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Cialis (Tadalafil)

Cialis (Tadalafil)

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  • ✔️ Treats erectile dysfunction with effects lasting up to 36 hours
  • ✔️ Works within 30–60 minutes of taking a single tablet
  • ✔️ Available as on-demand or daily low-dose regimen
  • ✔️ Suitable for men with diabetes or cardiovascular risk factors
  • ✔️ Less affected by food than other ED tablets

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Want to Buy Cialis Online UK?

 

Erectile dysfunction (ED) is more common than many people realise. According to the NHS, it affects around half of all men between the ages of 40 and 70 at some point in their lives. If you're looking to buy Cialis online UK, you're certainly not alone — and the good news is that effective, clinically proven treatment is available. Cialis contains the active ingredient tadalafil, a medicine that belongs to a class of drugs called PDE5 inhibitors. It's one of the most widely prescribed ED treatments in the UK, and for good reason. You can also explore our men's health range for additional support products.

Cialis is available in tablet form and comes in 5mg, 10mg, and 20mg strengths. The 10mg and 20mg doses are typically used on demand — meaning you take one tablet before anticipated sexual activity. The 5mg dose is sometimes prescribed for daily use. At Cured Pharmacy, we make the process straightforward, discreet, and clinically safe.

 

How Does Cialis (Tadalafil) Work?

 

Tadalafil works by relaxing the smooth muscle in the walls of blood vessels, particularly in the penis. This allows more blood to flow into the erectile tissue when you're sexually stimulated. It doesn't cause an erection on its own — sexual arousal is still needed. Here's a simplified breakdown of the mechanism:

  • Sexual stimulation triggers the release of nitric oxide in the erectile tissue.
  • Nitric oxide activates an enzyme that produces cyclic GMP (cGMP).
  • cGMP relaxes smooth muscle and increases blood flow to the penis.
  • Tadalafil inhibits PDE5, the enzyme that breaks down cGMP, prolonging the effect.
  • The result is a firmer, more sustained erection during sexual activity.

One of the things that sets tadalafil apart from other ED medicines is its duration of action — it can remain effective for up to 36 hours, earning it the nickname "the weekend pill."

 

Who Is Suitable for Cialis (Tadalafil)?

 

Cialis is licensed for use in adult men with erectile dysfunction. It may also be prescribed for benign prostatic hyperplasia (BPH) — an enlarged prostate — in some cases. It's suitable for a broad range of men, but a clinical assessment is always required before prescribing. You might be a good candidate if:

  • You're an adult male experiencing difficulty achieving or maintaining an erection.
  • Your ED has a physical cause, such as cardiovascular disease or diabetes.
  • Your ED has a psychological component and you want a reliable, longer-acting option.
  • You've tried other PDE5 inhibitors and found them less convenient due to their shorter window of action.

It is not suitable for women or children, and it must not be taken by men who use nitrate medicines for chest pain or heart conditions.

 

How Does Cialis Compare to Other ED Treatments?

 

Feature Cialis (Tadalafil) Viagra (Sildenafil)
Active ingredient Tadalafil Sildenafil
Duration of action Up to 36 hours 4–6 hours
Available doses 5mg, 10mg, 20mg 25mg, 50mg, 100mg
Daily use option Yes (5mg daily) No
Food interaction Minimal High-fat meals may delay effect

 

Is Cialis (Tadalafil) Clinically Proven and How Should It Be Stored?

