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Syndol Headache Relief - 30 Tablets

Syndol Headache Relief - 30 Tablets

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  • ✔️ Targets headache pain with four complementary active ingredients
  • ✔️ Relieves tension headache with mild muscle-relaxant doxylamine
  • ✔️ Caffeine content enhances analgesic effect for faster relief
  • ✔️ Suitable for migraine and moderate pain unresponsive to single analgesics
  • ✔️ Convenient 30-tablet pack for short-term headache management

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What Are Syndol Headache Relief Tablets?

 

If you've ever had a headache that just won't shift with ordinary paracetamol, you'll know how frustrating it can be. Syndol headache relief tablets are a combination analgesic designed for exactly those moments — when a standard single-ingredient painkiller isn't quite cutting it. Each tablet contains four active ingredients working together: paracetamol 450 mg, codeine phosphate 10 mg, doxylamine succinate 5 mg, and caffeine 30 mg. That combination targets headache pain from more than one angle, which is why many people find it more effective for stubborn or tension-type headaches than paracetamol alone.

Syndol is an over-the-counter medicine available without a prescription in the UK, though it does contain codeine — a mild opioid — so it carries specific warnings and restrictions. You can browse our full range of pain relief products if you'd like to compare options before deciding what's right for you.

 

How Do Syndol Tablets Work to Relieve Headache Pain?

 

Syndol's four-ingredient formula works through complementary mechanisms. Here's how each component contributes:

  • Paracetamol (450 mg): Acts centrally in the brain to reduce the perception of pain and lower fever. It's the backbone of the formulation.
  • Codeine phosphate (10 mg): A mild opioid analgesic that is converted to morphine in the body, enhancing pain relief beyond what paracetamol achieves alone.
  • Doxylamine succinate (5 mg): An antihistamine with mild sedative and muscle-relaxant properties — particularly useful when headache is accompanied by muscle tension or difficulty sleeping.
  • Caffeine (30 mg): Helps constrict dilated blood vessels and enhances the absorption and efficacy of the other analgesic ingredients.

Together, these ingredients address the pain signal itself, the muscular tension that often accompanies headaches, and the vascular component that can drive migraine-type pain.

 

Who Is Syndol Suitable For?

 

Syndol is intended for adults and young people aged 16 and over who need relief from moderate pain that hasn't responded adequately to a single analgesic. It's particularly well-suited to:

  • Adults with tension-type headaches accompanied by neck or shoulder muscle tightness
  • People experiencing migraine headaches where standard paracetamol or ibuprofen alone is insufficient
  • Adults with headaches that are disrupting sleep, where doxylamine's mild sedative effect may be beneficial
  • Those who need short-term relief from mild to moderate pain, including dental pain or muscular discomfort

It is not suitable for children under 12, people who are known codeine ultra-rapid metabolisers, or those with respiratory depression. Always read the full label before use.

 

How Does Syndol Compare to Other Headache Tablets?

 

Feature Syndol Headache Relief Standard Paracetamol (500 mg)
Active ingredients Paracetamol, codeine, doxylamine, caffeine Paracetamol only
Suitable for tension headache with muscle component Yes Partial
Contains opioid Yes (codeine 10 mg) No
Risk of dependence Yes — short-term use only No

 

How Should You Store Syndol Tablets?

 

Store Syndol headache relief tablets below 25°C in a dry place, away from direct sunlight. Keep them in their original packaging and out of the reach and sight of children. Do not use after the expiry date printed on the pack. If you're unsure whether a medicine is still safe to use, your pharmacist can advise you.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Syndol Headache Relief - 30 Tablets specifications
Treatment category Analgesic / Headache relief
Mechanism of action Central analgesia (paracetamol + codeine), muscle relaxation (doxylamine), vasoconstriction enhancement (caffeine)
Effective for Headache, migraine, tension headache, mild to moderate pain
Suitable for Adults and young people aged 16 and over
Active ingredients Paracetamol 450 mg, Codeine phosphate 10 mg, Doxylamine succinate 5 mg, Caffeine 30 mg
Pack size 30 tablets
UK classification Pharmacy (P) medicine
Drug class Combination analgesic (opioid-containing)
Preparation Tablet
Route of administration Oral

Specifications of Syndol Headache Relief - 30 Tablets

 

What Is Syndol and What Is It Used For?

