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Allerief 2mg per 5ml Oral Solution 150ml

Allerief 2mg per 5ml Oral Solution 150ml

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  • ✔️ Relieves hay fever, hives, and allergic skin reactions effectively
  • ✔️ Liquid format ideal for children aged one year and over
  • ✔️ Chlorphenamine maleate starts working within 30 to 60 minutes
  • ✔️ Measured dose format reduces risk of under- or over-dosing
  • ✔️ Suitable for both children and adults with allergy symptoms

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What Is Chlorphenamine Oral Solution for Children?

 

Allerief 2mg per 5ml Oral Solution is a liquid antihistamine medicine containing chlorphenamine maleate as its active ingredient. It is designed to relieve the uncomfortable symptoms that come with allergic conditions — think sneezing fits, itchy eyes, a streaming nose, or skin reactions like hives. Because it comes as a liquid, it is particularly well suited to younger children who cannot swallow tablets. If you are looking for a reliable chlorphenamine oral solution for children, this 150ml bottle offers a practical, measured dose format that is easy to administer at home. You can browse the full range of allergy and hay fever treatments available at Cured Pharmacy to find the right option for your family.

Chlorphenamine maleate has been used in the UK for decades and is listed on the NHS as a first-generation antihistamine. It works quickly — typically within 30 minutes — making it useful when symptoms flare unexpectedly. The oral solution format means you can measure an accurate dose using the supplied measuring device, reducing the risk of under- or over-dosing.

 

How Does Allerief Oral Solution Work?

 

Allerief works by blocking histamine H1 receptors in the body. When you are exposed to an allergen — pollen, pet dander, dust mites, or certain foods — your immune system releases histamine, a chemical that triggers the classic allergy response. By occupying those receptors before histamine can bind to them, chlorphenamine reduces or prevents the symptoms that follow.

  • Allergen exposure triggers mast cells to release histamine into surrounding tissue.
  • Histamine binds to H1 receptors, causing sneezing, itching, watery eyes, and nasal congestion.
  • Chlorphenamine maleate competitively blocks H1 receptors, preventing histamine from attaching.
  • Symptoms are reduced, often within 30 to 60 minutes of taking the dose.

Because chlorphenamine crosses the blood-brain barrier, it also has a mild sedative effect — which can actually be helpful at night when itching or sneezing is disrupting sleep, but is worth bearing in mind during the day.

 

Who Should Use Allerief Oral Solution?

 

Allerief oral solution is suitable for a wide range of patients, from young children to adults. It is particularly useful when a liquid formulation is needed — for example, for children who struggle with tablets, or for adults who prefer a liquid medicine. It is indicated for:

  • Children aged 1 year and over with hay fever or seasonal allergic rhinitis
  • Children and adults with allergic skin reactions such as urticaria (hives) or eczema-related itch
  • Patients experiencing insect bite reactions or mild food allergy symptoms
  • Adults who need short-term relief from allergy symptoms and prefer a liquid format

It is not suitable for babies under 1 year of age. Always check with your pharmacist if you are unsure whether this product is right for your child or yourself.

 

How Does Allerief Compare to Non-Sedating Antihistamines?

 

Feature Allerief 2mg/5ml (Chlorphenamine) Cetirizine Liquid (Non-Sedating)
Sedating effect Yes — may cause drowsiness Minimal sedation
Suitable age (liquid) From 1 year From 2 years (cetirizine liquid)
Dosing frequency Up to 4–6 times daily Once daily
Duration of action 4–6 hours Up to 24 hours

 

How Should You Store Allerief Oral Solution?

 

Store Allerief below 25°C in a dry place, away from direct sunlight. Keep the bottle tightly closed and out of the reach and sight of children. Do not use the solution after the expiry date printed on the label. Once opened, use within the period stated in the patient information leaflet — typically within a few months. If you are managing multiple allergy products at home, it is worth checking our baby and toddler health range for other age-appropriate medicines and health products.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Allerief 2mg per 5ml Oral Solution 150ml specifications
Treatment category Allergy & Hay Fever
Active ingredient Chlorphenamine maleate 2mg per 5ml
Mechanism of action H1 histamine receptor antagonist
Drug class First-generation (sedating) antihistamine
Preparation Oral solution
Route of administration Oral
Strengths 2mg per 5ml
Pack size 150ml
Suitable for Children aged 1 year and over; adults
UK classification General Sale List (GSL) / Pharmacy (P) medicine

Specifications of Allerief 2mg per 5ml Oral Solution 150ml

 

What Is Allerief Oral Solution and What Is It Used For?

