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ColdZyme Mouth & Throat Spray Spray 20ml

ColdZyme Mouth & Throat Spray Spray 20ml

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  • ✔️ Forms a protective barrier in the throat against cold viruses
  • ✔️ May reduce the duration of the common cold
  • ✔️ Suitable for adults and children aged 4 and over
  • ✔️ Contains trypsin enzyme to help break down viral proteins
  • ✔️ Convenient 20ml spray — easy to carry and use anywhere

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What Is ColdZyme Mouth Spray and How Can It Help?

 

Nobody enjoys the misery of a blocked nose, sore throat, and that general feeling of being run down. The common cold is one of the most frequent illnesses in the UK, with adults catching an average of two to four colds per year according to the NHS. ColdZyme mouth spray is a medical device — not a medicine — designed to help reduce both the risk of catching a cold and the duration of symptoms once they start. At just £13.18 for a 20ml bottle, it offers a convenient, easy-to-use option you can keep in your bag or desk drawer. If you're looking for other products to support your health during cold season, browse our Cold and Flu collection for a wider range of options.

ColdZyme is classified as a Class IIa medical device in the EU and UK. It contains a trypsin-based formulation derived from cod, combined with glycerol and other excipients. Because it works as a physical barrier rather than a pharmacological agent, it does not interact with most medicines in the way a conventional drug might.

 

How Does ColdZyme Mouth & Throat Spray Work?

 

The mechanism behind ColdZyme is straightforward but clever. When you spray it to the back of your throat, it forms a thin protective layer over the mucous membrane. This barrier is thought to reduce the ability of cold viruses — primarily rhinoviruses — to attach to and infect the cells lining your throat.

  • The trypsin enzyme in the formulation may help to break down viral proteins on contact.
  • Glycerol helps the spray adhere to the mucosal surface, prolonging the protective effect.
  • The barrier reduces viral load in the throat, which may shorten the duration of illness.
  • It works locally in the throat rather than being absorbed systemically.

A published randomised controlled trial found that ColdZyme significantly reduced the duration of the common cold compared to placebo. While the evidence base is still growing, the product has been available in Scandinavia for over a decade and has a well-established safety profile.

 

Who Should Consider Using ColdZyme Throat Spray?

 

ColdZyme is suitable for a wide range of people who want to take a proactive approach to cold prevention or early symptom management. It is particularly useful if you work in a busy environment, travel frequently, or have regular contact with young children — all situations where cold virus exposure is higher.

  • Adults who want to reduce the risk of catching a cold during high-exposure periods.
  • People who feel the first signs of a sore throat or cold coming on.
  • Children aged 4 years and over (under adult supervision).
  • Those who prefer a non-pharmacological approach to cold management.

It is not suitable for anyone with a known allergy to fish or cod, as the trypsin enzyme is derived from cod. Always read the label carefully before use.

 

How Does ColdZyme Compare to Other Cold Throat Sprays?

 

Feature ColdZyme Mouth & Throat Spray Standard Throat Anaesthetic Spray
Mechanism Physical barrier + enzyme action Local anaesthetic (numbing)
Reduces cold duration Yes (clinical evidence available) No
Suitable from age 4 Yes Varies by product
Drug interactions None known Possible with some medicines

 

Is ColdZyme Suitable for Everyday Use and How Should It Be Stored?

 

The ColdZyme mouth spray should be stored below 25°C and must not be frozen. Once opened, it should be used within three months. Keep the cap on when not in use to maintain hygiene and product integrity. It does not require refrigeration, making it easy to carry with you day to day.

If you are pregnant, breastfeeding, or have an underlying health condition, it is always worth checking with your pharmacist before starting any new product — even a medical device. You might also find it helpful to explore our Vitamins and Supplements collection for immune-support options to use alongside ColdZyme during winter months.

This product is a medical device. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

ColdZyme Mouth & Throat Spray 20ml specifications
Treatment category Cold and flu prevention / throat protection
Mechanism of action Forms a physical barrier on the throat mucosa; trypsin enzyme may degrade viral proteins
Effective May reduce cold duration and risk of infection when used at first sign of symptoms or during exposure
Suitable for Adults and children aged 4 years and over
Active ingredient Trypsin (cod-derived), glycerol
Pack size 20ml
UK classification Class IIa Medical Device
Preparation Oromucosal spray solution
Route of administration Oromucosal (sprayed to back of throat)

Specifications of ColdZyme Mouth & Throat Spray 20ml

 

What Is ColdZyme Mouth & Throat Spray and What Is It Used For?

