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Anadin Extra - 16 Caplets

Anadin Extra - 16 Caplets

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  • ✔️ Combines aspirin, paracetamol and caffeine for triple-action relief
  • ✔️ Targets headaches, cold pain, toothache and period pain
  • ✔️ Caffeine enhances absorption for faster-acting pain relief
  • ✔️ Suitable for adults and young people aged 16 and over
  • ✔️ Convenient 16-caplet pack for home or on-the-go use

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What Are Anadin Extra Caplets and How Do They Help?

 

If you've ever reached for something to tackle a stubborn headache or the aches that come with a cold, you'll know that not all pain relief works the same way. Anadin Extra caplets are a well-established over-the-counter option that combines three active ingredients — aspirin, paracetamol, and caffeine — to target mild to moderate pain from multiple angles. Each pack contains 16 caplets, making it a practical choice to keep at home or in your bag. You can browse our full pain relief collection if you'd like to compare other options available at Cured Pharmacy.

Anadin Extra is manufactured by Haleon and is classified as a General Sale List (GSL) medicine in the UK, meaning it's available without a prescription. It's designed for adults and young people aged 16 and over who need fast-acting relief from everyday pain.

 

How Do Anadin Extra Caplets Work in the Body?

 

The three-ingredient formula is what sets Anadin Extra apart from single-ingredient pain relievers. Each ingredient plays a distinct role:

  • Aspirin (300mg): A non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis, reducing inflammation and blocking pain signals at the site of injury or irritation.
  • Paracetamol (200mg): Works centrally in the brain to raise the pain threshold, complementing aspirin's peripheral action.
  • Caffeine (45mg): Acts as an adjuvant analgesic — it enhances the absorption and effectiveness of both aspirin and paracetamol, meaning the pain relief can kick in more quickly.

Together, these ingredients provide a synergistic effect. Clinical evidence supports the use of caffeine as an analgesic adjuvant, with studies showing it can meaningfully improve the efficacy of aspirin and paracetamol combinations compared to either ingredient used alone.

 

Who Is Anadin Extra Suitable For?

 

Anadin Extra caplets are suitable for a broad range of adults dealing with everyday pain. They're particularly useful when you need relief that works across more than one type of discomfort at the same time. Suitable uses include:

  • Headaches and migraines (mild to moderate)
  • Cold and flu-related aches and pains
  • Toothache and dental pain
  • Period pain and muscular aches
  • Sore throat pain

However, Anadin Extra is not suitable for everyone. It should not be given to children under 16 due to the aspirin content and the associated risk of Reye's syndrome. People with aspirin sensitivity, active peptic ulcers, or bleeding disorders should also avoid it. Always read the label carefully before use.

 

How Does Anadin Extra Compare to Standard Paracetamol?

 

Feature Anadin Extra Caplets Standard Paracetamol (500mg)
Active ingredients Aspirin, Paracetamol, Caffeine Paracetamol only
Anti-inflammatory action Yes (via aspirin) No
Suitable for under 16s No Yes (age-appropriate dose)
Suitable for aspirin-sensitive patients No Yes

 

How Should You Store Anadin Extra Caplets?

 

Store Anadin Extra caplets below 25°C in a dry place, away from direct sunlight and moisture. Keep them out of reach and sight of children at all times. Do not use the product after the expiry date printed on the packaging. If you're also managing other health conditions and looking for complementary support, you might find our vitamins and supplements range useful alongside your pain management routine.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Anadin Extra 16 Caplets specifications
Treatment category General Pain Relief
Mechanism of action Prostaglandin synthesis inhibition (aspirin), central pain threshold elevation (paracetamol), analgesic enhancement (caffeine)
Effective for Headache, cold and flu pain, toothache, period pain, muscular aches, sore throat
Suitable for Adults and young people aged 16 and over
Active ingredients Aspirin 300mg, Paracetamol 200mg, Caffeine 45mg per caplet
Pack size 16 caplets
UK classification General Sale List (GSL)
Drug class Analgesic / NSAID combination
Preparation Caplet (film-coated tablet)
Route of administration Oral

Specifications of Anadin Extra 16 Caplets

 

What Is Anadin Extra and What Is It Used For?

 

Anadin Extra 16 Caplets is an over-the-counter analgesic combination product used to relieve mild to moderate pain. Each caplet contains aspirin 300mg, paracetamol 200mg, and caffeine 45mg. It is indicated for the short-term relief of headache, migraine, cold and flu symptoms, toothache, period pain, neuralgia, and general muscular aches. It is not a prescription medicine and is available to adults and young people aged 16 and over without a GP referral.

