Wegovy vs Mounjaro: UK Results & Clinical Data 2025

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Wegovy vs Mounjaro UK Results - Cheapest Price £124.99

Compare real UK results and get the cheapest price on Mounjaro from £124.99 with £20 off your first order using code Weightlossnew.

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Our Pricing

Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £124.99

£31.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
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Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £159.00

£39.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
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Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £200.00

£50.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
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Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £225.00

£56.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
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Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £250.00

£62.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
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Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £267.00

£66.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
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Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £69.00

£17.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
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Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£99 £79.00

£19.75 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £99
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Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £99.00

£24.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
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Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £149.00

£37.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
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Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £179.00

£44.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
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Wegovy vs Mounjaro: Clinical Evidence & UK Results

When comparing wegovy vs mounjaro uk results, the clinical evidence shows distinct differences in weight loss outcomes, mechanisms of action, and patient experiences. At Cured Pharmacy, our UK-registered clinical team helps patients navigate these options with transparent pricing and expert guidance. Both medications are MHRA-licensed prescription treatments that require clinical assessment by a UK prescriber before dispensing.

How Mounjaro and Wegovy Work Differently

Mounjaro (tirzepatide) represents a significant advancement as the UK's first dual GIP/GLP-1 receptor agonist, activating two distinct hormonal pathways that regulate appetite, blood glucose, and energy metabolism [1]. This dual mechanism distinguishes it from single-pathway treatments and contributes to its enhanced clinical profile.

Wegovy (semaglutide) works through GLP-1 receptor activation alone, mimicking the natural glucagon-like peptide-1 hormone that reduces appetite and slows gastric emptying [2]. Both medications are administered as once-weekly subcutaneous injections, but their different mechanisms produce varying clinical outcomes in UK patients.

The dual-action approach of tirzepatide appears to produce more pronounced effects on insulin sensitivity and hepatic glucose production compared to GLP-1-only agonists, which may explain the superior weight loss results observed in head-to-head comparisons [1][3].

Clinical Trial Results: Wegovy vs Mounjaro UK Evidence

The SURMOUNT-1 trial demonstrated that Mounjaro patients achieved average weight reductions of 15.0%, 19.5%, and 20.9% at the 5mg, 10mg, and 15mg doses respectively over 72 weeks [1]. These results represent some of the highest efficacy figures recorded for any weight loss medication currently licensed in the UK.

In comparison, the STEP-1 trial for Wegovy showed an average 14.9% body weight reduction at the 2.4mg maintenance dose over 68 weeks [2]. While this represents clinically significant weight loss, the difference between the two medications becomes more apparent at higher dose comparisons.

Head-to-head data from the SURPASS-2 trial, which compared tirzepatide directly against semaglutide 1.0mg (the diabetes formulation), showed tirzepatide patients lost significantly more weight across all dose levels [3]. UK patients should note that individual results vary based on adherence, lifestyle modifications, and metabolic factors.

Real-World UK Patient Outcomes

Beyond controlled trials, UK prescribing data suggests both medications produce meaningful weight loss when combined with dietary changes and increased physical activity. Our clinical team at Cured Pharmacy observes that patients who maintain consistent injection schedules and engage with lifestyle support typically achieve results within the ranges reported in clinical trials, subject to individual variation.

Side Effects and Tolerability Comparison

Both medications share similar gastrointestinal side effect profiles, with nausea being the most commonly reported adverse event in clinical trials [1][2]. However, the incidence and severity can differ between the two treatments and typically diminish as patients adjust to therapy.

In the SURMOUNT-1 trial, nausea occurred in 29% of Mounjaro patients at the 10mg dose, while STEP-1 reported nausea in 44% of Wegovy patients at 2.4mg [1][2]. Gastrointestinal side effects including diarrhoea, constipation, and vomiting were reported with both medications, though individual tolerance varies considerably.

UK prescribers typically initiate treatment at low doses with gradual escalation to minimise side effects. At Cured Pharmacy, our clinical team provides comprehensive guidance on managing common adverse events, including dietary modifications and timing strategies that may improve tolerability throughout the titration period.

Managing Side Effects Effectively

Most gastrointestinal symptoms resolve within 4-8 weeks as the body adjusts to treatment. Patients who experience persistent or severe side effects should contact their prescriber, as dose adjustments or alternative treatments may be appropriate. Neither medication should be used during pregnancy or in patients with a personal or family history of medullary thyroid carcinoma.

