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Avene Cicalfate + Repairing Protective Cream - 40ml

Avene Cicalfate + Repairing Protective Cream - 40ml

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  • ✔️ Repairs and protects damaged, irritated, or post-procedure skin
  • ✔️ Sucralfate forms a barrier film over broken skin
  • ✔️ Copper-zinc sulphate reduces risk of secondary skin infection
  • ✔️ Fragrance-free and hypoallergenic — suitable for sensitive skin
  • ✔️ Safe for all ages including newborns and babies

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What Is Avene Cicalfate Cream and How Does It Help Skin?

 

If your skin is feeling raw, irritated, or just not quite right after a procedure or flare-up, you are not alone. Millions of people in the UK deal with damaged or sensitive skin on a daily basis, and finding something that genuinely helps — without causing further irritation — can feel like a challenge. Avene Cicalfate cream is a dermatologist-recommended, over-the-counter topical cream designed to support the skin's natural repair process while forming a protective barrier against external irritants. Available from our skin care collection, it is suitable for adults, children, and even babies.

The 40ml tube is compact enough to keep in a bag or medicine cabinet, making it easy to apply whenever your skin needs support. At just £6.39, it offers accessible skin repair without the need for a prescription.

 

How Does Avene Cicalfate+ Repairing Protective Cream Work?

 

The cream works through a combination of carefully selected ingredients that target different aspects of skin damage and irritation. Here is how each key component contributes:

  • Sucralfate: Forms a protective film over the damaged skin surface, helping to shield it from further irritation and supporting tissue repair.
  • Copper-zinc sulphate: Provides mild antibacterial action, reducing the risk of secondary infection in broken or compromised skin.
  • Avene Thermal Spring Water: Rich in silicates and with a unique mineral composition, this water has well-documented soothing and anti-irritant properties, helping to calm redness and discomfort.
  • Emollient base: Helps to restore moisture to dry, flaking skin and supports the skin barrier function.

Together, these ingredients create a multi-action approach — soothing, protecting, and repairing all at once. It is fragrance-free and formulated to minimise the risk of allergic reactions, which makes it particularly well-suited to reactive or post-procedure skin.

 

Who Should Use Avene Cicalfate+ Repairing Protective Cream?

 

This cream is designed for anyone whose skin needs a helping hand to recover. It is particularly useful in situations where the skin barrier has been disrupted or weakened. You might find it helpful if you experience any of the following:

  • Dry, cracked, or chapped skin — including on the hands, lips, or body
  • Skin irritation following cosmetic or dermatological procedures (such as laser treatment or chemical peels)
  • Minor cuts, grazes, or superficial wounds that need protection during healing
  • Nappy rash or skin folds irritation in babies and young children
  • Eczema-prone or atopic skin that is prone to flare-ups and sensitivity

It is also commonly used after sun exposure or as part of a post-operative skin care routine. Because it is fragrance-free and hypoallergenic, it is appropriate for even the most sensitive skin types.

 

How Does Avene Cicalfate+ Compare to Similar Skin Repair Creams?

 

Feature Avene Cicalfate+ 40ml Bepanthen Nappy Care Ointment
Primary use Skin repair and barrier protection Nappy rash prevention and healing
Key ingredient Sucralfate + copper-zinc sulphate Dexpanthenol (provitamin B5)
Suitable for face Yes Yes (limited use)
Fragrance-free Yes Yes
Post-procedure use Yes — commonly recommended Not specifically indicated

 

Is Avene Cicalfate Cream Suitable for All Skin Types and How Should It Be Stored?

 

Avene Cicalfate cream is formulated to be suitable for all skin types, including sensitive, atopic, and post-procedure skin. Its hypoallergenic, fragrance-free formula means it is unlikely to trigger reactions even in people with a history of skin sensitivity. You can also find a range of complementary options in our creams and ointments collection if you need additional skin care support.