 

What Do You Need to Know Before Using Anadin Extra?

 

Before taking Anadin Extra caplets, it's important to check whether this medicine is right for you. Do not take this product if any of the following apply:

  • You are allergic to aspirin, paracetamol, caffeine, or any other ingredient in the product
  • You have or have had a peptic ulcer or stomach bleeding
  • You have a bleeding disorder or are taking anticoagulant medicines
  • You are under 16 years of age (risk of Reye's syndrome with aspirin)
  • You are in the last trimester of pregnancy
  • You have severe kidney or liver impairment
  • You have asthma triggered by aspirin or other NSAIDs

The following medicines may interact with Anadin Extra. Always tell your pharmacist or GP if you are taking:

  • Anticoagulants such as warfarin or heparin
  • Other NSAIDs (e.g. ibuprofen, naproxen)
  • Methotrexate (used for arthritis or psoriasis)
  • Selective serotonin reuptake inhibitors (SSRIs)
  • Corticosteroids
  • Any other paracetamol-containing products

 

How Should You Use Anadin Extra Caplets?

 

Always take Anadin Extra exactly as described on the label or as directed by your pharmacist. Swallow the caplets whole with a full glass of water. Taking them with or after food may help reduce the chance of stomach upset.

  1. Check the packaging to confirm you are not already taking another aspirin or paracetamol product.
  2. Take 2 caplets with a full glass of water.
  3. Allow at least 4 hours between doses.
  4. Do not take more than 8 caplets in any 24-hour period.
  5. Do not use for more than 3 consecutive days without speaking to a pharmacist or doctor.
Age Group Dose Frequency Maximum Daily Dose
Adults and young people aged 16+ 2 caplets Up to 4 times daily 8 caplets (2,400mg aspirin / 1,600mg paracetamol)
Children under 16 Not suitable — do not use

 

What Are the Possible Side Effects of Anadin Extra?

 

Like all medicines, Anadin Extra can cause side effects, although not everyone will experience them. If you're managing other conditions alongside pain, our cold and flu range may also be relevant if your pain is symptom-related.

Common side effects (may affect up to 1 in 10 people):

  • Nausea or stomach discomfort
  • Indigestion or heartburn
  • Mild stomach pain

Less common side effects (may affect up to 1 in 100 people):

  • Gastrointestinal bleeding (seek medical attention immediately if you notice blood in stools or vomit)
  • Allergic reactions including skin rash, itching, or swelling
  • Bronchospasm in aspirin-sensitive individuals
  • Tinnitus (ringing in the ears) — a sign of aspirin toxicity; stop use and seek advice
  • Dizziness or headache worsening (medication overuse headache with prolonged use)

Stop taking Anadin Extra and seek immediate medical attention if you develop signs of a serious allergic reaction, including difficulty breathing, swelling of the face or throat, or a severe skin reaction.

 

How Should You Store Anadin Extra Caplets?

 

Correct storage helps maintain the quality and safety of your medicine. Follow these guidelines:

  • Store below 25°C in a dry place
  • Keep away from direct sunlight and moisture
  • Do not store in a bathroom or near a sink
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacist

If you have any questions about storage or suitability, our first aid section also contains useful products for home medicine cabinet essentials.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Anadin Extra caplets online in the UK?

You can buy Anadin Extra 16 Caplets directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £3.09. No prescription is required as it is a General Sale List (GSL) medicine. Simply add it to your basket and it will be dispatched to your door.

How do Anadin Extra caplets work in the body?

Anadin Extra works through a three-pronged approach: aspirin inhibits prostaglandin production to reduce inflammation and pain at the source, paracetamol raises the brain's pain threshold centrally, and caffeine acts as an adjuvant that enhances the absorption and effectiveness of both. This combination means the relief can be faster and more effective than using a single-ingredient product. It's a well-studied formulation that has been used in the UK for decades.

How do I take Anadin Extra step by step?

Take 2 caplets with a full glass of water, ideally with or after food to reduce the risk of stomach irritation. Wait at least 4 hours before taking another dose, and never exceed 8 caplets in a 24-hour period. If your symptoms haven't improved after 3 days, stop use and speak to your pharmacist or GP.

What is the correct dose of Anadin Extra for adults?