Feature Mounjaro (Tirzepatide) Wegovy (Semaglutide)
Mechanism Dual GIP/GLP-1 agonist GLP-1 agonist only
Average Weight Loss Up to 20.9% (72 weeks) 14.9% (68 weeks)
Dosing Frequency Once weekly injection Once weekly injection
Starting Dose 2.5mg weekly 0.25mg weekly
Maximum Dose 15mg weekly 2.4mg weekly
Common Side Effects Nausea (29%), diarrhoea, constipation Nausea (44%), diarrhoea, vomiting
Price at Cured Pharmacy From £69.00 From £69.00
MHRA Licensed Yes Yes

Dosing Schedules and Treatment Protocols

Mounjaro follows a structured escalation schedule starting at 2.5mg weekly for four weeks, then increasing to 5mg, with potential further increases to 10mg or 15mg based on clinical response and tolerability [4]. This gradual approach allows the body to adapt whilst minimising gastrointestinal side effects.

Wegovy initiates at 0.25mg weekly, escalating through 0.5mg, 1.0mg, and 1.7mg doses before reaching the 2.4mg maintenance dose, typically over 16-20 weeks [2]. The slower titration schedule reflects the medication's potency and helps optimise patient tolerance throughout the dose-escalation phase.

Both medications require consistent weekly administration on the same day each week for optimal results. UK patients should inject subcutaneously into the abdomen, thigh, or upper arm, rotating injection sites to reduce the risk of lipodystrophy. Missed doses should be administered within 5 days for Wegovy and 4 days for Mounjaro; otherwise, patients should skip the missed dose and resume their regular schedule.

Cost Considerations and UK Availability

At Cured Pharmacy, Mounjaro is available from £124.99 per pen with transparent upfront pricing before your free consultation. We guarantee the lowest prices in the UK for genuine, MHRA-licensed medications dispensed by our UK-registered clinical team under the supervision of Superintendent Pharmacist Tarun Kumar (GPhC 2233073).

Treatment costs vary based on your prescribed dose and treatment duration. Both Mounjaro and Wegovy require ongoing use to maintain weight loss results, and UK patients should factor long-term costs into their treatment decision. Our clinical team ensures you receive the most appropriate medication based on your medical history, weight loss goals, and individual circumstances rather than cost alone.

Supply availability for both medications has improved significantly across UK pharmacies following manufacturing expansions. Cured Pharmacy maintains consistent stock levels and provides discreet next-day delivery throughout the UK, ensuring treatment continuity for our patients.

Prescription Requirements and Assessment Process

All weight loss injections are prescription-only medicines in the UK and require clinical assessment by a registered prescriber. Our online consultation takes under 3 minutes and is reviewed by UK-registered clinicians who assess your suitability based on BMI, medical history, current medications, and contraindications. Prescriptions are only issued when clinically appropriate and safe.

Which Treatment Is Right for You?

The choice between Wegovy and Mounjaro depends on multiple clinical factors including your weight loss goals, previous treatment responses, side effect tolerance, and medical history. Clinical trial data suggests Mounjaro may produce greater absolute weight loss, particularly at higher doses, whilst Wegovy offers proven efficacy with an established UK prescribing history [1][2][3].

UK prescribers consider your BMI, comorbidities such as type 2 diabetes or cardiovascular disease, and any contraindications when recommending treatment. Patients with type 2 diabetes may particularly benefit from Mounjaro's dual mechanism, which demonstrates superior glycaemic control compared to GLP-1-only agonists [3].

At Cured Pharmacy, our clinical team provides personalised recommendations based on your individual circumstances. Both medications require commitment to lifestyle modifications including reduced calorie intake and increased physical activity to achieve optimal results. Your prescriber will monitor your progress and adjust treatment as needed to ensure safe, effective weight management.

Starting Your Weight Loss Journey

Begin with our free online consultation, which takes under 3 minutes to complete. Our UK-registered prescribers will review your medical information and recommend the most appropriate treatment option. If approved, your medication is dispensed from our UK pharmacy with discreet packaging and next-day delivery. Ongoing clinical support is available throughout your treatment journey.

Scientific References

  1. Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205–216. https://doi.org/10.1056/NEJMoa2206038
  2. Wilding, J. P. H., Batterham, R. L., Calanna, S., et al. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine, 384(11), 989–1002. https://doi.org/10.1056/NEJMoa2032183
  3. Frías, J. P., Davies, M. J., Rosenstock, J., et al. (2021). Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. New England Journal of Medicine, 385(6), 503–515. https://doi.org/10.1056/NEJMoa2107519
  4. Medicines and Healthcare products Regulatory Agency. (2023). Mounjaro 2.5 mg solution for injection in pre-filled pen: Summary of Product Characteristics. Retrieved from https://www.gov.uk/government/organisations/medicines-and-healthcare-products-regulatory-agency

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication. Individual results may vary, and weight loss medications work best when combined with reduced calorie intake and increased physical activity.