 

ColdZyme Mouth & Throat Spray 20ml is a Class IIa medical device used to help reduce the risk of catching the common cold and to shorten the duration of cold symptoms. It is applied directly to the back of the throat, where it forms a protective barrier against cold viruses. The NHS notes that the common cold is caused primarily by rhinoviruses and spreads easily through respiratory droplets and hand-to-face contact. ColdZyme offers a non-pharmacological way to help protect the throat during periods of high viral exposure — for example, during winter months or when you are around people who are already unwell.

It is not a treatment for influenza, COVID-19, or bacterial throat infections. If your symptoms are severe, persistent, or accompanied by a high fever, you should seek advice from your GP or call NHS 111.

 

What Do You Need to Know Before Using ColdZyme Spray?

 

Before using ColdZyme, it is important to check whether it is appropriate for you. Although it is a medical device rather than a medicine, there are still important contraindications and precautions to be aware of.

Do not use ColdZyme if:

  • You have a known allergy to fish or cod — the trypsin enzyme is derived from cod.
  • You are allergic to any other ingredient listed on the label (including glycerol or ethanol).
  • The child is under 4 years of age.

Take care and speak to a pharmacist if:

  • You are pregnant or breastfeeding.
  • You have a known immune deficiency or are taking immunosuppressant medicines.
  • You have a history of severe allergic reactions (anaphylaxis).

Drug interactions:

  • No clinically significant drug interactions have been identified for ColdZyme.
  • As a medical device acting locally in the throat, it is not absorbed systemically and is unlikely to interact with oral medicines.
  • If you are taking any prescribed medicines, check with your pharmacist if you are unsure.

 

How Should You Use ColdZyme Mouth & Throat Spray?

 

Using ColdZyme correctly is key to getting the most benefit from it. The spray should be directed to the back of the throat — not just the front of the mouth — to ensure the protective barrier forms where cold viruses are most likely to enter. For broader throat and ear, nose, and throat health support, explore our dedicated collection.

  1. Shake the bottle gently before each use.
  2. Remove the cap and hold the bottle upright.
  3. Point the nozzle towards the back of your throat.
  4. Press the pump twice to release two sprays.
  5. Swallow normally after spraying — do not rinse your mouth immediately afterwards.
  6. Replace the cap after use.
Indication Age Group Dose Frequency
Cold prevention (high exposure) Adults & children ≥4 years 2 sprays Every 2 hours while awake
Early cold symptoms Adults & children ≥4 years 2 sprays Every 2 hours while awake
Children under 4 years Under 4 Not recommended

 

What Are the Possible Side Effects of ColdZyme Spray?

 

ColdZyme is generally well tolerated. Because it acts locally in the throat and is not absorbed into the bloodstream, systemic side effects are not expected. However, as with any product applied to a mucous membrane, some people may notice mild local effects.

Common side effects:

  • Mild throat irritation or a slight burning sensation immediately after spraying.
  • Temporary change in taste.

Less common side effects:

  • Mild nausea if a large amount is swallowed.
  • Localised dryness in the throat.

If you experience signs of an allergic reaction — such as swelling of the mouth or throat, difficulty breathing, or a skin rash — stop using ColdZyme immediately and seek urgent medical attention. Allergic reactions to cod-derived ingredients, while uncommon, can be serious in susceptible individuals.

 

How Should You Store ColdZyme Mouth & Throat Spray?

 

Correct storage helps maintain the integrity of the formulation and ensures the product remains effective throughout its shelf life. You may also want to consider storing complementary products such as pain relief options alongside ColdZyme in your home medicine cabinet for cold season.

  • Store below 25°C.
  • Do not freeze.
  • Keep the bottle upright with the cap firmly in place when not in use.
  • Once opened, use within 3 months.
  • Keep out of the reach and sight of children.
  • Do not use after the expiry date printed on the label.
  • Do not store in direct sunlight or near a heat source.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy ColdZyme Mouth & Throat Spray online in the UK?

You can buy ColdZyme Mouth & Throat Spray 20ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is available without a prescription as it is classified as a medical device rather than a medicine. Simply add it to your basket and it will be dispatched to your door.

