Wegovy vs Mounjaro UK: Which Works Better? | Cured

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Wegovy vs Mounjaro UK - Cheapest Price From £69.00

Compare Wegovy and Mounjaro with the cheapest UK price from £124.99 plus £20 off your first order with code Weightlossnew.

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Our Pricing

Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £124.99

£31.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
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Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £159.00

£39.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
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Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £200.00

£50.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
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Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £225.00

£56.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
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Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £250.00

£62.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
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Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £267.00

£66.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
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Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £69.00

£17.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
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Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£99 £79.00

£19.75 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £99
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Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £99.00

£24.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
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Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £149.00

£37.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
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Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £179.00

£44.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
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Wegovy vs Mounjaro: Clinical Evidence and UK Treatment Comparison

When comparing wegovy vs mounjaro uk weight loss options, understanding the clinical trial data is essential for making an informed choice. Both medications are MHRA-licensed injectable treatments that work through related but distinct mechanisms, with Mounjaro (tirzepatide) offering dual-hormone action and Wegovy (semaglutide) targeting a single pathway. At Cured Pharmacy, our UK-registered prescribers assess which treatment aligns with your medical history, weight loss goals, and individual response factors.

How Wegovy and Mounjaro Work Differently

Wegovy contains semaglutide, a GLP-1 receptor agonist that mimics the glucagon-like peptide-1 hormone naturally produced in your gut [1]. This hormone slows gastric emptying, reduces appetite, and improves blood sugar regulation. Wegovy has been available in the UK since 2023 and is administered as a once-weekly subcutaneous injection, with doses gradually increased from 0.25mg to a maintenance dose of 2.4mg.

Mounjaro contains tirzepatide, the first dual GIP/GLP-1 receptor agonist licensed by the MHRA for weight management [2]. By activating both glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptors, tirzepatide produces a more comprehensive metabolic effect. This dual action appears to enhance weight loss beyond what single-pathway treatments achieve, though individual responses vary based on metabolic factors and adherence to lifestyle modifications.

Clinical Trial Results: Wegovy vs Mounjaro UK Evidence

The STEP 1 trial demonstrated that participants taking Wegovy 2.4mg achieved an average body weight reduction of 14.9% over 68 weeks, compared to 2.4% with placebo [1]. Approximately 50.5% of participants lost at least 15% of their initial body weight, and 86.4% achieved at least 5% weight loss when combined with lifestyle interventions.

In the SURMOUNT-1 trial, Mounjaro participants on the 15mg maintenance dose achieved an average weight reduction of 20.9% over 72 weeks, significantly higher than the comparator group [2]. At the 10mg dose, average weight loss was 19.5%, and even the 5mg dose produced 15% average reduction. These results represent the highest weight loss outcomes recorded in any obesity medication trial to date, though it's important to note that trial conditions include intensive dietary counselling and monitoring not always replicated in routine clinical practice.

Head-to-Head Comparison Data

While no large-scale direct comparison trial between Wegovy and Mounjaro has been published, indirect comparisons using similar trial populations suggest tirzepatide produces approximately 5-6 percentage points greater weight loss on average [3]. However, individual responses vary considerably based on baseline BMI, metabolic health, adherence to injection schedules, and concurrent lifestyle modifications. Your UK prescriber will consider these factors when recommending treatment, and some patients may achieve excellent results with either medication.

Side Effects and Tolerability Profile

Both medications share a similar side effect profile due to their GLP-1 activity, with gastrointestinal symptoms being most common [4]. Nausea affects approximately 44% of Wegovy users and 29-34% of Mounjaro users during dose escalation, though symptoms typically diminish after 4-8 weeks as the body adapts. Other frequent side effects include diarrhoea, constipation, vomiting, and abdominal discomfort.

The gradual dose titration schedule built into both treatments helps minimise these effects. Wegovy escalates over 16-20 weeks to reach the 2.4mg maintenance dose, while Mounjaro increases every four weeks from 2.5mg to the target dose. Approximately 4-7% of participants discontinue treatment due to gastrointestinal side effects in clinical trials [1][2]. Serious adverse events are rare but include potential pancreatitis, gallbladder disease, and hypoglycaemia when combined with certain diabetes medications.

Managing Side Effects in Clinical Practice

Our clinical team at Cured Pharmacy provides detailed guidance on minimising side effects through dietary adjustments, including smaller portions, avoiding high-fat meals, and staying well-hydrated. Taking the injection on the same day each week and not advancing to the next dose until current side effects have resolved can significantly improve tolerability. If you experience persistent vomiting, severe abdominal pain, or signs of pancreatitis, contact your prescriber immediately for clinical review.