 

Yes. Tadalafil has been extensively studied in clinical trials and is approved by the MHRA for use in the UK. When you buy Cialis online UK through a registered pharmacy, you can be confident you're receiving a genuine, licensed medicine. Store your tablets below 25°C in a dry place, away from direct sunlight. Keep them out of reach of children and do not use them after the expiry date printed on the packaging. If you're managing other health conditions alongside ED, it's worth browsing our condoms and sexual health collection for complementary products.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Cialis (Tadalafil) specifications
Treatment category Erectile dysfunction / Benign prostatic hyperplasia
Active ingredient Tadalafil
Mechanism of action PDE5 inhibitor — increases blood flow to the penis
Strengths 5mg, 10mg, 20mg
Pack sizes 4, 8, 12, 28 tablets (varies by strength)
Suitable for Adult men aged 18 and over
UK classification Prescription Only Medicine (POM)
Drug class PDE5 inhibitor
Preparation Film-coated tablet
Route of administration Oral
Effective Within 30–60 minutes; lasts up to 36 hours

Specifications of Cialis (Tadalafil)

 

What Is Cialis (Tadalafil) and What Is It Used For?

 

Cialis contains tadalafil, a PDE5 inhibitor licensed in the UK for the treatment of erectile dysfunction in adult men. Erectile dysfunction is defined as the persistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It can have physical causes — such as diabetes, high blood pressure, or cardiovascular disease — or psychological ones, including stress and anxiety. Tadalafil tablets online are also sometimes prescribed for the symptoms of benign prostatic hyperplasia (BPH), such as difficulty urinating. It is a prescription-only medicine in the UK.

 

What Do You Need to Know Before Using Cialis (Tadalafil)?

 

Before starting tadalafil, it's essential to tell your prescriber about all medicines you currently take and any health conditions you have. This medicine is not suitable for everyone.

Do not take Cialis if you:

  • Take nitrates (e.g. glyceryl trinitrate) for chest pain or heart conditions — this combination can cause a dangerous drop in blood pressure.
  • Have had a recent stroke or heart attack (within the last 90 days).
  • Have severe liver or kidney disease.
  • Have low blood pressure (hypotension) or uncontrolled high blood pressure.
  • Have been advised by a doctor to avoid sexual activity for cardiac reasons.
  • Are allergic to tadalafil or any other ingredient in the tablet.
  • Are under 18 years of age.

Known drug interactions — tell your prescriber if you take:

  • Alpha-blockers (e.g. tamsulosin, doxazosin) — may cause blood pressure to drop significantly.
  • Antifungals such as ketoconazole or itraconazole — may increase tadalafil levels in the blood.
  • HIV protease inhibitors (e.g. ritonavir) — may significantly increase tadalafil exposure.
  • Rifampicin or other CYP3A4 inducers — may reduce the effectiveness of tadalafil.
  • Other PDE5 inhibitors — do not combine with sildenafil or vardenafil.

 

How Should You Use Cialis (Tadalafil) Correctly?

 

Always use Cialis exactly as your prescriber has told you. Do not adjust your dose without speaking to a healthcare professional first. Here are the general steps for on-demand use:

  1. Take one tablet by mouth, swallowed whole with a glass of water.
  2. Take it at least 30 minutes before anticipated sexual activity.
  3. Do not take more than one tablet in any 24-hour period.
  4. Sexual stimulation is required for the medicine to work — it will not cause an automatic erection.
  5. If you are prescribed the 5mg daily dose, take it at the same time each day regardless of planned sexual activity.
Indication Age Group Dose Frequency
Erectile dysfunction (on demand) Adult men (18+) 10mg (may adjust to 5mg or 20mg) As needed, max once per 24 hours
Erectile dysfunction (daily) Adult men (18+) 5mg Once daily at the same time
Benign prostatic hyperplasia Adult men (18+) 5mg Once daily

 

What Are the Possible Side Effects of Cialis (Tadalafil)?

 

Like all medicines, tadalafil can cause side effects, although not everyone experiences them. Most side effects are mild and tend to resolve on their own. If you experience any severe or persistent symptoms, stop taking the medicine and seek medical advice promptly. You can also find general health support through our pain relief range if you experience mild headaches or muscle aches.