 

Allerief 2mg per 5ml Oral Solution contains chlorphenamine maleate, a first-generation antihistamine used to relieve symptoms caused by allergic conditions. It is used to treat hay fever (seasonal allergic rhinitis), perennial allergic rhinitis, urticaria (hives), insect bite reactions, and mild allergic skin reactions. It is available over the counter and does not require a prescription for most indications. The liquid format makes it especially practical for children aged 1 year and over who cannot swallow solid dosage forms.

 

What Do You Need to Know Before Using Allerief Oral Solution?

 

Before giving Allerief to yourself or your child, there are some important safety points to consider. Do not use this medicine if any of the following apply:

  • The patient is under 1 year of age
  • There is a known allergy to chlorphenamine maleate or any other ingredient in the solution
  • The patient is taking monoamine oxidase inhibitors (MAOIs) or has taken them within the last 14 days
  • The patient has acute asthma or a lower respiratory tract condition where secretions must not be suppressed
  • The patient has angle-closure glaucoma or urinary retention

You should also speak to your pharmacist or GP before using Allerief if the patient has epilepsy, liver disease, an enlarged prostate, or cardiovascular disease. The following medicines may interact with chlorphenamine:

  • Sedatives, sleeping tablets, or anxiolytics — increased sedation risk
  • Tricyclic antidepressants — enhanced anticholinergic effects
  • Alcohol — significantly increases drowsiness
  • Other antihistamines — additive sedative and anticholinergic effects
  • Phenytoin — chlorphenamine may inhibit its metabolism

 

How Should You Use Allerief Oral Solution?

 

Always use Allerief exactly as described in the patient information leaflet or as directed by your pharmacist. Use the measuring device provided to ensure an accurate dose — do not estimate using a household spoon.

  1. Shake the bottle gently before use if instructed on the label.
  2. Use the oral syringe or measuring cup provided to draw up the correct dose.
  3. Administer the dose directly into the mouth or mix with a small amount of water if needed.
  4. Replace the cap securely after each use.
  5. Record the time of each dose to avoid accidental double-dosing.
Age Group Dose Frequency Maximum Daily Dose
1–2 years 1mg (2.5ml) Twice daily 2mg
2–5 years 1mg (2.5ml) Up to 3 times daily 3mg
6–12 years 2mg (5ml) Up to 4–6 times daily 12mg
12 years and over / Adults 4mg (10ml) Every 4–6 hours 24mg

If you are managing allergy symptoms alongside other conditions, you may also find it helpful to explore our ear, nose and throat treatments for complementary relief options.

 

What Are the Possible Side Effects of Allerief Oral Solution?

 

Like all medicines, Allerief can cause side effects, although not everyone experiences them. Knowing what to look out for helps you manage them promptly.

Common side effects (may affect more than 1 in 10 people):

  • Drowsiness or sedation
  • Dry mouth, nose, or throat
  • Dizziness or impaired coordination
  • Headache
  • Blurred vision

Less common side effects (may affect fewer than 1 in 10 people):

  • Nausea or stomach upset
  • Difficulty passing urine (urinary retention)
  • Palpitations or rapid heartbeat
  • Paradoxical excitability in young children (restlessness, irritability)
  • Skin rash or hypersensitivity reactions

If your child becomes unusually excitable or agitated after taking Allerief, stop the medicine and speak to your pharmacist. Paradoxical stimulation is more common in young children and the elderly. If you notice signs of a serious allergic reaction — such as swelling of the face, lips, or throat, or difficulty breathing — seek emergency medical help immediately.

 

How Should You Store Allerief Oral Solution?

 

Correct storage keeps the medicine safe and effective for its full shelf life. Follow these guidelines:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the bottle tightly closed when not in use
  • Store out of the reach and sight of children
  • Do not use after the expiry date printed on the bottle or carton
  • Do not dispose of medicines via wastewater or household waste — return unused medicine to your pharmacy

If you are looking for additional support during allergy season, our eye care range includes antihistamine eye drops that can be used alongside oral antihistamines to target itchy, watery eyes directly.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Allerief 2mg/5ml oral solution online in the UK?

You can order Allerief 2mg per 5ml Oral Solution directly from Cured Pharmacy, a GPhC-registered online pharmacy. It is available without a prescription as an over-the-counter medicine. Simply add it to your basket and it will be dispatched to your door.

How does Allerief oral solution work in the body?

