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Hydrex Surgical Scrub 250ml

Hydrex Surgical Scrub 250ml

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  • ✔️ Contains 4% chlorhexidine gluconate for broad-spectrum antibacterial action
  • ✔️ Provides residual antimicrobial protection for hours after rinsing
  • ✔️ Clinically used for pre-operative skin and surgical hand preparation
  • ✔️ Kills gram-positive and gram-negative bacteria on contact
  • ✔️ Suitable for adults in clinical and pre-procedural settings

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What Is Chlorhexidine Surgical Scrub and How Does It Help?

 

Hydrex Surgical Scrub 250ml is a topical antiseptic solution designed for pre-operative skin preparation and surgical hand scrubbing. It contains 4% chlorhexidine gluconate as its active ingredient — a well-established antimicrobial agent used widely across NHS hospitals and clinical settings. Whether you're preparing skin before a minor procedure or need a reliable antiseptic cleanser, this product offers a clinically recognised approach to reducing surface bacteria. You can find it alongside other first aid essentials at Cured Pharmacy.

Infection prevention starts before any incision or wound care begins. That's why pre-operative skin cleansing with a product like this is considered standard practice in surgical environments. The NHS recommends antiseptic skin preparation as part of infection control protocols, and chlorhexidine-based products are among the most widely used agents for this purpose.

 

How Does Hydrex Surgical Scrub Work on the Skin?

 

The mechanism behind this product is straightforward but effective. Chlorhexidine gluconate works by binding to bacterial cell membranes and disrupting their integrity, which leads to leakage of cellular contents and ultimately cell death. It acts against a broad spectrum of micro-organisms, including gram-positive and gram-negative bacteria.

  • Binds rapidly to skin proteins, providing immediate antimicrobial action
  • Offers residual activity — continues working on the skin surface for several hours after rinsing
  • Effective against common pathogens including Staphylococcus aureus and Escherichia coli
  • Low risk of developing bacterial resistance compared to some other antiseptics

This residual effect is one of the key reasons chlorhexidine is preferred over plain soap or alcohol-only preparations in surgical contexts. It doesn't just clean — it keeps working.

 

Who Should Use Hydrex Surgical Scrub?

 

This product is primarily intended for use in clinical, surgical, or pre-procedural settings. It's suitable for healthcare professionals performing surgical hand scrubs, as well as patients who have been advised to cleanse their skin before a planned procedure. It may also be appropriate for use in wound care environments where antiseptic cleansing is required.

  • Healthcare workers requiring surgical hand preparation
  • Patients preparing skin before elective surgery or minor procedures
  • Individuals managing wounds in clinical or home settings under medical guidance
  • Those needing a reliable antiseptic cleanser for infection prevention

It is not intended for routine daily washing or cosmetic use. If you're unsure whether this product is right for your situation, speak to your pharmacist or GP before use.

 

How Does Hydrex Surgical Scrub Compare to Other Antiseptic Cleansers?

 

Feature Hydrex Surgical Scrub 4% Standard Antiseptic Soap
Active ingredient Chlorhexidine gluconate 4% w/v Triclosan or lower-strength chlorhexidine
Residual antimicrobial activity Yes — several hours post-application Minimal to none
Suitable for surgical prep Yes No
Broad-spectrum coverage Yes — gram-positive and gram-negative Limited spectrum

 

How Should You Store Hydrex Surgical Scrub and Is It Clinically Suitable for You?

 

Store Hydrex Surgical Scrub below 25°C, away from direct sunlight, and out of reach of children. Do not use after the expiry date printed on the bottle. Once opened, use within the period indicated on the packaging. The chlorhexidine surgical scrub formulation should be kept in its original container to avoid contamination.

This product is not suitable for people with a known hypersensitivity to chlorhexidine or any other ingredient in the formulation. Avoid contact with eyes, ears, the brain, meninges, and mucous membranes. It should not be used on open body cavities. If you have sensitive skin or a history of allergic reactions to antiseptics, consult a healthcare professional before use. You may also find relevant guidance in our skin care section.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Hydrex Surgical Scrub 250ml specifications
Treatment category Antiseptic / Pre-operative skin preparation
Active ingredient Chlorhexidine gluconate 4% w/v
Mechanism of action Disrupts bacterial cell membranes; broad-spectrum bactericidal activity
Suitable for Adults; surgical and clinical use
Pack size 250ml
UK classification General Sale / OTC
Drug class Antiseptic (biguanide)
Preparation Topical liquid scrub
Route of administration Topical (external use only)

Specifications of Hydrex Surgical Scrub 250ml

 

What Is Hydrex Surgical Scrub and What Is It Used For?