Common side effects (may affect up to 1 in 10 people):

  • Headache
  • Flushing (redness or warmth in the face, neck, or chest)
  • Indigestion or stomach discomfort
  • Back pain
  • Nasal congestion
  • Muscle aches

Less common side effects (may affect up to 1 in 100 people):

  • Dizziness
  • Blurred vision
  • Increased heart rate (tachycardia)
  • Swelling of the eyelids
  • Eye pain or redness
  • Prolonged erection lasting more than 4 hours (priapism) — seek emergency medical help immediately if this occurs
  • Sudden decrease or loss of vision or hearing — stop taking the medicine and seek urgent medical attention

 

How Should You Store Cialis (Tadalafil)?

 

Correct storage helps maintain the quality and safety of your medicine. Follow these guidelines:

  • Store below 25°C in a cool, dry place.
  • Keep away from direct sunlight and moisture.
  • Keep out of the sight and reach of children.
  • Do not use after the expiry date printed on the packaging.
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy for safe disposal.

If you're managing your overall wellbeing alongside ED treatment, our vitamins and supplements collection may offer useful complementary support.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Cialis online in the UK?

You can buy Cialis online in the UK through a GPhC-registered online pharmacy such as Cured Pharmacy. A valid prescription or an approved online consultation is required before the medicine can be dispensed. This ensures your safety and that the treatment is appropriate for you. Browse our men's health collection for more information on available treatments.

How does Cialis (Tadalafil) work in the body?

Tadalafil inhibits the enzyme PDE5, which normally breaks down a chemical called cGMP in the erectile tissue of the penis. By blocking PDE5, tadalafil allows cGMP to accumulate, which relaxes smooth muscle and increases blood flow during sexual stimulation. This process helps you achieve and maintain an erection. It does not work without sexual arousal.

How long does Cialis last compared to other ED tablets?

Cialis can remain effective for up to 36 hours after a single dose, which is considerably longer than sildenafil (Viagra), which typically lasts 4 to 6 hours. This extended window gives you more flexibility and spontaneity. It's one of the reasons many men prefer tadalafil for on-demand use.

What is the correct dose of Cialis for erectile dysfunction?

The standard starting dose for on-demand use is 10mg, taken at least 30 minutes before sexual activity. Your prescriber may increase this to 20mg or reduce it to 5mg depending on how well it works for you and whether you experience side effects. For daily use, the recommended dose is 5mg taken at the same time each day.

What is the best time to take Cialis?

For on-demand use, take Cialis at least 30 minutes before you plan to have sex — though some men find it works best when taken an hour beforehand. Unlike sildenafil, tadalafil is not significantly affected by food, so you can take it with or without a meal. If you're on the daily 5mg dose, take it at the same time every day to maintain consistent levels in your body.

What are the most common side effects of Cialis?

The most commonly reported side effects of tadalafil include headache, flushing, indigestion, back pain, nasal congestion, and muscle aches. These are usually mild and tend to pass within a few hours. If any side effect is severe or persistent, contact your GP or pharmacist for advice.

How do I manage side effects of Cialis?

Most side effects of tadalafil are mild and self-limiting. Staying well hydrated can help with headaches, and taking the tablet with food may reduce indigestion. If back pain or muscle aches are bothersome, over-the-counter pain relief may help — see our pain relief range for options. Always speak to your pharmacist before combining any medicines.

Who cannot take Cialis (Tadalafil)?

Cialis is contraindicated in men who take nitrate medicines for chest pain or heart conditions, as the combination can cause a severe and potentially life-threatening drop in blood pressure. It is also not suitable for men with severe liver disease, recent stroke or heart attack, or uncontrolled low blood pressure. Women and anyone under 18 should not take this medicine.

Can I take Cialis with alcohol?

Drinking moderate amounts of alcohol is generally considered acceptable when taking tadalafil, but excessive alcohol can increase the risk of side effects such as dizziness, low blood pressure, and headache. It can also make it harder to achieve an erection, which counteracts the purpose of the medicine. It's sensible to keep alcohol intake low when using Cialis.

What happens if I miss a dose of Cialis?

If you are taking Cialis on demand, there is no scheduled dose to miss — you simply take it when needed. If you are on the daily 5mg regimen and forget a dose, take it as soon as you remember unless it is almost time for your next dose, in which case skip the missed one. Never take two doses at the same time to make up for a missed one.

