Saxenda vs Wegovy UK - Compare Prices & Cheapest Option

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Saxenda vs Wegovy - Compare Prices & Cheapest UK Option

Compare Saxenda vs Wegovy at the cheapest UK price from £69.00 with £20 off using code Weightlossnew.

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£89.00 From £69.00 £20 discount using discount code Weightlossnew
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Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £124.99

£31.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
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Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £159.00

£39.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
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Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £200.00

£50.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
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Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £225.00

£56.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
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Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £250.00

£62.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
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Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £267.00

£66.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
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Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £69.00

£17.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
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Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£109 £89.00

£22.25 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £109
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Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £99.00

£24.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
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Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £149.00

£37.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
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Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £179.00

£44.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
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Wegovy (Oral Pill)
Weeks 1–4

1.5mg

1 pen • 4 Weeks

£83.00 £63.00

£20.75 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £83.00
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Wegovy (Oral Pill)
Weeks 5–8

4mg

1 pen • 4 Weeks

£110.00 £90.00

£27.50 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £110.00
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Wegovy (Oral Pill)
Weeks 9–12

9mg

1 pen • 4 Weeks

£140.00 £120.00

£35.00 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £140.00
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Wegovy (Oral Pill)
Weeks 13+

25mg

1 pen • 4 Weeks

£199.00 £179.00

£49.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199.00
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Saxenda vs Wegovy: Which Weight Loss Injection Works Best in the UK?

When comparing saxenda vs wegovy, many UK patients want to know which GLP-1 injection delivers better weight loss results, fewer side effects, and better value. Both Saxenda (liraglutide) and Wegovy (semaglutide) are prescription-only weight loss treatments licensed by the MHRA, but they differ significantly in dosing frequency, clinical efficacy, and cost. This comprehensive guide from Cured Pharmacy's clinical team examines the evidence to help you make an informed choice, subject to prescriber approval.

Saxenda vs Wegovy: Active Ingredients and How They Work

The saxenda vs wegovy comparison begins with understanding their active ingredients. Saxenda contains liraglutide, a GLP-1 receptor agonist that mimics the incretin hormone your body naturally produces after eating [1]. Wegovy contains semaglutide, a longer-acting GLP-1 analogue with a modified molecular structure that extends its half-life to approximately one week [2]. Both medications work by slowing gastric emptying, reducing appetite, and enhancing feelings of fullness, but their pharmacokinetic profiles differ substantially.

Liraglutide in Saxenda has a half-life of around 13 hours, requiring daily subcutaneous injections to maintain therapeutic levels [1]. Semaglutide in Wegovy, by contrast, has a half-life of approximately 7 days, allowing for once-weekly dosing [2]. This fundamental difference in duration of action explains why Wegovy offers greater dosing convenience, though both medications require gradual dose escalation to minimise gastrointestinal side effects. Our superintendent pharmacist Tarun Kumar notes that patient adherence often improves with less frequent dosing schedules, which may influence long-term weight loss outcomes.

Saxenda vs Wegovy Weight Loss Results: Clinical Trial Data

When evaluating saxenda vs wegovy for weight loss efficacy, the clinical trial data reveals important differences. The SCALE trial programme for Saxenda demonstrated that participants lost an average of 8% of their initial body weight over 56 weeks when combined with lifestyle modification [3]. In the pivotal STEP 1 trial for Wegovy, participants achieved an average weight loss of 14.9% over 68 weeks, nearly double the results seen with liraglutide [4]. These figures represent intention-to-treat analyses and include participants who discontinued treatment.

It's worth noting that individual results vary considerably, and both medications require ongoing lifestyle changes including reduced calorie intake and increased physical activity. In head-to-head comparisons, semaglutide consistently outperformed liraglutide for weight reduction, though both medications showed statistically significant benefits compared to placebo [4]. At Cured Pharmacy, we ensure every patient receives a thorough clinical assessment before starting either treatment, as prescriber approval depends on your BMI, medical history, and weight loss goals.

Real-World Weight Loss Expectations

Beyond clinical trials, real-world evidence suggests that saxenda vs wegovy outcomes depend heavily on adherence and lifestyle factors. Patients who maintain consistent injection schedules, follow a reduced-calorie diet, and engage in regular physical activity typically see the best results with either medication. Our clinical team at Cured Pharmacy provides ongoing support throughout your treatment journey, helping you optimise your weight loss programme regardless of which GLP-1 medication you choose.

