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Setlers Antacid Tablets 3-roll 36

Setlers Antacid Tablets 3-roll 36

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  • ✔️ Neutralises excess stomach acid to relieve heartburn fast
  • ✔️ Contains 500mg calcium carbonate per chewable tablet
  • ✔️ Convenient 3-roll pack of 36 tablets for on-the-go use
  • ✔️ Suitable for adults and children aged 12 and over
  • ✔️ Provides symptomatic relief from indigestion and acid discomfort

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Are Antacid Tablets for Heartburn Right for You?

 

That familiar burning feeling rising up your chest after a meal — heartburn is something millions of people in the UK experience regularly. Setlers Antacid Tablets offer a simple, affordable way to tackle it. Each pack contains 36 tablets across three convenient rolls, making them easy to keep in your bag, desk drawer, or kitchen cupboard. At just £2.99, they're one of the most accessible options for fast-acting relief from heartburn and indigestion. If you're looking for antacid tablets for heartburn that are easy to use and gentle on the stomach, Setlers are worth considering.

Heartburn affects a significant portion of the UK population. The NHS describes it as a burning sensation in the chest caused by stomach acid travelling up towards the throat — a condition known as acid reflux. It's often triggered by certain foods, lying down after eating, or being overweight. You can browse our full range of indigestion relief products if you're looking for additional support alongside these tablets.

 

How Do Setlers Antacid Tablets Work?

 

The active ingredient in Setlers Antacid Tablets is calcium carbonate 500mg. This works by directly neutralising the excess hydrochloric acid produced in your stomach. When you chew a tablet, the calcium carbonate reacts with the acid, raising the stomach's pH and reducing that uncomfortable burning sensation relatively quickly.

  • Calcium carbonate acts as a chemical base, reacting with stomach acid to form calcium chloride, water, and carbon dioxide.
  • The neutralisation process begins in the stomach shortly after the tablet is chewed.
  • Relief is typically felt within minutes of taking the tablet.
  • Unlike proton pump inhibitors (PPIs), antacids do not reduce acid production — they neutralise acid that is already present.

 

Who Should Use Setlers Antacid Tablets?

 

These tablets are suitable for adults and children aged 12 and over who experience occasional heartburn, acid indigestion, or an upset stomach. They're particularly useful after large meals, spicy food, or alcohol — common triggers for acid reflux symptoms. They are not intended for long-term daily use without medical supervision.

  • Adults experiencing occasional heartburn or indigestion
  • People who need a portable, convenient antacid solution
  • Those who prefer a chewable tablet over liquid antacids
  • Individuals looking for a low-cost, over-the-counter option

 

How Do Setlers Compare to Other Antacid Options?

 

Feature Setlers Antacid Tablets Gaviscon Advance Tablets
Active ingredient Calcium carbonate 500mg Sodium alginate 500mg, potassium bicarbonate 100mg
Mechanism Neutralises stomach acid Forms a raft barrier over stomach contents
Pack size 36 tablets (3-roll) 60 tablets
Suitable for pregnancy Consult GP/midwife first Consult GP/midwife first

 

How Should You Store Setlers Antacid Tablets?

 

Store Setlers Antacid Tablets below 25°C in a dry place, away from direct sunlight. Keep them out of reach and sight of children at all times. Do not use the tablets after the expiry date printed on the packaging. If you're managing multiple digestive health products, it's worth checking our IBS and cramps collection for complementary options.

These antacid tablets for heartburn are an over-the-counter (OTC) medicine classified as a General Sale List (GSL) product in the UK, meaning no prescription is required. That said, always read the label carefully before use.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Setlers Antacid Tablets 3-roll 36 specifications
Treatment category Heartburn & Indigestion
Mechanism of action Neutralises excess stomach acid via calcium carbonate
Effective for Heartburn, acid indigestion, upset stomach
Suitable for Adults and children aged 12 and over
Active ingredient Calcium carbonate 500mg
Pack size 36 tablets (3-roll)
UK classification General Sale List (GSL)
Drug class Antacid
Preparation Chewable tablet
Route of administration Oral

Specifications of Setlers Antacid Tablets 3-roll 36

 

What Are Setlers Antacid Tablets and What Are They Used For?