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Faq

Is Mounjaro better than Wegovy for weight loss?
Clinical trials suggest Mounjaro produces greater average weight loss (up to 20.9%) compared to Wegovy (14.9%), though individual results vary based on adherence, lifestyle factors, and metabolic response. Your UK prescriber will recommend the most appropriate option based on your medical history.
Can I switch from Wegovy to Mounjaro?
Yes, switching between treatments is possible under prescriber supervision. Your UK clinician will determine the appropriate starting dose of Mounjaro based on your current Wegovy dose and clinical response, ensuring safe transition without treatment gaps.
How quickly do Wegovy vs Mounjaro work?
Most patients notice appetite reduction within 1-2 weeks of starting either medication, with measurable weight loss typically evident by week 4. Maximum effects occur after reaching maintenance doses, which takes 16-20 weeks for Wegovy and 8-12 weeks for Mounjaro.
Which has fewer side effects, Wegovy or Mounjaro?
Clinical trial data shows Mounjaro had lower nausea rates (29%) compared to Wegovy (44%) at therapeutic doses, though both medications share similar gastrointestinal side effect profiles. Individual tolerance varies, and most side effects diminish within 4-8 weeks.
Do I need a prescription for Wegovy or Mounjaro in the UK?
Yes, both medications are prescription-only medicines in the UK and require clinical assessment by a registered prescriber. At Cured Pharmacy, our free online consultation connects you with UK-registered clinicians who assess your suitability before prescribing.
How much do Wegovy and Mounjaro cost in the UK?
At Cured Pharmacy, Mounjaro starts from £124.99 and Wegovy from £135.00, representing the lowest guaranteed prices in the UK for genuine MHRA-licensed medications. Final costs depend on your prescribed dose and treatment duration.
Can I use Wegovy and Mounjaro together?
No, these medications should never be used concurrently as they work through overlapping mechanisms, which would significantly increase the risk of adverse effects without additional benefit. Your prescriber will recommend one treatment based on your individual clinical needs.
What happens when I stop taking Wegovy or Mounjaro?
Weight regain is common after discontinuing GLP-1 medications, as the appetite-suppressing effects cease. UK clinical guidance recommends ongoing lifestyle modifications and, where appropriate, transitioning to maintenance strategies to preserve weight loss achieved during treatment.
Which shows better weight loss results in the UK - Wegovy or Mounjaro?
Clinical studies show Mounjaro (tirzepatide) typically delivers greater weight loss results than Wegovy, with patients losing an average of 15-20% body weight versus 10-15% with Wegovy. Cured Pharmacy can help you access either medication following a UK prescriber consultation to determine which is most suitable for your weight loss goals.
How do Wegovy vs Mounjaro UK results differ over 12 months?
UK patient data shows Mounjaro users often achieve peak weight loss around month 10-12, typically losing 2-3kg more than Wegovy users over the same period. Both medications require consistent weekly injections, and Cured Pharmacy offers ongoing support and competitive pricing for either treatment throughout your weight loss journey.
Can I switch from Wegovy to Mounjaro to improve my results?
Yes, many UK patients switch from Wegovy to Mounjaro if their weight loss plateaus or they want enhanced results. Cured Pharmacy's UK-registered prescribers can assess your current treatment response and safely transition you to Mounjaro, starting at the appropriate dose based on your previous medication experience.
Does Mounjaro cost more than Wegovy for better UK results?
Mounjaro starts from £124.99 at Cured Pharmacy, which is competitive pricing for superior weight loss results compared to Wegovy. While Wegovy's lower doses may seem cheaper initially, Mounjaro's dual-action mechanism often delivers better value through more effective weight loss outcomes and fewer patients needing to escalate doses.
Are Wegovy vs Mounjaro UK results consistent across all patients?
Individual results vary, but UK clinical data shows Mounjaro consistently outperforms Wegovy across diverse patient groups, with 60-70% of Mounjaro users achieving 15%+ weight loss versus 40-50% of Wegovy users. Cured Pharmacy provides personalized UK prescriber consultations to predict which medication will likely work best based on your health profile and weight loss history.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Last reviewed: 17 July 2026