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Soolantra Cream

Soolantra Cream

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  • ✔️ Targets Demodex mites — a key driver of rosacea inflammation
  • ✔️ Reduces inflammatory papules and pustules within 12 weeks
  • ✔️ Once-daily application for simple, consistent rosacea management
  • ✔️ Clinically studied ivermectin 1% cream for adult rosacea
  • ✔️ Suitable for adults with papulopustular rosacea unresponsive to other treatments

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What Is Soolantra Cream and How Does It Treat Rosacea?

 

Soolantra cream is a topical treatment containing ivermectin 10mg/g, used specifically to treat the inflammatory lesions associated with rosacea in adults. Rosacea is a chronic skin condition that causes redness, visible blood vessels, and small pus-filled bumps — mainly on the face. It affects millions of people in the UK and, while it cannot be cured, it can be managed effectively with the right treatment. If you've been struggling with persistent facial bumps and redness, this cream may be exactly what your skin needs. You can explore a wider range of options in our skin care collection.

Manufactured by Galderma, Soolantra is a clinically studied prescription-strength cream available in a 30g tube. It is applied once daily to the face and has been shown in clinical trials to significantly reduce the number of inflammatory lesions over a 12-week treatment period.

 

How Does Soolantra Cream Work on the Skin?

 

The active ingredient, ivermectin, works through two distinct mechanisms that together address the underlying drivers of rosacea inflammation:

  • Anti-parasitic action: Ivermectin targets Demodex mites — microscopic organisms that live in hair follicles and are found in higher numbers on the skin of people with rosacea. Reducing their population helps lower the inflammatory response they trigger.
  • Anti-inflammatory action: Ivermectin also inhibits the release of pro-inflammatory cytokines, directly reducing redness and swelling in the skin.
  • Lesion reduction: By addressing both the mite burden and the inflammatory cascade, the cream reduces the number and severity of papules and pustules over time.

This dual action is what sets ivermectin apart from older rosacea treatments that focus solely on inflammation.

 

Who Is Soolantra Cream Suitable For?

 

Soolantra cream is intended for adults aged 18 and over who have been diagnosed with papulopustular rosacea — the subtype characterised by inflammatory bumps and pustules. It is not suitable for treating the redness or flushing associated with erythematotelangiectatic rosacea alone.

It may be appropriate for you if:

  • You have been diagnosed with rosacea by a GP or dermatologist
  • You experience recurring papules or pustules on your face
  • Previous treatments such as metronidazole or azelaic acid have not provided adequate relief
  • You are looking for a once-daily topical treatment with a well-established safety profile

 

How Does Soolantra Cream Compare to Other Rosacea Treatments?

 

Feature Soolantra Cream (Ivermectin 1%) Metronidazole Cream (0.75%)
Active ingredient Ivermectin 10mg/g Metronidazole 7.5mg/g
Mechanism Anti-parasitic + anti-inflammatory Anti-inflammatory + antibacterial
Application frequency Once daily Once or twice daily
Typical treatment duration 12 weeks 12 weeks

 

How Should Soolantra Cream Be Stored?

 

Store soolantra cream below 25°C and keep it away from direct heat or sunlight. Do not freeze the product. Always keep it out of the sight and reach of children. Once opened, use within the period indicated on the packaging — do not use after the expiry date printed on the tube or carton. If you are managing multiple skin conditions, our creams and ointments collection includes a range of topical treatments to support your skincare routine.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Soolantra Cream specifications
Treatment category Rosacea / Dermatology
Active ingredient Ivermectin 10mg/g (1% w/w)
Mechanism of action Anti-parasitic (Demodex) and anti-inflammatory
Suitable for Adults aged 18 and over with papulopustular rosacea
Pack sizes 30g tube
Strengths 10mg/g (1%)
UK classification Prescription Only Medicine (POM)
Drug class Antiparasitic / Anti-inflammatory
Preparation Cream
Route of administration Topical (cutaneous)
Effective Significant lesion reduction typically seen at 12 weeks

Specifications of Soolantra Cream

 

What Is Soolantra Cream and What Is It Used For?