The recommended dose for adults and young people aged 16 and over is 2 caplets, taken up to 4 times daily with at least 4 hours between each dose. The maximum daily dose is 8 caplets. Do not take more than this, as exceeding the recommended dose increases the risk of serious side effects including liver damage from paracetamol and gastrointestinal bleeding from aspirin.

When is the best time to take Anadin Extra?

There is no single "best" time — Anadin Extra should be taken as soon as pain begins, as early intervention tends to be more effective. Taking it with food or milk can help protect the stomach lining from aspirin's irritant effect. Space your doses evenly throughout the day if you need repeat doses, and avoid taking a dose close to bedtime if you are sensitive to caffeine.

What are the common side effects of Anadin Extra and how do I manage them?

The most common side effects include nausea, indigestion, and mild stomach discomfort, all of which are linked to the aspirin content. Taking the caplets with food or a full glass of water can help reduce these effects. If you experience more serious symptoms such as stomach bleeding, ringing in the ears, or an allergic reaction, stop taking the product immediately and seek medical advice.

Is Anadin Extra suitable for children?

No — Anadin Extra must not be given to anyone under 16 years of age. The aspirin in the formula carries a risk of Reye's syndrome in children and teenagers, a rare but serious condition affecting the brain and liver. If you need pain relief for a child, speak to your pharmacist about age-appropriate alternatives available in our baby and toddler range.

Can I take Anadin Extra if I am pregnant or breastfeeding?

Anadin Extra is not recommended during pregnancy, particularly in the third trimester, as aspirin can affect the baby's circulation and may cause complications during labour. If you are breastfeeding, aspirin passes into breast milk and is generally not recommended. Always speak to your GP or midwife before taking any pain relief during pregnancy or while breastfeeding.

Can I take Anadin Extra with other medicines?

You should not take Anadin Extra alongside other aspirin or paracetamol-containing products, as this risks exceeding safe daily limits. It can also interact with anticoagulants like warfarin, other NSAIDs, methotrexate, SSRIs, and corticosteroids. Always tell your pharmacist or GP about all medicines you are currently taking before starting Anadin Extra.

Who should not take Anadin Extra?

Anadin Extra is not suitable for people who are allergic to aspirin or NSAIDs, have a history of peptic ulcers or gastrointestinal bleeding, have severe liver or kidney disease, or are in the last trimester of pregnancy. People with asthma that is triggered by aspirin should also avoid it. If you are unsure whether this product is right for you, speak to a pharmacist before purchasing.

What happens if I miss a dose of Anadin Extra?

Anadin Extra is taken as needed for pain rather than on a fixed schedule, so there is no "missed dose" in the traditional sense. Simply take your next dose when pain returns, ensuring at least 4 hours have passed since your last dose. Never double up to compensate for a missed dose.

How long can I take Anadin Extra for?

Anadin Extra is intended for short-term use only — no more than 3 consecutive days for pain relief without medical advice. Using pain relief medicines for longer than this can lead to medication overuse headache, where the headaches actually worsen over time. If your pain persists beyond 3 days, consult your GP to identify the underlying cause.

What are the alternatives to Anadin Extra?

Common alternatives include single-ingredient options such as paracetamol 500mg or ibuprofen 200–400mg, or other combination products. The right choice depends on your specific symptoms, medical history, and any other medicines you take. You can explore a wide range of options in our pain relief collection to find the most suitable product for your needs.

Does the caffeine in Anadin Extra cause side effects?

Each caplet contains 45mg of caffeine — roughly half the amount in a standard cup of coffee. For most people this is well tolerated, but if you are sensitive to caffeine you may notice mild restlessness, difficulty sleeping, or a slightly elevated heart rate. Avoid taking Anadin Extra late in the evening if you know caffeine affects your sleep.

What are the latest findings on aspirin and paracetamol combination products?

Research continues to support the use of aspirin-paracetamol-caffeine combinations for acute pain, with studies showing the triple combination outperforms individual ingredients for headache and migraine relief. The NHS and MHRA continue to recognise these combinations as safe and effective when used as directed in adults. Always follow current label guidance and consult a healthcare professional if you have any concerns about long-term use.

How Should You Use Anadin Extra?

Anadin Extra caplets are taken orally with a full glass of water. Taking them with or after food is advisable, as this can help protect the stomach lining from the irritant effect of aspirin. Follow these steps each time you take a dose:

Never take more than the recommended number of caplets at one time. If you accidentally take too many, seek medical attention immediately even if you feel well, as paracetamol overdose can cause delayed liver damage.

