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Buccastem M Buccal Tablets 8s (BRAND MAY VARY)

Buccastem M Buccal Tablets 8s (BRAND MAY VARY)

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  • ✔️ Relieves nausea and vomiting associated with migraine headaches
  • ✔️ Dissolves buccally — no swallowing needed when feeling sick
  • ✔️ Contains clinically established prochlorperazine maleate 3mg
  • ✔️ Suitable for adults experiencing travel sickness symptoms
  • ✔️ Compact 8-tablet pack — ideal for travel and on-the-go use

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What Are Buccastem M Buccal Tablets?

 

Feeling sick can stop you in your tracks — whether it's a migraine that's knocked you sideways or a long car journey that's left your stomach churning. Buccastem M buccal tablets offer a practical, clinically established way to manage nausea and vomiting in adults. Each pack contains 8 tablets, each delivering 3mg of prochlorperazine maleate via a buccal route — meaning the tablet dissolves between your upper lip and gum rather than being swallowed. This allows the active ingredient to be absorbed directly through the mucous membrane, which can be particularly useful when swallowing tablets is difficult due to nausea itself. You can find Buccastem M and other nausea remedies in our sickness and nausea collection.

Buccastem M is licensed for over-the-counter sale in the UK for adults aged 18 and over. It is classified as a Pharmacy (P) medicine, meaning it is available without a prescription but should be purchased from a registered pharmacy. The brand may vary depending on stock, but the active ingredient and dose remain the same.

 

How Do Buccastem M Buccal Tablets Work?

 

Prochlorperazine belongs to a group of medicines called phenothiazines. It works by blocking dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) — a region of the brain that detects toxins and triggers the vomiting reflex. By dampening this signal, prochlorperazine reduces both the sensation of nausea and the urge to vomit.

  • Prochlorperazine is absorbed through the buccal mucosa (the lining of the mouth)
  • It travels via the bloodstream to the brain's CTZ
  • Dopamine receptor blockade reduces nausea signals
  • Effect typically begins within 20–30 minutes of correct placement

Because the tablet bypasses the digestive system, it avoids first-pass metabolism in the liver — meaning more of the active ingredient reaches the bloodstream compared to a standard oral tablet.

 

Who Is Buccastem M Suitable For?

 

Buccastem M is intended for adults aged 18 and over who experience nausea and vomiting. It is particularly well-suited to people who struggle to keep oral tablets down when feeling sick. That said, it is not appropriate for everyone — always read the patient information leaflet before use.

  • Adults experiencing nausea and vomiting associated with migraine
  • People who find swallowing tablets difficult when nauseous
  • Adults seeking short-term relief from travel sickness symptoms
  • Those who have previously used prochlorperazine under medical supervision

It is not suitable for children, pregnant or breastfeeding women, or individuals with certain neurological or liver conditions. If you are unsure whether this product is right for you, speak to your pharmacist before purchasing.

 

How Does Buccastem M Compare to Other Nausea Tablets?

 

Feature Buccastem M (Prochlorperazine 3mg) Cyclizine (e.g. Valoid 50mg)
Active ingredient Prochlorperazine maleate Cyclizine hydrochloride
Route of administration Buccal (dissolves in mouth) Oral (swallowed)
Suitable for travel sickness Yes Yes
Suitable for migraine-related nausea Yes Less commonly used
Suitable for children No (adults only) Yes (from age 6 with guidance)
UK OTC availability Yes (Pharmacy medicine) Yes (Pharmacy medicine)

 

How Should You Store Buccastem M Buccal Tablets?

 

Store buccastem m buccal tablets below 25°C in a dry place, away from direct sunlight and moisture. Keep them in their original blister packaging until you are ready to use them. As with all medicines, store out of the reach and sight of children.

Do not use the tablets after the expiry date printed on the pack. If you are planning to take them on a trip abroad, our travel collection includes other useful products to keep you comfortable on the go. Check the packaging for any additional storage guidance specific to the batch you receive.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Buccastem M Buccal Tablets 8s specifications
Treatment category Nausea and vomiting
Active ingredient Prochlorperazine maleate 3mg
Mechanism of action Dopamine D2 receptor antagonist (phenothiazine)
Route of administration Buccal (between upper lip and gum)
Preparation Buccal tablet
Pack size 8 tablets
Strength 3mg
UK classification Pharmacy (P) medicine
Drug class Phenothiazine antiemetic
Suitable for Adults aged 18 and over
Effective for Nausea and vomiting (including migraine-related and travel sickness)

Specifications of Buccastem M Buccal Tablets 8s

 

What Is Buccastem M and What Is It Used For?