 

Soolantra cream contains ivermectin 10mg/g as its active ingredient. It is used to treat inflammatory lesions — specifically papules and pustules — caused by rosacea in adults. Rosacea is a long-term skin condition that primarily affects the face, causing redness, flushing, and spots. The NHS notes that rosacea is more common in women and people with lighter skin tones, though it can affect anyone. Soolantra is applied topically once daily and works to reduce both the number and severity of facial lesions over a 12-week treatment course.

 

What Do You Need to Know Before Using Soolantra Cream?

 

Before starting treatment, it is important to be aware of the following contraindications and warnings:

  • Do not use if you are allergic to ivermectin or any other ingredient in the cream
  • Not recommended for use in children or adolescents under 18 years of age
  • Avoid contact with eyes, lips, mouth, and mucous membranes — rinse thoroughly with water if accidental contact occurs
  • Use with caution if you have severe hepatic impairment
  • Avoid use during pregnancy unless clearly necessary and directed by a doctor
  • Breastfeeding mothers should avoid applying the cream to the chest area to prevent infant exposure
  • Do not use on broken, infected, or severely irritated skin

Regarding drug interactions, no clinically significant interactions have been identified at the topical dose used in Soolantra cream. However, you should inform your prescriber of all medicines you are currently taking, including other topical products applied to the face.

  • No significant interactions with oral medicines have been established at topical doses
  • Avoid using other topical facial products simultaneously unless advised by your doctor

 

How Should You Use Soolantra Cream Correctly?

 

  1. Wash your hands thoroughly before and after applying the cream
  2. Cleanse your face gently and pat dry before application
  3. Squeeze a pea-sized amount of cream onto your fingertip
  4. Apply to each of the five facial zones: forehead, chin, nose, left cheek, and right cheek
  5. Spread the cream in a thin, even layer across each area — do not rub vigorously
  6. Avoid the eyes, eyelids, lips, and inside of the nostrils
  7. Allow the cream to absorb before applying any other facial products or cosmetics
Indication Age Group Dose Frequency
Papulopustular rosacea Adults (18+) Pea-sized amount per facial zone (5 zones) Once daily (evening)
Not indicated Under 18 Not applicable Not applicable

If you are managing other skin concerns alongside rosacea, it may be worth exploring our skin care collection for complementary products recommended by our pharmacy team.

 

What Are the Possible Side Effects of Soolantra Cream?

 

Like all medicines, Soolantra cream can cause side effects, although not everyone experiences them. Most side effects are localised to the skin at the application site and tend to be mild.

Common side effects (may affect up to 1 in 10 people):

  • Burning or stinging sensation on the skin
  • Skin irritation or dryness at the application site
  • Itching (pruritus)

Less common side effects (may affect up to 1 in 100 people):

  • Worsening of rosacea symptoms temporarily
  • Contact dermatitis
  • Erythema (redness) at the application site
  • Acne-like skin reactions

If you experience a severe allergic reaction — such as swelling of the face, difficulty breathing, or widespread rash — stop using the cream immediately and seek urgent medical attention. For general first aid guidance while waiting for medical help, our first aid collection may be useful to have at home.

 

How Should You Store Soolantra Cream Safely?

 

  • Store below 25°C in a cool, dry place
  • Do not freeze
  • Keep away from direct sunlight and heat sources
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the tube and carton
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Soolantra cream online in the UK?

You can buy Soolantra cream online through Cured Pharmacy, a GPhC-registered UK online pharmacy. A short clinical consultation is completed before your order is dispensed to ensure the treatment is appropriate for you. Once approved, it is dispatched quickly to your door.

How does Soolantra cream work for rosacea?

Soolantra cream works through two mechanisms: it targets Demodex mites — microscopic parasites found in higher numbers on rosacea-affected skin — and it also exerts a direct anti-inflammatory effect by inhibiting pro-inflammatory cytokines. Together, these actions reduce the papules and pustules associated with rosacea. This dual approach is what distinguishes it from older topical rosacea treatments.

