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Perrigo Esomeprazole 7 Tablets

Perrigo Esomeprazole 7 Tablets

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  • ✔️ Reduces stomach acid production for up to 24 hours per dose
  • ✔️ Relieves frequent heartburn symptoms within two to three days
  • ✔️ Gastro-resistant tablet protects active ingredient for full efficacy
  • ✔️ Suitable for adults with heartburn on two or more days weekly
  • ✔️ One tablet daily — simple 14-day OTC treatment course

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What Are Esomeprazole 20mg Tablets Used For?

 

If you've ever felt that burning sensation creeping up your chest after a meal, you'll know how disruptive heartburn can be. Perrigo Esomeprazole 7 Tablets contain esomeprazole 20mg tablets, an over-the-counter proton pump inhibitor (PPI) clinically proven to reduce stomach acid and relieve the symptoms of frequent heartburn in adults. Each pack contains seven gastro-resistant tablets — enough for a full treatment course when used as directed. Available from Cured Pharmacy for just £4.99, this is a straightforward, accessible option for adults who experience heartburn two or more days per week.

Heartburn occurs when stomach acid flows back into the oesophagus, causing that familiar burning discomfort. It's extremely common in the UK — the NHS estimates that around one in five people experience it regularly. Esomeprazole works at the source of the problem rather than simply neutralising acid after the fact, which is why many people find it more effective than antacids for frequent symptoms. If you're also managing other digestive concerns, you might find our indigestion collection useful for complementary products.

 

How Does Perrigo Esomeprazole Work in the Stomach?

 

Esomeprazole belongs to a class of medicines called proton pump inhibitors. Rather than acting as a quick-fix antacid, it targets the mechanism that produces acid in the first place. Here's how it works:

  • Esomeprazole is absorbed into the bloodstream after you swallow the gastro-resistant tablet.
  • It travels to the parietal cells lining the stomach wall.
  • There, it irreversibly inhibits the hydrogen-potassium ATPase enzyme — often called the "proton pump" — which is responsible for secreting acid into the stomach.
  • With less acid being produced, the oesophagus has a chance to recover, and heartburn symptoms ease significantly.

Because the tablet is gastro-resistant, it passes through the stomach intact and is absorbed in the small intestine. This protects the active ingredient from being broken down by stomach acid before it can work. Full acid suppression typically builds over the first two to three days of treatment, so don't be discouraged if relief isn't instant on day one.

 

Who Is Perrigo Esomeprazole Suitable For?

 

This product is intended for adults aged 18 and over who experience frequent heartburn — defined as two or more episodes per week. It is not a treatment for occasional, one-off heartburn; for that, a simple antacid may be more appropriate. Perrigo Esomeprazole 7 Tablets are suitable for:

  • Adults aged 18 and over with frequent heartburn symptoms.
  • People who have not found adequate relief from antacids or H2 blockers.
  • Those who experience acid reflux symptoms regularly after meals or at night.
  • Individuals who want a short-course OTC option before consulting their GP.

It is not suitable for children or adolescents under 18, pregnant or breastfeeding women (without medical advice), or anyone with difficulty swallowing or unexplained weight loss — these symptoms require prompt GP assessment.

 

How Does Esomeprazole Compare to Other Heartburn Treatments?

 

Feature Perrigo Esomeprazole 20mg Antacids (e.g. Gaviscon)
Mechanism Reduces acid production at source Neutralises acid already present
Onset of action 1–3 days for full effect Within minutes
Duration of effect Up to 24 hours per dose 1–3 hours
Best suited for Frequent, recurring heartburn Occasional, mild heartburn

 

How Should You Store Perrigo Esomeprazole Tablets?

 

Store your esomeprazole 20mg tablets below 25°C in a dry place, away from direct sunlight and moisture. Keep the tablets in their original blister packaging until you're ready to use them — this helps maintain the integrity of the gastro-resistant coating. Always keep medicines out of the sight and reach of children.

Do not use the tablets after the expiry date printed on the pack. If you have unused tablets after completing your course, return them to your local pharmacy for safe disposal — do not flush them or put them in household waste. For other health essentials, browse our pain relief collection at Cured Pharmacy.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Perrigo Esomeprazole 7 Tablets specifications
Treatment category Heartburn / Acid reflux
Mechanism of action Proton pump inhibitor (PPI) — reduces gastric acid secretion
Effective for Frequent heartburn in adults (2+ episodes per week)
Suitable for Adults aged 18 and over
Active ingredient Esomeprazole magnesium dihydrate 20mg
Pack size 7 tablets
Strength 20mg
UK classification General Sale / Pharmacy (P) medicine
Drug class Proton pump inhibitor (PPI)
Preparation Gastro-resistant tablet
Route of administration Oral

Specifications of Perrigo Esomeprazole 7 Tablets

 

What Is Perrigo Esomeprazole and What Is It Used For?