 

Buccastem M buccal tablets contain prochlorperazine maleate 3mg as the active ingredient. They are used to relieve nausea and vomiting in adults aged 18 and over. The tablets are specifically licensed for nausea and vomiting associated with migraine headaches, and they are also used for travel sickness. Because the tablet dissolves in the mouth rather than being swallowed, it is particularly helpful when nausea makes it difficult to keep oral medicines down.

Prochlorperazine has been used clinically for decades and is well-recognised in UK medical practice as an antiemetic. It is available on prescription in higher doses, but the 3mg buccal formulation is available over the counter from registered pharmacies for short-term use.

 

What Do You Need to Know Before Using Buccastem M?

 

Before using Buccastem M, it is important to check whether it is appropriate for you. Do not use this medicine if any of the following apply:

  • You are under 18 years of age
  • You are pregnant or breastfeeding
  • You have Parkinson's disease or a related movement disorder
  • You have liver or kidney problems
  • You have a history of blood disorders or bone marrow suppression
  • You have epilepsy or a history of seizures
  • You have glaucoma or an enlarged prostate
  • You are allergic to prochlorperazine or any other phenothiazine

Buccastem M may interact with a number of other medicines. Tell your pharmacist or doctor if you are taking any of the following:

  • Antidepressants (including SSRIs, tricyclics, or MAOIs)
  • Antihypertensive medicines (blood pressure treatments)
  • Lithium
  • Antiepileptic medicines
  • Other medicines that cause drowsiness, including antihistamines
  • Alcohol (increases sedative effect)

If you are managing other digestive symptoms alongside nausea, you may also find our indigestion collection helpful for complementary products.

 

How Should You Use Buccastem M Correctly?

 

Using Buccastem M correctly is essential for it to work properly. The buccal route is different from swallowing a tablet — follow these steps carefully:

  1. Wash your hands before handling the tablet
  2. Remove one tablet from the blister pack
  3. Place the tablet between your upper lip and your gum (above the front teeth)
  4. Leave the tablet in place and allow it to dissolve slowly — do not chew or swallow it
  5. Avoid eating, drinking, or rinsing your mouth while the tablet is dissolving
  6. If a second dose is needed, place the next tablet on the opposite side of the mouth after four hours
Indication Age Group Dose Frequency
Nausea and vomiting (migraine) Adults 18+ 1 tablet (3mg) Twice daily (max 2 tablets in 24 hours)
Travel sickness Adults 18+ 1 tablet (3mg) Twice daily as needed
Children under 18 Not applicable Not suitable Not suitable

Do not use Buccastem M for more than two days without seeking medical advice. If your symptoms persist or worsen, consult your GP.

 

What Are the Possible Side Effects of Buccastem M?

 

Like all medicines, Buccastem M can cause side effects, although not everyone experiences them. Being aware of what to look out for helps you use this medicine safely.

Common side effects:

  • Drowsiness or sedation
  • Dry mouth
  • Mild dizziness
  • Local irritation at the site of tablet placement

Less common side effects:

  • Restlessness or agitation (akathisia)
  • Involuntary muscle movements or tremors (extrapyramidal effects)
  • Skin reactions such as rash or photosensitivity
  • Low blood pressure, particularly on standing (postural hypotension)
  • Blurred vision

Stop using Buccastem M immediately and seek urgent medical attention if you experience unusual or uncontrolled muscle movements, particularly of the face, tongue, or limbs. These may be signs of a rare but serious reaction called tardive dyskinesia or acute dystonia. If you are also managing pain alongside your nausea, our pain relief collection has a range of options to consider alongside your pharmacist's advice.

 

How Should You Store Buccastem M Buccal Tablets?

 

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and moisture
  • Store in the original blister packaging until use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Buccastem M buccal tablets online in the UK?

You can buy Buccastem M buccal tablets online from Cured Pharmacy, a GPhC-registered UK online pharmacy. They are available without a prescription as an over-the-counter Pharmacy (P) medicine for adults aged 18 and over. Browse our full sickness and nausea range for related products.

How do Buccastem M buccal tablets work in the body?

Buccastem M contains prochlorperazine maleate, a phenothiazine antiemetic that blocks dopamine D2 receptors in the brain's chemoreceptor trigger zone (CTZ). This reduces the nerve signals that trigger nausea and vomiting. The buccal route allows the medicine to be absorbed directly through the lining of the mouth, bypassing the stomach entirely.

How do I use Buccastem M buccal tablets step by step?