How do I apply Soolantra cream step by step?

Wash your hands, then cleanse and dry your face before applying. Use a pea-sized amount across each of the five facial zones — forehead, chin, nose, and both cheeks — spreading it in a thin, even layer. Avoid the eyes, lips, and nostrils, and allow the cream to absorb fully before applying any other products.

How long does Soolantra cream take to work?

Some patients begin to notice a reduction in inflammatory lesions within 4 weeks of starting treatment. However, the full clinical benefit of Soolantra cream is typically observed after 12 weeks of consistent once-daily use. Patience is important — do not stop treatment early if you do not see immediate results.

What is the correct dose of Soolantra cream?

The recommended dose is a pea-sized amount applied to each of the five facial zones once daily, preferably in the evening. This equates to approximately 0.5g of cream per application across the whole face. Do not apply more than directed, as this will not improve results and may increase the risk of skin irritation.

What are the side effects of Soolantra cream and how do I manage them?

The most common side effects are mild skin burning, stinging, itching, or dryness at the application site. These usually settle within the first few weeks as your skin adjusts. If irritation is persistent or severe, reduce application frequency temporarily and speak to your pharmacist or GP for guidance.

Who is eligible to use Soolantra cream?

Soolantra cream is suitable for adults aged 18 and over who have been diagnosed with papulopustular rosacea — the type characterised by inflammatory bumps and pustules on the face. It is not suitable for children, and it should be used with caution in people with severe liver problems or known allergy to ivermectin. A clinical consultation will confirm your suitability before purchase.

Can I use Soolantra cream if I am pregnant or breastfeeding?

Soolantra cream should be avoided during pregnancy unless clearly necessary and prescribed by a doctor, as safety data in pregnancy is limited. If you are breastfeeding, avoid applying the cream to the chest or breast area to prevent the baby coming into contact with it. Always discuss your situation with your GP before starting treatment.

What happens if I miss a dose of Soolantra cream?

If you forget to apply Soolantra cream one evening, simply apply it the following evening as usual. Do not apply a double dose to make up for a missed application. Consistency is important for best results, so try to build the application into your nightly skincare routine.

What is the difference between Soolantra cream and metronidazole cream for rosacea?

Soolantra (ivermectin 1%) targets both Demodex mites and skin inflammation, whereas metronidazole cream works primarily as an anti-inflammatory and antibacterial agent without any anti-parasitic action. Clinical studies have suggested that ivermectin cream may produce greater reductions in inflammatory lesion counts compared to metronidazole 0.75% cream over 12 weeks. Your prescriber can advise which is most appropriate for your rosacea subtype.

How long can you use Soolantra cream for?

The standard treatment course is 12 weeks. After this period, your doctor or pharmacist will review your response and advise whether to continue, pause, or repeat treatment. Long-term safety data supports repeat courses where clinically appropriate, but this should always be guided by a healthcare professional.

Can I wear makeup over Soolantra cream?

Yes, you can apply makeup after using Soolantra cream, but you should allow the cream to absorb fully into the skin first — typically a few minutes. Choose non-comedogenic, fragrance-free products where possible to avoid further irritating rosacea-prone skin. Avoid harsh exfoliants or alcohol-based toners while using this treatment.

Are there any alternatives to Soolantra cream for rosacea?

Yes — alternatives include topical metronidazole (Rozex), azelaic acid (Finacea), and oral antibiotics such as doxycycline for more severe cases. The NHS also recommends lifestyle measures such as avoiding known triggers like alcohol, spicy food, and sun exposure. You can browse our creams and ointments collection for other topical skin treatments available at Cured Pharmacy.

What are the latest studies on ivermectin cream for rosacea?

Clinical trials published in peer-reviewed dermatology journals have demonstrated that ivermectin 1% cream is significantly more effective than vehicle (placebo cream) in reducing inflammatory lesion counts in papulopustular rosacea over 12 weeks. Head-to-head studies comparing it with metronidazole 0.75% cream have also shown favourable outcomes for ivermectin in terms of lesion reduction and patient-reported outcomes. Your dermatologist or GP can discuss the evidence in the context of your individual case.

