Wegovy vs Mounjaro Side Effects UK | Cured Pharmacy

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Cheapest Wegovy vs Mounjaro Side Effects - UK Price

Compare side effects and get the cheapest UK price on Mounjaro from £124.99 plus £20 off with code Weightlossnew.

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Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £124.99

£31.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
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Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £159.00

£39.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
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Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £200.00

£50.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
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Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £225.00

£56.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
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Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £250.00

£62.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
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Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £267.00

£66.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
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Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £69.00

£17.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
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Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£99 £79.00

£19.75 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £99
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Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £99.00

£24.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
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Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £149.00

£37.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
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Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £179.00

£44.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
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Wegovy Oral Pill
Weeks 1–4

1.5mg

1 pen • 4 Weeks

£83.00 £63.00

£20.75 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £83.00
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Wegovy Oral Pill
Weeks 5–8

4mg

1 pen • 4 Weeks

£110.00 £90.00

£27.50 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £110.00
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Wegovy Oral Pill
Weeks 9–12

9mg

1 pen • 4 Weeks

£140.00 £120.00

£35.00 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £140.00
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Wegovy Oral Pill
Weeks 13+

25mg

1 pen • 4 Weeks

£199.00 £179.00

£49.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199.00
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Wegovy vs Mounjaro Side Effects: Expert Comparison

Published on: June 03, 2026

Understanding wegovy vs mounjaro side effects uk is essential before starting your weight loss journey. Both medications are GLP-1 receptor agonists licensed by the MHRA, but their side effect profiles differ in frequency, severity, and duration. As a UK-registered pharmacy with thousands of patient consultations, we've compiled this evidence-based comparison to help you make an informed decision with your prescriber.

Common Side Effects: Wegovy vs Mounjaro

Both Wegovy (semaglutide) and Mounjaro (tirzepatide) share a similar side effect profile because they target the GLP-1 pathway, which naturally slows gastric emptying and reduces appetite [1]. The most frequently reported side effects are gastrointestinal: nausea, diarrhoea, constipation, vomiting, and abdominal discomfort.

In the STEP 1 trial for semaglutide, 44% of participants experienced nausea, compared to 31% in the SURMOUNT-1 trial for tirzepatide [1][2]. However, severity and duration varied significantly between individuals, and most gastrointestinal symptoms reduced after the first 4-8 weeks as the body adapted to treatment.

Clinical data shows that side effects are dose-dependent for both medications. Starting at lower doses and gradually titrating upwards—as per UK prescribing guidelines—significantly reduces the risk of severe gastrointestinal symptoms [1][2]. Your UK prescriber will determine the appropriate escalation schedule based on your tolerance and weight loss progress.

Nausea and Vomiting: Which Causes More?

Nausea is the most commonly reported side effect for both Wegovy and Mounjaro, but incidence rates differ. In clinical trials, 44% of Wegovy patients reported nausea versus 31% of Mounjaro patients at comparable efficacy doses [1][2]. Vomiting occurred in approximately 24% of Wegovy users compared to 16% of Mounjaro users.

The difference may be attributed to tirzepatide's dual GIP/GLP-1 mechanism, which some researchers believe provides a more balanced effect on gastric motility [3]. However, individual responses vary considerably—some patients tolerate Wegovy better, while others find Mounjaro gentler on their digestive system.

Practical strategies to minimise nausea include taking the injection on an empty stomach, eating smaller meals throughout the day, avoiding high-fat foods, and staying well-hydrated. If nausea persists beyond 8 weeks or becomes severe, your UK prescriber may adjust your dose or recommend an alternative treatment.

Managing Nausea During Treatment

Most patients find that nausea improves significantly after the first month as their body adapts to the medication. Ginger supplements, smaller portion sizes, and avoiding lying down immediately after eating can help reduce symptoms. If nausea interferes with daily activities or prevents adequate nutrition, contact your prescriber immediately—dose adjustment or temporary treatment pause may be necessary.

Gastrointestinal Side Effects Beyond Nausea

Diarrhoea and constipation are common with both medications, though they affect patients differently. In STEP trials, 30% of Wegovy patients experienced diarrhoea, while 23% reported constipation [1]. SURMOUNT trials showed similar rates for Mounjaro: 27% diarrhoea and 21% constipation [2].

Abdominal pain and bloating occur in approximately 20-25% of patients on either medication, typically during dose escalation phases. These symptoms are usually mild to moderate and resolve within 2-4 weeks [3]. Severe or persistent abdominal pain, especially if accompanied by fever or vomiting, requires immediate medical attention to rule out pancreatitis—a rare but serious side effect.

