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Vagisan Cream - 50g

Vagisan Cream - 50g

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  • ✔️ Relieves vaginal dryness, itching, and irritation effectively
  • ✔️ Hormone-free formula safe for long-term daily use
  • ✔️ Suitable for menopausal and post-menopausal women
  • ✔️ Contains hyaluronic acid to restore natural vaginal moisture
  • ✔️ Can be used internally and externally for full comfort

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What Is Vagisan Cream — a Vaginal Dryness Cream?

 

Vaginal dryness is more common than many people realise. It affects women at various life stages — during and after menopause, while breastfeeding, or as a result of certain medications. If you've been experiencing itching, soreness, or discomfort during everyday activities or sex, you're far from alone. Vagisan cream for vaginal dryness is a hormone-free, over-the-counter moisturising cream designed to relieve exactly these symptoms. It's available in a 50g tube and can be used both internally and externally, making it a versatile option for ongoing vaginal comfort. You can explore more products for intimate and women's health in our dedicated collection.

Vagisan Cream is manufactured by the German brand Vagisan and is widely used across Europe. It does not contain oestrogen or any other hormones, which makes it suitable for women who cannot or prefer not to use hormonal treatments. The cream works by directly moisturising the vaginal mucosa and the surrounding skin, helping to restore comfort and reduce irritation.

 

How Does Vagisan Cream Work to Relieve Dryness?

 

The cream's moisturising action comes from a carefully formulated base that includes glycerol and hyaluronic acid — two ingredients well known for their ability to attract and retain water in tissue. Here's how it works:

  • Glycerol acts as a humectant, drawing moisture into the vaginal tissue and helping it stay hydrated.
  • Hyaluronic acid supports the skin's natural moisture-retaining capacity, which often declines with age or hormonal changes.
  • The cream's slightly acidic pH helps maintain the natural vaginal environment, which is important for overall vaginal health.
  • Applied to the vaginal entrance and surrounding area, it forms a protective, soothing layer that reduces friction and irritation.

Because it contains no hormones, it does not interfere with the body's hormonal balance. This makes it a practical choice for women who are on hormone-sensitive medications or who have had hormone-dependent cancers and have been advised to avoid oestrogen-based products.

 

Who Should Use Vagisan Cream?

 

Vagisan Cream is suitable for a wide range of women experiencing vaginal dryness for different reasons. It's particularly useful if you're looking for a non-hormonal, daily-use option. It may be appropriate for you if you:

  • Are going through perimenopause or menopause and experiencing vaginal dryness or discomfort
  • Are breastfeeding and noticing reduced vaginal lubrication due to lower oestrogen levels
  • Are taking medications such as antihistamines, antidepressants, or certain contraceptives that can cause dryness as a side effect
  • Prefer a hormone-free approach to managing vaginal dryness

It is not intended as a sexual lubricant, though it may improve comfort during intercourse when used regularly. If you're also looking for products to use during sex, our personal lubricants collection has a range of suitable options.

 

How Does Vagisan Cream Compare to Other Vaginal Moisturisers?

 

Feature Vagisan Cream 50g Replens Long-Lasting Moisturiser
Hormone-free Yes Yes
Application frequency Daily (or as needed) Every 2–3 days
Internal & external use Yes Internal only
Contains hyaluronic acid Yes No

 

Is Vagisan Cream Suitable for Long-Term Use?

 

Yes. Because Vagisan cream for vaginal dryness contains no hormones or steroids, it is considered safe for ongoing daily use. There is no known risk of dependency or tissue thinning associated with long-term application. That said, if your symptoms don't improve after four weeks of regular use, it's worth speaking to your GP — persistent vaginal dryness can sometimes indicate an underlying condition that warrants further investigation.