 

Syndol Headache Relief tablets are a combination analgesic used to relieve moderate pain that has not responded adequately to a single painkiller such as paracetamol or ibuprofen alone. They are indicated for headache, migraine, tension headache, and mild to moderate pain including dental pain and muscular discomfort. The product is classified as a Pharmacy (P) medicine in the UK, meaning it is available over the counter but should be sold under pharmacist supervision.

 

What Do You Need to Know Before Using Syndol?

 

Before taking Syndol, it's important to check whether it is appropriate for you. Do not take Syndol if any of the following apply:

  • You are allergic to paracetamol, codeine, doxylamine, caffeine, or any other ingredient in the tablet
  • You have severe liver or kidney disease
  • You have respiratory depression or obstructive airways disease
  • You are a known codeine ultra-rapid metaboliser (a genetic variation that causes codeine to convert to morphine very quickly, increasing overdose risk)
  • You are under 12 years of age
  • You are under 18 and have had your tonsils or adenoids removed for obstructive sleep apnoea
  • You are breastfeeding
  • You are taking or have recently taken monoamine oxidase inhibitors (MAOIs)

Speak to your pharmacist or GP before taking Syndol if you have a history of substance misuse, liver problems, or are taking other medicines that cause drowsiness. The following drug interactions are known:

  • Other CNS depressants (including alcohol, benzodiazepines, antihistamines) — increased sedation risk
  • Other paracetamol-containing products — risk of paracetamol overdose
  • MAOIs — potentially serious interaction; do not use within 14 days of stopping an MAOI
  • Anticoagulants such as warfarin — paracetamol may enhance anticoagulant effect with prolonged use

 

How Should You Use Syndol Tablets?

 

Always take Syndol exactly as directed on the label or as advised by your pharmacist. Do not exceed the stated dose.

  1. Take 2 tablets with a full glass of water.
  2. Allow at least 4 to 6 hours between doses.
  3. Do not take more than 8 tablets in any 24-hour period.
  4. Do not take for more than 3 consecutive days without seeking medical advice.
  5. Do not take alongside any other paracetamol-containing product.
Age Group Dose Frequency Maximum daily dose
Adults and young people aged 16+ 2 tablets Every 4–6 hours 8 tablets (24 hours)
Children under 12 Not suitable — do not use
Ages 12–15 Not recommended — seek pharmacist advice

If you are managing other types of discomfort alongside headache — for example, if you also experience IBS or abdominal cramps — speak to your pharmacist before combining medicines, as interactions are possible.

 

What Are the Possible Side Effects of Syndol?

 

Like all medicines, Syndol can cause side effects, though not everyone experiences them. Knowing what to look out for helps you use it safely.

Common side effects (may affect up to 1 in 10 people):

  • Drowsiness or sedation — particularly due to doxylamine
  • Constipation — a known effect of codeine
  • Nausea or stomach discomfort
  • Dry mouth

Less common side effects (may affect up to 1 in 100 people):

  • Dizziness or light-headedness
  • Headache on stopping the medicine (medication-overuse headache) with prolonged use
  • Difficulty urinating
  • Blurred vision
  • Skin rash or itching

Stop taking Syndol and seek immediate medical attention if you experience difficulty breathing, swelling of the face or throat, or signs of a serious allergic reaction. Codeine dependence can develop with regular use — this is why Syndol is intended for short-term use only.

 

How Should You Store Syndol Tablets?

 

  • Store below 25°C in a dry place away from direct heat and sunlight
  • Keep in the original blister packaging until use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

If you're looking for other short-term relief options or want to explore complementary approaches, our pain relief collection includes a range of analgesics and topical treatments suited to different needs.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Syndol headache relief tablets online in the UK?

You can buy Syndol Headache Relief 30 Tablets directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is available as an over-the-counter Pharmacy (P) medicine, so no prescription is needed. Simply add it to your basket and our pharmacy team will review your order before dispatch.

How does Syndol work in the body?

