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Systane Ultra UD Eye Drops - 30 Vials (0.7ml Each)

Systane Ultra UD Eye Drops - 30 Vials (0.7ml Each)

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  • ✔️ Relieves dry, gritty, and irritated eyes on contact
  • ✔️ Preservative-free formula safe for sensitive eyes
  • ✔️ Single-dose vials eliminate contamination risk entirely
  • ✔️ Suitable for contact lens wearers — remove before use
  • ✔️ 30 vials provide a generous supply for daily relief

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What Are Dry Eye Drops Single Dose Vials and How Do They Help?

 

Dry eyes are more common than you might think. The NHS estimates that dry eye syndrome affects millions of people in the UK, causing symptoms such as grittiness, burning, redness, and a feeling that something is stuck in your eye. Systane Ultra UD Eye Drops offer a preservative-free solution in convenient single-dose vials — ideal for people who need reliable, on-the-go relief without the worry of contamination. If you're exploring your options for dry eye drops single dose treatment, this product is worth a close look. You can browse our full range of eye care products to find the right solution for your needs.

Each pack contains 30 individual 0.7ml vials, giving you a generous supply for daily use. Because each vial is used once and then discarded, there's no risk of bacterial contamination that can sometimes occur with multi-dose bottles — a real advantage for anyone with sensitive or compromised eyes.

 

How Do Systane Ultra UD Eye Drops Work?

 

The active ingredients are polyethylene glycol 400 (0.4%) and propylene glycol (0.3%). These two polymers work together to create a lubricating, protective layer across the ocular surface, mimicking the function of your natural tear film. Here's how the mechanism unfolds:

  • Polyethylene glycol 400 acts as a humectant, drawing moisture to the eye surface and helping retain it.
  • Propylene glycol provides additional viscosity, helping the drop spread evenly across the cornea and conjunctiva.
  • Together, they stabilise the tear film, reducing evaporation and the friction that causes that characteristic gritty sensation.
  • The preservative-free formulation means the drops are gentle enough for frequent use without risking preservative-related toxicity to the ocular surface.

The result is fast, soothing relief that lasts longer than basic saline drops, making Systane Ultra UD a practical choice for moderate to severe dry eye symptoms.

 

Who Should Use Systane Ultra UD Eye Drops?

 

These drops are suitable for a wide range of people experiencing dry eye symptoms. They're particularly well-suited to those who are sensitive to preservatives, which rules out many standard multi-dose eye drops. Common triggers for dry eye include prolonged screen use, air conditioning, contact lens wear, certain medications, and environmental factors like wind or low humidity.

  • Adults experiencing mild to severe dry eye symptoms
  • People who are sensitive or allergic to preservatives in eye drops
  • Contact lens wearers (remove lenses before use; reinsert after 15 minutes)
  • Those recovering from eye surgery, subject to clinical advice
  • People who use eye drops frequently throughout the day

 

How Do Systane Ultra UD Compare to Multi-Dose Eye Drops?

 

Feature Systane Ultra UD (Single Dose) Standard Multi-Dose Eye Drops
Preservative-free Yes — each vial discarded after use Often contains preservatives (e.g. benzalkonium chloride)
Risk of contamination Minimal — single use only Higher — bottle opened repeatedly
Suitable for sensitive eyes Yes Not always
Portability Compact vials, easy to carry Bottle may be bulkier

 

How Should You Store Systane Ultra UD and Is It Clinically Suitable for You?

 

Store Systane Ultra UD below 25°C, away from direct sunlight and out of reach of children. Do not freeze the vials. Once a vial is opened, it must be used immediately and then discarded — never save a partially used vial for later, as this defeats the preservative-free benefit and introduces contamination risk. If you wear contact lenses or have a history of eye conditions such as glaucoma, always check with your optometrist or pharmacist before starting any new eye drop regimen. Dry eye drops single dose vials like these are a practical, hygienic format that suits people who need drops at work, while travelling, or throughout the day. If you're also managing other health conditions, our allergy and hay fever range may be relevant, as allergic eye symptoms can overlap with dry eye.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Systane Ultra UD Eye Drops - 30 Vials (0.7ml Each) specifications
Treatment category Dry eye / Ocular lubricant
Mechanism of action Lubricates and stabilises the tear film via polyethylene glycol 400 and propylene glycol
Effective for Dry, irritated, and uncomfortable eyes
Suitable for Adults and older children; preservative-sensitive individuals
Active ingredient Polyethylene glycol 400 0.4%, Propylene glycol 0.3%
Pack size 30 x 0.7ml single-dose vials
UK classification General Sale List (GSL)
Drug class Ocular lubricant / Artificial tear
Preparation Sterile ophthalmic solution
Route of administration Topical ophthalmic (instilled into the eye)

Specifications of Systane Ultra UD Eye Drops - 30 Vials (0.7ml Each)

 

What Is Systane Ultra UD and What Is It Used For?

