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Solpadeine Max - 24 Tablets

Solpadeine Max - 24 Tablets

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  • ✔️ Relieves moderate pain unresponsive to paracetamol alone
  • ✔️ Dual-action formula: paracetamol plus codeine phosphate
  • ✔️ Targets headache, dental, period and muscular pain
  • ✔️ Convenient 24-tablet pack for short-term pain episodes
  • ✔️ Suitable for adults and young people aged 16 and over

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What Are Solpadeine Max Tablets Used For?

 

Solpadeine Max tablets are a well-known over-the-counter pain relief medicine containing two active ingredients: paracetamol 500 mg and codeine phosphate 12.8 mg. They are specifically designed for the short-term relief of moderate pain — the kind that hasn't responded adequately to paracetamol, ibuprofen, or aspirin on their own. Whether you're dealing with a persistent headache, dental pain, muscular aches, or period pain, this combination can offer a step up in relief when single-ingredient options fall short. You can browse our full pain relief collection if you'd like to compare other options available at Cured Pharmacy.

Each pack contains 24 tablets, making it a practical choice to keep at home for those occasions when pain is more stubborn than usual. Because it contains codeine — a mild opioid — it is classified as a pharmacy (P) medicine in the UK, meaning it requires a pharmacist consultation before purchase. This is a safeguard, not a barrier, and our GPhC-registered team is here to help.

 

How Do Solpadeine Max Tablets Work?

 

The two active ingredients in Solpadeine Max work through different but complementary mechanisms, which is why the combination tends to be more effective than either ingredient alone for moderate pain.

  • Paracetamol (500 mg per tablet): Works centrally in the brain to inhibit the production of prostaglandins — chemical messengers that amplify pain signals. It also has a mild antipyretic (fever-reducing) effect.
  • Codeine phosphate (12.8 mg per tablet): An opioid analgesic that binds to mu-opioid receptors in the central nervous system, reducing the perception of pain. In the body, codeine is partially converted to morphine, which is responsible for much of its analgesic effect.
  • Combined effect: Together, these two ingredients target pain through different pathways, providing relief that is generally more effective for moderate pain than paracetamol alone.

 

Who Is Solpadeine Max Suitable For?

 

Solpadeine Max is intended for adults and young people aged 16 and over who are experiencing moderate pain that has not been adequately controlled by standard single-ingredient analgesics. It is not suitable for everyone, so it's important to check before use.

It may be appropriate for you if you:

  • Are aged 16 or over
  • Have moderate pain such as headache, dental pain, period pain, or muscular aches
  • Have already tried paracetamol or ibuprofen without sufficient relief
  • Do not have a history of opioid sensitivity or liver/kidney problems

It is not suitable for children under 12, or for those aged 12–18 with breathing difficulties. People with certain conditions — including liver disease, kidney impairment, or a history of substance dependence — should speak to a doctor before use.

 

How Does Solpadeine Max Compare to Solpadeine Plus?

 

Feature Solpadeine Max Solpadeine Plus
Active ingredients Paracetamol 500 mg + Codeine 12.8 mg Paracetamol 500 mg + Codeine 8 mg + Caffeine 30 mg
Codeine dose 12.8 mg per tablet 8 mg per tablet
Contains caffeine? No Yes
Best suited for Moderate pain needing stronger codeine dose Moderate pain with added caffeine boost

 

How Should You Store Solpadeine Max Tablets?

 

Store Solpadeine Max tablets below 25°C in a dry place, away from direct sunlight and moisture. Keep them in their original packaging and out of the reach and sight of children at all times. Do not use the tablets after the expiry date printed on the pack — if in doubt, return them to your local pharmacy for safe disposal.

If you're managing multiple health conditions and looking for other products alongside your pain relief, our vitamins and supplements collection may also be of interest. Always check for interactions with any supplements you take regularly.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Solpadeine Max 24 Tablets specifications
Treatment category Pain relief
Mechanism of action Opioid receptor agonist (codeine) + prostaglandin synthesis inhibitor (paracetamol)
Effective for Moderate pain including headache, dental pain, period pain, muscular aches
Suitable for Adults and young people aged 16 and over
Active ingredients Paracetamol 500 mg, Codeine Phosphate 12.8 mg
Pack size 24 tablets
UK classification Pharmacy (P) medicine
Drug class Opioid analgesic combination
Preparation Film-coated tablet
Route of administration Oral

Specifications of Solpadeine Max 24 Tablets

 

What Is Solpadeine Max and What Is It Used For?

