other paracetamol-containing products — risk of paracetamol overdose
  • Selective serotonin reuptake inhibitors (SSRIs) — increased bleeding risk with aspirin
  • Antiepileptics such as phenytoin — paracetamol may affect drug levels

 

How Should You Use Anadin Extra?

 

Always take Anadin Extra exactly as described on the label or as directed by your pharmacist. Swallow the tablets whole with a full glass of water. Taking them with or after food can help reduce the chance of stomach upset.

  1. Read the patient information leaflet before taking your first dose.
  2. Take 2 tablets with a full glass of water.
  3. Allow at least 4 hours between doses.
  4. Do not take more than 8 tablets in any 24-hour period.
  5. Do not use for more than 3 consecutive days without speaking to a doctor or pharmacist.
Indication Age Group Dose Frequency
Headache / migraine Adults & 16+ 2 tablets Up to 4 times daily (min. 4 hrs apart)
Period pain Adults & 16+ 2 tablets Up to 4 times daily (min. 4 hrs apart)
Dental pain Adults & 16+ 2 tablets Up to 4 times daily (min. 4 hrs apart)
Under 16 years Children Not suitable — do not use

 

What Are the Possible Side Effects of Anadin Extra?

 

Like all medicines, Anadin Extra can cause side effects, although not everyone experiences them. If you're concerned about any reaction, stop taking the tablets and speak to your pharmacist or GP. You can also find further support through our cold and flu collection if you're managing multiple symptoms at once.

Common side effects (may affect up to 1 in 10 people):

  • Nausea or stomach discomfort
  • Heartburn or indigestion
  • Mild stomach pain

Less common side effects (may affect up to 1 in 100 people):

  • Gastrointestinal bleeding (dark or tarry stools — seek urgent medical advice)
  • Allergic reactions including skin rash, itching, or swelling
  • Bronchospasm in aspirin-sensitive individuals
  • Tinnitus (ringing in the ears) at higher doses
  • Liver effects with prolonged paracetamol use above recommended doses

If you experience signs of a serious allergic reaction — such as difficulty breathing, swelling of the face or throat, or a severe skin reaction — stop taking the tablets immediately and call 999 or go to your nearest A&E.

 

How Should You Store Anadin Extra?

 

Correct storage helps maintain the quality and safety of your tablets. Follow these guidelines:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and moisture
  • Store in the original packaging until use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

If you're managing a range of health conditions alongside pain, it's worth exploring our vitamins and supplements collection to support your overall wellbeing.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Anadin Extra tablets online in the UK?

You can buy Anadin Extra tablets online from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £2.49. No prescription is needed as it is a General Sale Medicine. Browse our full pain relief collection for more analgesic options.

How does Anadin Extra work in the body?

Anadin Extra tablets work through three complementary mechanisms. Aspirin inhibits COX enzymes to reduce prostaglandin production, paracetamol raises the pain threshold centrally in the brain, and caffeine acts as an adjuvant that enhances the absorption and effectiveness of the other two ingredients. Together, they provide relief from mild to moderate pain more efficiently than any single ingredient alone.

What is the correct dose of Anadin Extra for adults?

The recommended adult dose is 2 tablets taken with a full glass of water, up to 4 times a day. You must leave at least 4 hours between each dose and must not exceed 8 tablets in any 24-hour period. Always follow the instructions on the pack or as directed by your pharmacist.

When is the best time to take Anadin Extra?

Take Anadin Extra as soon as your pain begins — early intervention tends to be more effective for conditions like migraine and tension headache. Taking the tablets with or after food can help reduce the risk of stomach irritation caused by the aspirin content. Avoid taking them late at night if you are sensitive to caffeine, as the 45 mg per tablet may affect sleep.

What are the side effects of Anadin Extra and how do I manage them?

The most common side effects are nausea, stomach discomfort, and heartburn, which can often be reduced by taking the tablets with food or milk. Less commonly, some people experience gastrointestinal bleeding, allergic reactions, or tinnitus. If you notice dark or tarry stools, difficulty breathing, or facial swelling, stop taking the tablets immediately and seek urgent medical attention.