Saxenda vs Wegovy Side Effects: What to Expect

The saxenda vs wegovy side effect profiles are similar, as both are GLP-1 receptor agonists, but the frequency and severity can differ. The most common adverse effects for both medications include nausea, diarrhoea, constipation, vomiting, and abdominal pain [1][2]. In clinical trials, approximately 44% of Saxenda users reported nausea, compared to 44% of Wegovy users in the STEP trials, though the once-weekly dosing of Wegovy may reduce the overall burden of daily gastrointestinal symptoms [3][4].

More serious but rare side effects include pancreatitis, gallbladder disease, and potential thyroid C-cell tumours (observed in rodent studies but not conclusively demonstrated in humans) [2]. Both medications carry a boxed warning regarding thyroid tumours and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. Our prescribers at Cured Pharmacy carefully screen for these contraindications during your online consultation to ensure treatment safety.

Managing Side Effects

When comparing saxenda vs wegovy tolerability, the gradual dose escalation protocols for both medications help minimise gastrointestinal side effects. Starting at lower doses and slowly increasing over 4-5 weeks allows your digestive system to adapt. Eating smaller, more frequent meals, avoiding high-fat foods, and staying well-hydrated can further reduce nausea and discomfort. If side effects become intolerable, your prescriber may adjust your dose or consider switching between medications, as individual tolerance varies.

Feature Saxenda Wegovy
Active Ingredient Liraglutide 6 mg/ml Semaglutide 2.4 mg
Dosing Frequency Daily injection Weekly injection
Maintenance Dose 3.0 mg daily 2.4 mg weekly
Average Weight Loss 8% body weight (56 weeks) 14.9% body weight (68 weeks)
Titration Period 5 weeks 16-20 weeks
Common Side Effects Nausea, diarrhoea, constipation Nausea, diarrhoea, vomiting
Starting Price (Cured Pharmacy) From £68.00 From £89.00
MHRA Licensed Yes Yes

Saxenda vs Wegovy Dosing and Administration

The saxenda vs wegovy dosing schedules differ significantly in frequency and titration. Saxenda requires daily subcutaneous injections, starting at 0.6 mg and increasing weekly by 0.6 mg increments until reaching the maintenance dose of 3.0 mg daily [1]. This 5-week titration period helps reduce gastrointestinal side effects. Wegovy, administered once weekly, begins at 0.25 mg and escalates monthly through 0.5 mg, 1.0 mg, 1.7 mg, and finally 2.4 mg as the maintenance dose over approximately 16-20 weeks [2].

Both medications are supplied in pre-filled, multi-dose injection pens for subcutaneous injection into the abdomen, thigh, or upper arm. Saxenda pens contain 18 mg of liraglutide (delivering 30 doses at the 3.0 mg maintenance level), while Wegovy pens are single-dose devices providing one weekly injection. The convenience of once-weekly dosing makes Wegovy particularly appealing for patients with busy schedules, though Saxenda's daily routine may suit those who prefer consistent daily medication habits. All injections should be administered at approximately the same time each day (Saxenda) or the same day each week (Wegovy) for optimal results.

Saxenda vs Wegovy Cost and UK Availability

When considering saxenda vs wegovy from a cost perspective, UK pricing varies between pharmacies and supply fluctuations. At Cured Pharmacy, Saxenda starts from £69.00 and Wegovy from £69.00, representing competitive UK pricing with transparent upfront costs shown before your consultation [5]. New patients can Save £20 off their first order using code Weightlossnew, making either treatment more accessible. These prices include your medication, clinical assessment by a UK-registered prescriber, and discreet home delivery.

NHS availability for both medications remains limited due to budget constraints and NICE guidance restricting use to specialist weight management services. Most UK patients access Saxenda or Wegovy through private prescriptions from registered online pharmacies like Cured Pharmacy. Our clinical team, led by superintendent pharmacist Tarun Kumar (GPhC 2233073), ensures every prescription meets MHRA standards and follows appropriate clinical guidelines. All consultations are completed online in under 3 minutes, with prescriptions issued the same day subject to clinical approval.

Long-Term Cost Considerations

When evaluating saxenda vs wegovy costs over time, consider that Saxenda requires daily injections (approximately 30 pens per year at maintenance dose) while Wegovy requires 52 injections annually. The total annual cost depends on your prescribed dose and treatment duration. Most patients use these medications for 6-12 months to achieve their target weight loss, then work with their prescriber to develop a maintenance plan. Cured Pharmacy offers ongoing prescription management and competitive pricing throughout your treatment journey.

Saxenda vs Wegovy: Which Should You Choose?