Feature Wegovy (Semaglutide) Mounjaro (Tirzepatide)
Active Mechanism GLP-1 receptor agonist Dual GIP/GLP-1 receptor agonist
Average Weight Loss (Clinical Trials) 14.9% over 68 weeks 20.9% over 72 weeks (15mg dose)
Maintenance Dose 2.4mg once weekly 5mg-15mg once weekly
Starting Price at Cured Pharmacy From £69.00 From £69.00
Common Side Effects Nausea (44%), diarrhoea, constipation Nausea (29-34%), diarrhoea, constipation
UK Licensing MHRA-approved 2023 MHRA-approved 2024

Dosing Schedules and Administration

Wegovy is administered once weekly via subcutaneous injection in the abdomen, thigh, or upper arm. The standard dose escalation follows this schedule: 0.25mg for weeks 1-4, 0.5mg for weeks 5-8, 1mg for weeks 9-12, 1.7mg for weeks 13-16, and 2.4mg maintenance from week 17 onwards. Each pre-filled pen contains a single dose, and injection technique is straightforward with minimal training required.

Mounjaro follows a similar once-weekly injection schedule but with different dose increments: starting at 2.5mg for four weeks, then increasing to 5mg, 7.5mg, 10mg, 12.5mg, and potentially 15mg based on individual response and tolerability [2]. The KwikPen device used for Mounjaro features a hidden needle and simple push-button mechanism, making self-administration accessible for most patients. Your UK prescriber determines the optimal maintenance dose based on weight loss progress and side effect profile after the initial titration period.

Cost Comparison and UK Availability

At Cured Pharmacy, Mounjaro is available from £124.99 per month, with pricing varying based on your prescribed dose following clinical assessment. Both medications require a prescription from a UK-registered prescriber, and our online consultation process takes under three minutes to complete. Unlike some providers, we display transparent pricing before you begin your assessment, ensuring no unexpected costs during the prescription process.

Supply availability for both treatments has improved significantly throughout 2024 following earlier shortages. We maintain consistent stock levels of all licensed doses and provide discreet next-day delivery across the UK. All medications dispensed by Cured Pharmacy are sourced directly from UK-licensed wholesalers and meet MHRA quality standards. Our superintendent pharmacist, Tarun Kumar (GPhC 2233073), oversees all dispensing to ensure pharmaceutical care meets General Pharmaceutical Council requirements.

Insurance and NHS Availability

NHS prescribing of both Wegovy and Mounjaro is currently restricted to specialist weight management services due to NICE guidance limitations and budget constraints. Most UK patients access these treatments through private prescription, either via online pharmacies or private GP services. Some private health insurance policies may cover weight loss medications when prescribed for obesity-related health conditions, though coverage varies by provider and policy terms. Check with your insurer regarding reimbursement eligibility before starting treatment.

Which Treatment Is Right for You?

Choosing between wegovy vs mounjaro uk options depends on multiple clinical factors that your prescriber will assess during consultation. Patients with higher baseline BMI (over 35) or those who haven't achieved adequate results with previous weight loss treatments may benefit from Mounjaro's enhanced efficacy profile [3]. However, Wegovy remains an excellent first-line option with extensive real-world safety data and proven cardiovascular benefits in long-term studies.

Your medical history plays a crucial role in treatment selection. Both medications are contraindicated in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2. Patients with history of pancreatitis, severe gastroparesis, or inflammatory bowel disease require careful evaluation before starting either treatment. Our UK prescribers review your complete medical profile, current medications, and weight loss goals to recommend the most appropriate option, and treatment can be adjusted if initial response is suboptimal.

Monitoring and Long-Term Success

Successful weight management with either medication requires ongoing monitoring and lifestyle modifications. We recommend regular follow-up consultations every 12 weeks to assess progress, adjust dosing if needed, and address any concerns. Clinical trials show that weight loss plateaus typically occur around 60-72 weeks, after which maintaining lifestyle changes becomes essential for sustaining results [1][2]. Both medications are licensed for long-term use, and discontinuation often results in weight regain, making indefinite treatment necessary for many patients to maintain clinical benefits.