Store the cream below 25°C, away from direct sunlight, and keep it out of reach of children. Check the expiry date before use and do not use the product if the tube has been damaged or previously opened by someone else.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Vagisan Cream 50g specifications
Treatment category Vaginal dryness / intimate moisturiser
Mechanism of action Topical moisturisation of vaginal mucosa using humectants and hyaluronic acid
Effective for Vaginal dryness, itching, irritation, and discomfort
Suitable for Adult women; hormone-free use; menopausal and post-menopausal women
Active ingredient Glycerol, hyaluronic acid (moisturising base; no hormones)
Pack size 50g tube
UK classification General Sale / OTC
Drug class Vaginal moisturiser (non-hormonal)
Preparation Cream
Route of administration Vaginal and external topical

Specifications of Vagisan Cream 50g

 

What Is Vagisan Cream and What Is It Used For?

 

Vagisan Cream is a non-hormonal vaginal moisturising cream used to relieve the symptoms of vaginal dryness. These symptoms can include itching, burning, soreness, and discomfort during everyday activities or sexual intercourse. The cream is suitable for adult women of all ages and is particularly helpful for those experiencing dryness related to menopause, breastfeeding, or medication side effects. It is available over the counter without a prescription and can be used as part of a regular daily routine. The NHS recognises vaginal dryness as a common and treatable condition, and non-hormonal moisturisers are among the first-line options recommended for women who prefer to avoid hormonal treatments.

 

What Do You Need to Know Before Using Vagisan Cream?

 

Before using Vagisan Cream, read the following carefully. Do not use this product if any of the following apply to you:

  • You are allergic to any of the ingredients in the cream
  • You have an active vaginal infection — treat the infection first before using a moisturiser
  • You have unexplained vaginal bleeding — consult your GP before use
  • You are under 18 years of age

There are also some important warnings to be aware of:

  • Vagisan Cream can damage latex condoms and diaphragms, reducing their effectiveness as contraceptives — use non-latex alternatives if needed
  • If symptoms worsen or do not improve after four weeks, stop use and speak to your GP
  • Avoid contact with eyes
  • This product is for external and vaginal use only — do not swallow

In terms of drug interactions, Vagisan Cream is not known to interact with oral or systemic medications. However, because it is oil-based, it may affect the integrity of latex-based medical devices as noted above. If you are using any other vaginal products, including antifungal creams or pessaries, speak to your pharmacist before combining them. You can browse our thrush treatments collection if you suspect a concurrent infection.

 

How Should You Use Vagisan Cream?

 

Using Vagisan Cream correctly will help you get the most benefit from it. Follow these steps:

  1. Wash your hands thoroughly before and after application.
  2. Remove the cap and pierce the tube seal if using for the first time.
  3. Squeeze a small amount of cream (approximately 1–2g) onto a clean fingertip or the applicator provided.
  4. Apply gently to the vaginal entrance and the surrounding external area, or use the applicator for internal application.
  5. Use once daily, preferably in the evening before bed, to allow the cream to absorb overnight.
  6. Replace the cap after use and store the tube in a cool, dry place.
Indication Age Group Dose Frequency
Vaginal dryness and irritation Adult women (18+) 1–2g (small fingertip amount) Once daily
Maintenance / ongoing comfort Adult women (18+) 1–2g Every 1–2 days as needed

 

What Are the Possible Side Effects of Vagisan Cream?

 

Vagisan Cream is generally well tolerated. Side effects are uncommon, but as with any topical product, some women may experience a reaction, particularly when first starting use.

Common side effects:

  • Mild local irritation at the application site
  • Temporary burning or stinging sensation
  • Slight redness of the surrounding skin

Less common side effects:

  • Increased vaginal discharge (usually temporary)
  • Skin sensitivity or allergic reaction to one of the excipients

If you experience a severe allergic reaction — including swelling of the face, lips, or throat, difficulty breathing, or a widespread rash — stop using the product immediately and seek urgent medical attention. These reactions are rare but require prompt assessment. If you're managing other intimate health concerns alongside vaginal dryness, our condoms and sexual health collection may also be of interest.

 

How Should You Store Vagisan Cream?

 

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the tube
  • Do not freeze
  • Once opened, use within the period indicated on the packaging
  • Do not store in the bathroom, where humidity and temperature fluctuations can affect the product

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Vagisan Cream online in the UK?

