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Avanafil Pack Sizes: Strengths, Prices and How to Order Safely in the UK
Published: 6 November 2026
Avanafil pack sizes in the UK are available in three strengths—50mg, 100mg, and 200mg—each designed to treat erectile dysfunction with a fast onset of action. Avanafil is the active ingredient in Spedra, a prescription-only medicine that can work in as little as 15–30 minutes, making it one of the fastest-acting oral treatments for ED [6]. Understanding the different pack sizes, how they are supplied, and what affects the price helps you choose the right option and order safely after an online consultation with a UK-registered prescriber.
Key takeaways
- Avanafil is available in 50mg, 100mg, and 200mg strengths, with 100mg as the usual starting dose.
- Spedra (avanafil) costs £20.95 per pack, or £16.76 for your first order with code Ednew.
- Avanafil works in 15–30 minutes, faster than most other oral ED treatments.
- All avanafil products require a prescription after an online consultation with a UK-registered prescriber.
- Larger pack sizes may offer better value, but starting with a smaller pack helps you assess suitability.
What avanafil pack sizes are available in the UK?
Avanafil is licensed in the UK in three tablet strengths: 50mg, 100mg, and 200mg [6]. The usual starting dose is 100mg, taken about 15–30 minutes before sexual activity, and your prescriber may adjust this to 200mg if needed or reduce it to 50mg if you experience side effects or have certain medical conditions [6]. Each strength is supplied as film-coated tablets, and pack sizes typically range from 4 to 8 tablets, though availability can vary between pharmacies and suppliers.
At Cured Pharmacy, Spedra (avanafil) is available at £20.95 per pack, or £16.76 for your first order when you use the code Ednew. All avanafil products are prescription-only medicines, so you will need to complete an online consultation that is reviewed by a UK-registered prescriber before your order is dispensed. The prescriber will check your medical history, current medicines, and any conditions that might affect suitability, ensuring you receive the correct strength and pack size for your needs.
Because avanafil is taken on demand—only when you plan to have sex—the number of tablets you need depends on how often you are sexually active. Some men prefer smaller packs to start with, while others find larger packs more convenient and cost-effective over time. Your prescriber can advise on the most suitable pack size based on your individual circumstances and treatment goals.
How avanafil pack sizes compare to other ED treatments
Avanafil belongs to the same class of medicines as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra)—all are PDE5 inhibitors that help improve blood flow to the penis during sexual stimulation [1][2]. What sets avanafil apart is its rapid onset: it can start working in 15–30 minutes, compared to about 1 hour for sildenafil, 25–60 minutes for vardenafil, and at least 30 minutes for on-demand tadalafil [3][4][5][6].
Pack sizes for avanafil are similar to those of other PDE5 inhibitors, typically containing 4 or 8 tablets per pack. Sildenafil is available in 25mg, 50mg, and 100mg strengths; tadalafil comes in 10mg and 20mg for on-demand use (and 2.5mg or 5mg for daily use); vardenafil is supplied as 5mg, 10mg, or 20mg tablets [3][4][5]. Each medicine has a different duration of action: avanafil lasts for up to 6 hours, sildenafil and vardenafil for about 4–5 hours, while tadalafil can remain effective for up to 36 hours [4][6].
Choosing between avanafil and other ED treatments depends on your lifestyle, how quickly you need the medicine to work, and how long you want the effect to last. Some men prefer the speed of avanafil for spontaneity, while others value the longer window offered by tadalafil. Your prescriber will discuss these options during your consultation and recommend the most appropriate treatment and pack size for you.
At a glance
What affects the price of avanafil pack sizes?
The price of avanafil in the UK is influenced by several factors, including whether you are buying the branded product (Spedra) or a generic version, the tablet strength, the number of tablets in the pack, and the pharmacy's pricing structure. Spedra is currently the main branded avanafil product available in the UK, and generic versions may become more widely available over time as patents expire, which could reduce costs [11].
At Cured Pharmacy, Spedra (avanafil) is priced at £20.95 per pack, with a first-order discount bringing the cost down to £16.76 when you use the code Ednew. This price includes the online consultation with a UK-registered prescriber, dispensing by a GPhC-registered pharmacy, and delivery to your address. Because avanafil is a newer PDE5 inhibitor, it tends to be more expensive than older generics such as sildenafil or tadalafil, which are available from as little as £0.45 and £7.95 per pack respectively.
Larger pack sizes can offer better value per tablet, but the upfront cost is higher. If you are new to avanafil or trying it for the first time, starting with a smaller pack allows you to assess how well it works for you and whether you experience any side effects before committing to a larger supply. Your prescriber can help you decide on the most cost-effective and clinically appropriate pack size during your consultation.
