Wegovy vs Mounjaro UK - Compare Prices & Effectiveness

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Wegovy vs Mounjaro - Compare Prices & Cheapest UK

Compare Wegovy and Mounjaro at the cheapest UK price from £124.99 with £20 off code Weightlossnew.

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£145.00 From £124.99 £20 discount using discount code Weightlossnew
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Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £124.99

£31.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
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Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £159.00

£39.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
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Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £200.00

£50.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
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Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £225.00

£56.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
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Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £250.00

£62.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
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Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £267.00

£66.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
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Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £69.00

£17.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
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Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£109 £89.00

£22.25 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £109
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Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £99.00

£24.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
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Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £149.00

£37.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
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Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £179.00

£44.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
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Wegovy (Oral Pill)
Weeks 1–4

1.5mg

1 pen • 4 Weeks

£83.00

£20.75 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

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Wegovy (Oral Pill)
Weeks 5–8

4mg

1 pen • 4 Weeks

£110.00

£27.50 / Per Week

First step up – continues building tolerance for long-term success

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Wegovy (Oral Pill)
Weeks 9–12

9mg

1 pen • 4 Weeks

£140.00

£35.00 / Per Week

Mid-range dose – where most patients start seeing meaningful results

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Wegovy (Oral Pill)
Weeks 13+

25mg

1 pen • 4 Weeks

£199.00

£49.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

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Wegovy vs Mounjaro: Which Weight Loss Injection Is Right for You?

When comparing wegovy vs mounjaro, UK patients often ask which injectable weight loss treatment delivers better results and represents better value. Both Wegovy (semaglutide) and Mounjaro (tirzepatide) are prescription-only GLP-1 receptor agonists licensed by the MHRA for chronic weight management, yet they work through different mechanisms and demonstrate distinct efficacy profiles in clinical trials. As a UK-registered pharmacy with superintendent pharmacist Tarun Kumar (GPhC 2233073) overseeing clinical assessments, we help patients understand the evidence-based differences between these two leading treatments.

Wegovy vs Mounjaro: How They Work Differently

Understanding the wegovy vs mounjaro mechanism of action reveals why these treatments produce different results. Wegovy contains semaglutide, a GLP-1 (glucagon-like peptide-1) receptor agonist that mimics a single gut hormone to regulate appetite, slow gastric emptying, and improve glycaemic control [1]. Mounjaro contains tirzepatide, the first dual GIP/GLP-1 receptor agonist, which activates both glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptors simultaneously [2].

This dual-action mechanism in Mounjaro may explain why tirzepatide demonstrated superior weight loss outcomes in head-to-head trials. The GIP component enhances insulin secretion, reduces glucagon levels, and may improve fat metabolism beyond what GLP-1 agonism alone achieves [2]. Wegovy's single-pathway approach still produces clinically significant weight reduction, with the STEP trial programme showing average weight loss of 15-17% of initial body weight over 68 weeks [1]. Both medications require subcutaneous injection and are subject to prescriber approval following clinical assessment by a UK-registered healthcare professional.

Clinical Evidence: Wegovy vs Mounjaro Weight Loss Results

The wegovy vs mounjaro efficacy debate centres on robust clinical trial data from the STEP and SURPASS programmes. In the STEP 1 trial, adults using Wegovy 2.4mg weekly achieved an average 14.9% body weight reduction over 68 weeks, with 86.4% of participants losing at least 5% of their initial weight [1]. The SURPASS-2 trial directly compared tirzepatide against semaglutide 1mg (the diabetes dose, not the 2.4mg Wegovy dose) and found tirzepatide 15mg produced superior weight loss of up to 15.7kg compared to 6.7kg with semaglutide 1mg [3].

More recent data from the SURMOUNT-1 trial demonstrated that Mounjaro at the highest 15mg maintenance dose led to average weight loss of 20.9% over 72 weeks, significantly exceeding Wegovy's outcomes [3]. However, direct head-to-head trials comparing tirzepatide to semaglutide 2.4mg (Wegovy dose) remain limited. Both treatments show progressive weight loss that plateaus around 60-72 weeks, with maintenance requiring continued use. Individual response varies considerably based on adherence, lifestyle modifications, baseline BMI, and metabolic factors.

Real-World Effectiveness in UK Patients

Beyond controlled trials, real-world evidence from UK prescribing data suggests both wegovy vs mounjaro deliver meaningful weight reduction when combined with dietary changes and increased physical activity. Patients typically begin noticing appetite suppression within the first 4-8 weeks, with measurable weight loss appearing by week 12. Clinical guidelines from NICE recommend continuing treatment only if patients achieve at least 5% weight loss after 6 months, ensuring cost-effectiveness and appropriate use of NHS resources [4].

