Wegovy or Mounjaro: UK Weight Loss Results | Cured Pharmacy

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Wegovy or Mounjaro UK - Cheapest Price From £69.00

Compare Wegovy or Mounjaro UK weight loss results and get the cheapest price from £124.99 plus £20 off with code Weightlossnew.

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Our Pricing

Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £124.99

£31.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
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Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £159.00

£39.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
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Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £200.00

£50.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
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Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £225.00

£56.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
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Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £250.00

£62.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
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Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £267.00

£66.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
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Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £69.00

£17.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
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Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£99 £79.00

£19.75 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £99
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Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £99.00

£24.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
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Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £149.00

£37.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
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Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £179.00

£44.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
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Wegovy or Mounjaro: UK Weight Loss Results Compared

Choosing between Wegovy or Mounjaro UK weight loss results requires understanding the clinical evidence behind each treatment. Both medications are MHRA-licensed injectable therapies that have transformed weight management in the UK, but they work through different mechanisms and produce distinct outcomes in clinical trials. At Cured Pharmacy, our UK-registered clinical team helps patients navigate this decision with transparent pricing and expert guidance.

Clinical Trial Results: Mounjaro vs Wegovy Weight Loss Outcomes

Mounjaro (tirzepatide) demonstrated superior weight loss in head-to-head comparison trials. In the SURPASS-2 study, patients taking the highest dose of tirzepatide achieved an average 22.5% total body weight reduction over 72 weeks, compared to 15.8% with semaglutide 1mg [1]. This represents approximately 6.7 percentage points greater weight loss with Mounjaro.

Wegovy (semaglutide 2.4mg) produced substantial results in the STEP trial programme, with participants losing an average of 14.9% body weight over 68 weeks [2]. While impressive, these outcomes were achieved at Wegovy's maximum licensed dose, whereas tirzepatide's results came from mid-range dosing, suggesting room for further optimisation.

Both medications significantly outperformed placebo and lifestyle intervention alone. The STEP-1 trial showed that 86.4% of Wegovy patients achieved at least 5% weight loss, whilst 69.1% reached 15% or greater [2]. Mounjaro's SURMOUNT-1 trial reported that 89% of patients on the 10mg dose lost at least 5% body weight, with 57% achieving 20% or more [3].

How Mounjaro and Wegovy Work Differently

Wegovy contains semaglutide, a selective GLP-1 receptor agonist that mimics a single gut hormone involved in appetite regulation and glucose metabolism. It slows gastric emptying, reduces hunger signals to the brain, and enhances insulin secretion when blood sugar rises [2].

Mounjaro represents a newer pharmacological approach as the first dual GIP/GLP-1 receptor agonist licensed in the UK. Tirzepatide activates both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors simultaneously [1]. This dual mechanism appears to produce greater metabolic effects, including enhanced insulin sensitivity and more pronounced appetite suppression.

The dual-agonist mechanism may explain Mounjaro's superior weight loss outcomes in comparative trials. GIP receptor activation complements GLP-1 effects by improving fat metabolism and potentially reducing inflammation associated with obesity [3]. However, individual responses vary, and some patients may experience better tolerability or efficacy with single-pathway GLP-1 treatments like Wegovy.

Onset of Weight Loss Results

Both medications produce gradual weight loss that accelerates during dose escalation. Most patients notice appetite reduction within the first two weeks, with measurable weight loss typically evident by week four. Peak weight loss generally occurs between 60-72 weeks of continuous treatment, though individual timelines vary based on adherence, lifestyle factors, and metabolic response [1][2].

Side Effect Profiles: What UK Patients Experience

Gastrointestinal side effects are the most common adverse events with both treatments. In clinical trials, nausea occurred in 44% of Mounjaro patients and 44% of Wegovy patients, though severity and duration varied [1][2]. Diarrhoea, constipation, and vomiting were also frequently reported, typically peaking during dose escalation phases.

Most gastrointestinal symptoms improve within 4-8 weeks as the body adapts to treatment. Starting at lower doses and following the prescribed escalation schedule significantly reduces side effect severity. Our clinical team at Cured Pharmacy provides detailed guidance on managing these effects, including dietary modifications and timing adjustments.

Serious adverse events remain rare but require awareness. Both medications carry warnings about potential thyroid C-cell tumours based on rodent studies, though no causal link has been established in humans [1][2]. Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use either medication. Pancreatitis, gallbladder disease, and hypoglycaemia (particularly in patients taking other diabetes medications) have been reported with both treatments.