Is Anadin Extra suitable for children?

No — Anadin Extra is not suitable for anyone under 16 years of age. The aspirin content carries a risk of Reye's syndrome, a rare but serious condition affecting the brain and liver, in children and teenagers. For pain relief in younger children, age-appropriate paracetamol or ibuprofen products should be used instead.

Can I take Anadin Extra if I am pregnant or breastfeeding?

Anadin Extra should not be taken during the last trimester of pregnancy due to the aspirin content, which can affect the foetal circulation and may delay labour. Use during the first and second trimesters should only occur on medical advice. If you are breastfeeding, speak to your GP or pharmacist before taking this product, as aspirin passes into breast milk.

Can I take Anadin Extra with other medicines?

You should not take Anadin Extra alongside other aspirin- or paracetamol-containing products, as this increases the risk of overdose. It also interacts with anticoagulants such as warfarin, other NSAIDs, methotrexate, and SSRIs. Always tell your pharmacist about all medicines, supplements, and herbal remedies you are taking before starting Anadin Extra.

What happens if I miss a dose of Anadin Extra?

Anadin Extra is taken as needed for pain relief rather than on a fixed schedule, so there is no "missed dose" in the traditional sense. If your pain returns and at least 4 hours have passed since your last dose, you can take another 2 tablets. Never double up doses to compensate for a missed one.

How long can I take Anadin Extra for?

Anadin Extra is intended for short-term use only. Do not take it for more than 3 consecutive days for pain relief without consulting a doctor or pharmacist. Prolonged use of aspirin-containing products can increase the risk of gastrointestinal bleeding and other complications. If your pain persists beyond 3 days, seek professional medical advice.

Who should not take Anadin Extra?

Anadin Extra is not suitable for people who are allergic to aspirin or any NSAID, those with active peptic ulcers, bleeding disorders such as haemophilia, severe kidney or liver disease, or aspirin-sensitive asthma. It is also contraindicated in children under 16 and in the third trimester of pregnancy. If you are unsure whether it is right for you, speak to your pharmacist before taking it.

What are the alternatives to Anadin Extra?

Common alternatives include standard paracetamol 500 mg tablets, ibuprofen 200–400 mg, or aspirin 300 mg taken alone. The right choice depends on your symptoms, medical history, and any other medicines you take. You can explore a range of options in our pain relief collection or ask your pharmacist for personalised advice.

Does Anadin Extra contain caffeine and will it keep me awake?

Yes, each Anadin Extra tablet contains 45 mg of caffeine, which means a full 2-tablet dose provides 90 mg — roughly equivalent to one cup of coffee. For most people this is unlikely to cause significant sleep disruption, but if you are caffeine-sensitive or taking your dose in the evening, it is worth being aware of this. People who regularly consume large amounts of caffeine may notice less of an effect.

Can I drink alcohol while taking Anadin Extra?

It is advisable to avoid alcohol while taking Anadin Extra. Alcohol combined with aspirin significantly increases the risk of stomach bleeding and gastrointestinal irritation. Alcohol also places additional strain on the liver, which is relevant given the paracetamol content of this product. If you do drink, keep consumption to a minimum and never exceed the recommended dose.

What are the latest findings on caffeine as an analgesic adjuvant?

Research published in clinical literature consistently supports the role of caffeine as an analgesic adjuvant — studies suggest that adding caffeine to aspirin or paracetamol can improve pain relief by approximately 40% compared to the analgesic alone. This is why combination products like Anadin Extra have remained a staple of OTC pain management for many years. If you're managing ongoing discomfort alongside other health concerns, our IBS and cramps collection may also be of interest.

How Should You Use Anadin Extra?

Anadin Extra tablets are taken orally with a full glass of water. To reduce the chance of stomach irritation from the aspirin content, it is best to take them with or shortly after food. Never crush or chew the tablets — swallow them whole.

What Is the Correct Dose of Anadin Extra?

The standard dose for adults and young people aged 16 and over is 2 tablets per dose. Do not take more than this at one time, and always leave a minimum of 4 hours between doses. Children under 16 must not take Anadin Extra under any circumstances.