Why is avanafil more expensive than sildenafil or tadalafil?
Avanafil is a newer medicine, first approved in Europe in 2013, and is still under patent protection in some markets, which means fewer generic alternatives are available [11]. Sildenafil and tadalafil have been on the market for much longer—sildenafil since 1998 and tadalafil since 2003—and generic versions are now widely available, driving prices down significantly [9]. The research, development, and regulatory costs associated with bringing a new medicine to market are reflected in the price of branded products like Spedra.
Despite the higher cost, some men find avanafil's faster onset and favourable side-effect profile worth the extra expense, particularly if they value spontaneity or have not responded well to other PDE5 inhibitors. Your prescriber will discuss the benefits and costs of each option with you, helping you make an informed choice based on your clinical needs and budget.
How to order avanafil pack sizes safely online
To order avanafil safely in the UK, you must use a registered online pharmacy that requires a valid prescription or offers a regulated online consultation service. Cured Pharmacy is registered with the General Pharmaceutical Council (GPhC 9012511) and operates in full compliance with UK medicines law. When you place an order for Spedra (avanafil), you will complete a confidential online questionnaire about your health, current medicines, and any medical conditions.
A UK-registered prescriber—either a doctor or an independent prescribing pharmacist—will review your answers to ensure avanafil is safe and suitable for you. They will check for contraindications (such as use of nitrates, nicorandil, or riociguat), interactions with other medicines (including alpha-blockers and potent CYP3A4 inhibitors), and any cardiovascular conditions that might make sexual activity inadvisable [6][12]. If the prescriber approves your request, your medicine will be dispensed by our GPhC-registered pharmacy and delivered discreetly to your address.
Never buy avanafil from unregistered websites or sources that do not require a consultation. Counterfeit or unlicensed ED medicines can contain incorrect doses, harmful ingredients, or no active ingredient at all, putting your health at serious risk. Always check that the pharmacy is registered with the GPhC and displays its registration number on its website. If you have any questions about your treatment, our pharmacists are available to provide advice and support throughout your care.
What happens during the online consultation?
The online consultation for avanafil involves answering questions about your general health, any heart or blood-pressure conditions, current medicines (including over-the-counter and herbal products), and your experience with ED. The prescriber will ask about symptoms such as chest pain, dizziness, or recent cardiovascular events, as these can affect whether avanafil is safe for you [2][6].
You will also be asked about medicines that can interact with avanafil, including nitrates (such as GTN spray or isosorbide mononitrate), alpha-blockers (such as tamsulosin or doxazosin), and potent CYP3A4 inhibitors (such as ritonavir, ketoconazole, or clarithromycin) [6][12]. If you are taking any of these, the prescriber may recommend a different treatment or adjust the dose. The consultation is confidential, and your answers are reviewed by a qualified healthcare professional who is trained to assess ED treatments safely and effectively.
Start with a smaller pack
If you are new to avanafil, choose a smaller pack (4 tablets) to see how well it works and whether you tolerate it before ordering a larger supply.
Understanding avanafil strengths and dosing
Avanafil is available in 50mg, 100mg, and 200mg tablets, and the recommended starting dose for most men is 100mg, taken approximately 15–30 minutes before sexual activity [6]. If the 100mg dose is effective but you experience side effects, your prescriber may reduce the dose to 50mg. If 100mg does not provide sufficient benefit, the dose can be increased to a maximum of 200mg, but only if your prescriber considers it safe and appropriate [6].
Avanafil should be taken no more than once in any 24-hour period, and it only works when you are sexually aroused—it will not cause an erection on its own [6]. The tablet should be swallowed whole with water, and it can be taken with or without food, though a heavy, high-fat meal may delay its onset of action. Because avanafil works relatively quickly, it offers more flexibility than some other ED treatments, allowing for greater spontaneity.
If you have kidney or liver problems, your prescriber may recommend a lower starting dose or advise against avanafil altogether, depending on the severity of your condition [6]. Older men (over 65) can usually take the standard doses, but the prescriber will assess your overall health and any other medicines you are taking. Always follow the dose prescribed for you and do not take more than recommended, as this increases the risk of side effects without improving effectiveness.
Common questions about avanafil pack sizes and supply
Many men wonder whether they should start with a smaller or larger pack of avanafil. If you are new to this treatment, a smaller pack (typically 4 tablets) is a sensible choice, allowing you to see how well it works and whether you tolerate it before ordering a larger supply. If you have used avanafil before and know it suits you, a larger pack can be more convenient and may offer better value per tablet.