Scientific References

  1. Wilding, J. P. H., et al. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine, 384(11), 989–1002. https://doi.org/10.1056/NEJMoa2032183
  2. Jastreboff, A. M., et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205–216. https://doi.org/10.1056/NEJMoa2206038
  3. Urva, S., et al. (2022). Comparison of the efficacy of tirzepatide and semaglutide, both at 15 mg, in the SURPASS-2 trial. Diabetes, Obesity and Metabolism, 24(9), 1780–1783. https://doi.org/10.1111/dom.14755
  4. Smits, M. M., & Van Raalte, D. H. (2021). Safety of Semaglutide. Frontiers in Endocrinology, 12, 645563. https://doi.org/10.3389/fendo.2021.645563

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication. Individual results may vary, and weight loss outcomes depend on adherence to lifestyle modifications alongside medication use.

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Faq

Is Mounjaro better than Wegovy for weight loss?
Clinical trials show Mounjaro produces higher average weight loss (20.9% vs 14.9%), but individual results vary based on metabolic factors, adherence, and lifestyle modifications. Your UK prescriber will recommend the most suitable option based on your medical history and treatment goals.
Can I switch from Wegovy to Mounjaro?
Yes, switching between treatments is possible under prescriber supervision. Your clinician will determine the appropriate starting dose of Mounjaro based on your current Wegovy dose and response, typically beginning with the 2.5mg starter dose and titrating upward.
How quickly do Wegovy and Mounjaro work?
Most patients notice appetite reduction within 1-2 weeks of starting either medication, with measurable weight loss typically beginning after 4-8 weeks. Maximum weight loss effects occur around 60-72 weeks when combined with lifestyle modifications.
Do I need a prescription for Wegovy or Mounjaro in the UK?
Yes, both medications are prescription-only medicines (POM) in the UK and require clinical assessment by a UK-registered prescriber. At Cured Pharmacy, our free online consultation takes under three minutes and is reviewed by qualified prescribers.
What happens if I miss a dose of Wegovy or Mounjaro?
If you miss a dose and it's within 5 days of your scheduled injection day, take it as soon as you remember. If more than 5 days have passed, skip the missed dose and resume your normal schedule with the next injection.
Are there any foods to avoid while taking these medications?
No specific foods are prohibited, but high-fat, greasy, or very large portions may worsen gastrointestinal side effects. Smaller, more frequent meals with adequate protein and fibre typically improve tolerability and support weight loss goals.
Can I take Wegovy or Mounjaro if I have type 2 diabetes?
Both medications are licensed for weight management in patients with and without type 2 diabetes, though dosing and monitoring may differ. Your prescriber will review your current diabetes medications to avoid hypoglycaemia risk, particularly if you take insulin or sulfonylureas.
How long do I need to stay on Wegovy or Mounjaro?
Both medications are licensed for long-term use, and clinical evidence shows weight regain typically occurs after discontinuation. Most patients require indefinite treatment to maintain weight loss benefits, though this decision should be made in consultation with your prescriber based on individual response and goals.
Is Mounjaro more effective than Wegovy for weight loss in the UK?
Clinical trials show Mounjaro delivers greater average weight loss than Wegovy, with patients losing up to 22.5% body weight compared to Wegovy's 15% average. Cured Pharmacy offers both medications with UK-registered prescriber consultations to help you choose the right option for your weight loss goals.
How do Wegovy and Mounjaro prices compare in the UK?
Mounjaro starts from £124.99 at Cured Pharmacy while Wegovy starts from £69.00 for lower doses, though comparable therapeutic doses differ. Use code Weightlossnew to save £20 off your first order of either treatment, making Cured Pharmacy the cheapest UK source for both medications.
Can I switch from Wegovy to Mounjaro through Cured Pharmacy?
Yes, you can switch from Wegovy to Mounjaro after completing a new consultation with our UK-registered prescribers. Cured Pharmacy will assess your weight loss progress on Wegovy and determine the appropriate starting dose of Mounjaro to ensure safe and effective transition between treatments.
Which has fewer side effects - Wegovy or Mounjaro?
Both Wegovy and Mounjaro share similar side effects including nausea, diarrhea and constipation, though individual tolerance varies. Cured Pharmacy provides full side effect guidance during your consultation and offers ongoing support to manage any symptoms you experience with either weight loss treatment.
Does the NHS prescribe Wegovy or Mounjaro for weight loss?
The NHS prescribes both medications but with strict eligibility criteria and long waiting lists in many areas. Cured Pharmacy offers faster access to both Wegovy and Mounjaro from £124.99 with same-day prescriptions from UK-registered clinicians, saving you months of waiting time.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Last reviewed: 17 July 2026