Wegovy vs Mounjaro UK - Compare Prices & Effectiveness

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Wegovy vs Mounjaro UK - Compare Prices & Cheapest Option

Compare Wegovy vs Mounjaro at the cheapest UK price from £124.99 — Save £20 off with code Weightlossnew.

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Woman using Cured Pharmacy online consultation for weight loss treatment

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Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £124.99

£31.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
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Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £159.00

£39.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
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Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £200.00

£50.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
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Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £225.00

£56.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
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Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £250.00

£62.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
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Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £267.00

£66.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
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Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £69.00

£17.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
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Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£109 £89.00

£22.25 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £109
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Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £99.00

£24.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
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Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £149.00

£37.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
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Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £179.00

£44.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
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Wegovy (Oral Pill)
Weeks 1–4

1.5mg

1 pen • 4 Weeks

£83.00 £63.00

£20.75 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £83.00
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Wegovy (Oral Pill)
Weeks 5–8

4mg

1 pen • 4 Weeks

£110.00 £90.00

£27.50 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £110.00
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Wegovy (Oral Pill)
Weeks 9–12

9mg

1 pen • 4 Weeks

£140.00 £120.00

£35.00 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £140.00
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Wegovy (Oral Pill)
Weeks 13+

25mg

1 pen • 4 Weeks

£199.00 £179.00

£49.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199.00
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Wegovy vs Mounjaro: Which Weight Loss Injection Is Best for You?

When comparing Wegovy vs Mounjaro, both GLP-1 receptor agonist injections offer proven weight loss results, but they differ in mechanism, efficacy, and cost. Mounjaro (tirzepatide) targets both GLP-1 and GIP receptors, whilst Wegovy (semaglutide) targets GLP-1 alone—a distinction that influences their comparative effectiveness. As a UK-registered pharmacy with transparent pricing and expert clinical support, Cured Pharmacy helps patients navigate this choice with confidence.

How Wegovy vs Mounjaro Work Differently in Your Body

Understanding the pharmacological difference between Wegovy vs Mounjaro is essential for informed decision-making. Wegovy contains semaglutide, a GLP-1 (glucagon-like peptide-1) receptor agonist that mimics a natural gut hormone to reduce appetite, slow gastric emptying, and improve blood sugar regulation [1]. Mounjaro, however, contains tirzepatide—a dual GIP/GLP-1 receptor agonist that activates both glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 pathways simultaneously [2].

This dual-action mechanism gives Mounjaro a theoretical advantage in metabolic impact. Clinical trials suggest the additional GIP receptor activation may enhance insulin secretion, improve lipid metabolism, and potentially amplify weight loss compared to GLP-1 monotherapy [2]. Both medications are administered as once-weekly subcutaneous injections and require gradual dose escalation to minimise gastrointestinal side effects, which are common to the GLP-1 class.

Wegovy vs Mounjaro Weight Loss Results: What Clinical Trials Show

Head-to-head data on Wegovy vs Mounjaro efficacy comes primarily from the SURPASS-2 trial, which directly compared tirzepatide to semaglutide 1mg (the dose used in Ozempic, not Wegovy's higher 2.4mg maintenance dose) [3]. In that study, participants on tirzepatide 15mg lost an average of 12.4kg over 40 weeks, compared to 6.2kg on semaglutide 1mg—a statistically significant difference.

However, when comparing maximum approved doses—Wegovy 2.4mg vs Mounjaro 15mg—the gap narrows. The STEP 1 trial demonstrated that Wegovy 2.4mg produced an average weight loss of 14.9% of body weight over 68 weeks in adults without diabetes [1]. The SURMOUNT-1 trial showed Mounjaro 15mg achieved an average of 20.9% body weight reduction over 72 weeks [4]. Both medications outperform older weight loss treatments significantly, but Mounjaro appears to deliver greater average weight loss at maximum doses, subject to individual response and tolerability.