 

Hydrex Surgical Scrub 250ml is a topical antiseptic preparation containing 4% chlorhexidine gluconate. It is used to reduce the number of micro-organisms on the skin before surgical procedures, invasive clinical interventions, or wound care. It is also used for surgical hand scrubbing by healthcare professionals to minimise the risk of transferring bacteria during procedures.

Chlorhexidine gluconate is one of the most widely studied antiseptic agents in clinical medicine. The NHS uses chlorhexidine-based preparations as part of standard infection prevention and control protocols. This product is for external use only and must not be swallowed or applied to mucous membranes.

 

What Do You Need to Know Before Using Hydrex Surgical Scrub?

 

Before using this product, read the following carefully. There are specific situations where this scrub should not be used, and certain precautions you should be aware of.

Do not use Hydrex Surgical Scrub if you:

  • Are allergic to chlorhexidine gluconate or any other ingredient in the formulation
  • Need to apply it near the eyes, ears, or brain — contact with these areas can cause serious harm
  • Have open body cavities that require treatment — this product is not suitable for internal use
  • Are applying it to mucous membranes

Warnings and precautions:

  • Chlorhexidine is ototoxic — even small amounts entering the ear canal can cause permanent hearing damage
  • Avoid contact with the eyes; if accidental contact occurs, rinse immediately with plenty of water
  • Do not use on neonates without specific medical guidance
  • Hypersensitivity reactions, including anaphylaxis, have been reported with chlorhexidine — seek emergency help if you develop swelling, difficulty breathing, or a rash after use
  • Keep away from naked flames — the product contains ingredients that may be flammable when wet

Drug interactions:

  • No clinically significant systemic drug interactions are expected with topical use
  • Avoid combining with anionic surfactants (found in some soaps), as these may reduce the effectiveness of chlorhexidine
  • Do not use alongside iodine-based antiseptics on the same skin area simultaneously

 

How Should You Use Hydrex Surgical Scrub?

 

Always follow the instructions provided with the product or as directed by your healthcare professional. The steps below are for general guidance only.

  1. Wet the skin or hands thoroughly with water before applying the scrub
  2. Apply a sufficient amount of Hydrex Surgical Scrub to the area to be cleansed
  3. Lather and scrub the skin for a minimum of two minutes, paying attention to all surfaces
  4. Rinse thoroughly with clean water
  5. Repeat if directed by your healthcare professional or surgical protocol
  6. Pat dry with a sterile or clean towel — do not rub vigorously
Indication Age Group Application Frequency
Pre-operative skin prep Adults Apply to surgical site, lather 2 minutes, rinse As directed by clinical protocol
Surgical hand scrub Adults (healthcare workers) Apply to wet hands and forearms, scrub 2–3 minutes, rinse Before each surgical procedure
General antiseptic cleansing Adults Apply to affected area, lather, rinse As advised by a healthcare professional

If you are using this product as part of a pre-operative preparation at home, follow the specific instructions given to you by your surgical team. You may also find useful guidance in our creams and ointments section for complementary wound care products.

 

What Are the Possible Side Effects of Hydrex Surgical Scrub?

 

Like all medicines, Hydrex Surgical Scrub can cause side effects, although not everyone will experience them. Most reactions are mild and localised to the skin.

Common side effects:

  • Mild skin dryness or tightness after use
  • Redness or irritation at the application site
  • Temporary stinging sensation, particularly on broken or sensitive skin

Less common side effects:

  • Contact dermatitis — an allergic skin reaction causing itching, blistering, or a rash
  • Skin discolouration with prolonged or repeated use
  • Hypersensitivity reactions, including urticaria (hives)

Serious allergic reactions (anaphylaxis) to chlorhexidine have been reported, though they are rare. If you experience swelling of the face, throat, or tongue, difficulty breathing, or a sudden drop in blood pressure after use, call 999 immediately. The NHS advises that any suspected anaphylaxis requires emergency medical treatment.

 

How Should You Store Hydrex Surgical Scrub?

 

Correct storage helps maintain the product's effectiveness and safety. Follow these guidelines:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Store in the original container with the cap tightly closed
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the label
  • Do not dispose of via wastewater or household waste — return unused product to your pharmacy

For more information on safe storage of medicines and antiseptic products, visit the NHS website or speak to your pharmacist. If you need additional pain relief or wound care products to complement your recovery, browse our full range at Cured Pharmacy.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Hydrex Surgical Scrub 250ml online in the UK?

You can buy Hydrex Surgical Scrub 250ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is available without a prescription and can be ordered for home delivery. Browse our first aid collection for related products.

How does Hydrex Surgical Scrub work in the body?

Hydrex Surgical Scrub contains 4% chlorhexidine gluconate, which binds to bacterial cell membranes and disrupts their structure, causing cell death. It works against a broad range of gram-positive and gram-negative bacteria. Importantly, it also provides residual antimicrobial activity on the skin surface for several hours after rinsing.