Place one tablet between your upper lip and gum, above your front teeth, and allow it to dissolve slowly — do not chew or swallow it. Avoid eating, drinking, or rinsing your mouth while the tablet is in place. If a second dose is needed, place the next tablet on the opposite side of the mouth at least four hours later.

What is the correct dose of Buccastem M for adults?

The recommended adult dose is one 3mg tablet placed buccally, up to twice daily. Do not exceed two tablets in any 24-hour period. If your symptoms have not improved after two days of use, stop taking the tablets and consult your GP or pharmacist.

When is the best time to take Buccastem M for travel sickness?

For travel sickness, it is generally advisable to take Buccastem M before your journey begins, so the medicine has time to be absorbed and take effect. Place the tablet buccally around 20–30 minutes before you expect to travel. A second tablet can be taken during the journey if needed, at least four hours after the first.

What are the side effects of Buccastem M buccal tablets?

Common side effects include drowsiness, dry mouth, and mild dizziness. Less commonly, some people experience restlessness, involuntary muscle movements (extrapyramidal effects), or skin reactions. Stop use immediately and seek medical advice if you notice unusual or uncontrolled movements of the face, tongue, or limbs.

Who should not use Buccastem M buccal tablets?

Buccastem M is not suitable for children under 18, pregnant or breastfeeding women, or people with Parkinson's disease, liver problems, epilepsy, glaucoma, or a history of blood disorders. It is also not appropriate for anyone with a known allergy to prochlorperazine or other phenothiazines. Always read the patient information leaflet before use.

Can I take Buccastem M if I am pregnant or breastfeeding?

No — Buccastem M is not recommended during pregnancy or breastfeeding. Prochlorperazine can pass into breast milk and may affect a nursing infant. If you are pregnant and experiencing nausea, speak to your GP or midwife about safe alternatives.

What happens if I miss a dose of Buccastem M?

If you miss a dose, take it as soon as you remember — unless it is nearly time for your next scheduled dose, in which case skip the missed one. Never take two tablets at the same time to make up for a missed dose. Stick to the maximum of two tablets in any 24-hour period.

Can Buccastem M interact with other medicines?

Yes — prochlorperazine can interact with antidepressants (including SSRIs, tricyclics, and MAOIs), antihypertensives, lithium, antiepileptics, and other sedating medicines. Alcohol also increases the sedative effect. Always tell your pharmacist about all medicines you are currently taking before using Buccastem M.

How long can I use Buccastem M for?

Buccastem M is intended for short-term use only — no more than two consecutive days without medical advice. If your nausea or vomiting persists beyond this, you should consult your GP to identify and treat the underlying cause. Prolonged use without supervision is not recommended.

What are alternatives to Buccastem M for nausea relief?

Common OTC alternatives include cyclizine (e.g. Valoid), promethazine (e.g. Phenergan), and domperidone (e.g. Motilium). Each works differently and suits different causes of nausea, so the right choice depends on your individual circumstances. Speak to a pharmacist for personalised guidance, or explore our travel collection for travel-specific options.

Is Buccastem M suitable for children?

No — Buccastem M buccal tablets are only licensed for adults aged 18 and over. They must not be given to children or teenagers. If a child is experiencing nausea or travel sickness, speak to a pharmacist or GP about age-appropriate alternatives.

Does Buccastem M cause drowsiness?

Yes, drowsiness is one of the most commonly reported side effects of prochlorperazine. You should not drive, operate heavy machinery, or perform tasks requiring full alertness until you know how Buccastem M affects you. Alcohol will make drowsiness worse, so avoid it while using this medicine.

What are the latest findings on prochlorperazine for nausea?

Prochlorperazine remains a well-established antiemetic in UK clinical practice and is included in NHS guidance for the management of nausea and vomiting associated with migraine. It continues to be recommended in the British National Formulary (BNF) for short-term antiemetic use in adults. No significant changes to its OTC use guidance have been issued by the MHRA in recent years.

How Should You Use Buccastem M Buccal Tablets?

Buccastem M is used via the buccal route, which means the tablet is placed in the mouth to dissolve — not swallowed. This is an important distinction. Getting the technique right ensures the medicine is absorbed properly and works as intended.

Follow these steps each time you use a tablet:

If the tablet falls out before it has fully dissolved, do not replace it with another one unless four hours have passed since the first tablet was placed.

What Is the Correct Dose of Buccastem M?

The dose of Buccastem M depends on the reason you are using it. Always follow the dosage instructions in the patient information leaflet and never exceed the maximum daily dose. The table below summarises the recommended doses for adults.