 

Systane Ultra UD Eye Drops are a sterile, preservative-free ocular lubricant used to relieve the symptoms of dry eye syndrome. Dry eye occurs when your eyes don't produce enough tears, or when the tears evaporate too quickly — leaving the surface of the eye exposed and uncomfortable. The NHS recognises dry eye as a very common condition, particularly in older adults, people who spend long hours in front of screens, and those in dry or air-conditioned environments. These single-dose vials deliver a lubricating solution directly to the eye, providing temporary but meaningful relief from dryness, burning, grittiness, and light sensitivity. Each vial is used once and discarded, making them a hygienic choice for everyday use.

 

What Do You Need to Know Before Using Systane Ultra UD?

 

Before using these drops, it's important to be aware of the following contraindications and warnings:

  • Do not use if you are allergic to polyethylene glycol 400, propylene glycol, or any other ingredient in the formulation.
  • Remove soft contact lenses before instilling the drops; wait at least 15 minutes before reinserting them.
  • Do not use if the vial seal is broken before you open it.
  • Discard each vial immediately after use — do not store or reuse opened vials.
  • If you experience eye pain, changes in vision, or worsening redness after use, stop and seek medical advice promptly.
  • Consult your GP or optometrist if your dry eye symptoms persist for more than a few days despite treatment.
  • Keep out of reach of children.

Known drug interactions with topical ocular lubricants are minimal. However, if you are using other eye drops or eye medications, allow at least 5 minutes between instilling different products to avoid dilution or interaction.

  • No significant systemic drug interactions are currently documented for this formulation.
  • If you use prescription eye drops (e.g. for glaucoma), always instil those first and use lubricating drops afterwards.

 

How Should You Use Systane Ultra UD?

 

Using these drops correctly ensures you get the most benefit and avoid any risk of contamination. Follow these steps each time:

  1. Wash your hands thoroughly with soap and water before handling the vial.
  2. Twist off the top of one single-dose vial carefully.
  3. Tilt your head back slightly and look upward.
  4. Gently pull down your lower eyelid to create a small pocket.
  5. Hold the vial close to your eye without touching it, and squeeze 1 to 2 drops into the lower eyelid pocket.
  6. Blink gently to spread the solution across the eye surface.
  7. Discard the vial immediately — do not save any remaining solution.
  8. Repeat for the other eye if needed, using the same vial before discarding.
Indication Age Group Dose Frequency
Dry eye symptom relief Adults 1–2 drops per eye As needed throughout the day
Dry eye symptom relief Older children (on clinical advice) 1 drop per eye As directed by a healthcare professional

If you are also managing seasonal eye irritation alongside dryness, you may find it helpful to explore our allergy and hay fever range for complementary products.

 

What Are the Possible Side Effects of Systane Ultra UD?

 

Side effects with preservative-free lubricating eye drops are generally uncommon. Most people tolerate Systane Ultra UD very well. That said, it's worth knowing what to look out for.

Common side effects:

  • Temporary blurred vision immediately after instillation (usually clears within a minute or two)
  • Mild stinging or burning sensation on first contact with the eye

Less common side effects:

  • Eye redness or irritation that persists beyond a few minutes
  • Sticky or crusty eyelids
  • Watery eyes
  • Sensitivity to light

If you notice any severe or unexpected reaction — including significant pain, swelling around the eye, or sudden vision changes — stop using the drops and seek medical advice immediately. The NHS advises that any sudden change in vision should be assessed promptly by a healthcare professional.

 

How Should You Store Systane Ultra UD?

 

Correct storage keeps the drops safe and effective for the duration of the pack. Follow these guidelines:

  • Store below 25°C in a cool, dry place.
  • Do not freeze the vials.
  • Keep away from direct sunlight and heat sources.
  • Store out of reach and sight of children.
  • Do not use after the expiry date printed on the packaging.
  • Once a vial is opened, use immediately and discard — never store an opened vial for later use.

For a broader look at products that support your eye health and general wellbeing, our vitamins and supplements range includes options that may support tear production and ocular health from the inside out.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Systane Ultra UD eye drops online in the UK?

You can buy Systane Ultra UD Eye Drops — 30 x 0.7ml vials — directly from Cured Pharmacy online for £12.49, with no prescription required. They are classified as a General Sale List (GSL) medicine, meaning they are available over the counter. Browse our full eye care collection for more dry eye and ocular health products.