Store the cream below 25°C, away from direct sunlight and out of the reach of children. Do not use after the expiry date printed on the packaging. Once opened, use within 12 months.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Avene Cicalfate+ Repairing Protective Cream 40ml specifications
Treatment category Skin repair and barrier protection
Mechanism of action Forms protective film over damaged skin; antibacterial and soothing action
Effective for Irritated, damaged, dry, or post-procedure skin
Suitable for Adults, children, and babies; all skin types including sensitive
Active ingredients Sucralfate, copper-zinc sulphate, Avene Thermal Spring Water
Pack size 40ml
UK classification General Sale (GSL) / Cosmetic
Preparation Cream
Route of administration Topical (applied to skin)

Specifications of Avene Cicalfate+ Repairing Protective Cream 40ml

 

What Is Avene Cicalfate+ Repairing Protective Cream and What Is It Used For?

 

Avene Cicalfate+ Repairing Protective Cream is a topical skin care product designed to soothe, protect, and repair damaged or irritated skin. It is used for a wide range of skin concerns, including minor wounds, post-procedure skin recovery, dry and cracked skin, nappy rash, and eczema-prone skin. The NHS recognises that maintaining a healthy skin barrier is essential for managing conditions like eczema and dry skin, and emollient-based products play a key role in that process.

The cream is suitable for use on the face and body, and is appropriate for all ages — from newborns to older adults. It does not require a prescription and can be purchased over the counter.

 

What Do You Need to Know Before Using Avene Cicalfate+ Cream?

 

Before applying this cream, there are a few important things to be aware of. While it is generally very well tolerated, certain situations call for extra caution.

Do not use this cream if:

  • You are allergic to any of the ingredients listed on the packaging
  • You have a known hypersensitivity to sucralfate or copper-zinc compounds
  • The skin area is infected — seek medical advice before applying any topical product to infected skin

Use with caution if:

  • You are applying to broken or deeply wounded skin — consult a pharmacist or GP first
  • You are using other topical products on the same area, as layering products may affect absorption
  • You are pregnant or breastfeeding — while no specific risks are known, always check with your GP or midwife before using new products during pregnancy

Known drug interactions:

  • No significant drug interactions have been identified for topical use of this product
  • Avoid applying immediately before or after other medicated topical treatments without pharmacist guidance

 

How Should You Use Avene Cicalfate+ Repairing Protective Cream?

 

Using this cream correctly will help you get the most benefit from it. Follow these steps each time you apply it:

  1. Wash your hands thoroughly before handling the cream.
  2. Gently cleanse the affected skin area and pat dry with a clean cloth.
  3. Squeeze a small amount of cream onto your fingertip — a thin layer is sufficient.
  4. Apply gently to the affected area using light, circular motions.
  5. Allow the cream to absorb before covering with clothing or a dressing.
  6. Wash your hands again after application unless the hands themselves are being treated.
Indication Age Group Dose Frequency
Dry or irritated skin All ages Thin layer 1–2 times daily
Post-procedure skin Adults Thin layer As directed by clinician
Nappy rash Babies and toddlers Thin layer At each nappy change
Minor cuts or grazes All ages Thin layer 1–2 times daily until healed

If you are using this cream on a baby or young child, you may also find useful guidance in our baby and toddler collection, which includes a range of products suitable for young, sensitive skin.

 

What Are the Possible Side Effects of Avene Cicalfate+ Cream?

 

Side effects with this cream are uncommon, but it is important to know what to look out for. The NHS advises that any topical product can occasionally cause a reaction, particularly in people with very sensitive or reactive skin.

Common side effects (may affect a small number of users):

  • Mild stinging or tingling sensation immediately after application
  • Temporary redness at the application site

Less common side effects:

  • Contact dermatitis — a localised allergic skin reaction causing itching, rash, or blistering
  • Worsening of skin irritation in rare cases

If you notice any signs of a serious allergic reaction — such as swelling of the face, lips, or throat, difficulty breathing, or widespread hives — stop using the cream immediately and seek urgent medical attention. This type of reaction is rare but requires prompt care.