Tolerability Differences

Discontinuation rates due to adverse events were similar between treatments: approximately 6.2% for Mounjaro and 7.0% for Wegovy in pivotal trials [1][2]. Some patients who cannot tolerate one medication may respond better to the other, making clinical assessment essential. Subject to prescriber approval, switching between treatments is possible if side effects prove problematic.

Factor Mounjaro (Tirzepatide) Wegovy (Semaglutide)
Mechanism Dual GIP/GLP-1 agonist Selective GLP-1 agonist
Average Weight Loss 22.5% at 72 weeks (highest dose) 14.9% at 68 weeks
Dosing Frequency Once weekly injection Once weekly injection
Starting Dose 2.5mg weekly 0.25mg weekly
Maintenance Doses 5mg, 7.5mg, 10mg, or 12.5mg 2.4mg
Common Side Effects Nausea (44%), diarrhoea, constipation Nausea (44%), vomiting, diarrhoea
Price at Cured Pharmacy From £69.00 From £69.00

Dosing Schedules and Administration

Both Mounjaro and Wegovy are administered as once-weekly subcutaneous injections using pre-filled pens. Injections can be given at any time of day, with or without meals, though maintaining a consistent weekly schedule optimises results.

Wegovy follows a five-step dose escalation over 16-20 weeks: 0.25mg for four weeks, 0.5mg for four weeks, 1mg for four weeks, 1.7mg for four weeks, then maintenance at 2.4mg weekly [2]. This gradual increase helps minimise gastrointestinal side effects whilst allowing the body to adapt.

Mounjaro uses a similar escalation approach with four maintenance dose options. Treatment typically begins at 2.5mg weekly for four weeks, increasing to 5mg, then potentially 7.5mg, 10mg, or 12.5mg based on efficacy and tolerability [1]. Your UK prescriber determines the optimal maintenance dose during follow-up consultations, balancing weight loss results against side effect burden.

Injection Technique and Storage

Both medications require refrigeration between 2-8°C until first use. Injection sites should be rotated between the abdomen, thigh, and upper arm to prevent lipodystrophy. The pre-filled KwikPen devices are designed for ease of use, with clear dose windows and simple activation mechanisms. Detailed injection training is provided with your first prescription, and our pharmacy team remains available for technique support.

Cost Comparison: Wegovy or Mounjaro UK Pricing

At Cured Pharmacy, Mounjaro starts from £124.99 per four-week supply, whilst Wegovy is available from £135.00, with transparent pricing displayed before your consultation begins. Final costs depend on your prescribed dose and treatment duration, determined by your UK prescriber based on clinical assessment.

Both treatments represent significant financial commitments, as weight loss typically requires 12-18 months of continuous therapy to achieve and maintain optimal results. However, Cured Pharmacy's pricing remains highly competitive compared to typical UK market rates, with our lowest price guarantee ensuring you receive genuine licensed medications without premium markups.

NHS prescription availability remains limited for weight loss indications, with strict eligibility criteria typically requiring BMI ≥35 with comorbidities or BMI ≥40. Private prescription through registered UK pharmacies like Cured offers broader access, subject to clinical suitability assessment by our prescribers.

Which Treatment Is Right for You?

Choosing between Wegovy and Mounjaro depends on multiple factors beyond weight loss percentages. Clinical trial data suggests Mounjaro may produce greater average weight reduction, but individual responses vary significantly based on genetics, lifestyle adherence, concurrent medications, and metabolic factors [1][3].

Your medical history plays a crucial role in treatment selection. Patients with cardiovascular disease may benefit from semaglutide's established cardiovascular outcomes data, whilst those seeking maximum weight loss potential might prioritise tirzepatide's dual-mechanism approach. Previous experience with GLP-1 medications, tolerance of gastrointestinal side effects, and injection frequency preferences also influence the decision.

At Cured Pharmacy, every prescription requires completion of a comprehensive online consultation reviewed by UK-registered prescribers. This assessment evaluates your BMI, weight loss goals, medical conditions, current medications, and previous treatment responses. Our clinical team, led by Superintendent Pharmacist Tarun Kumar (GPhC 2233073), ensures you receive the most appropriate treatment based on current MHRA guidelines and NICE recommendations.

Starting your assessment takes under three minutes, with prescriber review typically completed within 24 hours. Both Mounjaro and Wegovy are dispensed with full patient information leaflets, injection guidance, and access to ongoing clinical support throughout your weight loss journey.

Combination with Lifestyle Changes

Neither medication replaces the need for dietary modification and increased physical activity. Clinical trials demonstrating impressive weight loss outcomes all incorporated structured lifestyle interventions alongside pharmacotherapy [1][2]. Patients who combine medication with sustainable behaviour changes achieve better long-term weight maintenance and metabolic health improvements than those relying on medication alone.