You can buy Vagisan Cream 50g directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is available without a prescription as an over-the-counter product. No consultation is required, and it can be ordered discreetly to your door.

How does Vagisan Cream work for vaginal dryness?

Vagisan Cream works by delivering glycerol and hyaluronic acid directly to the vaginal tissue, where they attract and retain moisture. This helps restore the natural hydration of the vaginal mucosa without using hormones. Regular use helps maintain comfort and reduce irritation over time.

How do I use Vagisan Cream step by step?

Wash your hands, then apply a small amount (around 1–2g) to the vaginal entrance and surrounding area using a fingertip or the included applicator. Use once daily, ideally at night before bed. Replace the cap and store the tube below 25°C after each use.

What is the correct dose of Vagisan Cream?

The recommended dose is approximately 1–2g applied once daily for active symptoms. For ongoing maintenance, some women reduce frequency to every one to two days once comfort is restored. Always follow the instructions in the patient information leaflet supplied with the product.

What are the side effects of Vagisan Cream?

Side effects are uncommon but can include mild local irritation, a temporary burning sensation, or slight redness at the application site. Less commonly, some women may notice a temporary increase in vaginal discharge. Stop use and consult a pharmacist or GP if symptoms worsen or an allergic reaction occurs.

How do I manage side effects of Vagisan Cream?

If you experience mild irritation, try reducing application frequency to every other day and see if symptoms settle. Avoid applying to broken or inflamed skin. If irritation persists or worsens, discontinue use and speak to your pharmacist or GP for further advice.

Who is eligible to use Vagisan Cream?

Vagisan Cream is suitable for adult women aged 18 and over who are experiencing vaginal dryness, itching, or irritation. It is particularly well suited to women going through menopause, those who are breastfeeding, or those on medications that cause dryness as a side effect. It is not suitable for use in children or adolescents.

Can I use Vagisan Cream with condoms?

No — Vagisan Cream can weaken latex condoms and diaphragms, making them less effective as contraceptives. If you are sexually active and using barrier contraception, switch to non-latex alternatives when using this cream. For a range of suitable options, visit our condoms and sexual health collection.

Is Vagisan Cream safe to use during menopause?

Yes. Vagisan Cream is hormone-free and is one of the most commonly recommended non-hormonal options for menopausal vaginal dryness. The NHS advises that vaginal moisturisers are a suitable first-line treatment for women who prefer to avoid or cannot use hormonal therapies. It can be used safely alongside other menopausal treatments unless your GP advises otherwise.

What happens if I miss a dose of Vagisan Cream?

If you forget to apply Vagisan Cream one evening, simply apply it the next time you remember and continue with your usual routine. Do not apply a double amount to make up for a missed application. Consistency over time is more important than any single application.

What are alternatives to Vagisan Cream for vaginal dryness?

Other non-hormonal vaginal moisturisers include Replens Long-Lasting Moisturiser and YES VM. For women who are eligible, vaginal oestrogen treatments (available on prescription) can also be highly effective. You can explore related products in our women's health collection or speak to your GP about prescription options.

How long does it take for Vagisan Cream to work?

Many women notice an improvement in comfort and reduced irritation within a few days of starting regular use. Full benefit is typically felt after one to two weeks of consistent daily application. If there is no improvement after four weeks, consult your GP.

How long can you use Vagisan Cream for?

Vagisan Cream is suitable for long-term daily use because it contains no hormones or steroids. There is no recommended maximum duration of use. However, if your symptoms change, worsen, or are accompanied by unusual discharge or bleeding, seek medical advice promptly.

Is Vagisan Cream the same as a vaginal lubricant?

No — Vagisan Cream is a vaginal moisturiser, not a lubricant. Moisturisers are designed for regular daily use to maintain vaginal hydration over time, whereas lubricants are used specifically during sexual activity to reduce friction. Both can be used together if needed; see our personal lubricants collection for options.

What are the latest studies on vaginal moisturisers like Vagisan Cream?