What Is the Correct Dose of Anadin Extra?

The dose varies by age group. Children under 16 must not take this product under any circumstances due to the aspirin content. For adults, the dose is straightforward and consistent regardless of the type of pain being treated.

The maximum daily dose is 8 caplets (equivalent to 2,400mg aspirin and 1,600mg paracetamol). Do not exceed this limit.

When Is the Best Time to Use Anadin Extra?

Take Anadin Extra as soon as pain begins — early treatment is generally more effective than waiting until pain becomes severe. If you are prone to morning headaches, having a dose ready with breakfast can be helpful, though always ensure at least 4 hours have passed since any previous dose. Be mindful of the caffeine content (45mg per caplet, 90mg per dose) if you are taking an evening dose, as this may affect sleep in caffeine-sensitive individuals.

If you are using Anadin Extra for cold and flu symptoms, it can be taken at regular intervals throughout the day to maintain consistent symptom relief, provided you stay within the maximum daily dose.

How Long Can You Use Anadin Extra For?

Anadin Extra is designed for short-term use only. Do not use it for more than 3 consecutive days for pain relief without consulting a pharmacist or GP. Prolonged use of aspirin-containing products can increase the risk of gastrointestinal side effects, and using any pain reliever too frequently can lead to medication overuse headache — a condition where the headaches become more frequent and harder to treat over time.

If your symptoms persist, worsen, or keep returning, this is a sign that you should seek professional medical advice rather than continuing to self-medicate. A pharmacist can help you assess whether a different approach is needed.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Anadin Extra?

Most people tolerate Anadin Extra well when taken as directed, but some individuals do experience side effects, particularly related to the aspirin content. The most frequently reported effects are gastrointestinal in nature.

  • Nausea or feeling sick
  • Indigestion or heartburn
  • Mild stomach pain or discomfort
  • Stomach irritation

Taking the caplets with food or a full glass of water can significantly reduce the likelihood of these effects. If nausea is persistent, speak to your pharmacist about whether a different pain relief option might suit you better.

What Are the Less Common Side Effects of Anadin Extra?

Less common side effects occur in a smaller proportion of users but are important to be aware of. If you notice any of the following, stop taking the product and seek medical advice promptly.

  • Tinnitus (ringing or buzzing in the ears) — this can be a sign of aspirin toxicity
  • Dizziness or light-headedness
  • Skin rash or itching
  • Worsening of headache with prolonged use (medication overuse headache)
  • Mild restlessness or difficulty sleeping, related to caffeine content

These effects are uncommon but worth monitoring, especially if you are taking Anadin Extra regularly or at the higher end of the recommended dose range.

What Are the Serious Side Effects of Anadin Extra?

Serious side effects are rare but require immediate medical attention. Do not delay seeking help if you experience any of the following:

  • Signs of gastrointestinal bleeding — black or tarry stools, vomiting blood, or severe abdominal pain
  • Severe allergic reaction (anaphylaxis) — difficulty breathing, swelling of the face, lips, tongue, or throat, or a sudden drop in blood pressure
  • Bronchospasm or worsening asthma in aspirin-sensitive individuals
  • Signs of liver damage from paracetamol overdose — jaundice (yellowing of skin or eyes), severe upper abdominal pain, or dark urine

If you suspect you have taken too much paracetamol or aspirin, go to your nearest A&E immediately, even if you feel well. Paracetamol overdose can cause serious liver damage that may not be apparent for several days.

What Should You Do If You Experience Side Effects?

For mild side effects such as nausea or indigestion, try taking the caplets with food and plenty of water. If the side effect is bothersome or does not resolve, stop taking Anadin Extra and speak to your pharmacist. They can advise on whether to continue, switch to an alternative, or refer you to your GP.

For any serious or unexpected side effect, stop use immediately and seek urgent medical attention. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk — this helps improve medicine safety for everyone.

Can Anadin Extra Interact With Other Medicines?

Yes — Anadin Extra has several clinically significant interactions. Aspirin can enhance the effect of anticoagulants such as warfarin, increasing bleeding risk. It can also interact with other NSAIDs, methotrexate, SSRIs, and corticosteroids. Taking Anadin Extra alongside any other paracetamol-containing product risks exceeding the safe daily paracetamol limit, which can cause liver damage. Always inform your pharmacist or GP of all medicines, supplements, and herbal remedies you are taking before using this product.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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