How do Systane Ultra UD eye drops work in the eye?

Systane Ultra UD contains polyethylene glycol 400 and propylene glycol, which together form a lubricating film over the surface of the eye. This film mimics the natural tear film, reducing friction, retaining moisture, and relieving the discomfort associated with dry eye syndrome. The drops are preservative-free, which means they are gentle enough for frequent daily use without risking damage to the ocular surface.

How do I use Systane Ultra UD eye drops step by step?

Wash your hands first, then twist off the top of one vial. Tilt your head back, pull down your lower eyelid gently, and squeeze 1 to 2 drops into the pocket formed. Blink gently to spread the solution, then discard the vial immediately — even if solution remains. Never save an opened vial for later use, as this introduces contamination risk.

How often can I use Systane Ultra UD eye drops throughout the day?

These drops can be used as often as needed to relieve dry eye symptoms — there is no strict maximum number of times per day for lubricating drops. However, if you find yourself needing them very frequently or your symptoms are not improving, it's worth speaking to your optometrist or GP to investigate an underlying cause. Persistent dry eye can sometimes be linked to conditions such as blepharitis or Sjögren's syndrome.

Are Systane Ultra UD eye drops truly preservative free?

Yes — Systane Ultra UD are genuinely preservative-free because each vial is a single-use unit that is discarded after one application. This is different from some multi-dose bottles that claim to be "preservative-free in the eye" but still contain preservatives that break down on contact with the ocular surface. For people with sensitive eyes or those who react to benzalkonium chloride (a common preservative), single-dose vials like these are a much safer option.

Can I use Systane Ultra UD eye drops with contact lenses?

You should remove your soft contact lenses before instilling Systane Ultra UD drops, and wait at least 15 minutes before reinserting them. This is standard advice for most eye drops, as the solution can interact with lens materials and potentially cause irritation or affect lens clarity. Hard (rigid gas permeable) lens wearers should also follow the same precaution and check with their optometrist if unsure.

What are the side effects of Systane Ultra UD eye drops?

Side effects are uncommon but can include temporary blurred vision immediately after instillation, mild stinging or burning on first contact, and occasionally eye redness or watering. These effects are usually brief and resolve within a minute or two. If you experience persistent pain, significant redness, or any change in vision, stop using the drops and seek medical advice promptly.

Who is eligible to use Systane Ultra UD eye drops?

Systane Ultra UD are suitable for most adults experiencing dry eye symptoms, including those with sensitive eyes or preservative intolerance. They are also used by contact lens wearers (with lenses removed), people who work in air-conditioned environments, and those with screen-related eye fatigue. Consult a pharmacist or GP before using in young children or if you have a diagnosed eye condition such as glaucoma.

What happens if I accidentally use too many drops at once?

Using more drops than needed is unlikely to cause serious harm, as the ingredients are lubricants rather than active pharmaceutical drugs. You may experience temporary blurred vision or a watery sensation. Simply blink gently and allow the excess to drain naturally. If you have any concerns, contact your pharmacist for reassurance.

What are the alternatives to Systane Ultra UD eye drops?

Alternatives include other preservative-free single-dose lubricating drops such as HyloFresh, Artelac Rebalance, and Clinitas Soothe. Multi-dose options like Hylo-Forte or Viscotears are also available, though these may contain preservatives. The right choice depends on the severity of your symptoms and whether you have preservative sensitivity — your pharmacist or optometrist can help you decide. You can explore our eye care range for available options.

How long can I use Systane Ultra UD eye drops for?

Systane Ultra UD can be used long-term as a lubricating aid for chronic dry eye, as they contain no preservatives that could cause cumulative ocular surface damage. Many people use them daily for months or years. That said, if your symptoms worsen or change significantly over time, it's worth having your eyes reviewed by an optometrist to ensure there isn't an underlying condition that needs treatment.

Are Systane Ultra UD eye drops suitable during pregnancy or breastfeeding?

Topical ocular lubricants like Systane Ultra UD are generally considered low risk during pregnancy and breastfeeding, as systemic absorption from eye drops is minimal. However, as with any medicine used during pregnancy or whilst breastfeeding, it is always best to check with your GP or midwife before starting a new product. They can confirm it is appropriate for your individual circumstances.

Can dry eye drops single dose vials be used after eye surgery?

Preservative-free lubricating drops are commonly recommended after procedures such as LASIK or cataract surgery to support healing and comfort, but you should only use them if specifically advised by your surgeon or ophthalmologist. They will guide you on timing, frequency, and which products are appropriate for your post-operative care plan. Do not self-prescribe eye drops following surgery without professional guidance.