Allerief contains chlorphenamine maleate, which blocks H1 histamine receptors throughout the body. When an allergen triggers histamine release, chlorphenamine prevents histamine from binding to those receptors, reducing symptoms like sneezing, itching, and a runny nose. It begins to work within 30 to 60 minutes of taking a dose.

How do I give Allerief oral solution to my child step by step?

Use the measuring syringe or cup provided with the bottle to draw up the correct dose for your child's age. Administer it directly into the mouth or mix with a small amount of water if your child prefers. Always replace the cap tightly after use and record the time of each dose to avoid accidental repeat dosing.

What is the correct dose of Allerief for a 3-year-old?

Children aged 2 to 5 years should receive 1mg of chlorphenamine, which is 2.5ml of Allerief oral solution, up to three times daily. Do not exceed this dose without advice from a pharmacist or GP. Always use the measuring device provided rather than a household spoon.

What is the best time to give Allerief to a child with hay fever?

For hay fever, giving a dose in the morning before your child goes outside can help prevent symptoms from developing. Because chlorphenamine can cause drowsiness, an evening dose may also help if nighttime itching or sneezing is disrupting sleep. Speak to your pharmacist about the best timing for your child's specific symptoms.

Does Allerief oral solution cause drowsiness in children?

Yes, drowsiness is a common side effect of chlorphenamine because it is a first-generation, sedating antihistamine. This can be useful at bedtime but may affect concentration and alertness during the day. If daytime sedation is a concern, speak to your pharmacist about non-sedating alternatives such as cetirizine.

Who is eligible to take Allerief 2mg/5ml oral solution?

Allerief is suitable for children aged 1 year and over, as well as adults. It is not suitable for babies under 1 year of age. People with certain conditions — including angle-closure glaucoma, urinary retention, or those taking MAOIs — should not use it without medical advice.

What happens if I give my child too much Allerief?

Overdose with chlorphenamine can cause excessive sedation, excitability (particularly in young children), rapid heartbeat, and in severe cases, convulsions. If you think your child has taken too much, contact NHS 111 or go to your nearest A&E immediately. Take the medicine bottle with you so healthcare staff can see exactly what was taken.

What happens if I miss a dose of Allerief?

If you miss a dose, take it as soon as you remember — unless it is nearly time for the next scheduled dose. In that case, skip the missed dose and continue as normal. Never double up doses to compensate for a missed one, as this increases the risk of side effects.

Can adults take Allerief 2mg/5ml oral solution?

Yes, adults and young people aged 12 and over can take Allerief oral solution. The usual adult dose is 4mg (10ml) every four to six hours, up to a maximum of 24mg in 24 hours. If you find the liquid format inconvenient, chlorphenamine is also available in tablet form — speak to your pharmacist for guidance.

What are the alternatives to Allerief oral solution for hay fever?

Non-sedating antihistamines such as cetirizine or loratadine are widely used alternatives and are available as liquids for children. Nasal corticosteroid sprays are also recommended for persistent hay fever symptoms. You can explore the full allergy and hay fever range at Cured Pharmacy to compare your options.

Can I use Allerief oral solution alongside other allergy medicines?

You should not take Allerief alongside other antihistamines without pharmacist advice, as this increases the risk of side effects including excessive sedation. Nasal sprays or antihistamine eye drops are generally safe to use at the same time, but always check with your pharmacist first. Our eye care range includes antihistamine drops suitable for allergic conjunctivitis.

How long can you use Allerief oral solution for?

Allerief is intended for short-term use to relieve acute allergy symptoms. If symptoms persist beyond a few days, or if you need to use it regularly throughout hay fever season, speak to your GP or pharmacist. They can advise on longer-term management strategies and whether a different treatment would be more appropriate.

Is Allerief oral solution safe during pregnancy or breastfeeding?

Chlorphenamine is not recommended during the third trimester of pregnancy or while breastfeeding without medical advice, as it may pass into breast milk and cause sedation in the infant. If you are pregnant or breastfeeding and need allergy relief, speak to your GP or midwife before taking any antihistamine.

What are the latest guidelines on using antihistamines for children in the UK?

NHS guidance recommends that sedating antihistamines like chlorphenamine should be used with caution in young children due to the risk of paradoxical excitability and sedation. Non-sedating antihistamines are often preferred for daytime use in children. Always follow the age-specific dosing instructions and consult your pharmacist if you are unsure which antihistamine is most appropriate.

How Should You Use Allerief Oral Solution?