 

How Should You Store Avene Cicalfate+ Repairing Protective Cream?

 

Correct storage helps to maintain the quality and effectiveness of the cream. You can also browse our first aid collection for other products that support skin healing and wound care at home.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Do not freeze
  • Keep the tube tightly closed when not in use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the tube or carton
  • Once opened, use within 12 months

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Avene Cicalfate cream online in the UK?

You can buy Avene Cicalfate+ Repairing Protective Cream 40ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £6.39. No prescription is needed, and it is available to order at any time. Browse our full skin care collection for complementary products too.

How does Avene Cicalfate cream work in the body?

Avene Cicalfate cream works topically — it does not enter the bloodstream. Sucralfate forms a protective film over damaged skin, copper-zinc sulphate provides mild antibacterial action, and Avene Thermal Spring Water soothes inflammation. Together, these ingredients support the skin's natural healing process from the outside in.

How do I use Avene Cicalfate+ cream step by step?

Cleanse the affected area and pat it dry, then apply a thin layer of the cream using gentle circular motions. Use one to two times daily, or as directed by your clinician for post-procedure skin. Always wash your hands before and after application unless you are treating the hands themselves.

How often should I apply Avene Cicalfate cream?

For most skin concerns, applying the cream once or twice daily is sufficient. For nappy rash in babies, it can be applied at each nappy change. If you are using it following a dermatological procedure, follow the specific guidance given by your clinician or dermatologist.

Is Avene Cicalfate cream suitable for babies and children?

Yes, Avene Cicalfate+ is formulated to be suitable for all ages, including newborns and young children. It is commonly used for nappy rash and skin irritation in babies. If your child is under three months old or has a skin condition, speak to your GP or health visitor before use. You can also explore our baby and toddler collection for more options.

Can I use Avene Cicalfate cream on my face?

Yes, the cream can be applied to the face for conditions such as dry patches, post-procedure irritation, or minor skin damage. Avoid direct contact with the eyes and mucous membranes. If you are using it after a facial procedure, follow your clinician's specific aftercare instructions.

What are the side effects of Avene Cicalfate cream?

Side effects are uncommon but may include mild stinging or temporary redness at the application site. In rare cases, contact dermatitis — an allergic skin reaction — may occur. If you experience worsening irritation, swelling, or difficulty breathing, stop use immediately and seek medical advice.

How do I manage side effects of Avene Cicalfate cream?

If you experience mild stinging or redness, reduce application frequency and monitor the skin. If irritation persists or worsens after 48 hours, stop using the cream and consult your pharmacist or GP. For signs of a serious allergic reaction, seek urgent medical attention.

Who is eligible to use Avene Cicalfate+ Repairing Protective Cream?

The cream is suitable for adults, children, and babies with dry, irritated, damaged, or post-procedure skin. It is particularly well-suited to people with sensitive or atopic skin. Those with a known allergy to any of the ingredients should not use it — check the full ingredient list on the packaging before first use.

Can I use Avene Cicalfate cream during pregnancy or breastfeeding?

No specific risks have been identified with topical use of Avene Cicalfate+ during pregnancy or breastfeeding. However, as a precaution, always consult your GP or midwife before introducing any new topical product during pregnancy. Avoid applying to the nipple area if breastfeeding.

What happens if I miss an application of Avene Cicalfate cream?

If you forget to apply the cream at your usual time, simply apply it as soon as you remember. Do not apply a double amount to make up for a missed application — just continue with your normal routine. Consistency helps, but missing one application is unlikely to significantly affect your results.

What are alternatives to Avene Cicalfate cream?

Alternatives include Bepanthen Nappy Care Ointment (dexpanthenol-based), Sudocrem Antiseptic Healing Cream, or other emollient barrier creams available in our creams and ointments collection. The best choice depends on your specific skin concern — speak to a pharmacist if you are unsure which product suits you.