Real-World Weight Loss Expectations for Wegovy vs Mounjaro

In clinical practice, results vary widely based on adherence, lifestyle factors, starting BMI, and metabolic health. Most patients on either Wegovy or Mounjaro begin noticing appetite suppression within the first two weeks, with measurable weight loss typically evident by week four. Optimal results require staying on treatment for at least six months, combined with a reduced-calorie diet and increased physical activity. Neither medication is a standalone solution—they are adjuncts to comprehensive lifestyle modification.

Side Effects: Wegovy vs Mounjaro Tolerability and Safety

The side effect profiles of Wegovy vs Mounjaro are broadly similar, as both belong to the GLP-1 receptor agonist class. The most common adverse effects include nausea, vomiting, diarrhoea, constipation, and abdominal discomfort, particularly during dose escalation [1][2]. These gastrointestinal symptoms are typically mild to moderate and diminish over time as the body adjusts.

Some trial data suggest Mounjaro may cause slightly higher rates of nausea and vomiting at higher doses compared to Wegovy, though individual tolerability varies [3][4]. Both medications carry a boxed warning in the US regarding thyroid C-cell tumours observed in rodent studies—though no causal link has been established in humans, neither should be used in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2.

Rare but serious risks include pancreatitis, gallbladder disease, and hypoglycaemia (especially when combined with insulin or sulfonylureas). All patients require clinical assessment by a UK-registered prescriber before starting either treatment, with ongoing monitoring for adverse effects and treatment response.

Feature Wegovy Mounjaro
Active Ingredient Semaglutide 2.4mg Tirzepatide up to 15mg
Mechanism GLP-1 receptor agonist Dual GIP/GLP-1 receptor agonist
Average Weight Loss 14.9% body weight (68 weeks) 20.9% body weight (72 weeks)
Dosing Frequency Once weekly injection Once weekly injection
Starting Price (Cured Pharmacy) From £89.00 From £145.00
Common Side Effects Nausea, vomiting, diarrhoea Nausea, vomiting, diarrhoea
NHS Availability Limited (NICE approved, not widely commissioned) Limited (NICE approved 2024)
Prescription Required Yes Yes

Wegovy vs Mounjaro UK Price Comparison and Availability

Cost is a critical factor when choosing between Wegovy vs Mounjaro, as neither is routinely available on NHS prescription for weight loss alone—most patients access them privately. At Cured Pharmacy, Wegovy starts from £124.99 per injection pen, whilst Mounjaro starts from £124.99, reflecting differences in manufacturing, licensing, and market positioning [5].

Supply availability fluctuates across the UK due to high demand and manufacturing constraints. Wegovy experienced significant shortages throughout 2023 and early 2024, though supply has stabilised. Mounjaro, approved more recently for weight management in the UK, has generally maintained better stock levels. Cured Pharmacy provides transparent upfront pricing and real-time stock visibility, ensuring patients can make informed decisions without hidden consultation fees.

Insurance and NHS Coverage for Wegovy vs Mounjaro

NHS England has restricted access to both medications due to budget constraints and supply issues. NICE guidelines recommend semaglutide 2.4mg (Wegovy) for weight management in adults with a BMI ≥35 (or ≥32.5 in certain ethnic groups) with at least one weight-related comorbidity, but local ICBs may not commission it. Tirzepatide (Mounjaro) received NICE approval for weight management in early 2024 under similar criteria, though rollout remains limited. Most UK patients currently access these treatments privately, with costs ranging from approximately £124.99 to £124.99+ per month depending on dose and provider.

Dosing and Administration: Wegovy vs Mounjaro Schedules

Both Wegovy vs Mounjaro require gradual dose titration to improve gastrointestinal tolerability. Wegovy starts at 0.25mg weekly for four weeks, increasing monthly through 0.5mg, 1mg, 1.7mg, and finally 2.4mg maintenance dose [1]. Mounjaro begins at 2.5mg weekly for four weeks, then escalates to 5mg, 7.5mg, 10mg, 12.5mg, and up to 15mg maximum [2].

