Wegovy vs Saxenda vs Mounjaro UK | Compare All 3 Pens

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Wegovy vs Saxenda vs Mounjaro: Which Weight Loss Pen?

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LIVE PRICING

Our Pricing

Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £135.00

£36.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
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Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £169.00

£44.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
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Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £210.00

£55.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
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Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £235.00

£61.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
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Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £260.00

£67.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
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Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £277.00

£71.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
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Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £79.00

£22.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
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Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£109 £99.00

£27.25 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £109
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Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £109.00

£29.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
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Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £159.00

£42.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
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Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £189.00

£49.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
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Wegovy vs Saxenda vs Mounjaro: Which Weight Loss Pen?

Comparing wegovy vs saxenda vs mounjaro uk options can feel overwhelming when you're ready to start your weight loss journey. At Cured Pharmacy, our UK-registered clinical team helps patients understand the key differences between these three MHRA-licensed injectable treatments, so you can make an informed choice based on real clinical evidence and your individual health profile.

How Each Weight Loss Injection Works

Mounjaro (tirzepatide) is the UK's first dual GIP/GLP-1 receptor agonist, activating two natural hormone pathways that regulate appetite, blood sugar, and energy metabolism [1]. This dual mechanism distinguishes it from single-pathway alternatives and contributes to its superior weight loss outcomes in head-to-head trials.

Wegovy (semaglutide) works as a GLP-1 receptor agonist, mimicking the glucagon-like peptide-1 hormone that reduces appetite and slows gastric emptying [2]. Administered once weekly, it achieved an average 14.9% body weight reduction over 68 weeks in the STEP 1 trial [2].

Saxenda (liraglutide) is also a GLP-1 receptor agonist but requires daily injections due to its shorter half-life [3]. In the SCALE Obesity and Prediabetes trial, patients achieved an average 8% body weight reduction over 56 weeks [3]. While clinically effective, the daily administration schedule and lower efficacy compared to newer treatments make it less popular among UK patients seeking maximum convenience and results.

Wegovy vs Saxenda vs Mounjaro: Clinical Efficacy Compared

When comparing efficacy data from pivotal trials, Mounjaro demonstrates the highest average weight loss. In the SURPASS-2 trial, patients on the 15mg maintenance dose achieved up to 22.5% body weight reduction over 72 weeks [1]. Wegovy produced an average 14.9% reduction in the STEP 1 trial [2], whilst Saxenda achieved approximately 8% reduction in the SCALE trial [3].

These figures represent averages from controlled clinical trials, and individual results vary based on adherence, lifestyle modifications, and metabolic factors. All three treatments are most effective when combined with a reduced-calorie diet and increased physical activity, as recommended by NICE guidelines for weight management [4].

Real-World Effectiveness

Clinical trial data provides essential benchmarks, but real-world effectiveness depends on patient adherence, tolerability, and prescriber titration protocols. Our UK clinical team at Cured Pharmacy monitors patient progress through follow-up consultations, adjusting doses as needed to optimise outcomes whilst minimising side effects.

Dosing Schedules and Administration

Mounjaro and Wegovy share the convenience of once-weekly subcutaneous injections, typically administered on the same day each week. Mounjaro starts at 2.5mg weekly and titrates up to a maximum of 15mg, whilst Wegovy begins at 0.25mg and increases to a maintenance dose of 2.4mg over 16-20 weeks [1][2].

Saxenda requires daily injections, starting at 0.6mg and increasing to a maintenance dose of 3mg over five weeks [3]. The daily regimen demands greater commitment but allows for more gradual dose adjustments if side effects occur.

Injection Technique and Comfort

All three treatments use pre-filled pen devices designed for self-administration into the abdomen, thigh, or upper arm. Patients typically report minimal discomfort, and our pharmacy team provides detailed injection technique guidance with every first prescription to ensure confidence and proper administration.

Treatment Active Ingredient Injection Frequency Average Weight Loss Starting Price
Mounjaro Tirzepatide (dual GIP/GLP-1) Once weekly Up to 22.5% over 72 weeks From £145
Wegovy Semaglutide (GLP-1) Once weekly Average 14.9% over 68 weeks From £89
Saxenda Liraglutide (GLP-1) Daily injection Average 8% over 56 weeks From £68

Side Effects and Tolerability Profile

Gastrointestinal side effects are common across all three GLP-1 treatments, particularly during dose escalation. Nausea, diarrhoea, constipation, and abdominal discomfort affect approximately 20-50% of patients but typically diminish over 4-8 weeks as the body adapts [1][2][3].

Mounjaro's dual-agonist mechanism may produce slightly higher rates of GI side effects initially, but clinical trials show similar discontinuation rates compared to Wegovy [1]. Saxenda's daily dosing allows for more gradual titration, which some patients find easier to tolerate, though the overall side effect profile remains comparable [3].

Rare but serious side effects include pancreatitis, gallbladder disease, and thyroid C-cell tumours (observed in rodent studies). All three medications carry the same MHRA warnings and contraindications, including a prohibition for patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 [4].

Cost Comparison and Value for Money

Pricing for weight loss injections varies significantly across UK pharmacies and depends on prescribed dose strength. At Cured Pharmacy, we maintain transparent upfront pricing with no hidden consultation fees or subscription traps.