Wegovy vs Mounjaro Dosing and Administration Schedules

The wegovy vs mounjaro dosing protocols differ in titration speed and maximum maintenance doses. Wegovy follows a 16-week dose escalation: starting at 0.25mg weekly, increasing every 4 weeks through 0.5mg, 1mg, 1.7mg, reaching the maintenance dose of 2.4mg weekly [1]. This gradual titration minimises gastrointestinal side effects while allowing physiological adaptation.

Mounjaro uses a faster 12-week escalation schedule, beginning at 2.5mg weekly and increasing every 4 weeks through 5mg, 7.5mg, 10mg, 12.5mg, with a maximum dose of 15mg weekly [2]. The higher maximum dose may contribute to Mounjaro's superior weight loss outcomes but also increases the risk of dose-dependent adverse effects. Both medications are administered via subcutaneous injection in the abdomen, thigh, or upper arm, using pre-filled single-dose pens. Patients should rotate injection sites weekly and take their dose on the same day each week, with flexibility to adjust the day if needed as long as at least 48 hours separate consecutive doses.

Feature Wegovy (Semaglutide) Mounjaro (Tirzepatide)
Active Ingredient Semaglutide 2.4mg Tirzepatide up to 15mg
Mechanism GLP-1 receptor agonist Dual GIP/GLP-1 receptor agonist
Average Weight Loss 14.9% over 68 weeks 20.9% over 72 weeks
Dosing Frequency Once weekly injection Once weekly injection
Starting Dose 0.25mg weekly 2.5mg weekly
Maintenance Dose 2.4mg weekly 5mg to 15mg weekly
Titration Period 16 weeks 12 weeks
Price at Cured Pharmacy From £89.00 From £145.00
Common Side Effects Nausea, diarrhoea, vomiting Nausea, diarrhoea, vomiting
MHRA Licensed Yes Yes

Side Effects: Wegovy vs Mounjaro Safety Profiles

When evaluating wegovy vs mounjaro side effects, both medications share a similar adverse event profile dominated by gastrointestinal symptoms. The most common side effects include nausea (affecting 20-44% of users), diarrhoea, vomiting, constipation, abdominal pain, and dyspepsia [1][2]. These symptoms typically peak during dose escalation phases and diminish with continued use as the body adapts.

Mounjaro's higher maximum dose may correlate with slightly increased incidence of GI adverse events at the 15mg maintenance level, though discontinuation rates remain comparable between treatments (approximately 4-7% due to side effects) [3]. Both medications carry MHRA warnings regarding potential risks of pancreatitis, gallbladder disease, and thyroid C-cell tumours (observed in rodent studies but not confirmed in humans). Patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use either medication.

Managing Common Adverse Effects

The wegovy vs mounjaro tolerability comparison shows that most gastrointestinal side effects can be managed through dietary modifications: eating smaller portions, avoiding high-fat meals, staying well-hydrated, and consuming bland foods during the initial weeks. If nausea persists, patients should contact their prescriber to discuss temporary dose reduction or anti-emetic options. Serious adverse events requiring immediate medical attention include severe abdominal pain (possible pancreatitis), persistent vomiting leading to dehydration, or signs of allergic reaction.

Cost Analysis: Wegovy vs Mounjaro UK Pricing

The wegovy vs mounjaro price comparison reveals significant differences in UK private prescription costs. At Cured Pharmacy, Wegovy is available from £124.99 per 4-week supply, representing the cheapest UK price for this MHRA-licensed semaglutide formulation. Mounjaro pricing starts from £124.99 per 4-week supply, reflecting the newer dual-agonist technology and higher manufacturing costs.

Patients can Save £20 off their first order with code Weightlossnew, making initial treatment more accessible. While Mounjaro carries a higher upfront cost, some patients may find the potentially greater weight loss outcomes justify the price difference. Both treatments require ongoing monthly prescriptions for sustained weight management, so annual costs range from approximately £124.99 for Wegovy to £124.99 for Mounjaro. Neither medication is routinely available on NHS prescription for weight loss alone, though NHS England has announced plans for limited rollout in specialist weight management services [4].

Wegovy vs Mounjaro: Which Should You Choose?