Does Soolantra cream treat the redness and flushing of rosacea?

Soolantra cream is specifically indicated for the inflammatory lesions (papules and pustules) of rosacea, not for the persistent background redness or flushing associated with erythematotelangiectatic rosacea. If facial redness is your primary concern, speak to your GP about other treatment options such as brimonidine gel. For general skin health support, explore our skin care collection.

How Should You Use Soolantra Cream?

Soolantra cream is applied directly to the skin of the face once daily. Always wash your hands before and after application, and make sure your face is clean and dry before you begin.

Do not apply to broken, infected, or severely irritated skin. If you experience significant irritation, speak to your pharmacist or GP before continuing.

What Is the Correct Dose of Soolantra Cream?

The dose of Soolantra cream is the same for all eligible adults. Using more than the recommended amount will not improve results and may increase the likelihood of skin irritation.

The total amount applied per application is approximately 0.5g across the whole face. Do not apply to areas of the body other than the face unless specifically directed by your prescriber.

When Is the Best Time to Use Soolantra Cream?

Soolantra cream is best applied in the evening, as part of your nightly skincare routine. Applying it at night allows the cream to work undisturbed while you sleep, and reduces the chance of it being washed off or diluted by sweat or sunscreen during the day. Try to apply it at roughly the same time each evening to maintain consistency — this is important for achieving the best results over the 12-week treatment period.

How Long Can You Use Soolantra Cream For?

The recommended treatment duration is 12 weeks. Clinical evidence shows that the greatest reduction in inflammatory lesions occurs over this period, with some improvement visible from around week 4. After completing a 12-week course, your prescriber will assess your response and advise whether further treatment is needed. Do not stop treatment early without speaking to your doctor, even if your skin appears to have improved — rosacea is a chronic condition and symptoms can return.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Soolantra Cream?

Most people tolerate Soolantra cream well, but some do experience mild side effects at the application site, particularly during the first few weeks of treatment. These are usually temporary and tend to improve as your skin adjusts.

  • Burning or stinging sensation on the skin
  • Skin dryness or flaking
  • Itching (pruritus) at the application site
  • Mild redness or irritation

What Are the Less Common Side Effects of Soolantra Cream?

Less common side effects occur in fewer than 1 in 100 people. If you notice any of the following, mention them to your GP or pharmacist at your next appointment, particularly if they are persistent or worsening.

  • Temporary worsening of rosacea symptoms
  • Contact dermatitis (an allergic skin reaction)
  • Acne-like breakouts at the application site
  • Increased skin sensitivity
  • Swelling or oedema at the application site

What Are the Serious Side Effects of Soolantra Cream?

Serious side effects are rare with topical ivermectin at the doses used in Soolantra cream. However, you should be aware of the signs of a serious allergic reaction (anaphylaxis or severe hypersensitivity), which — though uncommon — requires immediate medical attention.

Stop using the cream and seek urgent medical help if you experience any of the following:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Widespread skin rash or hives
  • Dizziness or feeling faint

What Should You Do If You Experience Side Effects?

If you experience mild irritation such as burning or dryness, try applying the cream every other day for a week or two before returning to daily use. Keep the skin well moisturised with a gentle, fragrance-free moisturiser. Avoid using other active skincare ingredients — such as retinoids or acids — at the same time as Soolantra cream, as these can compound irritation. If side effects are severe or do not settle, stop using the cream and contact your GP or pharmacist promptly.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Soolantra Cream Interact With Other Medicines?

No clinically significant drug interactions have been identified with Soolantra cream at the topical doses used. Because systemic absorption through the skin is very low, the risk of interactions with oral medicines is considered minimal. That said, you should always inform your prescriber or pharmacist of all medicines you are taking — including other topical products applied to the face — before starting treatment. Avoid applying other prescription topical treatments to the same areas of the face at the same time unless specifically advised to do so by your doctor.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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