How is Cialis different from Viagra (Sildenafil)?

Both Cialis and Viagra are PDE5 inhibitors used to treat erectile dysfunction, but they differ in several important ways. Tadalafil lasts up to 36 hours, while sildenafil typically lasts 4 to 6 hours. Tadalafil is also available as a daily low-dose option, and it is less affected by food intake than sildenafil. The choice between them often comes down to personal preference and lifestyle.

What are the alternatives to Cialis for erectile dysfunction?

The main alternatives to Cialis include sildenafil (Viagra), vardenafil (Levitra), and avanafil (Spedra) — all of which are PDE5 inhibitors. Non-pharmacological options include lifestyle changes such as reducing alcohol, stopping smoking, exercising regularly, and managing stress. Your GP or prescriber can help you decide which treatment is most appropriate for your situation.

How long can you stay on Cialis?

Tadalafil can be used long-term under the supervision of a prescriber. Many men take it for months or years without significant issues, provided they have regular reviews to ensure it remains appropriate. Your prescriber may periodically reassess your need for treatment, particularly if your underlying health conditions change.

Is Cialis safe for men with diabetes or high blood pressure?

Tadalafil can be used by men with diabetes or well-controlled high blood pressure, but a careful clinical assessment is essential before prescribing. Men with diabetes are at higher risk of ED, and tadalafil is commonly used in this group. However, if you take antihypertensive medicines, your prescriber will need to check for potential interactions that could lower your blood pressure too much.

What are the latest studies on Tadalafil for erectile dysfunction?

Tadalafil has been studied extensively since its approval, with clinical evidence consistently supporting its efficacy and tolerability for ED. Research has also explored its use in pulmonary arterial hypertension and benign prostatic hyperplasia, where it has shown positive outcomes. The NHS and MHRA continue to recognise tadalafil as a first-line treatment option for erectile dysfunction in adult men.

How Should You Use Cialis (Tadalafil)?

Always use Cialis exactly as your prescriber has instructed. Swallow the tablet whole with a full glass of water — do not crush or chew it. Tadalafil can be taken with or without food, which makes it more flexible than some other erectile dysfunction medicines. Follow these steps for on-demand use:

What Is the Correct Dose of Cialis (Tadalafil)?

The appropriate dose of tadalafil depends on your individual circumstances, including the reason for treatment and how well you tolerate the medicine. Your prescriber will advise you on the most suitable dose. The table below summarises the standard dosing guidance:

When Is the Best Time to Use Cialis (Tadalafil)?

For on-demand dosing, take your tablet at least 30 minutes before sexual activity. Many men find that taking it around an hour beforehand gives the best results. Because tadalafil lasts up to 36 hours, you don't need to time it as precisely as shorter-acting alternatives — this flexibility is one of its key advantages. If you're on the daily 5mg dose, consistency matters more than timing relative to sex; simply take it at the same time each day to maintain steady levels in your bloodstream.

How Long Can You Use Cialis (Tadalafil) For?

Tadalafil can be used on a long-term basis under the ongoing supervision of a prescriber. There is no fixed maximum duration of treatment, but your prescriber will review your prescription periodically to ensure it remains appropriate and effective for you. If your underlying health conditions change — for example, if you develop a new cardiovascular condition or start a new medicine — it's important to inform your prescriber promptly, as this may affect whether tadalafil continues to be suitable.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Cialis (Tadalafil)?

Most men who take tadalafil tolerate it well, but like all medicines, it can cause side effects. Common side effects affect up to 1 in 10 people and are usually mild and short-lived. They often improve as your body adjusts to the medicine.

  • Headache
  • Flushing (warmth or redness in the face, neck, or chest)
  • Indigestion or stomach discomfort
  • Back pain
  • Nasal congestion or runny nose
  • Muscle aches

What Are the Less Common Side Effects of Cialis (Tadalafil)?

