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DIFFLAM 3mg Lozenges - Lemon Flavour (20)

DIFFLAM 3mg Lozenges - Lemon Flavour (20)

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  • ✔️ Relieves sore throat pain and inflammation locally
  • ✔️ Benzydamine HCl targets throat discomfort directly
  • ✔️ Suitable for adults and children aged 6 and over
  • ✔️ Convenient lemon-flavoured lozenge — no water needed
  • ✔️ Pack of 20 lozenges for multi-day symptom relief

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Are Difflam Lozenges Good for Sore Throat Relief?

 

A sore throat can make even swallowing feel like a chore. Whether it's come on with a cold, followed a bout of tonsillitis, or appeared after a dental procedure, the discomfort is hard to ignore. Difflam lozenges sore throat relief is exactly what this product is designed to deliver — each lemon-flavoured lozenge contains 3mg of benzydamine hydrochloride, a locally acting anti-inflammatory that gets to work right where it hurts. You'll find this and similar products in our Ear, Nose & Throat range at Cured Pharmacy.

Difflam has been a trusted name in throat care for decades. The lemon flavour makes the experience more pleasant, which matters when you're already feeling rough. Each pack contains 20 lozenges, giving you a solid supply to see you through the worst of it.

 

How Do Difflam 3mg Lozenges Work in the Body?

 

Benzydamine hydrochloride is a non-steroidal anti-inflammatory drug (NSAID) that acts locally rather than being absorbed systemically in significant amounts. When you allow the lozenge to dissolve slowly in your mouth, the active ingredient coats the mucous membranes of the throat and mouth, targeting inflammation directly at the source.

  • Inhibits the production of prostaglandins — chemicals that trigger pain and swelling in inflamed tissue
  • Produces a mild local anaesthetic effect, temporarily numbing the area and reducing the sensation of pain
  • Maintains contact with the throat lining as the lozenge dissolves, prolonging the therapeutic effect
  • Does not require systemic absorption to be effective, reducing the risk of whole-body side effects

The result is targeted, localised relief that kicks in relatively quickly — usually within 15 to 30 minutes of the lozenge dissolving.

 

Who Is Difflam 3mg Lemon Lozenge Suitable For?

 

These lozenges are suitable for a wide range of people dealing with throat and mouth discomfort. They're particularly useful when the pain is localised and you want relief without reaching for a systemic painkiller like ibuprofen or paracetamol.

  • Adults and teenagers aged 12 and over with a sore throat caused by infection, irritation, or inflammation
  • Children aged 6 to 11 years, at a reduced dose and under adult supervision
  • People recovering from minor dental procedures or mouth ulcers causing throat discomfort
  • Those who prefer a localised treatment rather than a tablet or liquid medicine

They are not suitable for children under 6 years of age. If you have a known allergy to benzydamine or other NSAIDs such as aspirin or ibuprofen, you should avoid this product.

 

How Do Difflam Lozenges Compare to Other Sore Throat Remedies?

 

Feature Difflam 3mg Lozenges Standard Anaesthetic Lozenges (e.g. Strepsils Intensive)
Active ingredient Benzydamine HCl 3mg (NSAID) Flurbiprofen 8.75mg (NSAID)
Mechanism Local anti-inflammatory + mild anaesthetic Local anti-inflammatory
Suitable age 6 years and over 12 years and over
Flavour Lemon Various

 

How Should You Store Difflam 3mg Lozenges?

 

Store your Difflam lozenges below 25°C in a dry place, away from direct sunlight. Keep them out of reach and sight of children at all times — the lemon flavour can make them appealing to young children who might mistake them for sweets. Do not use the lozenges after the expiry date printed on the packaging.

If you're managing multiple symptoms alongside a sore throat — such as nasal congestion or a cough — you might also want to explore our Cold and Flu collection for complementary remedies. Difflam lozenges sore throat relief works best as part of a broader approach to symptom management during illness.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

DIFFLAM 3mg Lozenges - Lemon Flavour (20) specifications
Treatment category Sore throat and mouth pain relief
Active ingredient Benzydamine hydrochloride 3mg
Mechanism of action Local NSAID — inhibits prostaglandin synthesis; mild local anaesthetic effect
Suitable for Adults and children aged 6 years and over
Pack size 20 lozenges
Strength 3mg benzydamine hydrochloride per lozenge
UK classification General Sale List (GSL)
Drug class Non-steroidal anti-inflammatory drug (NSAID)
Preparation Lozenge
Route of administration Oral (buccal dissolution)
Flavour Lemon

Specifications of DIFFLAM 3mg Lozenges - Lemon Flavour (20)

 

What Is Difflam 3mg Lemon Lozenge and What Is It Used For?