Syndol contains four active ingredients that work together. Paracetamol reduces pain signals centrally, codeine phosphate is a mild opioid that boosts pain relief, doxylamine succinate provides mild sedation and muscle relaxation, and caffeine enhances the analgesic effect and helps constrict dilated blood vessels. This multi-ingredient approach makes it more effective for complex headaches than a single-ingredient painkiller.

How do I take Syndol tablets step by step?

Take 2 tablets with a full glass of water. Wait at least 4 to 6 hours before taking another dose, and never exceed 8 tablets in a 24-hour period. Do not take alongside any other product containing paracetamol, and do not use for more than 3 consecutive days without speaking to a pharmacist or GP.

What is the correct dose of Syndol for adults?

The recommended dose for adults and young people aged 16 and over is 2 tablets every 4 to 6 hours as needed. The maximum dose is 8 tablets in any 24-hour period. Syndol is not suitable for children under 12, and caution is advised for those aged 12 to 15 — always seek pharmacist guidance for younger age groups.

What is the best time to take Syndol tablets?

Take Syndol as soon as your headache begins for the most effective relief — early intervention tends to work better than waiting until pain is severe. Because doxylamine can cause drowsiness, many people find it helpful to take a dose in the evening when sedation is less disruptive. Avoid taking it before driving or operating machinery.

What are the side effects of Syndol and how do I manage them?

The most common side effects are drowsiness, constipation, nausea, and dry mouth. Drowsiness is largely due to doxylamine — avoid alcohol and do not drive if affected. Constipation from codeine can be managed by staying well hydrated and eating fibre-rich foods. If side effects are severe or persistent, stop taking Syndol and speak to your pharmacist or GP.

Who is eligible to take Syndol tablets?

Syndol is suitable for adults and young people aged 16 and over who need relief from moderate headache or pain that hasn't responded to a single analgesic. It is not suitable for children under 12, people with severe liver or kidney disease, those with respiratory depression, known codeine ultra-rapid metabolisers, or women who are breastfeeding. Always check the full list of contraindications before use.

Can I take Syndol if I am pregnant or breastfeeding?

Syndol is not recommended during pregnancy, especially in the third trimester, due to the codeine content which can affect the baby's breathing. It must not be taken while breastfeeding, as codeine passes into breast milk and can cause serious harm to a nursing infant. Always consult your GP or midwife before taking any pain relief during pregnancy or whilst breastfeeding.

What happens if I miss a dose of Syndol?

Syndol is taken as needed for pain rather than on a fixed schedule, so there is no "missed dose" in the traditional sense. If your pain returns and at least 4 to 6 hours have passed since your last dose, you can take another 2 tablets. Never double up doses to compensate, and always stay within the maximum of 8 tablets per 24 hours.

How long can I take Syndol for?

Syndol should not be used for more than 3 consecutive days without medical advice. Prolonged use of codeine-containing medicines carries a risk of dependence and can actually worsen headaches over time — a condition known as medication-overuse headache. If your headaches are frequent or recurring, speak to your GP about longer-term management options.

Can Syndol cause dependence or addiction?

Yes — because Syndol contains codeine, a mild opioid, there is a risk of physical and psychological dependence with regular or prolonged use. This risk is why it is classified as a Pharmacy medicine and should only be used short-term. If you find yourself needing Syndol frequently, speak to your GP or pharmacist about alternative pain management strategies.

What are the alternatives to Syndol for headache relief?

For mild headaches, standard paracetamol 500 mg or ibuprofen 200–400 mg are first-line options. For migraine, triptans (available on prescription) may be more appropriate. You can explore a range of over-the-counter options in our pain relief collection. Your pharmacist can help you choose the most suitable product based on your symptoms and medical history.

Can I drink alcohol while taking Syndol?

No — you should avoid alcohol while taking Syndol. Both codeine and doxylamine have sedative effects, and combining them with alcohol significantly increases the risk of excessive drowsiness, dizziness, and impaired coordination. Alcohol can also increase the risk of liver damage when taken alongside paracetamol, particularly in those who drink regularly.

Can I take Syndol with other medicines?