 

Setlers Antacid Tablets are an over-the-counter medicine used to relieve the symptoms of heartburn, acid indigestion, and an upset or sour stomach. Each tablet contains 500mg of calcium carbonate as the active ingredient. They work by neutralising excess stomach acid, providing symptomatic relief rather than treating any underlying cause. These tablets are not intended to treat gastro-oesophageal reflux disease (GORD) or peptic ulcers — if you suspect either condition, please speak to your GP.

Heartburn is described by the NHS as a burning sensation in the chest, often after eating, which can be accompanied by an unpleasant taste in the mouth caused by stomach acid. Setlers Antacid Tablets are designed for short-term, as-needed use to manage these occasional symptoms.

 

What Do You Need to Know Before Using Setlers Antacid Tablets?

 

Before taking these tablets, it's important to check whether they are appropriate for you. Do not take Setlers Antacid Tablets if any of the following apply:

  • You are allergic to calcium carbonate or any other ingredient in the tablets
  • You have hypercalcaemia (high levels of calcium in the blood)
  • You have kidney stones or severe kidney disease
  • You are taking other calcium-containing supplements that may lead to excessive calcium intake
  • You have been told by a doctor to follow a low-calcium diet

Speak to your pharmacist or GP before use if you are pregnant, breastfeeding, or have any other medical condition. The following medicines may interact with calcium carbonate antacids — take them at least 2 hours apart:

  • Tetracycline antibiotics (e.g. doxycycline)
  • Bisphosphonates (e.g. alendronic acid, used for osteoporosis)
  • Iron supplements
  • Thyroid medicines (e.g. levothyroxine)
  • Some antifungal medicines (e.g. itraconazole)

 

How Should You Use Setlers Antacid Tablets?

 

Always use Setlers Antacid Tablets exactly as described on the label or as directed by your pharmacist. Do not exceed the recommended dose.

  1. Chew or suck 1 to 2 tablets slowly.
  2. Do not swallow the tablets whole — chewing ensures the calcium carbonate is released effectively.
  3. Take when symptoms occur, or as directed by your pharmacist.
  4. Allow at least 2 hours between taking these tablets and any other medicines listed in the interactions section above.
  5. Do not take more than 6 tablets in any 24-hour period.
Indication Age Group Dose Frequency
Heartburn / Indigestion Adults & children 12+ 1–2 tablets Up to 3 times daily (max 6 tablets/24 hrs)
Not recommended Under 12 years Seek medical advice

 

What Are the Possible Side Effects of Setlers Antacid Tablets?

 

Like all medicines, Setlers Antacid Tablets can cause side effects, although not everyone experiences them. Most people tolerate calcium carbonate antacids well when taken at the recommended dose.

Common side effects:

  • Constipation
  • Flatulence (wind)
  • Belching

Less common side effects:

  • Nausea
  • Stomach discomfort
  • Hypercalcaemia (raised blood calcium) — more likely with prolonged high-dose use
  • Milk-alkali syndrome — a rare condition associated with excessive calcium carbonate intake alongside dairy products

Stop taking the tablets and seek medical advice if you notice any unusual or severe symptoms. If you're also managing other digestive concerns, you may find our sickness and nausea collection helpful.

 

How Should You Store Setlers Antacid Tablets?

 

  • Store below 25°C in a dry place, away from direct sunlight and moisture
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the packaging
  • Do not store in a bathroom or near a sink where humidity may affect the tablets
  • Dispose of any unused medicine safely — ask your pharmacist how to do this

If you're looking for additional support for digestive health or related conditions, explore our constipation relief range, as antacid use can occasionally contribute to changes in bowel habits.

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Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Setlers Antacid Tablets online in the UK?

You can buy Setlers Antacid Tablets 3-roll 36 directly from Cured Pharmacy online for just £2.99, with no prescription required. They are classified as a General Sale List (GSL) medicine in the UK, so they are available over the counter. Simply add them to your basket and choose your preferred delivery option at checkout.

How do Setlers Antacid Tablets work in the body?