Each medication is supplied in pre-filled, single-use injection pens designed for subcutaneous self-administration into the abdomen, thigh, or upper arm. Patients rotate injection sites weekly to minimise local reactions. Missed doses should be taken within five days for Wegovy or within four days for Mounjaro; otherwise, skip the missed dose and resume the regular schedule. Both medications require refrigeration before first use, though Wegovy pens can be stored at room temperature for up to 28 days once in use.

Who Should Choose Wegovy vs Mounjaro? Clinical Considerations

Deciding between Wegovy vs Mounjaro depends on individual clinical factors, cost sensitivity, and treatment goals. Mounjaro may be preferable for patients seeking maximum average weight loss and who can tolerate higher upfront costs, particularly those with type 2 diabetes (as tirzepatide also has robust glycaemic benefits) [4]. Wegovy offers a proven track record, broader real-world experience, and lower cost per dose, making it an excellent first-line choice for many patients.

Neither medication is suitable for patients with a history of medullary thyroid carcinoma, MEN 2 syndrome, or severe gastrointestinal disease. Pregnant or breastfeeding women should not use either treatment. Patients with a history of pancreatitis, gallstones, or diabetic retinopathy require careful risk-benefit assessment. At Cured Pharmacy, every prescription undergoes clinical review by our UK-registered prescribers, led by Superintendent Pharmacist Tarun Kumar (GPhC 2233073), ensuring safe, personalised treatment decisions.

Ultimately, the 'best' choice between Wegovy vs Mounjaro is the one you can afford, tolerate, and sustain long-term. Both are highly effective tools when combined with lifestyle modification, and switching between them is possible if initial results or tolerability are suboptimal.

How to Get Started with Wegovy vs Mounjaro at Cured Pharmacy

Starting treatment is straightforward: complete a free online consultation (under three minutes) on the Cured Pharmacy website, where a UK prescriber reviews your medical history, current medications, and weight loss goals. If clinically appropriate, your prescription is issued and dispensed from our GPhC-registered pharmacy (9012511), with discreet next-day delivery across the UK. New patients Save £20 off their first order with code Weightlossnew, making Wegovy available from £124.99—the cheapest UK price for genuine, licensed medication with full clinical support.

Scientific References

  1. Wilding, J. P., et al. (2021). Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine, 384(11), 989-1002. [accessed 15 August 2026]
  2. Frias, J. P., et al. (2021). Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes. New England Journal of Medicine, 385(6), 503-515. [accessed 15 August 2026]
  3. Frías, J. P., et al. (2021). Efficacy and safety of tirzepatide in type 2 diabetes: The SURPASS-2 trial. Diabetes Care, 44(11), 2523-2532. [accessed 15 August 2026]
  4. Jastreboff, A. M., et al. (2022). Tirzepatide once weekly for the treatment of obesity. New England Journal of Medicine, 387(3), 205-216. [accessed 15 August 2026]
  5. National Institute for Health and Care Excellence. (2023). Semaglutide for managing overweight and obesity [TA875]. [accessed 15 August 2026]
  6. NHS. (2026). Tirzepatide: a medicine to manage type 2 diabetes and treat obesity. https://www.nhs.uk/medicines/tirzepatide/ Accessed 15 August 2026.
  7. NHS. (2026). Overweight and obesity in adults. https://www.nhs.uk/conditions/overweight-and-obesity/ Accessed 15 August 2026.
  8. NHS England. (2026). Weight management injections. https://www.england.nhs.uk/ourwork/prevention/obesity/medicines-for-obesity/weight-management-injections/ Accessed 15 August 2026.

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication.

Trusted by thousands

Real people, real results

Jane L.

"Brilliant. Lost 4 stone on mounjaro no side effects at all. Cured pharmacy are excellent. Always helpful pens sent out quickly always comes with needles and sterile wipes. If you want to go on GLP-1 go to cured pharmacy. So professional. Thank you cured pharmacy you changed my health and well being."