You must not take Syndol with other paracetamol-containing products, MAOIs, or other medicines that cause drowsiness such as sleeping tablets, antihistamines, or anxiety medicines. Codeine can also interact with certain antidepressants and anticoagulants like warfarin. Always tell your pharmacist about all medicines you are currently taking before starting Syndol. If you're also managing digestive issues, check our IBS and cramps range for compatible options.

What are the latest findings on codeine-containing headache tablets?

Current NHS and MHRA guidance highlights the risk of medication-overuse headache with regular use of codeine-containing analgesics — a condition where the very medicine used to treat headache ends up causing more frequent headaches over time. Clinical guidance consistently recommends limiting codeine-based analgesics to short-term use only and exploring preventative strategies for chronic headache sufferers. Speak to your GP if you are using pain relief more than 10 to 15 days per month.

How Should You Use Syndol Headache Relief Tablets?

Syndol tablets are taken orally with water. Always read the label carefully before use and follow the steps below to ensure you take them safely and effectively.

What Is the Correct Dose of Syndol Headache Relief Tablets?

The dose varies by age group. Always follow the guidance below and never exceed the maximum daily dose. Taking more than the recommended amount of paracetamol can cause serious liver damage, even if you feel well at the time.

When Is the Best Time to Use Syndol Headache Relief Tablets?

Take Syndol at the first sign of a headache for the most effective relief — waiting until pain is severe can reduce how well the medicine works. Because doxylamine causes drowsiness in some people, evening use may be more practical if you need to remain alert during the day. Do not take Syndol before driving, operating heavy machinery, or performing tasks that require full concentration.

How Long Can You Use Syndol Headache Relief Tablets For?

Syndol is intended for short-term use only. Do not take it for more than 3 consecutive days without seeking advice from your pharmacist or GP. Using codeine-containing medicines too frequently — more than 10 to 15 days per month — can lead to medication-overuse headache, where the treatment itself begins to trigger more frequent headaches. If your headaches are recurring or worsening, speak to your GP about longer-term management. Codeine dependence can develop with regular use, even at the doses found in over-the-counter products.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Syndol Tablets?

Most people tolerate Syndol well when taken as directed, but some side effects can occur. The most common are related to the codeine and doxylamine components of the tablet.

  • Drowsiness or sedation
  • Constipation
  • Nausea or stomach discomfort
  • Dry mouth

What Are the Less Common Side Effects of Syndol Tablets?

Less frequently, some people experience the following effects. These are still worth being aware of, particularly if you are taking Syndol for the first time.

  • Dizziness or light-headedness
  • Blurred vision
  • Difficulty urinating
  • Skin rash or itching
  • Headache on stopping the medicine (medication-overuse headache) with prolonged use

What Are the Serious Side Effects of Syndol Tablets?

Serious side effects are rare but require immediate medical attention. Stop taking Syndol straight away and call 999 or go to your nearest A&E if you experience any of the following:

  • Difficulty breathing or slowed breathing
  • Swelling of the face, lips, tongue, or throat (signs of a serious allergic reaction)
  • Severe skin reactions such as blistering or peeling
  • Signs of liver damage — yellowing of the skin or eyes, dark urine, severe abdominal pain

Paracetamol overdose can cause serious liver damage even when symptoms are not immediately apparent. If you suspect you or someone else has taken too much, go to A&E immediately and take the packaging with you.

What Should You Do If You Experience Side Effects of Syndol?

For mild side effects such as drowsiness or constipation, reducing activity, staying hydrated, and eating a fibre-rich diet can help. Avoid alcohol entirely during treatment, as it significantly worsens sedation. If side effects are troublesome or do not resolve, stop taking Syndol and speak to your pharmacist. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Syndol Interact With Other Medicines?

Yes — Syndol has several clinically important interactions. Do not take it alongside other paracetamol-containing products, as this increases the risk of paracetamol overdose. Combining Syndol with other sedating medicines — including antihistamines, benzodiazepines, sleeping tablets, or alcohol — significantly increases drowsiness. MAOIs must not be taken within 14 days of Syndol. Warfarin users should be aware that regular paracetamol use can enhance anticoagulant effects. Always tell your pharmacist about every medicine you are taking before starting Syndol.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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