Setlers Antacid Tablets contain calcium carbonate, which acts as a chemical base and neutralises excess hydrochloric acid in the stomach. This reaction raises the stomach's pH, reducing the burning sensation associated with heartburn and indigestion. Unlike proton pump inhibitors, antacids work immediately on acid already present rather than reducing future acid production.

How do I take Setlers Antacid Tablets step by step?

Chew or suck 1 to 2 tablets slowly when symptoms occur — do not swallow them whole, as chewing allows the active ingredient to work more effectively. You can take them up to three times daily, but do not exceed 6 tablets in any 24-hour period. If you are taking other medicines, leave at least 2 hours between them and your antacid dose.

What is the correct dose of Setlers Antacid Tablets for adults?

The recommended dose for adults and children aged 12 and over is 1 to 2 tablets, taken up to three times daily as needed. The maximum dose is 6 tablets in 24 hours. Children under 12 should not take these tablets without specific medical advice.

When is the best time to take Setlers Antacid Tablets?

Setlers Antacid Tablets are best taken when symptoms arise — typically after meals, or when you feel the onset of heartburn or indigestion. Some people find taking them after eating a large or spicy meal helps prevent discomfort before it becomes severe. They can also be taken before bed if lying down tends to trigger your symptoms, though persistent night-time heartburn should be discussed with your GP.

Are there any side effects of Setlers Antacid Tablets?

Most people tolerate Setlers Antacid Tablets well at the recommended dose. The most commonly reported side effects include constipation, flatulence, and belching. Rarely, prolonged or excessive use may lead to raised blood calcium levels (hypercalcaemia), so it is important not to exceed the stated dose or use them long-term without medical guidance.

How do I manage side effects of Setlers Antacid Tablets?

If you experience constipation, increasing your fluid intake and dietary fibre can help — you may also find our constipation relief range useful. Flatulence and belching usually resolve on their own and are not a cause for concern. If any side effect is persistent or troubling, stop taking the tablets and speak to your pharmacist or GP.

Who is eligible to take Setlers Antacid Tablets?

Setlers Antacid Tablets are suitable for adults and young people aged 12 and over who experience occasional heartburn or indigestion. They are not suitable for people with hypercalcaemia, severe kidney disease, or those on a medically restricted low-calcium diet. Always check with your pharmacist if you are unsure whether these tablets are right for you.

Can I take Setlers Antacid Tablets during pregnancy?

Heartburn is very common during pregnancy, and calcium carbonate antacids are generally considered low-risk for short-term use. However, you should always consult your midwife or GP before taking any medicine during pregnancy, as individual circumstances vary. They can advise on the safest option for you and your baby.

What happens if I miss a dose of Setlers Antacid Tablets?

Because Setlers Antacid Tablets are taken as needed rather than on a fixed schedule, there is no "missed dose" in the traditional sense. Simply take a tablet when your symptoms return, and do not double up to compensate. If you find you are needing antacids very frequently, this is a sign you should speak to your GP about the underlying cause.

Do Setlers Antacid Tablets interact with other medicines?

Yes — calcium carbonate can reduce the absorption of certain medicines if taken at the same time. These include tetracycline antibiotics, bisphosphonates (such as alendronic acid), iron supplements, levothyroxine, and some antifungal medicines. To avoid this, take Setlers at least 2 hours before or after any of these medicines.

How long can you use Setlers Antacid Tablets for?

Setlers Antacid Tablets are intended for short-term, occasional use only. If your symptoms persist for more than 7 days, worsen, or are accompanied by other symptoms such as difficulty swallowing, unexplained weight loss, or vomiting, you should stop use and consult your GP promptly. Long-term daily use of antacids without medical supervision is not recommended.

What are the alternatives to Setlers Antacid Tablets?

There are several alternatives depending on the severity and frequency of your symptoms. Other antacids include Rennie (calcium carbonate and magnesium carbonate) and Gaviscon (sodium alginate), which forms a physical barrier over stomach contents. For more frequent or severe symptoms, your GP may recommend an H2 blocker such as famotidine or a proton pump inhibitor such as omeprazole. You can also explore our broader indigestion relief range for more options.

Are Setlers Antacid Tablets suitable for vegetarians or vegans?