Some men ask whether they can switch between different avanafil pack sizes or strengths. Yes, your prescriber can adjust your dose or pack size at any time based on your response to treatment, side effects, or changes in your health or other medicines. If you find that 100mg is too strong or not strong enough, let your prescriber know during a follow-up consultation, and they can recommend a different strength.
Another common question is whether avanafil is available over the counter in the UK. No, avanafil (Spedra) is a prescription-only medicine and cannot be purchased without a prescription or a regulated online consultation [6][12]. This ensures that a qualified healthcare professional checks your suitability and safety before you start treatment. If you have new or worsening ED, it is important to see your GP, as ED can be an early warning sign of cardiovascular disease or diabetes [1][2].
Can I get avanafil on the NHS?
Avanafil is not routinely available on NHS prescription for most men with ED. NHS prescribing of ED treatments is generally restricted to certain medical conditions, such as diabetes, prostate cancer, severe pelvic injury, or other specific diagnoses, and local policies vary [2]. Most men will need to obtain avanafil privately, either from their GP (if the GP offers private prescriptions) or from a registered online pharmacy such as Cured Pharmacy.
If you are unsure whether you might be eligible for NHS treatment, speak to your GP. Even if you are not eligible for an NHS prescription, your GP can provide valuable advice, investigate any underlying causes of ED, and ensure that private treatment is safe for you. Cured Pharmacy offers a convenient and confidential alternative for men who prefer or need to access treatment privately.
When to get urgent help
- Erection lasting more than 4 hours (priapism) – go to A&E immediately
- Sudden loss of vision or hearing – stop taking avanafil and seek urgent medical help
- Chest pain during or after sex – stop activity, call 999, and do not take nitrate medicines
- Severe dizziness, fainting, or very low blood pressure – seek same-day medical advice
- Allergic reaction (rash, swelling of face or throat, difficulty breathing) – call 999
Call 999 or go to A&E in an emergency, or contact NHS 111 for urgent advice.
Scientific References
- NHS. (n.d.). Erectile dysfunction (impotence). NHS website. https://www.nhs.uk/conditions/erection-problems-erectile-dysfunction/ [accessed 6 November 2026]
- National Institute for Health and Care Excellence. (n.d.). Erectile dysfunction. Clinical Knowledge Summaries. https://cks.nice.org.uk/topics/erectile-dysfunction/ [accessed 6 November 2026]
- Joint Formulary Committee. (n.d.). Avanafil. British National Formulary. NICE. https://bnf.nice.org.uk/drugs/avanafil/ [accessed 6 November 2026]
- National Institute for Health and Care Excellence. (2014). Erectile dysfunction: avanafil (ESNM45). https://www.nice.org.uk/advice/esnm45 [accessed 6 November 2026]
- Electronic Medicines Compendium. (n.d.). Summaries of Product Characteristics and Patient Information Leaflets. https://www.medicines.org.uk/emc/ [accessed 6 November 2026]
Information on this page is for educational purposes only and is not medical advice. Prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting or changing any medication.
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Common Questions
Can't find your answer? Our UK pharmacists review every consultation and can help.
What is the usual starting dose for avanafil?
The recommended starting dose is 100mg, taken about 15–30 minutes before sexual activity. Your prescriber may adjust this to 50mg or 200mg depending on how well it works and whether you experience side effects.
How many avanafil tablets come in a pack?
Pack sizes typically contain 4 or 8 tablets, though availability can vary. Your prescriber will recommend a suitable pack size based on how often you plan to use the treatment.
Can I take avanafil every day?
Avanafil is designed for on-demand use, not daily dosing. You should take it only when you plan to have sex, and no more than once in any 24-hour period.
Is avanafil faster than Viagra or Cialis?
Yes, avanafil can start working in as little as 15–30 minutes, making it one of the fastest-acting oral ED treatments. Sildenafil takes about 1 hour, and tadalafil at least 30 minutes.
Can I buy avanafil without a prescription in the UK?
No, avanafil (Spedra) is a prescription-only medicine. You must complete an online consultation or see a prescriber in person before it can be supplied.
What should I do if 100mg avanafil does not work?
Speak to your prescriber, who may increase your dose to 200mg or suggest trying a different ED treatment. Do not increase the dose yourself without medical advice.
Can I take avanafil with alcohol?
Small amounts of alcohol are unlikely to cause problems, but heavy drinking can worsen ED and increase the risk of dizziness or low blood pressure when combined with avanafil.
How long does avanafil last?
Avanafil can remain effective for up to 6 hours, though this varies between individuals. It only works when you are sexually stimulated.
Medically reviewed by
Tarun Kumar, Superintendent Pharmacist (GPhC 2233073)