How do I use Hydrex Surgical Scrub step by step?

Wet the skin thoroughly, apply the scrub, and lather for at least two minutes before rinsing well with water. Avoid contact with eyes, ears, and mucous membranes throughout the process. If you are using it as part of a pre-operative protocol, follow the specific instructions given by your surgical team.

What is the correct amount of Hydrex Surgical Scrub to use?

Use enough product to create a thorough lather over the entire area being cleansed — typically a few millilitres for hand scrubbing or a larger amount for body site preparation. There is no fixed dose in millilitres for topical use; the key is adequate coverage and contact time. Follow your healthcare professional's instructions if you have been given specific guidance.

Is Hydrex Surgical Scrub safe for sensitive skin?

People with sensitive skin or a known history of reactions to chlorhexidine should exercise caution and consult a pharmacist or GP before use. Mild dryness or irritation can occur even in those without a formal allergy. If you notice significant redness, itching, or a rash, discontinue use and seek advice.

Can Hydrex Surgical Scrub be used on children?

Hydrex Surgical Scrub is primarily intended for adult use in clinical or pre-operative settings. Use in children, particularly neonates, should only take place under direct medical supervision. If you are looking for antiseptic products suitable for younger patients, speak to your GP or paediatric nurse for guidance.

What are the side effects of Hydrex Surgical Scrub?

The most common side effects are mild skin dryness, redness, or a temporary stinging sensation at the application site. Less commonly, contact dermatitis or hypersensitivity reactions may occur. Rarely, serious allergic reactions including anaphylaxis have been reported — if you experience swelling, difficulty breathing, or hives, seek emergency medical help immediately.

Can I use Hydrex Surgical Scrub near my eyes or ears?

No — you must not allow Hydrex Surgical Scrub to come into contact with your eyes, ears, or mucous membranes. Chlorhexidine is ototoxic, meaning even small amounts entering the ear canal can cause permanent hearing damage. If accidental eye contact occurs, rinse immediately and thoroughly with clean water.

How does Hydrex Surgical Scrub compare to regular antiseptic soap?

Unlike standard antiseptic soaps, Hydrex Surgical Scrub contains 4% chlorhexidine gluconate, which provides residual antimicrobial activity lasting several hours after application — something most regular soaps cannot offer. It also covers a broader spectrum of bacteria, making it more appropriate for surgical and clinical settings. Regular antiseptic soaps are generally suitable for everyday hygiene rather than pre-operative preparation.

What are alternatives to Hydrex Surgical Scrub?

Alternatives include other chlorhexidine-based surgical scrubs such as Hibiscrub (also 4% chlorhexidine gluconate), or povidone-iodine-based preparations for patients with chlorhexidine hypersensitivity. The choice of alternative should be guided by your healthcare professional based on your specific clinical needs and any known allergies. You can explore our skin care range for related topical products.

How long does Hydrex Surgical Scrub remain effective after application?

Chlorhexidine gluconate binds to skin proteins and continues to exert antimicrobial activity for several hours after rinsing — this is known as residual or substantive activity. The exact duration can vary depending on the area of skin, subsequent contact with water, and individual skin characteristics. This residual effect is one of the key reasons it is preferred in surgical settings over plain soap.

Can I use Hydrex Surgical Scrub before a minor procedure at home?

If your GP or surgical team has specifically instructed you to cleanse your skin before a planned procedure, Hydrex Surgical Scrub may be appropriate for that purpose. Always follow the exact instructions provided by your healthcare team regarding timing, technique, and the area to be cleansed. Do not use it as a general daily cleanser without clinical guidance.

Is Hydrex Surgical Scrub the same as Hibiscrub?

Both Hydrex Surgical Scrub and Hibiscrub contain 4% chlorhexidine gluconate as their active ingredient and are used for similar indications including surgical hand scrubbing and pre-operative skin preparation. They are different branded products but share the same active ingredient and concentration. Your healthcare provider may specify one over the other based on local formulary preferences.

What are the latest studies on chlorhexidine surgical scrubs?

Clinical evidence consistently supports chlorhexidine gluconate as an effective agent for reducing surgical site infections when used for pre-operative skin preparation. Studies published in peer-reviewed journals have found chlorhexidine-alcohol preparations to be more effective than povidone-iodine for certain surgical sites. NHS infection prevention guidelines continue to recommend chlorhexidine-based products as a first-line option for surgical skin preparation.

How should I store Hydrex Surgical Scrub to keep it effective?