 

Perrigo Esomeprazole 7 Tablets contain esomeprazole magnesium dihydrate 20mg as the active ingredient. Esomeprazole is a proton pump inhibitor (PPI) — a type of medicine that reduces the amount of acid your stomach produces. This product is used to relieve the symptoms of frequent heartburn in adults aged 18 and over. Frequent heartburn is defined as experiencing symptoms on two or more days per week. It is not intended for the immediate relief of a single heartburn episode.

Heartburn symptoms include a burning feeling in the chest or throat, an unpleasant sour taste in the mouth, and discomfort that often worsens after eating, bending over, or lying down. The NHS describes heartburn as very common and usually not serious, but persistent or severe symptoms should always be assessed by a GP.

 

What Do You Need to Know Before Using Perrigo Esomeprazole?

 

Before taking these tablets, read the following carefully. There are situations where esomeprazole is not appropriate, and some medicines can interact with it.

Do not take Perrigo Esomeprazole if you:

  • Are allergic to esomeprazole, any other PPI (such as omeprazole, lansoprazole, pantoprazole), or any of the other ingredients.
  • Are under 18 years of age.
  • Are taking medicines for HIV such as atazanavir or nelfinavir.
  • Have difficulty swallowing, persistent nausea or vomiting, unexplained weight loss, or blood in your vomit or stools — see your GP urgently.
  • Are pregnant or breastfeeding, unless advised by your doctor.

Known drug interactions — tell your pharmacist if you are taking:

  • Clopidogrel (a blood-thinning medicine) — esomeprazole may reduce its effectiveness.
  • Methotrexate — PPIs may increase methotrexate levels in the blood.
  • Ketoconazole or itraconazole — absorption of these antifungals may be affected.
  • Digoxin — esomeprazole may increase digoxin levels.
  • Warfarin or other anticoagulants — monitoring may be required.
  • Cilostazol, diazepam, or phenytoin — plasma levels may be altered.

 

How Should You Take Perrigo Esomeprazole Correctly?

 

Always use this medicine exactly as described in this leaflet or as directed by your pharmacist. Taking it correctly makes a real difference to how well it works.

  1. Take one tablet (20mg) once daily, every morning.
  2. Swallow the tablet whole with a glass of water — do not crush, chew, or split it.
  3. Take it at least 30 to 60 minutes before eating your first meal of the day.
  4. Continue for up to 14 days, even if symptoms improve sooner.
  5. If symptoms do not improve after 14 days, stop taking the tablets and consult your GP.
Indication Age Group Dose Frequency
Frequent heartburn Adults 18+ 20mg (1 tablet) Once daily for up to 14 days
Children under 18 Not applicable Not suitable Not suitable

If you're managing other digestive symptoms alongside heartburn, our IBS and cramps collection includes a range of products that may help with broader gut discomfort.

 

What Are the Possible Side Effects of Perrigo Esomeprazole?

 

Like all medicines, esomeprazole can cause side effects, although not everyone gets them. Most side effects are mild and resolve on their own.

Common side effects (may affect up to 1 in 10 people):

  • Headache
  • Diarrhoea
  • Nausea or feeling sick
  • Stomach pain or discomfort
  • Flatulence (wind)
  • Constipation

Less common side effects (may affect up to 1 in 100 people):

  • Dizziness
  • Dry mouth
  • Insomnia or disturbed sleep
  • Skin rash or itching
  • Swelling of the feet or ankles

Stop taking the tablets and seek immediate medical attention if you experience a severe allergic reaction (swelling of the face, lips, tongue, or throat; difficulty breathing; severe skin rash). Long-term use of PPIs has been associated with low magnesium levels and an increased risk of bone fractures — this is more relevant to prescription-strength, long-term use rather than a 14-day OTC course, but it's worth being aware of.

 

How Should You Store Perrigo Esomeprazole Tablets?

 

  • Store below 25°C in a dry place, away from direct heat and sunlight.
  • Keep in the original blister packaging to protect the gastro-resistant coating.
  • Keep out of the sight and reach of children at all times.
  • Do not use after the expiry date printed on the pack.
  • Return any unused tablets to your local pharmacy — do not dispose of via household waste or flush down the toilet.