How long can you use Avene Cicalfate cream for?

You can use Avene Cicalfate+ until the skin has healed, which typically takes a few days to a few weeks depending on the condition being treated. If your skin has not improved after two weeks of regular use, consult your GP or pharmacist. There is no strict maximum duration for use as a general skin protectant.

Is Avene Cicalfate cream fragrance-free and hypoallergenic?

Yes, Avene Cicalfate+ is fragrance-free and formulated to be hypoallergenic, making it suitable for even the most reactive skin types. It is also free from parabens and has been tested under dermatological supervision. This makes it a popular choice for people with eczema-prone or post-procedure skin.

What does the latest research say about sucralfate in skin repair?

Sucralfate has been studied for its wound-healing and barrier-forming properties in dermatology. Research published in peer-reviewed journals supports its use as a topical agent that adheres to damaged tissue and promotes healing. Avene Cicalfate+ incorporates sucralfate as a key ingredient based on this evidence base, alongside the well-documented soothing properties of Avene Thermal Spring Water.

How Should You Use Avene Cicalfate+ Repairing Protective Cream?

Using the cream correctly makes a real difference to how quickly your skin recovers. Always start with clean, dry skin — applying to dirty or damp skin can reduce the effectiveness of the protective film and increase the risk of irritation. Here is a simple step-by-step guide:

What Is the Correct Dose of Avene Cicalfate+ Cream?

A thin layer is all that is needed — more is not better with this type of cream. Applying too thick a layer can feel uncomfortable and may not improve results. The table below gives a general guide based on the indication and age group.

When Is the Best Time to Use Avene Cicalfate+ Cream?

There is no single "best" time — it depends on your routine and the reason you are using it. For general dry or irritated skin, applying once in the morning and once in the evening works well for most people. If you are using it after a dermatological procedure, your clinician may give you a specific schedule to follow, and it is important to stick to that guidance. For nappy rash, apply at every nappy change to maintain continuous protection.

How Long Can You Use Avene Cicalfate+ Cream For?

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What Are the Most Common Side Effects of Avene Cicalfate+ Cream?

Avene Cicalfate+ is generally very well tolerated, and most people use it without experiencing any side effects at all. That said, as with any topical product, a small number of users may notice mild reactions, particularly when first starting to use it.

  • Mild stinging or tingling sensation immediately after application
  • Temporary redness or warmth at the application site
  • A slight greasy or occlusive feeling on the skin

What Are the Less Common Side Effects of Avene Cicalfate+ Cream?

Less commonly, some people may experience a more pronounced skin reaction. These are not typical but are worth being aware of, especially if you have a history of sensitive or reactive skin.

  • Contact dermatitis — a localised allergic reaction causing itching, rash, or blistering
  • Worsening of existing skin irritation or dryness
  • Skin peeling or flaking at the application site

What Are the Serious Side Effects of Avene Cicalfate+ Cream?

Serious side effects are rare but can occur in people with a hypersensitivity to one or more of the ingredients. If you notice any of the following, stop using the cream immediately and seek urgent medical attention. Do not wait to see if symptoms resolve on their own.

  • Swelling of the face, lips, tongue, or throat (angioedema)
  • Difficulty breathing or swallowing
  • Widespread hives or urticaria across the body
  • Severe blistering or skin breakdown at the application site

What Should You Do If You Experience Side Effects of Avene Cicalfate+ Cream?

For mild reactions such as stinging or temporary redness, try reducing the frequency of application and monitor the skin over 24 to 48 hours. If the reaction settles, you may be able to continue using the cream at a lower frequency. If irritation persists or worsens, stop using the product and consult your pharmacist or GP. They can help identify whether the reaction is related to the cream or to the underlying skin condition itself.

You should report any suspected side effects from cosmetic or topical products to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps to improve safety monitoring for all users.

Can Avene Cicalfate+ Cream Interact With Other Medicines?

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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