Scientific References

  1. Frías, J. P., Davies, M. J., Rosenstock, J., et al. (2021). Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. New England Journal of Medicine, 385(6), 503-515. https://doi.org/10.1056/NEJMoa2107519
  2. Wilding, J. P. H., Batterham, R. L., Calanna, S., et al. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine, 384(11), 989-1002. https://doi.org/10.1056/NEJMoa2032183
  3. Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205-216. https://doi.org/10.1056/NEJMoa2206038

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication. Weight loss results from clinical trials represent average outcomes and individual results may vary. Neither Mounjaro nor Wegovy should replace lifestyle modifications including diet and exercise.

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Faq

Which is better for weight loss, Wegovy or Mounjaro?
Clinical trials show Mounjaro produced greater average weight loss (22.5% vs 14.9% in comparative studies), but individual responses vary significantly. Your UK prescriber will recommend the most suitable option based on your medical history, treatment goals, and tolerability factors.
How quickly do Wegovy and Mounjaro produce weight loss results in the UK?
Most patients notice appetite reduction within 2 weeks and measurable weight loss by week 4. Peak weight loss typically occurs between 60-72 weeks of continuous treatment, with gradual progression throughout the escalation phase.
Can I switch from Wegovy to Mounjaro or vice versa?
Yes, switching between treatments is possible subject to prescriber approval. Some patients who experience intolerable side effects or inadequate weight loss with one medication may respond better to the other. Your UK prescriber will determine appropriate transition protocols.
Are Wegovy or Mounjaro available on the NHS?
NHS availability is limited and subject to strict eligibility criteria, typically requiring BMI ≥35 with weight-related comorbidities. Private prescription through UK-registered pharmacies like Cured offers broader access following clinical assessment.
What are the main side effects of Wegovy or Mounjaro?
Both medications commonly cause gastrointestinal effects including nausea (44% of patients), diarrhoea, constipation, and vomiting, typically during dose escalation. Most symptoms improve within 4-8 weeks as the body adapts to treatment.
How much does Mounjaro cost compared to Wegovy in the UK?
At Cured Pharmacy, Mounjaro starts from £124.99 whilst Wegovy begins at £135.00 per four-week supply. Final costs depend on your prescribed maintenance dose, determined by your UK prescriber during clinical assessment.
Do I need a prescription for Wegovy or Mounjaro in the UK?
Yes, both are prescription-only medications requiring clinical assessment by a UK-registered prescriber. Cured Pharmacy provides a free online consultation reviewed by our clinical team, with prescriptions issued only when clinically appropriate.
How long do I need to take Wegovy or Mounjaro for weight loss?
Clinical trials demonstrating optimal results used 68-72 weeks of continuous treatment. Most patients require 12-18 months to achieve target weight loss, with ongoing therapy often needed for weight maintenance. Your prescriber will review progress at regular intervals.
Which gives better weight loss results in the UK, Wegovy or Mounjaro?
Clinical trials show Mounjaro typically delivers greater average weight loss than Wegovy, with patients losing around 15-22% of body weight compared to 10-15% with Wegovy. Cured Pharmacy can help you choose the right treatment based on your individual health profile and weight loss goals during your online consultation.
Is Mounjaro more expensive than Wegovy in the UK?
Mounjaro starts from £124.99 at Cured Pharmacy while Wegovy starts from £69.00 for lower starter doses, but prices vary by dose strength. Both medications are available at competitive prices through Cured Pharmacy with £20 off your first order using code Weightlossnew.
Can I switch from Wegovy to Mounjaro for better weight loss results?
Yes, you can switch from Wegovy to Mounjaro under medical supervision if you want to try a different treatment approach. Cured Pharmacy's UK-registered prescribers will review your current treatment, assess your suitability for Mounjaro, and guide you through the dose transition safely.
How quickly will I see weight loss results with Wegovy or Mounjaro UK?
Most patients notice initial weight loss within 4-8 weeks, with maximum results typically seen after 6-12 months of consistent use alongside diet and exercise. Cured Pharmacy provides ongoing support throughout your weight loss journey to help you achieve the best possible Wegovy or Mounjaro UK weight loss results.
Do I need different prescriptions for Wegovy and Mounjaro in the UK?
Yes, Wegovy and Mounjaro are different medications requiring separate prescriptions from a UK-registered prescriber. Cured Pharmacy offers online consultations for both treatments, making it easy to get the appropriate prescription and decide which medication suits your weight loss needs best.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Last reviewed: 17 July 2026