If you're looking for other health essentials while you're here, our vitamins and supplements collection includes magnesium supplements and other products that support general wellbeing.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Perrigo Esomeprazole 7 Tablets online in the UK?

You can buy Perrigo Esomeprazole 7 Tablets directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £4.99. No prescription is needed for this OTC 20mg pack. Simply add to your basket and complete your order — it's that straightforward.

How does esomeprazole work in the body?

Esomeprazole is a proton pump inhibitor that blocks the hydrogen-potassium ATPase enzyme in the stomach lining, which is responsible for producing acid. By switching off this pump, it significantly reduces the volume of acid your stomach secretes. This gives the oesophagus time to recover and relieves the burning sensation associated with heartburn.

How do I take Perrigo Esomeprazole tablets step by step?
  1. Take one 20mg tablet each morning.
  2. Swallow it whole with a full glass of water — never crush or chew.
  3. Take it 30 to 60 minutes before your first meal.
  4. Continue for up to 14 days as directed.

If symptoms persist beyond 14 days, stop and consult your GP rather than repeating the course.

What is the best time of day to take esomeprazole?

The best time to take esomeprazole is first thing in the morning, at least 30 to 60 minutes before breakfast. Taking it before food allows the medicine to be absorbed properly and reach the proton pumps before they are activated by eating. Consistency matters — try to take it at the same time each day for the best results.

How do I manage side effects of esomeprazole?

Most side effects — such as headache, nausea, or loose stools — are mild and tend to settle within a few days as your body adjusts. Staying well hydrated and taking the tablet before food can help reduce stomach discomfort. If side effects are severe or persistent, stop taking the tablets and speak to your pharmacist or GP.

Who is eligible to take Perrigo Esomeprazole tablets?

This product is suitable for adults aged 18 and over who experience frequent heartburn on two or more days per week. It is not suitable for children, pregnant or breastfeeding women without medical advice, or anyone taking HIV medicines such as atazanavir. Always read the full patient information leaflet before use.

What happens if I miss a dose of esomeprazole?

If you forget to take your tablet, take it as soon as you remember — provided it's not nearly time for your next dose. If it is close to your next scheduled dose, simply skip the missed one and carry on as normal. Never take two tablets at once to compensate for a missed dose.

What are the alternatives to esomeprazole for heartburn?

Alternatives include other PPIs such as omeprazole, as well as H2 blockers like famotidine, and antacids such as Gaviscon or calcium carbonate preparations. Antacids work faster but for a shorter time, making them better for occasional heartburn. You can explore a range of options in our indigestion collection to find what suits you best.

How long can you take esomeprazole over the counter?

The recommended OTC course is a maximum of 14 consecutive days. If your symptoms do not improve within that time, or if they return within four months, you should see your GP rather than starting another course without medical supervision. Long-term use of PPIs should always be managed by a healthcare professional.

Can I take esomeprazole with other medicines?

Esomeprazole can interact with several medicines, including clopidogrel, methotrexate, ketoconazole, digoxin, and warfarin. Always tell your pharmacist about every medicine you are taking — including herbal remedies and supplements — before starting esomeprazole. Your pharmacist can check for interactions quickly and advise you accordingly.

Is esomeprazole safe during pregnancy or breastfeeding?

Esomeprazole should not be taken during pregnancy or while breastfeeding without first speaking to your doctor or midwife. The NHS advises that the safety of PPIs in pregnancy has not been fully established for OTC use. Your GP can advise on safer alternatives if needed during this time.

Can esomeprazole cause long-term problems?

A short 14-day OTC course carries very low risk of long-term effects. However, prolonged use of PPIs — particularly at prescription doses — has been associated with low magnesium levels, reduced vitamin B12 absorption, and a small increased risk of bone fractures. These concerns are primarily relevant to long-term, high-dose use under medical supervision, not a standard OTC course.

What are the latest studies on esomeprazole for heartburn?

Esomeprazole has been extensively studied and is one of the most widely used PPIs globally. Clinical evidence consistently supports its effectiveness in reducing gastric acid and relieving heartburn symptoms. Current NHS and NICE guidance continues to recommend PPIs as first-line treatment for frequent heartburn and gastro-oesophageal reflux disease (GORD).

Can I drink alcohol while taking esomeprazole?

Alcohol itself can worsen heartburn and acid reflux by relaxing the lower oesophageal sphincter and increasing acid production, so it's best to limit alcohol intake while taking esomeprazole. There is no direct dangerous interaction between alcohol and esomeprazole, but drinking may reduce the effectiveness of your treatment. Moderation is sensible during your course.