When evaluating cost, consider both the monthly expenditure and the clinical efficacy data. Treatments with higher upfront costs may deliver superior weight loss outcomes, potentially reducing the overall duration and total cost of therapy. Our UK prescribers discuss cost-effectiveness during your free consultation, ensuring your treatment choice aligns with both your clinical needs and budget.

NHS vs Private Prescription Access

NHS prescribing criteria for weight loss medications are restrictive, typically requiring a BMI of 35+ with comorbidities or 40+ without, plus documented evidence of failed lifestyle interventions [4]. Private prescriptions through UK-registered online pharmacies like Cured Pharmacy offer broader access for eligible patients with a BMI of 30+ (or 27+ with weight-related health conditions), subject to prescriber approval following clinical assessment.

Which Weight Loss Injection Is Right for You?

Choosing between Mounjaro, Wegovy, and Saxenda depends on your weight loss goals, tolerance for side effects, preference for injection frequency, and budget. Patients seeking maximum efficacy and willing to manage potential GI side effects often prefer Mounjaro, given its superior clinical trial outcomes [1].

Wegovy offers a strong balance of efficacy and tolerability with once-weekly convenience, making it the most prescribed weight loss injection in the UK [2]. Saxenda remains a viable option for patients who prefer daily dosing control or have previously used liraglutide-based treatments successfully [3].

At Cured Pharmacy, your treatment decision is guided by our UK-registered prescribers during a free online consultation under 3 minutes. We assess your medical history, current medications, BMI, and weight loss objectives to recommend the most appropriate option. All three treatments require ongoing clinical monitoring and lifestyle modifications for optimal results.

Starting Your Weight Loss Journey

Begin with our free online clinical assessment, which takes under 3 minutes to complete. Our UK prescribers review your submission within 24 hours and, if approved, your medication is dispensed from our GPhC-registered pharmacy with discreet next-day delivery across the UK. Superintendent pharmacist Tarun Kumar (GPhC 2233073) oversees all clinical protocols to ensure safe, evidence-based prescribing aligned with MHRA and NICE guidelines.

Scientific References

  1. Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205–216. https://doi.org/10.1056/NEJMoa2206038
  2. Wilding, J. P. H., Batterham, R. L., Calanna, S., et al. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine, 384(11), 989–1002. https://doi.org/10.1056/NEJMoa2032183
  3. Pi-Sunyer, X., Astrup, A., Fujioka, K., et al. (2015). A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. New England Journal of Medicine, 373(1), 11–22. https://doi.org/10.1056/NEJMoa1411892
  4. National Institute for Health and Care Excellence. (2023). Obesity: identification, assessment and management (CG189). NICE. https://www.nice.org.uk/guidance/cg189

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication. Individual results may vary, and weight loss outcomes depend on adherence to treatment, dietary modifications, and physical activity levels.

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Faq

Which is better: Wegovy vs Saxenda vs Mounjaro?
Mounjaro demonstrates the highest average weight loss in clinical trials (up to 22.5%), followed by Wegovy (14.9%) and Saxenda (8%). However, the 'best' treatment depends on your individual medical profile, tolerance for side effects, and preference for injection frequency, which a UK prescriber assesses during consultation.
Can I switch from Saxenda to Wegovy or Mounjaro?
Yes, patients can switch between GLP-1 treatments under prescriber guidance. Your UK clinician will assess your response to Saxenda and determine appropriate starting doses for Wegovy or Mounjaro to minimise side effects during transition.
How long does it take to see results with these injections?
Most patients notice appetite reduction within 1-2 weeks, with measurable weight loss typically evident by week 4-6. Maximum efficacy is usually achieved after 6-12 months of consistent treatment combined with lifestyle modifications.
Do I need a prescription for Wegovy, Saxenda, or Mounjaro?
Yes, all three are prescription-only medications in the UK. At Cured Pharmacy, our UK-registered prescribers conduct a free online clinical assessment to determine eligibility and safety before prescribing any weight loss injection.
What are the main side effects of wegovy vs saxenda vs mounjaro uk?
All three treatments share similar side effects, predominantly gastrointestinal (nausea, diarrhoea, constipation) during dose escalation. These typically diminish within 4-8 weeks as your body adapts to the medication.
Can I use these injections if I have diabetes?
Mounjaro and Wegovy (at lower doses marketed as Ozempic) are licensed for type 2 diabetes management. However, using these medications for weight loss when you have diabetes requires careful prescriber assessment of your glycaemic control and current diabetes medications to avoid hypoglycaemia.
How much weight can I lose on Mounjaro vs Wegovy vs Saxenda?
Clinical trials show average weight loss of up to 22.5% with Mounjaro, 14.9% with Wegovy, and 8% with Saxenda over 56-72 weeks. Individual results vary based on starting weight, adherence, diet, exercise, and metabolic factors.
Are wegovy vs saxenda vs mounjaro uk treatments available on the NHS?
NHS prescribing is limited to patients meeting strict eligibility criteria (typically BMI 35+ with comorbidities or 40+ without) and often involves long waiting lists. Private prescriptions through UK-registered pharmacies like Cured Pharmacy offer faster access for eligible patients, subject to clinical approval.