Always use Allerief 2mg per 5ml Oral Solution exactly as described in the patient information leaflet or as directed by your pharmacist. Using the correct measuring device is essential — never estimate the dose using a household teaspoon, as this can lead to inaccurate dosing. The oral syringe or measuring cup provided with the bottle is calibrated specifically for this purpose.

Follow these steps each time you administer a dose:

What Is the Correct Dose of Allerief Oral Solution?

The dose of Allerief depends on the patient's age. Always follow the age-appropriate dose below and do not exceed the stated maximum daily dose. If you are unsure about the correct dose for your child, speak to your pharmacist before administering.

When Is the Best Time to Use Allerief Oral Solution?

For hay fever and seasonal allergies, taking a dose in the morning before going outdoors can help prevent symptoms from developing throughout the day. Because chlorphenamine can cause drowsiness, an evening or bedtime dose may be particularly useful if nighttime sneezing, itching, or a blocked nose is disrupting sleep. For urticaria or insect bite reactions, doses can be taken as needed within the maximum daily limits.

Try to space doses evenly throughout the day and avoid taking a dose too close to the previous one. If your child needs to be alert and focused during school hours, discuss timing with your pharmacist — a non-sedating antihistamine may be more suitable for daytime use.

How Long Can You Use Allerief Oral Solution For?

Allerief is suitable for short-term relief of allergy symptoms. For acute reactions such as insect bites or mild urticaria, a course of a few days is usually sufficient. For seasonal hay fever, it can be used throughout the pollen season, but if you find yourself needing it daily for extended periods, it is worth speaking to your GP about longer-term allergy management options.

If symptoms do not improve after a few days of treatment, or if they worsen at any point, stop using the medicine and seek advice from your pharmacist or GP. Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Allerief Oral Solution?

The most frequently reported side effect of Allerief is drowsiness. Because chlorphenamine maleate is a first-generation antihistamine, it crosses the blood-brain barrier and has a sedative effect. This affects some people more than others and tends to be more pronounced in young children and older adults.

  • Drowsiness or sedation
  • Dry mouth, nose, or throat
  • Dizziness or light-headedness
  • Headache
  • Blurred vision
  • Impaired coordination or concentration

What Are the Less Common Side Effects of Allerief Oral Solution?

Some people experience side effects that are less frequent but still worth knowing about. These tend to occur more often at higher doses or in people who are more sensitive to antihistamines. If any of the following persist or become troublesome, speak to your pharmacist.

  • Nausea or stomach discomfort
  • Difficulty passing urine (urinary retention)
  • Palpitations or a faster than normal heartbeat
  • Paradoxical excitability — restlessness, irritability, or insomnia, particularly in young children
  • Skin rash or mild hypersensitivity reaction
  • Constipation

What Are the Serious Side Effects of Allerief Oral Solution?

Serious side effects are rare but require immediate medical attention. Stop using Allerief and seek emergency help if you or your child experiences any of the following:

  • Signs of a severe allergic reaction (anaphylaxis): swelling of the face, lips, tongue, or throat; difficulty breathing; a sudden drop in blood pressure
  • Seizures or convulsions — more likely in cases of overdose
  • Severe urinary retention causing inability to pass urine
  • Extreme agitation or confusion

If you suspect an overdose — for example, if a child has accidentally taken more than the recommended amount — contact NHS 111 or go to your nearest A&E immediately. Take the medicine bottle with you.

What Should You Do If You Experience Side Effects?

Mild side effects such as drowsiness or a dry mouth often improve as the body adjusts to the medicine. Staying well hydrated can help with dry mouth. If drowsiness is affecting daily activities, consider adjusting the timing of doses — for example, taking the main dose in the evening. Do not drive or operate machinery if you feel drowsy after taking Allerief.

If side effects are persistent, severe, or unexpected, stop taking the medicine and speak to your pharmacist or GP. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Allerief Oral Solution Interact With Other Medicines?

Yes. Chlorphenamine maleate can interact with several medicines, and some combinations can be dangerous. Always tell your pharmacist or GP about all medicines you or your child are taking, including over-the-counter products and herbal remedies. Key interactions include:

  • MAOIs (monoamine oxidase inhibitors) — do not use together; risk of serious adverse effects
  • Sedatives, sleeping tablets, or benzodiazepines — increased sedation
  • Tricyclic antidepressants — enhanced anticholinergic effects such as dry mouth and urinary retention
  • Alcohol — significantly worsens drowsiness; avoid alcohol while taking Allerief
  • Phenytoin — chlorphenamine may slow its breakdown, increasing phenytoin levels

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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