Less common side effects affect up to 1 in 100 people. These are generally not serious, but you should mention them to your prescriber if they persist or become troublesome.

  • Dizziness or light-headedness
  • Blurred vision
  • Increased heart rate (tachycardia)
  • Swelling of the eyelids
  • Eye redness or pain
  • Nausea
  • Sweating

What Are the Serious Side Effects of Cialis (Tadalafil)?

Serious side effects are rare but require immediate medical attention. Stop taking tadalafil and seek emergency help if you experience any of the following:

  • A prolonged erection lasting more than 4 hours (priapism) — this can cause permanent damage if not treated promptly.
  • Sudden decrease or complete loss of vision in one or both eyes.
  • Sudden decrease or loss of hearing, sometimes accompanied by ringing in the ears or dizziness.
  • Chest pain, particularly during or after sexual activity — this may indicate a cardiac event.
  • Severe allergic reaction: swelling of the face, lips, tongue, or throat; difficulty breathing; or a widespread skin rash.

What Should You Do If You Experience Side Effects of Cialis?

If you experience mild side effects such as headache or flushing, these will usually resolve on their own within a few hours. Staying hydrated and resting can help. For more persistent or distressing symptoms, contact your GP or pharmacist. You should also report any suspected side effects through the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk. Never stop taking a prescribed medicine without speaking to your healthcare provider first, unless you are experiencing a serious reaction.

Can Cialis (Tadalafil) Interact With Other Medicines?

Yes — tadalafil has several clinically significant drug interactions. The most important is with nitrates (such as glyceryl trinitrate or isosorbide mononitrate), which are used for chest pain. Taking tadalafil with nitrates can cause a sudden and severe drop in blood pressure. Alpha-blockers used for high blood pressure or prostate problems can also interact, as can certain antifungal medicines, HIV treatments, and antibiotics such as rifampicin. Always give your prescriber and pharmacist a full list of all medicines, supplements, and herbal remedies you are taking before starting tadalafil.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Frequently Asked Question


Cialis usually starts working in about 30 minutes, but it can sometimes take a little longer depending on your body and whether you’ve eaten. For some men, it kicks in even faster when taken on an empty stomach.


This is what makes Cialis famous — it lasts for up to 36 hours. That doesn’t mean you’ll have an erection for 36 hours straight, but that your body will be ready to respond naturally any time during that window.

You can, but try to keep it light. Heavy drinking can make it harder to get or maintain an erection, which kind of defeats the purpose of the tablet.

Yes — food doesn’t affect Cialis much. But for quicker results, it’s best to take it on an empty stomach or after a light meal.

That’s normal. It can take a few tries before you see full results, especially if it’s your first time. Try to relax, stay aroused, and give your body a few chances to adjust.
Not usually. Most side effects (like headaches or flushing) are mild and go away as your body adjusts. Long-term issues are very rare.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

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Content last updated: 31 Mar 2025

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How fast does Cialis start working?


Cialis usually starts working in about 30 minutes, but it can sometimes take a little longer depending on your body and whether you’ve eaten. For some men, it kicks in even faster when taken on an empty stomach.

How long does Cialis last?


This is what makes Cialis famous — it lasts for up to 36 hours. That doesn’t mean you’ll have an erection for 36 hours straight, but that your body will be ready to respond naturally any time during that window.

Can I drink alcohol while taking Cialis?

You can, but try to keep it light. Heavy drinking can make it harder to get or maintain an erection, which kind of defeats the purpose of the tablet.

Can I take Cialis with food?

Yes — food doesn’t affect Cialis much. But for quicker results, it’s best to take it on an empty stomach or after a light meal.

What should I do if Cialis doesn’t work the first time? That’s normal. It can take a few tries before you see full results, especially if it’s your first time. Try to relax, stay aroused, and give your body a few chances to adjust. Does Cialis cause any long-term side effects? Not usually. Most side effects (like headaches or flushing) are mild and go away as your body adjusts. Long-term issues are very rare.