Do not take more than two tablets in any 24-hour period. If your symptoms have not improved after two days, stop using the tablets and seek medical advice.

When Is the Best Time to Use Buccastem M?

For travel sickness, place the tablet buccally around 20–30 minutes before your journey begins. This gives the medicine time to be absorbed and reach effective levels in your bloodstream before motion-related nausea sets in. For migraine-related nausea, use the tablet as soon as symptoms begin — early use tends to be more effective than waiting until nausea is severe.

If you need a second dose during the day, remember to wait at least four hours after the first tablet and place it on the opposite side of the mouth. Timing your doses correctly helps maintain consistent symptom relief throughout the day.

How Long Can You Use Buccastem M For?

Buccastem M is intended for short-term use only. You should not use it for more than two consecutive days without consulting a doctor or pharmacist. If your nausea or vomiting continues beyond this period, it is important to seek medical advice to identify and address the underlying cause.

Prolonged use of prochlorperazine without medical supervision carries a risk of side effects, including movement disorders. This product is not suitable for ongoing or preventative use without a GP's guidance.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

Customer Reviews

Based on 3 reviews
67%
(2)
33%
(1)
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J
Janis McCarthy

Effective treatment for nausea accompanying migraines

G
Geoff Brown

Product is good although Cuccastem brand is quite often not available and substitute provided

S
Susan Holmes

I always keep a box of these anti sickness tablets as I sometimes get vertigo which makes nauseas. These meds work a treat for my nausea,and I don't get ANY negative side effects from them. They are ONLY for when I get the odd bout of nausea. So very pleased with purchase hase and service from CURED PHARMACY. Ordered on 22/11/25 and arrived as stated ,well packaged and intact.

What Are the Most Common Side Effects of Buccastem M?

Most people tolerate Buccastem M well when used as directed, but like all medicines, it can cause side effects. The most frequently reported ones are mild and tend to resolve on their own once the medicine is stopped.

  • Drowsiness or sedation
  • Dry mouth
  • Mild dizziness
  • Local irritation or discomfort at the site where the tablet is placed

If drowsiness is affecting you, avoid driving, cycling, or operating machinery until you feel fully alert again. Alcohol will make drowsiness significantly worse, so it is best avoided while using this medicine.

What Are the Less Common Side Effects of Buccastem M?

Some people experience side effects that are less frequent but worth being aware of. These are more likely to occur if the medicine is used for longer than recommended or at higher doses.

  • Restlessness or agitation (akathisia)
  • Tremor or muscle stiffness
  • Blurred vision
  • Low blood pressure on standing (postural hypotension), which may cause light-headedness
  • Skin rash or increased sensitivity to sunlight (photosensitivity)
  • Difficulty passing urine

If you notice any of these effects, stop using Buccastem M and speak to your pharmacist or GP before continuing.

What Are the Serious Side Effects of Buccastem M?

Serious side effects are rare when Buccastem M is used correctly and for short periods, but they can occur. The most significant concern with prochlorperazine is the risk of extrapyramidal side effects — these are movement-related reactions caused by the medicine's effect on dopamine pathways in the brain.

Seek urgent medical attention if you experience any of the following:

  • Uncontrolled or involuntary movements of the face, tongue, jaw, or limbs
  • Muscle spasms or abnormal postures (acute dystonia)
  • Severe restlessness that you cannot control
  • Yellowing of the skin or eyes (jaundice — may indicate liver problems)
  • Unusual bruising or signs of infection (may indicate blood disorders)

What Should You Do If You Experience Side Effects?

If you experience mild side effects such as drowsiness or dry mouth, these usually resolve without treatment once the medicine is stopped. For more troublesome or persistent effects, stop using Buccastem M and contact your pharmacist or GP for advice. In the case of serious reactions — particularly unusual muscle movements — stop the medicine immediately and seek urgent medical help.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. Reporting side effects helps improve medicine safety for everyone.

Can Buccastem M Interact With Other Medicines?

Yes — prochlorperazine has a number of clinically significant interactions. It can enhance the sedative effects of other CNS depressants, including antihistamines, opioid analgesics, and benzodiazepines. When taken alongside antihypertensive medicines, it may cause an excessive drop in blood pressure. Concurrent use with lithium or antidepressants — particularly MAOIs — requires caution due to the risk of increased neurological side effects.

Always tell your pharmacist about every medicine you are currently taking, including herbal remedies and supplements, before using Buccastem M. This is especially important if you are taking medicines for mental health conditions, epilepsy, or heart problems.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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