Tadalafil and Naftidrofuryl: Can You Take Them Together?

Tadalafil and Naftidrofuryl: Understanding the Interaction

Published: 23 October 2026

If you're considering tadalafil and naftidrofuryl together, you'll want to know whether this combination is safe. Tadalafil is a PDE5 inhibitor used to treat erectile dysfunction (ED), while naftidrofuryl is a vasodilator prescribed for peripheral arterial disease and circulation problems. No major interaction between tadalafil and naftidrofuryl is commonly reported in clinical references, but because both medicines can affect blood flow and blood pressure, your prescriber will carefully review your individual circumstances during your consultation [2][4].

What Is Tadalafil and How Does It Work?

Tadalafil is a prescription medicine licensed in the UK for erectile dysfunction. It belongs to a group of medicines called PDE5 inhibitors, which work by relaxing blood vessels in the penis, allowing increased blood flow when you are sexually aroused [4]. Tadalafil does not cause an erection on its own—sexual stimulation is still needed.

Tadalafil is available in two main forms: on-demand tablets (usually 10mg or 20mg taken at least 30 minutes before sexual activity, with effects lasting up to 36 hours) and daily low-dose tablets (2.5mg or 5mg taken once a day) [4]. The branded version is known as Cialis, but generic tadalafil is widely available and works in exactly the same way.

At Cured Pharmacy, tadalafil is available from £7.95 after an online consultation with a UK-registered prescriber. Because tadalafil can interact with other medicines and is not suitable for everyone, a clinical assessment is required before it can be supplied [2][4].

What Is Naftidrofuryl and Why Is It Prescribed?

Naftidrofuryl is a vasodilator medicine prescribed to improve blood flow in people with peripheral arterial disease (PAD), a condition where narrowed arteries reduce circulation to the legs and other parts of the body. It is commonly used to relieve symptoms such as leg pain during walking (intermittent claudication) and night cramps.

Naftidrofuryl works by widening blood vessels and improving the ability of red blood cells to carry oxygen to tissues. It does not directly affect the heart or blood pressure in the same way as some other cardiovascular medicines, but it does influence circulation throughout the body.

Because naftidrofuryl affects blood flow, your prescriber will want to know if you are taking it when you request treatment for erectile dysfunction. This allows them to assess whether any additional monitoring or dose adjustments are needed to keep you safe [2].

Can You Take Tadalafil and Naftidrofuryl Together?

No major interaction between tadalafil and naftidrofuryl is commonly reported in UK clinical references. However, both medicines influence blood flow and circulation, so there is a theoretical possibility that taking them together could add to blood-pressure-lowering effects, potentially causing dizziness or light-headedness in some people [2][4].

Your prescriber will review your full medical history, current medicines, and overall cardiovascular health during your consultation. They will check whether you have any conditions that make tadalafil unsuitable—such as recent heart attack or stroke, unstable angina, severe heart failure, or very low blood pressure—and whether the combination with naftidrofuryl is appropriate for you [2][4].

It is important to declare naftidrofuryl (and all other medicines, including over-the-counter products and supplements) when you complete your online consultation. Do not stop or change your prescribed naftidrofuryl without speaking to your GP or prescriber first, as this medicine is treating an important underlying condition.

What Your Prescriber Will Check

During your consultation, the prescriber will ask about your blood pressure, heart health, and any symptoms you experience when taking naftidrofuryl. They will also check for other medicines that are known to interact more seriously with tadalafil, such as nitrates, nicorandil, riociguat, or alpha-blockers [2][4]. If you are stable on naftidrofuryl and have no other contraindications, tadalafil may be prescribed, often starting at a lower dose to monitor how you respond.

Other Medicines That Interact With Tadalafil and Naftidrofuryl

While tadalafil and naftidrofuryl do not have a well-documented major interaction, tadalafil does interact seriously with certain other medicines. You must never take tadalafil with nitrates (such as GTN spray, isosorbide mononitrate, or isosorbide dinitrate), nicorandil, riociguat, or amyl/alkyl nitrites (poppers), as the combination can cause a dangerous drop in blood pressure [4].