 

Difflam 3mg Lozenges in lemon flavour are an over-the-counter medicine used to relieve pain and inflammation in the mouth and throat. The active ingredient, benzydamine hydrochloride, belongs to the NSAID class of medicines. It is used to treat sore throats associated with conditions such as pharyngitis, tonsillitis, and mouth ulcers, as well as discomfort following dental procedures or minor oral surgery. The NHS recognises benzydamine as an effective localised treatment for oropharyngeal pain.

Each lozenge is designed to dissolve slowly in the mouth, releasing the active ingredient gradually to coat the affected area. This makes it particularly convenient — no water needed, and the lemon flavour helps mask the slight numbing sensation that benzydamine can produce.

 

What Do You Need to Know Before Using Difflam Lozenges?

 

Before using these lozenges, read the following carefully. Some people should not use this product, and others may need to take extra care.

Do not use Difflam 3mg lozenges if you:

  • Are allergic to benzydamine hydrochloride or any other ingredient in the lozenge
  • Have a known hypersensitivity to aspirin or other NSAIDs (e.g. ibuprofen)
  • Are under 6 years of age
  • Have been told by a doctor to avoid NSAIDs

Take extra care and speak to your pharmacist or GP if you:

  • Are pregnant or breastfeeding — NSAID use in pregnancy, especially in the third trimester, is generally not recommended by the NHS
  • Have asthma, as some people with asthma are sensitive to NSAIDs
  • Have a history of peptic ulcers or gastrointestinal problems (though systemic absorption is minimal with lozenges)
  • Are taking other NSAID-containing medicines concurrently

Known drug interactions:

  • No clinically significant interactions are expected at OTC lozenge doses due to minimal systemic absorption
  • If you are taking anticoagulants (blood thinners) or other NSAIDs, consult your pharmacist before use

 

How Should You Use Difflam 3mg Lozenges Correctly?

 

Using these lozenges correctly ensures you get the most benefit while minimising any risk of side effects. Follow these steps carefully.

  1. Place one lozenge in your mouth
  2. Allow it to dissolve slowly — do not chew or swallow it whole
  3. Let the dissolved liquid coat the back of your throat as naturally as possible
  4. Wait at least 2 to 3 hours before taking the next lozenge
  5. Do not exceed the maximum daily dose for your age group
Age Group Dose Frequency Maximum Daily Dose
Adults & children 12+ 1 lozenge Every 2–3 hours 8 lozenges per 24 hours
Children aged 6–11 1 lozenge Every 3 hours 6 lozenges per 24 hours
Children under 6 Not suitable — do not use

If symptoms persist beyond 3 days or worsen at any point, stop using the lozenges and consult your GP. You can also browse our Pain Relief collection if you need additional support for associated discomfort such as headache or body aches during illness.

 

What Are the Possible Side Effects of Difflam Lozenges?

 

Like all medicines, Difflam lozenges can cause side effects, although not everyone experiences them. Most side effects are mild and localised.

Common side effects:

  • Temporary numbness or tingling sensation in the mouth or throat
  • Mild oral irritation at the site of dissolution

Less common side effects:

  • Nausea
  • Dry mouth
  • Altered taste sensation
  • Mild burning sensation in the mouth

Rarely, benzydamine can cause hypersensitivity reactions. If you notice swelling of the face, lips, or throat, difficulty breathing, or a skin rash after using this product, stop immediately and seek urgent medical attention. This could indicate a serious allergic reaction (anaphylaxis).

 

How Should You Store Difflam 3mg Lozenges Safely?

 

Correct storage keeps the lozenges effective and safe for the duration of their shelf life. If you're also managing other medicines at home, our First Aid collection includes useful storage and home health essentials.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and moisture
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the pack
  • Do not store in a bathroom cabinet where humidity may affect the lozenges
  • Dispose of unused medicines responsibly — return to your local pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Difflam lozenges for sore throat online in the UK?

You can buy Difflam 3mg Lemon Lozenges directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, without a prescription. Simply add the pack of 20 to your basket and select your preferred delivery option at checkout. No GP visit is required as this is a General Sale List medicine.

How do Difflam 3mg lozenges work for a sore throat?