Research published in recent years supports the use of non-hormonal vaginal moisturisers as effective first-line treatments for genitourinary syndrome of menopause (GSM), which includes vaginal dryness and irritation. Studies have shown that regular use of moisturisers containing hyaluronic acid can significantly improve vaginal comfort and quality of life. The NHS and NICE both recognise non-hormonal moisturisers as a valid treatment option for women who prefer to avoid oestrogen.

How Should You Use Vagisan Cream?

Vagisan Cream is applied directly to the vaginal entrance and surrounding external area. It can also be used internally with the applicator provided. Always wash your hands before and after application to maintain hygiene and reduce the risk of introducing bacteria.

What Is the Correct Dose of Vagisan Cream?

The standard dose for adults is approximately 1–2g of cream applied once daily. This is roughly equivalent to a small fingertip amount. Do not apply more than the recommended amount, as this will not increase effectiveness and may cause unnecessary irritation.

When Is the Best Time to Use Vagisan Cream?

The best time to apply Vagisan Cream is in the evening, just before bed. Applying it at night allows the cream to absorb fully into the vaginal tissue without being disturbed by movement or clothing. This also reduces the likelihood of the cream transferring to underwear during the day.

If you prefer to apply it in the morning, that is also acceptable — the key is consistency. Using it at the same time each day helps you build a routine and ensures you don't miss applications.

How Long Can You Use Vagisan Cream For?

Because Vagisan Cream contains no hormones or steroids, it is safe for long-term daily use with no defined maximum treatment duration. Many women use it continuously as part of their daily intimate care routine, particularly during and after menopause when vaginal dryness tends to be an ongoing concern.

If your symptoms do not improve after four weeks of regular use, or if they worsen at any point, stop using the cream and consult your GP. Persistent or changing symptoms should always be assessed by a healthcare professional to rule out other causes.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Vagisan Cream?

Vagisan Cream is generally well tolerated, and most women use it without experiencing any adverse effects. However, as with any topical product applied to sensitive tissue, some mild reactions can occur, particularly when you first start using it.

  • Mild local irritation at the application site
  • Temporary burning or stinging sensation immediately after application
  • Slight redness of the vaginal entrance or surrounding skin

These effects are usually short-lived and tend to settle within a few minutes of application. If they persist beyond the first few uses, reduce the frequency of application and see whether symptoms improve.

What Are the Less Common Side Effects of Vagisan Cream?

Less commonly, some women may notice the following after using Vagisan Cream. These are not dangerous in most cases, but they are worth monitoring.

  • A temporary increase in vaginal discharge, which usually resolves on its own
  • Skin sensitivity or a mild allergic reaction to one of the excipients in the cream
  • A feeling of heaviness or fullness in the vaginal area after internal application

If any of these effects are bothersome or do not resolve within a few days, stop using the product and speak to your pharmacist or GP.

What Are the Serious Side Effects of Vagisan Cream?

Serious side effects from Vagisan Cream are rare. However, you should stop using the product immediately and seek urgent medical attention if you experience any of the following signs of a severe allergic reaction:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • A widespread skin rash or hives
  • Dizziness or feeling faint

These symptoms suggest anaphylaxis, which is a medical emergency. Call 999 or go to your nearest A&E department immediately if this occurs.

What Should You Do If You Experience Side Effects?

For mild side effects such as temporary irritation or redness, try reducing the frequency of application to every other day and see whether your skin adjusts. Avoid applying the cream to broken, inflamed, or infected skin. If you suspect you are reacting to a specific ingredient, check the full list of excipients in the patient information leaflet and discuss alternatives with your pharmacist.

You can also report suspected side effects to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps regulators monitor the safety of medicines used in the UK.

Can Vagisan Cream Interact With Other Medicines?

Vagisan Cream is not known to interact with oral or systemic medications. However, because it contains oil-based excipients, it can degrade latex condoms and diaphragms, reducing their effectiveness as contraceptives. If you are using latex barrier contraception, switch to non-latex alternatives during treatment. If you are using other vaginal products — such as antifungal creams, pessaries, or hormonal treatments — speak to your pharmacist before combining them with Vagisan Cream to avoid any potential interference.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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