The wegovy vs mounjaro decision ultimately depends on individual clinical circumstances, weight loss goals, budget, and tolerability. Mounjaro may be preferable for patients seeking maximum weight reduction and who can tolerate the higher cost and potentially more pronounced gastrointestinal effects during titration. Clinical trial data suggests tirzepatide produces approximately 5-6% greater total body weight loss compared to semaglutide 2.4mg, which may be significant for patients with higher baseline BMI or those who have plateaued on other treatments [3].

Wegovy remains an excellent first-line option offering proven efficacy at a more accessible price point, with extensive real-world safety data from several years of UK prescribing. Patients with significant cost sensitivity or those new to GLP-1 therapy may prefer starting with Wegovy and switching to Mounjaro only if weight loss plateaus below target. Both medications require commitment to long-term use, as weight regain typically occurs when treatment is discontinued [1][2].

At Cured Pharmacy, our UK-registered clinical team conducts comprehensive online assessments to determine which treatment aligns with your medical history, contraindications, concurrent medications, and weight management objectives. All prescriptions are issued by qualified UK prescribers following MHRA and GPhC guidelines, ensuring safe and appropriate use of these prescription-only medicines. Transparent pricing is provided upfront before consultation, with discreet next-day delivery across the UK.

Starting Your Treatment Journey

Whether you choose Wegovy or Mounjaro following clinical assessment, success requires combining medication with sustainable lifestyle changes including calorie reduction, increased physical activity, and behavioural modifications. Regular monitoring of weight, BMI, and metabolic markers helps track progress and inform ongoing treatment decisions. Our clinical team remains available throughout your journey to address side effects, adjust dosing schedules, or discuss switching between treatments if initial response is suboptimal.

Scientific References

  1. Wilding, J. P., Batterham, R. L., Calanna, S., Davies, M., Van Gaal, L. F., Lingvay, I., ... & Kushner, R. F. (2021). Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine, 384(11), 989-1002.
  2. Frias, J. P., Davies, M. J., Rosenstock, J., Pérez Manghi, F. C., Fernández Landó, L., Bergman, B. K., ... & SURPASS-2 Investigators. (2021). Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes. New England Journal of Medicine, 385(6), 503-515.
  3. Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., ... & SURMOUNT-1 Investigators. (2022). Tirzepatide once weekly for the treatment of obesity. New England Journal of Medicine, 387(3), 205-216.
  4. National Institute for Health and Care Excellence. (2023). Semaglutide for managing overweight and obesity [TA875]. NICE.

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication.

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Faq

Which is more effective for weight loss, Wegovy vs Mounjaro?
Clinical trials show Mounjaro (tirzepatide) produces greater average weight loss of approximately 20.9% compared to Wegovy's 14.9%, though individual results vary based on adherence, lifestyle factors, and metabolic response.
Is Mounjaro worth the extra cost compared to Wegovy?
Mounjaro costs approximately £124.99 more per month than Wegovy at Cured Pharmacy, which may be justified for patients seeking maximum weight reduction or those who haven't achieved goals with semaglutide-based treatments.
Can I switch from Wegovy to Mounjaro or vice versa?
Yes, patients can switch between wegovy vs mounjaro under prescriber guidance, though a brief washout period and retitration from a lower dose is typically recommended to minimise side effects and ensure safety.
Do Wegovy and Mounjaro have the same side effects?
Both share similar gastrointestinal side effects including nausea, diarrhoea, and vomiting, with Mounjaro potentially showing slightly higher incidence at maximum doses due to its dual-agonist mechanism and higher mg strength.
How long does it take to see results with Wegovy vs Mounjaro?
Most patients notice appetite suppression within 4-8 weeks and measurable weight loss by week 12 with both treatments, with maximum weight reduction typically occurring around 60-72 weeks of continued use.
Are Wegovy and Mounjaro available on the NHS?
Currently, neither medication is routinely available on NHS prescription for weight loss alone, though NHS England has announced plans for limited specialist service rollout subject to strict eligibility criteria.
Which has fewer side effects, Wegovy or Mounjaro?
The wegovy vs mounjaro side effect profiles are comparable, with discontinuation rates of 4-7% for both medications, though Wegovy's slower titration schedule and lower maximum dose may offer slightly better initial tolerability for some patients.
Can I use Wegovy or Mounjaro if I have diabetes?
Both medications are licensed for weight management in adults with or without type 2 diabetes, though dose adjustments to existing diabetes medications may be necessary to prevent hypoglycaemia when starting treatment.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Last reviewed: 27 July 2026