 

Solpadeine Max 24 Tablets is a combination analgesic medicine used for the short-term relief of moderate pain in adults and young people aged 16 and over. It is indicated when pain has not been adequately controlled by paracetamol, ibuprofen, or aspirin used alone. Typical conditions it is used for include headache, migraine, dental pain, period pain, rheumatic pain, and muscular aches. It is not intended for long-term or chronic pain management.

 

What Do You Need to Know Before Using Solpadeine Max?

 

Before taking Solpadeine Max, it is essential to check whether it is safe for you. There are several important contraindications and warnings to be aware of.

Do not take Solpadeine Max if you:

  • Are under 12 years of age
  • Are aged 12–18 and have a breathing problem (e.g. asthma)
  • Are allergic to paracetamol, codeine, or any other ingredient in the tablet
  • Have severe liver or kidney disease
  • Are a known ultra-rapid CYP2D6 metaboliser (your body converts codeine to morphine too quickly)
  • Are breastfeeding
  • Have a history of opioid dependence or substance misuse

Tell your pharmacist or doctor if you:

  • Have liver or kidney problems
  • Have a history of constipation or bowel obstruction
  • Have an underactive thyroid (hypothyroidism)
  • Have adrenal gland problems (Addison's disease)
  • Have an enlarged prostate
  • Are pregnant or planning to become pregnant

Drug interactions — do not take with:

  • Monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping them
  • Other medicines containing paracetamol (risk of overdose)
  • Other opioid medicines or strong sedatives
  • Certain antidepressants (e.g. tricyclics, SSRIs) — may increase risk of side effects
  • Anticoagulants such as warfarin — regular use of paracetamol may enhance anticoagulant effect

If you experience pain alongside digestive symptoms, our IBS and cramps collection may offer additional support products worth discussing with your pharmacist.

 

How Should You Use Solpadeine Max?

 

Always take Solpadeine Max exactly as directed on the label or as advised by your pharmacist. Do not exceed the stated dose.

  1. Swallow 2 tablets whole with a full glass of water.
  2. Allow at least 4 hours between doses.
  3. Do not take more than 8 tablets in any 24-hour period.
  4. Do not use for more than 3 consecutive days without seeking medical advice.
  5. If pain persists or worsens, consult your GP.
Age Group Dose Frequency Maximum daily dose
Adults and young people aged 16+ 2 tablets Every 4–6 hours as needed 8 tablets (4 g paracetamol)
Children under 12 Not suitable — do not use
Adolescents aged 12–15 Not recommended without medical supervision

 

What Are the Possible Side Effects of Solpadeine Max?

 

Like all medicines, Solpadeine Max can cause side effects, although not everyone experiences them. Codeine in particular carries a risk of dependence if used for longer than recommended.

Common side effects:

  • Constipation
  • Nausea or feeling sick
  • Drowsiness or sedation
  • Dizziness

Less common side effects:

  • Headache (paradoxically, with overuse)
  • Dry mouth
  • Skin rash or itching
  • Difficulty passing urine
  • Mood changes

Stop taking Solpadeine Max and seek immediate medical attention if you develop signs of a serious allergic reaction, such as swelling of the face, lips, or throat, difficulty breathing, or a severe skin reaction. Paracetamol overdose is a medical emergency — if you suspect an overdose, go to A&E immediately even if you feel well, as liver damage may not be apparent for several days.

 

How Should You Store Solpadeine Max?

 

  • Store below 25°C in a dry place away from direct heat and sunlight.
  • Keep in the original blister packaging until use.
  • Keep out of the reach and sight of children at all times.
  • Do not use after the expiry date printed on the pack.
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy.

If you're also managing cold or flu symptoms alongside pain, take a look at our cold and flu collection for complementary products — but always check with your pharmacist before combining medicines.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Solpadeine Max tablets online in the UK?

You can buy Solpadeine Max 24 tablets online from Cured Pharmacy, a GPhC-registered UK online pharmacy. Because it contains codeine, you will need to complete a short online consultation to confirm suitability before your order is dispensed. Visit our pain relief collection to browse and order securely.

How does Solpadeine Max work in the body?