How does ColdZyme mouth spray work in the body?

ColdZyme works by forming a thin protective barrier on the mucous membrane at the back of the throat. This barrier is thought to reduce the ability of cold viruses — mainly rhinoviruses — to attach to and infect throat cells. The trypsin enzyme in the formulation may also help to break down viral proteins on contact, reducing viral load locally.

How do I use ColdZyme Mouth & Throat Spray step by step?

Shake the bottle, remove the cap, and point the nozzle towards the back of your throat. Press the pump twice to deliver two sprays, then swallow normally — do not rinse your mouth straight away, as this would remove the protective barrier. Repeat every two hours while awake during periods of cold exposure or at the first sign of symptoms.

What is the correct dose of ColdZyme spray for adults?

The recommended dose for adults is two sprays directed to the back of the throat, repeated every two hours while awake. There is no need to increase the dose — using more sprays per application does not improve the protective effect. Always follow the instructions provided with the product.

Can children use ColdZyme Mouth & Throat Spray?

ColdZyme is generally considered suitable for children aged 4 years and over, used under adult supervision. It is not recommended for children under 4 years of age. If you are unsure whether it is appropriate for your child, speak to your pharmacist or GP before use.

When is the best time to use ColdZyme cold throat spray?

The best time to start using ColdZyme is either at the very first sign of a sore throat or cold symptoms, or proactively during periods of high exposure — such as when travelling on public transport, attending crowded events, or spending time with someone who has a cold. Starting early gives the barrier the best chance to reduce viral load before infection takes hold.

Are there any side effects of using ColdZyme spray?

ColdZyme is generally well tolerated, but some users may notice mild throat irritation or a temporary change in taste immediately after spraying. These effects are usually short-lived and resolve on their own. If you experience any signs of an allergic reaction — such as swelling, difficulty breathing, or a rash — stop use immediately and seek medical attention.

Is ColdZyme safe to use if I have a fish allergy?

No — ColdZyme must not be used by anyone with a known allergy to fish or cod, as the trypsin enzyme in the formulation is derived from cod. Even if your fish allergy is mild, the risk of a reaction means you should avoid this product entirely. Speak to your pharmacist about alternative options for cold prevention.

Can I use ColdZyme spray if I am pregnant or breastfeeding?

There is limited specific data on the use of ColdZyme during pregnancy or breastfeeding. Because it acts locally in the throat and is not absorbed systemically, the risk is considered low, but you should always consult your GP or midwife before using any new product during pregnancy or while breastfeeding.

How long can you use ColdZyme for?

ColdZyme can be used throughout the duration of a cold or during any period of high exposure risk, such as the winter cold season. If your symptoms have not improved after 10 days, or if they worsen significantly, you should seek advice from a pharmacist or GP. The opened bottle should be used within three months of opening.

Does ColdZyme interact with other medicines?

No clinically significant drug interactions have been identified for ColdZyme. Because it is a medical device that acts locally in the throat and is not absorbed into the bloodstream, it is unlikely to interfere with oral medicines. If you are taking prescribed medicines and are unsure, check with your pharmacist for personalised advice.

What are the alternatives to ColdZyme for cold prevention?

Alternatives include vitamin C and zinc supplements, which some evidence suggests may modestly reduce cold duration — you can find these in our Vitamins and Supplements collection. Good hand hygiene, avoiding touching your face, and staying away from people with colds remain the most evidence-based preventive measures according to the NHS. Throat lozenges and anaesthetic sprays can help manage symptoms but do not reduce cold duration.

What happens if I miss a dose of ColdZyme spray?

If you forget to use ColdZyme at your usual two-hourly interval, simply use it as soon as you remember and then continue with your regular schedule. Do not double up by using extra sprays to compensate for a missed application. Consistency is important — the protective barrier needs to be maintained throughout the day for best effect.

What does the latest research say about ColdZyme spray?

A randomised, double-blind, placebo-controlled trial published in the journal Open Journal of Respiratory Diseases found that ColdZyme significantly reduced the duration of the common cold compared to placebo. The study also reported a reduction in symptom severity in the ColdZyme group. While the evidence base is still developing, the product has been used clinically in Scandinavia for over a decade with a well-established safety record.

Is ColdZyme a medicine or a medical device?