Difflam lozenges contain benzydamine hydrochloride, an NSAID that acts locally in the mouth and throat to reduce inflammation and block pain signals. As the lozenge dissolves, it coats the throat lining directly, providing targeted relief without significant systemic absorption. The mild local anaesthetic effect also helps to temporarily numb the area, easing the discomfort of swallowing.

How do I use Difflam 3mg lozenges step by step?

Using Difflam lozenges correctly is straightforward:

  1. Place one lozenge in your mouth
  2. Allow it to dissolve slowly — do not chew
  3. Repeat every 2 to 3 hours as needed
  4. Do not exceed 8 lozenges in 24 hours (adults and children 12+)

No water is needed, making them convenient to use anywhere.

What is the correct dose of Difflam lozenges for adults?

Adults and young people aged 12 and over should dissolve one lozenge in the mouth every 2 to 3 hours, up to a maximum of 8 lozenges in any 24-hour period. Do not exceed this dose. If your symptoms are not improving after 3 days, speak to your pharmacist or GP.

Can children use Difflam 3mg lozenges?

Yes, children aged 6 to 11 years can use Difflam 3mg lozenges at a reduced dose of one lozenge every 3 hours, up to a maximum of 6 lozenges per day. Children under 6 years of age must not use this product. Always supervise children when using lozenges to prevent choking.

What are the side effects of Difflam lozenges?

Most people tolerate Difflam lozenges well. The most commonly reported side effects include:

  • Temporary numbness or tingling in the mouth
  • Mild oral irritation
  • Nausea (less common)

If you experience swelling, difficulty breathing, or a rash, stop use immediately and seek urgent medical attention as this may indicate an allergic reaction.

Are Difflam lozenges safe to use during pregnancy?

If you are pregnant or breastfeeding, you should consult your doctor or pharmacist before using Difflam lozenges. Benzydamine is an NSAID, and NSAID use during pregnancy — particularly in the third trimester — is generally not recommended by the NHS. Your healthcare provider can advise on the safest alternative for managing throat pain during pregnancy.

How long can you use Difflam lozenges for?

Difflam lozenges are intended for short-term use only. If your symptoms have not improved within 3 days, or if they worsen at any point, you should stop using the lozenges and seek advice from your GP or pharmacist. Prolonged use without medical supervision is not recommended.

What happens if I accidentally take too many Difflam lozenges?

If you or someone else takes more than the recommended number of lozenges, contact NHS 111 or your nearest A&E department for advice. Take the packaging with you so healthcare professionals can see exactly what has been taken. Overdose with lozenges at OTC doses is unlikely to cause serious harm, but it is always better to seek guidance promptly.

What are the alternatives to Difflam lozenges for a sore throat?

There are several alternatives available for sore throat relief, including flurbiprofen lozenges (e.g. Strepsils Intensive), lidocaine-based sprays, and simple honey and lemon remedies for mild discomfort. You can explore a wider range of options in our Ear, Nose & Throat collection. The right choice depends on your age, medical history, and the severity of your symptoms.

Can I use Difflam lozenges alongside paracetamol or ibuprofen?

Because benzydamine in Difflam lozenges acts locally with minimal systemic absorption, it is generally considered safe to use alongside paracetamol for additional pain relief. However, combining Difflam lozenges with oral ibuprofen means you are taking two NSAIDs simultaneously, which is not recommended without medical advice. Always check with your pharmacist if you are unsure.

Do Difflam lozenges help with mouth ulcers?

Yes, benzydamine hydrochloride is also used to relieve pain associated with mouth ulcers and minor oral inflammation. The lozenge dissolves in the mouth and the active ingredient coats the affected mucous membranes, reducing localised pain and swelling. For broader oral health support, visit our Oral Health collection.

Are Difflam lozenges suitable for people with asthma?

Some people with asthma are sensitive to NSAIDs, including benzydamine, and may experience worsening of symptoms. If you have asthma and have previously reacted to aspirin or ibuprofen, you should not use Difflam lozenges without first speaking to your GP or pharmacist. If you have asthma but have never had an NSAID reaction, it is still advisable to seek professional guidance before use.

What is the best time to use Difflam lozenges?

You can use Difflam lozenges at any time of day when throat pain is present, spacing doses at least 2 to 3 hours apart. Many people find them particularly helpful before meals, as swallowing food can be especially painful with a sore throat. Using one before bed may also help ease overnight discomfort, though you should not exceed the maximum daily dose.

What does the latest research say about benzydamine for sore throat?