Solpadeine Max contains paracetamol, which reduces pain signals in the brain by inhibiting prostaglandin synthesis, and codeine phosphate, which binds to opioid receptors in the central nervous system to reduce pain perception. Codeine is partially converted to morphine in the body, which contributes to its analgesic effect. Together, these two ingredients address moderate pain through complementary pathways.

What is the correct dose of Solpadeine Max for adults?

Adults and young people aged 16 and over should take 2 tablets every 4 to 6 hours when needed. The maximum dose is 8 tablets in any 24-hour period. Do not use for more than 3 consecutive days without speaking to a doctor or pharmacist.

Can I take Solpadeine Max with ibuprofen?

Solpadeine Max does not contain ibuprofen, so it can generally be taken alongside ibuprofen if clinically appropriate for your situation. However, always check with your pharmacist before combining pain relief medicines, as individual health factors can affect what is safe for you. Never exceed the recommended dose of either medicine.

What are the side effects of Solpadeine Max tablets?

Common side effects include constipation, nausea, and drowsiness, which are related to the codeine content. Less commonly, you may experience dizziness, dry mouth, or skin itching. Stop use and seek medical advice promptly if you develop signs of an allergic reaction or any serious symptoms.

Is Solpadeine Max suitable for children?

No — Solpadeine Max must not be given to children under 12 years of age under any circumstances. It is also not recommended for adolescents aged 12 to 18 who have breathing problems such as asthma, as codeine can cause serious respiratory side effects in this group. For children's pain relief options, speak to your pharmacist about age-appropriate alternatives.

How long can I use Solpadeine Max for?

Solpadeine Max is intended for short-term use only — no more than 3 consecutive days. Using codeine-containing medicines beyond this can lead to physical dependence and a condition known as medication-overuse headache. If your pain persists beyond 3 days, please consult your GP rather than continuing to self-medicate.

What happens if I miss a dose of Solpadeine Max?

If you miss a dose, take it as soon as you remember — provided at least 4 hours have passed since your last dose. Never take a double dose to make up for a missed one, as this increases the risk of side effects and paracetamol toxicity. Always stay within the maximum of 8 tablets in any 24-hour period.

Can I take Solpadeine Max during pregnancy?

Solpadeine Max is not recommended during pregnancy, particularly in the third trimester, as codeine can cause neonatal withdrawal symptoms and respiratory depression in the newborn. Paracetamol alone is generally considered the preferred analgesic during pregnancy, but you should always seek advice from your midwife or GP before taking any medicine while pregnant.

Can I drink alcohol while taking Solpadeine Max?

You should avoid alcohol while taking Solpadeine Max. Alcohol can increase the sedative effects of codeine, raising the risk of drowsiness, dizziness, and impaired coordination. Combining alcohol with paracetamol also increases the risk of liver damage, particularly if you drink regularly or in large amounts.

Who should not take Solpadeine Max tablets?

Solpadeine Max is not suitable for children under 12, people who are breastfeeding, those with severe liver or kidney disease, or anyone with a known allergy to paracetamol or codeine. People who are ultra-rapid CYP2D6 metabolisers should also avoid it, as they convert codeine to morphine unusually quickly, increasing the risk of serious side effects. Always complete the pharmacist consultation before purchasing.

What are the alternatives to Solpadeine Max for moderate pain?

Alternatives for moderate pain include standard paracetamol, ibuprofen, aspirin, or combination products such as Solpadeine Plus (which contains a lower codeine dose plus caffeine). The right choice depends on your specific pain type, medical history, and any other medicines you take. Browse our pain relief collection to explore the options available.

Can Solpadeine Max cause dependence?

Yes — because Solpadeine Max contains codeine, there is a risk of physical and psychological dependence if it is used for longer than recommended or at higher doses than stated. This risk is why it should only be used for up to 3 days at a time. If you find yourself needing it regularly, speak to your GP about alternative pain management strategies.

What is the latest guidance on codeine-containing medicines in the UK?

The MHRA and NHS have issued guidance emphasising that codeine-containing medicines should only be used for short-term pain relief (up to 3 days) and are not appropriate for children under 12. There is also specific guidance warning against use in adolescents with respiratory conditions and in breastfeeding mothers, due to the risk of serious adverse effects from codeine's conversion to morphine.

Does Solpadeine Max help with dental pain?

Yes — dental pain is one of the recognised indications for Solpadeine Max, particularly when standard paracetamol or ibuprofen has not provided sufficient relief. It should still only be used for up to 3 days, and you should seek dental treatment for the underlying cause of the pain as soon as possible. If you also experience mouth soreness or oral discomfort, our oral health collection may have additional supportive products.