What is the latest research on dry eye treatment with lubricating drops?

Current clinical evidence supports the use of preservative-free lubricating drops as a first-line treatment for mild to moderate dry eye disease, with guidelines from bodies such as NICE and the British Contact Lens Association recommending them for their safety profile and tolerability. Research continues to explore the role of omega-3 supplementation and warm compress therapy alongside lubricating drops for more persistent cases. If you're interested in nutritional support for eye health, our vitamins and supplements range may be worth exploring.

How should I store Systane Ultra UD eye drops to keep them effective?

Store the vials below 25°C in a cool, dry place away from direct sunlight and heat. Do not freeze them, as this can affect the formulation. Always check the expiry date before use, and remember that once a vial is opened it must be used immediately and then discarded — storing an opened vial, even for a few hours, is not recommended and could introduce contamination.

How Should You Use Systane Ultra UD Eye Drops?

Using Systane Ultra UD correctly is straightforward, but a few simple steps make a real difference to both comfort and hygiene. Always wash your hands thoroughly before handling the vials, and never touch the tip of the vial to your eye or any other surface.

What Is the Correct Dose of Systane Ultra UD Eye Drops?

The standard dose is 1 to 2 drops per eye per application. There is no fixed maximum number of daily applications for lubricating drops, but you should use the lowest number of applications that keeps your symptoms under control. If you are unsure how often to use them, your pharmacist or optometrist can advise based on the severity of your dry eye.

When Is the Best Time to Use Systane Ultra UD Eye Drops?

Use the drops whenever your eyes feel dry, gritty, or uncomfortable — there is no single "best" time of day. Many people find them particularly helpful first thing in the morning when eyes can feel stiff after sleep, during prolonged screen use, or when in air-conditioned or heated environments. If you wear contact lenses, use the drops before inserting your lenses in the morning (after removing them) or whenever discomfort arises during the day.

How Long Can You Use Systane Ultra UD Eye Drops For?

Systane Ultra UD can be used long-term without the concerns associated with preservative-containing drops, as there is no cumulative preservative exposure to the ocular surface. Many people with chronic dry eye use lubricating drops daily for months or years as part of their ongoing eye care routine. However, if your symptoms worsen, change in character, or do not respond to treatment after a couple of weeks, arrange a review with your optometrist or GP to rule out an underlying condition.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Systane Ultra UD Eye Drops?

Most people tolerate Systane Ultra UD very well, and side effects are generally mild and short-lived. Because the drops are preservative-free, the risk of preservative-related irritation — a common complaint with multi-dose bottles — is eliminated entirely.

  • Temporary blurred vision immediately after instillation (usually clears within 1–2 minutes)
  • Mild stinging or burning sensation on first contact with the eye surface
  • Watery eyes or a brief sensation of excess moisture

What Are the Less Common Side Effects of Systane Ultra UD Eye Drops?

Less frequently, some people may notice the following effects. These are not dangerous in most cases, but you should monitor them and seek advice if they persist or worsen.

  • Persistent eye redness beyond a few minutes after instillation
  • Sticky or crusty eyelids, particularly after use near bedtime
  • Mild sensitivity to light (photophobia)
  • A feeling of something in the eye that doesn't resolve after blinking

What Are the Serious Side Effects of Systane Ultra UD Eye Drops?

Serious side effects are rare with lubricating eye drops, but they can occasionally occur — particularly if you have an undiagnosed eye condition or an allergy to one of the ingredients. Stop using the drops immediately and seek urgent medical attention if you experience any of the following:

  • Sudden or significant change in vision
  • Severe eye pain that does not resolve
  • Marked swelling of the eyelids or surrounding tissue
  • Signs of an allergic reaction, such as rash, itching, or difficulty breathing

What Should You Do If You Experience Side Effects?

If you notice mild side effects such as temporary blurring or brief stinging, these are usually nothing to worry about and will resolve on their own within a minute or two. Simply blink gently and allow the drops to settle. If side effects are persistent, worsening, or unexpected, stop using the product and contact your pharmacist or GP for advice. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Systane Ultra UD Eye Drops Interact With Other Medicines?

No clinically significant drug interactions have been documented for this formulation. However, if you are using other eye drops — particularly prescription medications such as glaucoma treatments — always instil those first and leave at least 5 minutes before using Systane Ultra UD. This prevents dilution of the prescribed medication and ensures both products work as intended. Always inform your pharmacist of all eye drops and medicines you are currently using.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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