Benzydamine hydrochloride has been used clinically for several decades and is well-established in the management of oropharyngeal pain. Published clinical literature supports its efficacy as a locally acting anti-inflammatory and mild anaesthetic for sore throat and mouth conditions. It remains a recommended option in UK pharmacy practice for short-term symptomatic relief of throat pain, as reflected in BNF guidance on oropharyngeal preparations.

How Should You Use Difflam 3mg Lemon Lozenges?

Difflam 3mg Lemon Lozenges are designed to be dissolved slowly in the mouth — not chewed or swallowed whole. Allowing the lozenge to dissolve naturally ensures the active ingredient, benzydamine hydrochloride, coats the throat and mouth lining effectively, delivering localised relief where it is needed most.

Follow these steps each time you use a lozenge:

What Is the Correct Dose of Difflam 3mg Lozenges?

Always use the lowest effective dose for the shortest time necessary. The table below summarises the recommended doses by age group. Never exceed the stated maximum daily dose.

When Is the Best Time to Use Difflam Lozenges?

You can use Difflam lozenges at any point during the day when throat or mouth pain is present, provided you space doses at least 2 to 3 hours apart. Many people find it helpful to take a lozenge approximately 15 to 20 minutes before a meal, as this can ease the discomfort of swallowing food when the throat is inflamed.

Taking a lozenge before bed may also help reduce overnight throat discomfort, though you should always ensure you remain within the maximum daily dose. Do not use more lozenges than recommended in an attempt to speed up recovery.

How Long Can You Use Difflam Lozenges For?

Difflam lozenges are intended for short-term use only and should not be used continuously for more than 3 days without medical advice. If your sore throat or mouth pain has not improved after 3 days, or if symptoms worsen or are accompanied by a high fever, difficulty breathing, or a severe rash, stop using the lozenges and consult your GP promptly.

Prolonged use beyond the recommended period without professional guidance is not advisable. If you find yourself needing throat relief regularly, speak to your pharmacist or doctor to rule out an underlying condition that may require a different treatment approach.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Difflam Lozenges?

Most people who use Difflam 3mg Lemon Lozenges do not experience significant side effects. Because benzydamine hydrochloride acts locally in the mouth and throat with minimal systemic absorption, the side effects that do occur tend to be mild and confined to the oral cavity.

  • Temporary numbness or tingling sensation in the mouth or throat
  • Mild burning or stinging at the site of dissolution
  • Mild oral irritation

These effects are generally short-lived and resolve once the lozenge has fully dissolved and the medicine disperses. They are a known pharmacological effect of benzydamine rather than a sign that something is wrong.

What Are the Less Common Side Effects of Difflam Lozenges?

A smaller number of people may experience side effects that are less frequently reported. These are still generally mild but worth being aware of before you start using the product.

  • Nausea
  • Dry mouth
  • Altered or unusual taste sensation
  • Headache

If any of these side effects persist or become bothersome, stop using the lozenges and speak to your pharmacist. In most cases, these effects resolve quickly once use is discontinued.

What Are the Serious Side Effects of Difflam Lozenges?

Serious side effects with Difflam lozenges are rare but can occur, particularly in people with a known sensitivity to NSAIDs. The most significant concern is a hypersensitivity or allergic reaction. Symptoms to watch for include:

  • Swelling of the face, lips, tongue, or throat (angioedema)
  • Difficulty breathing or swallowing
  • Skin rash, hives, or itching
  • Sudden drop in blood pressure or feeling faint

If you experience any of these symptoms, stop using the lozenges immediately and call 999 or go to your nearest A&E. This may indicate anaphylaxis, which is a medical emergency.

What Should You Do If You Experience Side Effects from Difflam Lozenges?

For mild side effects such as tingling or nausea, simply stopping use is usually sufficient. If you are concerned about a side effect or it does not resolve, contact your pharmacist or GP for advice. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk — this helps improve medicine safety for everyone.

Never ignore a side effect that feels unusual or severe. Your pharmacist is always a good first point of contact for reassurance and guidance on whether to continue or stop treatment.

Can Difflam Lozenges Interact With Other Medicines?

Because benzydamine hydrochloride in Difflam lozenges is absorbed locally with minimal entry into the bloodstream, clinically significant drug interactions at OTC doses are not expected. However, caution is advised if you are already taking oral NSAIDs such as ibuprofen or naproxen, as combining two NSAID-containing products is generally not recommended without medical advice. If you are taking anticoagulants (blood thinners) such as warfarin, speak to your pharmacist before use as a precaution.

Always tell your pharmacist about all medicines you are currently taking, including herbal remedies and supplements, before starting any new treatment.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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