Ann-Marie

"I absolutely love this product, I have been using 2.5mg as maintenance dose and have managed to control my weight without any side effects and can still eat well balanced meals. The pharmacy is very efficient friendly and helpful I would not purchase from anywhere else."

Sacha W.

"So far I'm really impressed by my results it's crazy cause I'm not snacking like how I used to do and I see my face slimming down already and it's only been 2 and a half weeks. Can't wait to give my feedback in 5 months time thank you cured pharmacy."

Kimberly G.

"Mounjaro has corrected my hormonal weight gain during menopause. I am using it now to maintain that balance. The results for me have been exceptional!"

Jennifer

"Great really helps cure those nasty habits can't wait for my next mounjaro pen."

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Faq

How much is Mounjaro 2.5mg?
Mounjaro 2.5mg costs from £124.99 at Cured Pharmacy, You just need to have a free online consultation, to check your eligibility.
How much is Mounjaro 5mg?
Mounjaro 5mg costs from £159.00 at Cured Pharmacy, You just need to have a free online consultation, to check your eligibility.
Which is better for weight loss, Wegovy or Mounjaro?
Clinical trials show Mounjaro (tirzepatide) produces greater average weight loss than Wegovy (semaglutide) at maximum doses—20.9% vs 14.9% body weight reduction. However, individual response varies, and Wegovy remains highly effective with a longer track record and lower cost.
Is Mounjaro worth the extra cost compared to Wegovy?
Mounjaro costs approximately £124.99 vs Wegovy's £124.99 at Cured Pharmacy. The additional cost may be justified if you prioritise maximum weight loss potential or have type 2 diabetes, but Wegovy offers excellent value and proven efficacy for most patients.
Can I switch from Wegovy to Mounjaro or vice versa?
Yes, switching between Wegovy vs Mounjaro is possible under prescriber guidance. Your clinician will determine the appropriate starting dose based on your current treatment and response, typically requiring a brief washout period.
Do Wegovy and Mounjaro have the same side effects?
Both Wegovy vs Mounjaro share similar gastrointestinal side effects—nausea, vomiting, diarrhoea, and constipation—as they belong to the same GLP-1 drug class. Severity and frequency vary individually, with dose escalation helping to minimise symptoms.
How long does it take to see results with Wegovy vs Mounjaro?
Most patients notice appetite suppression within 1-2 weeks on either Wegovy or Mounjaro, with measurable weight loss by week 4. Optimal results require at least 6 months of treatment combined with diet and exercise modifications.
Are Wegovy and Mounjaro available on the NHS?
Both medications have NICE approval for weight management, but NHS access is extremely limited due to budget constraints. Most UK patients access Wegovy vs Mounjaro privately, with Cured Pharmacy offering the cheapest UK prices from £124.99.
Which injection is easier to use, Wegovy or Mounjaro?
Both use pre-filled, single-use injection pens with similar administration techniques. Patients report comparable ease of use for Wegovy vs Mounjaro, with once-weekly subcutaneous injections into the abdomen, thigh, or upper arm.
Can I take Wegovy or Mounjaro if I have type 2 diabetes?
Yes, both Wegovy and Mounjaro are suitable for patients with type 2 diabetes—in fact, Mounjaro is also licensed as Mounjaro for diabetes management. Your prescriber will adjust other diabetes medications to prevent hypoglycaemia when starting either treatment.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Reviewed on: June 03, 2026

Last reviewed: 15 August 2026

Last updated on 15 August 2026.

Review History

Our experts continually monitor new findings in health and medicine, and we update our articles when new information becomes available.

Why this page was updated on 15 August 2026

Content checked and updated as part of our periodic review, to ensure accuracy and currentness.

Current version (15 August 2026)

Edited by: The Editorial Team

Medically reviewed by:

Tarun Kumar, GPhC No. 2233073, Prescribing Pharmacist


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