Store Hydrex Surgical Scrub below 25°C in a cool, dry place away from direct sunlight and heat sources. Keep the bottle tightly closed in its original container and out of reach of children. Do not use the product after its expiry date, and return any unused product to your pharmacy for safe disposal rather than pouring it down the drain.

How Should You Use Hydrex Surgical Scrub?

Hydrex Surgical Scrub is for external use only. Always apply to wet skin and avoid contact with eyes, ears, and mucous membranes. If you have been given specific instructions by your surgical team or healthcare professional, follow those instructions precisely rather than the general guidance below.

What Is the Correct Dose of Hydrex Surgical Scrub?

There is no fixed millilitre dose for topical antiseptic scrubs — the amount used should be sufficient to create a thorough lather over the entire area being treated. The table below provides general guidance based on indication and age group. Always defer to your healthcare professional's instructions if they differ from the below.

When Is the Best Time to Use Hydrex Surgical Scrub?

For pre-operative skin preparation, your surgical team will advise you on the exact timing — this is often the night before and/or the morning of your procedure. For surgical hand scrubbing in clinical settings, the scrub should be performed immediately before each procedure begins. Do not apply moisturisers or other skin products to the area after scrubbing, as these may reduce the residual antimicrobial effect.

If you are using this product for general antiseptic cleansing under medical guidance, apply it at the time recommended by your healthcare professional. Timing matters — applying too early before a procedure may reduce the residual protective effect on the skin.

How Long Can You Use Hydrex Surgical Scrub For?

Hydrex Surgical Scrub is intended for short-term, targeted use rather than prolonged daily application. Repeated or extended use without clinical indication may increase the risk of skin dryness, irritation, or contact dermatitis. If you have been prescribed a course of pre-operative washes, follow the duration specified by your surgical team — typically one to three days before a planned procedure.

If you find you need to use an antiseptic cleanser on a longer-term basis for wound management or infection prevention, speak to your GP or pharmacist to ensure this product remains appropriate for your needs. Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Hydrex Surgical Scrub?

Most people who use Hydrex Surgical Scrub tolerate it well, particularly when it is used correctly and for the intended purpose. However, as with any topical antiseptic, some people may experience mild reactions at the application site.

  • Skin dryness or tightness after use
  • Mild redness or erythema at the application site
  • Temporary stinging or burning sensation, particularly on broken or sensitive skin
  • Skin flaking with repeated use

These effects are generally mild and resolve on their own once you stop using the product or reduce the frequency of application.

What Are the Less Common Side Effects of Hydrex Surgical Scrub?

Less commonly, some individuals may develop more noticeable skin reactions. These are more likely in people with a history of skin sensitivity or previous reactions to antiseptic products.

  • Contact dermatitis — presenting as itching, blistering, or a spreading rash
  • Urticaria (hives) — raised, itchy welts on the skin
  • Skin discolouration with prolonged or repeated use in the same area
  • Photosensitivity — increased sensitivity to sunlight in treated areas

If you notice any of these reactions, stop using the product and consult your pharmacist or GP. Do not continue using it in the hope that the reaction will settle on its own.

What Are the Serious Side Effects of Hydrex Surgical Scrub?

Serious adverse reactions to chlorhexidine gluconate are rare but have been documented. Anaphylaxis — a severe, life-threatening allergic reaction — has been reported following exposure to chlorhexidine, including topical use. Symptoms of anaphylaxis include sudden swelling of the face, lips, or throat, difficulty breathing, a rapid or weak pulse, dizziness, and loss of consciousness.

Chlorhexidine is also ototoxic. If the product accidentally enters the ear canal, it can cause irreversible hearing damage. This is a serious risk and is why the product must never be used near the ears or in any situation where it could enter the ear canal.

What Should You Do If You Experience Side Effects?

If you develop mild skin irritation, stop using the product and allow the skin to recover. Applying a gentle, fragrance-free moisturiser may help soothe dryness. If the irritation persists for more than 48 hours or worsens, seek advice from your pharmacist or GP.

For any signs of a serious allergic reaction or anaphylaxis, call 999 immediately. Do not wait to see if symptoms improve. If you have previously experienced a reaction to chlorhexidine, inform your healthcare team before any procedure where antiseptic skin preparation is planned, so an alternative can be used.

Can Hydrex Surgical Scrub Interact With Other Medicines?

Because Hydrex Surgical Scrub is applied topically and is not absorbed systemically in significant amounts, clinically meaningful drug interactions are not expected. However, you should avoid using it at the same time as anionic surfactants — found in some soaps and cleansers — as these can reduce the effectiveness of chlorhexidine. Similarly, do not apply iodine-based antiseptics to the same skin area simultaneously, as this may cause a chemical interaction and skin staining.

Always inform your healthcare professional of all products you are using on your skin, particularly if you are undergoing a surgical procedure. If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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