Does esomeprazole help with sickness and nausea as well as heartburn?

Esomeprazole is specifically indicated for heartburn and acid reflux — it is not a treatment for nausea or vomiting caused by other conditions. If nausea is related to excess stomach acid or reflux, reducing acid production may indirectly help. For nausea from other causes, visit our sickness and nausea collection for more targeted options.

How Should You Use Perrigo Esomeprazole Tablets?

Using esomeprazole correctly is important to get the most from your treatment. The tablet has a special gastro-resistant coating, which means it must be swallowed whole — never crushed, broken, or chewed. Follow these steps each day during your course:

If you have difficulty swallowing tablets, speak to your pharmacist before use — do not attempt to dissolve or crush the tablet, as this will destroy the gastro-resistant coating and reduce effectiveness.

What Is the Correct Dose of Perrigo Esomeprazole?

The recommended OTC dose for adults is one 20mg tablet once daily. Do not take more than one tablet per day unless specifically directed by a doctor. The table below summarises the dosing guidance for this product.

If you require ongoing acid suppression beyond 14 days, this must be assessed and managed by your GP. Higher prescription doses exist but are not available OTC.

When Is the Best Time to Use Perrigo Esomeprazole?

Timing genuinely matters with esomeprazole. The medicine works by blocking proton pumps, which are most active when stimulated by food. Taking your tablet 30 to 60 minutes before breakfast gives the drug time to be absorbed and reach the stomach lining before your first meal triggers acid production. Taking it after food significantly reduces its effectiveness. Set a daily reminder if you find it easy to forget — consistency across the 14-day course is key to achieving good symptom control.

How Long Can You Use Perrigo Esomeprazole For?

This OTC product is intended for a single course of up to 14 consecutive days. Most people notice an improvement in heartburn symptoms within two to three days, though the full benefit builds gradually over the course. Do not extend the course beyond 14 days without speaking to your GP first. If your symptoms return within four months of completing a course, you should seek medical advice rather than purchasing another pack independently — recurring or persistent symptoms may indicate an underlying condition such as GORD that requires proper diagnosis and management.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Perrigo Esomeprazole?

Most people tolerate esomeprazole well, but like all medicines, it can cause side effects in some people. Common side effects affect up to 1 in 10 users and are generally mild. They often settle on their own within a few days as your body adjusts to the medicine.

  • Headache
  • Diarrhoea
  • Nausea or feeling sick
  • Stomach pain or abdominal discomfort
  • Flatulence (wind)
  • Constipation

What Are the Less Common Side Effects of Perrigo Esomeprazole?

Less common side effects affect up to 1 in 100 people. These are not experienced by most users, but it's worth being aware of them so you can recognise them if they occur.

  • Dizziness or light-headedness
  • Dry mouth
  • Insomnia or disturbed sleep
  • Skin rash, itching, or hives
  • Swelling of the feet or ankles (peripheral oedema)
  • Raised liver enzymes (detected on blood tests)

What Are the Serious Side Effects of Perrigo Esomeprazole?

Serious side effects are rare but require immediate medical attention. Stop taking esomeprazole and seek emergency help if you experience any of the following:

  • Signs of a severe allergic reaction: swelling of the face, lips, tongue, or throat; difficulty breathing; severe skin rash or blistering.
  • Severe or sudden stomach pain — this could indicate a more serious condition.
  • Muscle weakness, irregular heartbeat, or muscle cramps — these may suggest low magnesium levels (hypomagnesaemia), which can occur with prolonged PPI use.
  • Yellowing of the skin or eyes (jaundice) — a rare sign of liver problems.

What Should You Do If You Experience Side Effects?

If you experience mild side effects, they will often resolve without any action needed. Staying well hydrated and taking the tablet before food can help reduce gastrointestinal discomfort. If a side effect is bothering you or does not improve after a few days, stop taking the tablets and speak to your pharmacist or GP. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Perrigo Esomeprazole Interact With Other Medicines?

Yes — esomeprazole has several clinically significant drug interactions. It can reduce the antiplatelet effect of clopidogrel, potentially increasing cardiovascular risk. It may increase plasma levels of methotrexate, digoxin, and cilostazol. Absorption of antifungals such as ketoconazole and itraconazole may be reduced. Esomeprazole should not be taken alongside HIV medicines atazanavir or nelfinavir. Always inform your pharmacist of every medicine you are currently taking — including over-the-counter products, herbal remedies, and supplements — before starting this treatment.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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