The suitability of Setlers Antacid Tablets for vegetarians or vegans depends on the excipients (inactive ingredients) used in the formulation, which can vary. It is best to check the patient information leaflet included in the pack or contact the manufacturer directly to confirm suitability for your dietary requirements.

What are the latest findings on calcium carbonate antacids for heartburn?

Calcium carbonate remains a well-established and widely recommended first-line treatment for mild, occasional heartburn and indigestion, as supported by NHS guidance. Current clinical thinking emphasises that antacids are appropriate for short-term symptom relief, while lifestyle changes — such as avoiding trigger foods, eating smaller meals, and not lying down immediately after eating — are equally important for long-term management. For persistent or severe symptoms, proton pump inhibitors or H2 blockers may be more appropriate under medical supervision.

How Should You Use Setlers Antacid Tablets?

Setlers Antacid Tablets are designed to be chewed or sucked — not swallowed whole. Chewing the tablet allows the calcium carbonate to be released and begin neutralising stomach acid more quickly. Always read the patient information leaflet supplied with the pack before use.

What Is the Correct Dose of Setlers Antacid Tablets?

The dose varies by age group. Children under 12 should not take these tablets unless specifically directed by a doctor. Always stick to the recommended dose — taking more than advised does not improve symptom relief and may increase the risk of side effects.

When Is the Best Time to Use Setlers Antacid Tablets?

Take Setlers Antacid Tablets as soon as you notice symptoms of heartburn or indigestion — there is no need to wait until discomfort becomes severe. Many people find them most useful after eating a large, rich, or spicy meal, or when lying down triggers symptoms. If you regularly experience heartburn at night, taking a tablet before bed may help, though persistent night-time symptoms should be discussed with your GP.

How Long Can You Use Setlers Antacid Tablets For?

These tablets are intended for short-term, occasional use to manage mild symptoms. If you find yourself needing them every day, or if your symptoms have not improved after 7 days of use, you should stop taking them and seek advice from your GP. Persistent or worsening heartburn may indicate an underlying condition such as gastro-oesophageal reflux disease (GORD) that requires a different approach to treatment.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Setlers Antacid Tablets?

Most people who take Setlers Antacid Tablets at the recommended dose experience no significant side effects. However, as with any medicine, some people may notice mild digestive changes. These are generally not serious and often resolve on their own.

  • Constipation
  • Flatulence (wind)
  • Belching

What Are the Less Common Side Effects of Setlers Antacid Tablets?

Less commonly, some people may experience the following, particularly if the tablets are taken more frequently than recommended or over a prolonged period:

  • Nausea
  • Stomach discomfort or bloating
  • Hypercalcaemia (raised blood calcium levels) — symptoms can include nausea, weakness, confusion, or increased thirst
  • Milk-alkali syndrome — a rare condition associated with very high calcium carbonate intake alongside large amounts of dairy; symptoms include nausea, vomiting, and confusion

What Are the Serious Side Effects of Setlers Antacid Tablets?

Serious side effects from Setlers Antacid Tablets are rare when the product is used as directed. The most clinically significant risk is hypercalcaemia, which can occur with excessive or prolonged use. Symptoms to watch for include muscle weakness, confusion, increased urination, and an irregular heartbeat. If you experience any of these, stop taking the tablets immediately and seek urgent medical attention.

What Should You Do If You Experience Side Effects?

If you notice any side effect that concerns you, stop taking Setlers Antacid Tablets and speak to your pharmacist or GP as soon as possible. For mild side effects such as constipation, increasing your fluid intake and dietary fibre may help. Do not take a higher dose in an attempt to improve symptom relief — this will not help and may increase the risk of unwanted effects. You can report suspected side effects to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Setlers Antacid Tablets Interact With Other Medicines?

Yes. Calcium carbonate can reduce the absorption of certain medicines when taken at the same time. To avoid interactions, take Setlers at least 2 hours before or after the following:

  • Tetracycline antibiotics (e.g. doxycycline, tetracycline)
  • Bisphosphonates (e.g. alendronic acid)
  • Iron supplements
  • Levothyroxine (thyroid medicine)
  • Itraconazole and other azole antifungals

Always tell your pharmacist about all medicines, supplements, and herbal remedies you are taking before starting a new product.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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