How Should You Use Solpadeine Max?

Solpadeine Max tablets should be swallowed whole with a full glass of water. Do not crush or chew the tablets, and always take them at the intervals specified — taking them too close together increases the risk of side effects and paracetamol toxicity.

Follow these steps each time you take a dose:

What Is the Correct Dose of Solpadeine Max?

The dose of Solpadeine Max varies by age group. It is important to follow the dosage guidance carefully, as exceeding the recommended dose of paracetamol can cause serious liver damage, even if you feel well at the time.

When Is the Best Time to Use Solpadeine Max?

Solpadeine Max can be taken at any time of day when pain relief is needed, provided the 4-hour gap between doses is maintained. Taking it with or after food may help reduce the likelihood of nausea, particularly if your stomach is sensitive.

Bear in mind that codeine can cause drowsiness, so if you need to drive or operate machinery, consider whether this medicine is appropriate at that time. Evening doses may be preferable if drowsiness is a concern during your working day.

How Long Can You Use Solpadeine Max For?

Solpadeine Max is intended for short-term use only — a maximum of 3 consecutive days. This limit exists because codeine carries a risk of dependence with prolonged use, and regular use of any painkiller for more than a few days can lead to medication-overuse headache, where the medicine itself begins to cause the pain it was meant to treat.

If your pain has not improved after 3 days, or if it worsens at any point, stop taking Solpadeine Max and speak to your GP. Do not self-medicate beyond the recommended duration.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Solpadeine Max?

The most frequently reported side effects of Solpadeine Max are linked to its codeine content. Codeine acts on the central nervous system and the gut, which is why digestive and sedative effects are the most common complaints. Most people tolerate the medicine well when taken at the correct dose for a short period.

  • Constipation
  • Nausea or feeling sick
  • Drowsiness or sedation
  • Dizziness or light-headedness

What Are the Less Common Side Effects of Solpadeine Max?

Some people experience less frequent side effects that are still worth being aware of. These tend to occur more often if the medicine is taken at higher doses or for longer than recommended.

  • Dry mouth
  • Headache (particularly with overuse — known as medication-overuse headache)
  • Skin rash or itching
  • Difficulty passing urine
  • Mood changes or feeling unusually euphoric or low
  • Stomach discomfort

What Are the Serious Side Effects of Solpadeine Max?

Serious side effects are uncommon but require immediate medical attention if they occur. Paracetamol overdose is a particular concern — it can cause severe liver damage that may not become apparent for several days after the overdose. If you think you or someone else has taken too much, go to A&E immediately, even if you feel well.

Seek urgent medical help if you experience any of the following:

  • Signs of a serious allergic reaction: swelling of the face, lips, tongue, or throat; difficulty breathing; severe skin rash
  • Slow or shallow breathing (particularly in elderly patients or those with respiratory conditions)
  • Severe abdominal pain or yellowing of the skin or eyes (signs of liver problems)
  • Seizures
  • Extreme confusion or loss of consciousness

Can Solpadeine Max Interact With Other Medicines?

Yes — Solpadeine Max can interact with several other medicines, which is why it is important to tell your pharmacist about everything you are currently taking. The most clinically significant interactions involve medicines that affect the central nervous system or liver metabolism.

  • MAOIs: Do not take within 14 days of stopping a monoamine oxidase inhibitor — serious and potentially life-threatening interactions can occur.
  • Other paracetamol-containing products: Taking these alongside Solpadeine Max risks exceeding the safe daily paracetamol limit of 4 g, which can cause liver damage.
  • Warfarin and other anticoagulants: Regular paracetamol use may enhance the anticoagulant effect, increasing bleeding risk.
  • Sedatives, sleeping tablets, or other opioids: Combining these with codeine increases the risk of excessive sedation and respiratory depression.
  • Certain antidepressants (SSRIs, tricyclics): May increase the risk of serotonin-related side effects.

What Should You Do If You Experience Side Effects?

If you experience mild side effects such as constipation or nausea, these often improve as your body adjusts. Staying well hydrated and taking the tablets with food can help. If side effects are troublesome or persistent, stop taking the medicine and speak to your pharmacist or GP about alternative pain relief options.

For serious side effects or suspected overdose, do not wait — seek emergency medical attention immediately. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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