ColdZyme is classified as a Class IIa medical device, not a medicine. This means it works through a physical or mechanical action — forming a barrier in the throat — rather than through a pharmacological, immunological, or metabolic mechanism. You can browse our wider range of ear, nose, and throat products for both medical devices and medicines that support throat health.

How Should You Use ColdZyme Mouth & Throat Spray?

Using ColdZyme correctly makes a real difference to how well it works. The spray must reach the back of the throat — not just the front of the mouth — to form an effective protective barrier where cold viruses are most likely to enter. Always shake the bottle before use and keep the cap on between applications to maintain hygiene.

Follow these steps each time you use ColdZyme:

What Is the Correct Dose of ColdZyme Mouth & Throat Spray?

The dose is the same for adults and children aged 4 years and over. Two sprays per application is the standard dose — there is no benefit to using more sprays at once, and doing so will not improve the protective effect. The key is frequency and consistency throughout the day.

Use the table below as a quick reference guide:

When Is the Best Time to Use ColdZyme Spray?

Timing matters with ColdZyme. The earlier you start using it, the better — ideally at the very first sign of a scratchy throat or cold symptoms, or before entering a high-risk environment such as a crowded commute, a long-haul flight, or a visit to someone who is unwell. Using it proactively during peak cold season can also help reduce your risk of catching a cold in the first place.

Try to space your applications evenly throughout the day, roughly every two hours while you are awake. If you are using it preventatively, you can begin a day or two before anticipated exposure and continue until the risk period has passed.

How Long Can You Use ColdZyme Mouth & Throat Spray For?

ColdZyme can be used for the full duration of a cold or throughout any period of elevated exposure risk. Most colds resolve within 7 to 10 days according to the NHS. If your symptoms have not improved after 10 days, or if they worsen or are accompanied by a high fever, seek advice from your pharmacist or GP rather than continuing to self-treat.

Once opened, the bottle should be used within three months. Do not use the product beyond its expiry date, and discard it if the solution appears discoloured or the spray mechanism is not functioning correctly.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of ColdZyme Spray?

ColdZyme is generally very well tolerated. Because it acts locally in the throat and is not absorbed into the bloodstream, the risk of systemic side effects is extremely low. Most people use it without any problems at all. That said, a small number of users do report mild local effects, particularly when they first start using the spray.

  • Mild throat irritation or a slight burning sensation immediately after spraying.
  • Temporary change in taste lasting a few minutes after application.
  • Mild dryness at the back of the throat.

What Are the Less Common Side Effects of ColdZyme Spray?

Less commonly, some users may notice effects that go slightly beyond mild local irritation. These are still not serious in most cases, but they are worth being aware of before you start using the product.

  • Mild nausea if a larger-than-recommended amount is accidentally swallowed.
  • Increased throat sensitivity in people with pre-existing throat conditions.
  • A feeling of excess mucus or coating at the back of the throat shortly after use.

What Are the Serious Side Effects of ColdZyme Spray?

Serious side effects are rare but possible, particularly in individuals who have an undiagnosed allergy to fish or cod. The trypsin enzyme in ColdZyme is derived from cod, and anyone with a fish allergy should not use this product. Signs of a serious allergic reaction (anaphylaxis) include swelling of the mouth, lips, or throat, difficulty breathing or swallowing, a sudden drop in blood pressure, or a widespread skin rash. These symptoms require immediate emergency medical attention — call 999 or go to your nearest A&E department without delay.

What Should You Do If You Experience Side Effects of ColdZyme?

If you notice mild throat irritation or a taste change, these effects usually resolve within a few minutes and do not require any action. You can continue using ColdZyme as directed. However, if side effects are persistent, worsen over time, or cause you significant discomfort, stop using the product and speak to your pharmacist. Do not try to manage a suspected allergic reaction at home — seek urgent medical help immediately.

It is always a good idea to keep a note of any new symptoms that appear after starting a new product, even a medical device. This information will be helpful if you need to speak to a healthcare professional.

Can ColdZyme Spray Interact With Other Medicines?

No clinically significant interactions between ColdZyme and other medicines have been identified. As a medical device that works locally in the throat without systemic absorption, it is not expected to affect the way other medicines work in your body. If you are taking prescribed medicines — particularly immunosuppressants or anticoagulants — and you are unsure about using ColdZyme alongside them, it is always sensible to check with your pharmacist before starting.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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