The saxenda vs wegovy decision ultimately depends on your individual circumstances, preferences, and clinical suitability. Wegovy typically delivers superior weight loss results based on clinical trial data (14.9% vs 8% average body weight reduction) and offers the convenience of once-weekly dosing [3][4]. However, Saxenda may be preferred by patients who have previously used liraglutide-based medications, prefer daily dosing routines, or find the lower starting price more accessible.

Both medications require a BMI of 30 kg/m² or above (or 27 kg/m² with weight-related comorbidities such as type 2 diabetes, hypertension, or sleep apnoea) for prescribing eligibility in the UK [5]. Your prescriber will assess your medical history, current medications, and contraindications during your consultation. Factors such as previous GLP-1 experience, tolerance to gastrointestinal side effects, lifestyle considerations, and budget all influence the optimal choice. At Cured Pharmacy, our clinical team provides personalised recommendations based on your unique situation, ensuring you receive the most appropriate treatment subject to prescriber approval.

Starting Your Weight Loss Journey

Whether you choose Saxenda or Wegovy, success requires commitment to lifestyle changes alongside medication. Both GLP-1 treatments work best when combined with a reduced-calorie diet (typically 500-1000 calorie deficit daily) and at least 150 minutes of moderate physical activity weekly. Cured Pharmacy provides ongoing support, prescription management, and access to UK-registered clinicians throughout your weight loss programme. Start your assessment today to determine which medication suits your needs, with prices from £69.00 for Saxenda or £69.00 for Wegovy, plus £20 off your first order with code Weightlossnew.

Scientific References

  1. Pi-Sunyer, X., Astrup, A., Fujioka, K., et al. (2015). A randomized, controlled trial of 3.0 mg of liraglutide in weight management. New England Journal of Medicine, 373(1), 11-22.
  2. Wilding, J. P., Batterham, R. L., Calanna, S., et al. (2021). Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine, 384(11), 989-1002.
  3. Davies, M. J., Bergenstal, R., Bode, B., et al. (2015). Efficacy of liraglutide for weight loss among patients with type 2 diabetes: The SCALE diabetes randomized clinical trial. JAMA, 314(7), 687-699.
  4. Rubino, D., Abrahamsson, N., Davies, M., et al. (2021). Effect of continued weekly subcutaneous semaglutide vs placebo on weight loss maintenance in adults with overweight or obesity: The STEP 4 randomized clinical trial. JAMA, 325(14), 1414-1425.
  5. National Institute for Health and Care Excellence. (2023). Semaglutide for managing overweight and obesity. Technology appraisal guidance [TA875].

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication.

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Faq

Is Wegovy more effective than Saxenda for weight loss?
Yes, clinical trials show Wegovy (semaglutide) delivers greater average weight loss (14.9%) compared to Saxenda (8%) over similar timeframes, though individual results vary and both require lifestyle changes.
Can I switch from Saxenda to Wegovy?
Yes, many patients transition from Saxenda to Wegovy under prescriber guidance. Your clinician will create a safe switching protocol, typically involving a washout period and gradual Wegovy titration to minimise side effects.
Which has fewer side effects, Saxenda or Wegovy?
Both saxenda vs wegovy comparisons show similar gastrointestinal side effect profiles (nausea, diarrhoea, constipation), though Wegovy's weekly dosing may reduce the overall burden of daily symptoms experienced with Saxenda.
How long does it take to see results with Saxenda vs Wegovy?
Most patients notice appetite reduction within 1-2 weeks with either medication. Meaningful weight loss (5% body weight) typically occurs within 12-16 weeks with Saxenda and 8-12 weeks with Wegovy when combined with diet and exercise.
Do I need a prescription for Saxenda or Wegovy in the UK?
Yes, both are prescription-only medicines requiring clinical assessment by a UK-registered prescriber. Cured Pharmacy provides free online consultations, with prescriptions issued subject to clinical approval within hours.
Which is cheaper in the UK, Saxenda or Wegovy?
At Cured Pharmacy, Saxenda starts from £69.00 while Wegovy starts from £69.00. New patients Save £20 off their first order with code Weightlossnew, making either treatment accessible with transparent upfront pricing.
Can I use Saxenda and Wegovy together?
No, you should never use saxenda vs wegovy medications simultaneously, as both are GLP-1 receptor agonists and combining them significantly increases the risk of severe side effects including hypoglycaemia and gastrointestinal complications.
How long can I stay on Saxenda or Wegovy?
Treatment duration varies by individual response and clinical need. Most patients use either medication for 6-12 months to achieve target weight loss, then work with prescribers to develop a maintenance plan, which may include continued use at lower doses.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Last reviewed: 30 July 2026