Alpha-blockers used for prostate symptoms or high blood pressure (such as doxazosin, tamsulosin, alfuzosin, terazosin, prazosin, silodosin, or indoramin) can also lower blood pressure when combined with tadalafil. If you take an alpha-blocker, you should be stable on it before starting tadalafil, and your prescriber will usually recommend the lowest dose of the ED medicine [2][4].

Potent CYP3A4 inhibitors—including some HIV medicines (ritonavir, cobicistat), antifungals (ketoconazole, itraconazole), antibiotics (clarithromycin), and Paxlovid—can raise tadalafil levels in your blood, requiring dose adjustments. Conversely, CYP3A4 inducers such as rifampicin, carbamazepine, phenytoin, and St John's wort can make tadalafil less effective [4]. Your prescriber will check all of these during your consultation.

Practical Advice When Taking Tadalafil and Naftidrofuryl

If your prescriber approves tadalafil while you are taking naftidrofuryl, start with the lowest effective dose and monitor how you feel. Stand up slowly from sitting or lying down, especially in the first few days, to reduce the risk of dizziness or light-headedness. Avoid heavy alcohol, as it can worsen erectile dysfunction and add to blood-pressure-lowering effects [1][4].

Take tadalafil as directed—on-demand tablets should be taken at least 30 minutes before sexual activity, while daily tablets are taken at the same time each day. Do not take more than the prescribed dose, and do not combine tadalafil with another PDE5 inhibitor (such as sildenafil or vardenafil) [4].

Keep all your regular GP appointments and monitoring for peripheral arterial disease. If you notice new symptoms—such as chest pain during sex, sudden vision or hearing loss, or an erection lasting more than four hours—seek urgent medical help. Report any persistent dizziness, fainting, or worsening leg symptoms to your GP or prescriber promptly [1][2].

Lifestyle Measures to Support Both Conditions

Both erectile dysfunction and peripheral arterial disease share common risk factors, including smoking, high blood pressure, high cholesterol, diabetes, and lack of physical activity [1][2]. Stopping smoking, eating a balanced diet, maintaining a healthy weight, and taking regular exercise can improve circulation, heart health, and erectile function. Your GP can offer support with smoking cessation, blood pressure control, and cholesterol management, which will benefit both conditions.

How to Get Tadalafil Safely at Cured Pharmacy

Cured Pharmacy is a GPhC-registered online pharmacy (GPhC 9012511) offering a range of erectile dysfunction treatments after a clinical consultation with a UK-registered prescriber. You complete a short online questionnaire about your health, current medicines (including naftidrofuryl), and symptoms. A prescriber reviews your answers and, if appropriate, approves your treatment [2].

Tadalafil is available from £7.95 (£6.36 on your first order with code Ednew). We also offer other PDE5 inhibitors, including sildenafil from £0.45, vardenafil from £16.95, and avanafil (Spedra) from £20.95. Branded Cialis is available from £12.00. All prices include the consultation, prescription, and delivery.

If you have not seen your GP about erectile dysfunction before, we encourage you to do so. ED can be an early warning sign of heart disease, diabetes, or other health conditions that need investigation and treatment [1][2]. Your GP can arrange tests, review your cardiovascular risk, and refer you to a specialist if needed. Online treatment is a convenient option once any underlying causes have been explored.

What Happens During Your Online Consultation

You will be asked about your medical history, current medicines (including naftidrofuryl), blood pressure, heart health, and any symptoms you experience. The prescriber will check for contraindications and interactions, and may recommend a lower starting dose or additional monitoring if needed [2][4]. If tadalafil is not suitable, the prescriber will explain why and suggest alternatives, which may include a different PDE5 inhibitor, a referral to your GP, or non-medicine options such as vacuum devices or counselling.

Scientific References

1. NHS. (n.d.). Erectile dysfunction (impotence). NHS website. https://www.nhs.uk/conditions/erection-problems-erectile-dysfunction/ [accessed 23 October 2026]
2. National Institute for Health and Care Excellence. (n.d.). Erectile dysfunction. Clinical Knowledge Summaries. https://cks.nice.org.uk/topics/erectile-dysfunction/ [accessed 23 October 2026]
3. Joint Formulary Committee. (n.d.). Tadalafil. British National Formulary. NICE. https://bnf.nice.org.uk/drugs/tadalafil/ [accessed 23 October 2026]

Information on this page is for educational purposes only and is not medical advice. Prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting or changing any medication.

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