When Is the Best Time to Use Anadin Extra?

Take Anadin Extra as soon as your pain starts — acting early generally produces better results, particularly for migraine and tension headache. If you are caffeine-sensitive, be mindful that each 2-tablet dose contains 90 mg of caffeine, so avoid taking it close to bedtime if you find caffeine affects your sleep.

Taking the tablets with a meal or snack is particularly advisable if you have a history of stomach sensitivity, as this helps protect the stomach lining from aspirin's irritant effect.

How Long Can You Use Anadin Extra For?

Anadin Extra is designed for short-term use only. Do not take it for more than 3 consecutive days for pain relief without first speaking to a doctor or pharmacist. Using aspirin-containing products for extended periods without medical supervision increases the risk of gastrointestinal complications, including stomach bleeding.

If your pain is persistent, recurring, or worsening, this may indicate an underlying condition that requires proper diagnosis and treatment. A healthcare professional can help identify the cause and recommend a more appropriate management plan.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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Derek Whitton

They always seem to get rid of head aches quickly.

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Anonymous

They are perfect to sort my headaches out
Thank you very much

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Anonymous

Very efficiently run business, with prompt delivery services.
Very pleased with my business with them and hope to continue too. Thank you

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Jenny Stanford

Still waiting for order

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Anonymous

All OK.

What Are the Most Common Side Effects of Anadin Extra?

Most people tolerate Anadin Extra well when taken as directed, but some individuals do experience side effects — particularly those related to the aspirin content. Stomach-related symptoms are the most frequently reported. Taking the tablets with food can help reduce these effects.

  • Nausea or feeling sick
  • Stomach discomfort or pain
  • Heartburn or indigestion
  • Mild stomach irritation

What Are the Less Common Side Effects of Anadin Extra?

Less commonly, some people may experience more noticeable reactions. These are worth being aware of, particularly if you have a history of gastrointestinal problems or are taking other medicines that affect the stomach or blood clotting.

  • Tinnitus (ringing in the ears) — more likely at higher doses of aspirin
  • Skin rash or itching
  • Mild allergic reactions such as hives
  • Dizziness or light-headedness
  • Increased tendency to bruise or bleed

What Are the Serious Side Effects of Anadin Extra?

Serious side effects are uncommon but require immediate medical attention if they occur. Gastrointestinal bleeding is the most significant risk associated with aspirin use, particularly in people with a history of ulcers or those taking anticoagulants. Signs of bleeding include vomiting blood or material that looks like coffee grounds, and passing black or tarry stools.

Severe allergic reactions (anaphylaxis) are rare but can occur. Symptoms include sudden swelling of the face, lips, tongue or throat, difficulty breathing, and a rapid drop in blood pressure. If you experience any of these, call 999 immediately. Aspirin-sensitive asthma — where aspirin triggers bronchospasm — is another serious reaction that requires you to stop the medicine and seek urgent care.

What Should You Do If You Experience Side Effects of Anadin Extra?

For mild side effects such as nausea or heartburn, try taking the tablets with food and plenty of water. If symptoms persist or worsen, stop taking Anadin Extra and speak to your pharmacist or GP. You should not simply increase the dose or switch to another NSAID without professional advice, as this may compound the problem.

In the event of a suspected overdose — for example, if someone has taken too many tablets — call 999 or go to your nearest A&E immediately. Paracetamol overdose in particular can cause serious liver damage that may not be immediately apparent, so prompt treatment is essential even if the person feels well initially.

Can Anadin Extra Interact With Other Medicines?

Yes. Anadin Extra has several clinically significant interactions. Aspirin increases the anticoagulant effect of warfarin, raising the risk of serious bleeding. Taking it alongside other NSAIDs such as ibuprofen or naproxen increases the risk of gastrointestinal side effects. Methotrexate toxicity can be increased by aspirin. SSRIs combined with aspirin also raise bleeding risk. Additionally, taking any other paracetamol-containing product at the same time risks exceeding the safe daily paracetamol limit. Always inform your pharmacist of all medicines, supplements, and herbal remedies you are currently taking before using Anadin Extra.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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