Maintaining adequate fibre intake, drinking plenty of water, and establishing regular meal times can help regulate bowel movements. If constipation persists, gentle laxatives may be appropriate, but consult your pharmacist or prescriber before starting any new medication alongside your weight loss treatment.

Side Effect Wegovy (Semaglutide) Mounjaro (Tirzepatide) Management Tips
Nausea 44% of patients 31% of patients Eat smaller meals, avoid high-fat foods
Vomiting 24% of patients 16% of patients Stay hydrated, contact prescriber if severe
Diarrhoea 30% of patients 27% of patients Increase fibre, maintain hydration
Constipation 23% of patients 21% of patients Adequate water intake, gentle laxatives if needed
Abdominal Pain 20-25% of patients 20-25% of patients Usually resolves in 2-4 weeks
Treatment Discontinuation 7% due to side effects 6.2% due to side effects Most occur in first 12 weeks

Serious Side Effects: What to Watch For

While rare, both Wegovy and Mounjaro carry risks of serious adverse events that require immediate medical attention. Pancreatitis occurred in less than 0.2% of patients in clinical trials for both medications, but symptoms—severe abdominal pain radiating to the back, persistent vomiting, and fever—warrant emergency assessment [1][2].

Gallbladder problems, including gallstones and cholecystitis, were reported more frequently in patients losing significant weight rapidly. This is a consequence of rapid weight loss itself rather than a direct drug effect, but patients should be aware of symptoms: severe right-sided abdominal pain, yellowing of skin or eyes, and clay-coloured stools [3].

Thyroid C-cell tumours were observed in rodent studies, leading to a boxed warning for both medications. However, no causal relationship has been established in humans. Both Wegovy and Mounjaro are contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 [1][2].

Hypoglycaemia Risk

If you're taking Wegovy or Mounjaro alongside other diabetes medications—particularly insulin or sulphonylureas—you may be at increased risk of low blood sugar. Symptoms include shakiness, sweating, confusion, and rapid heartbeat. Your prescriber will adjust your existing diabetes medications to minimise this risk, but always carry a fast-acting glucose source if you're on combination therapy.

Tolerability and Treatment Discontinuation Rates

Discontinuation rates due to adverse events provide insight into real-world tolerability. In STEP 1, 7% of Wegovy patients discontinued treatment due to side effects, compared to 6.2% in SURMOUNT-1 for Mounjaro [1][2]. These similar rates suggest comparable overall tolerability, though individual experiences vary widely.

Most discontinuations occurred during the first 12 weeks of treatment, coinciding with dose escalation. Patients who successfully reached maintenance doses typically experienced fewer and milder side effects thereafter [3]. This highlights the importance of gradual titration and close monitoring during the initial treatment phase.

At Cured Pharmacy, our UK prescribers conduct follow-up assessments to monitor your progress and adjust treatment if needed. If side effects become intolerable on one medication, switching to the alternative GLP-1 treatment may be appropriate—many patients who struggle with one medication tolerate the other well.

Long-Term Safety Data

Semaglutide has been used for diabetes management since 2017, providing several years of real-world safety data. Tirzepatide is newer, approved for weight loss in 2023, but its diabetes formulation (Mounjaro) has accumulated substantial safety evidence since 2022. Both medications have demonstrated acceptable long-term safety profiles in ongoing extension studies, with no unexpected adverse events emerging beyond the first year of treatment [3].

Wegovy vs Mounjaro Side Effects: Making Your Choice

Choosing between Wegovy and Mounjaro based on side effects alone is challenging because individual responses vary significantly. Clinical trial data suggests Mounjaro may cause slightly less nausea, but the difference is modest and may not apply to your specific situation [1][2].

Your decision should consider multiple factors: side effect profile, efficacy data, dosing convenience, cost, and personal medical history. Wegovy is available from £135.00 at Cured Pharmacy, while Mounjaro starts from £124.99 reflecting different market positioning and efficacy profiles. Both require once-weekly injections and gradual dose escalation.

During your free online consultation, our UK prescribers will review your medical history, current medications, previous weight loss attempts, and personal preferences. If you have a history of severe gastrointestinal conditions, one medication may be more suitable than the other. Your prescriber can also discuss strategies to minimise side effects regardless of which treatment you start.

Scientific References

  1. Wilding, J. P. H., et al. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine, 384(11), 989–1002. https://doi.org/10.1056/NEJMoa2032183 [accessed 13 August 2026]
  2. Jastreboff, A. M., et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205–216. https://doi.org/10.1056/NEJMoa2206038 [accessed 13 August 2026]
  3. Nauck, M. A., et al. (2021). GLP-1 Receptor Agonists in the Treatment of Type 2 Diabetes – State-of-the-Art. Molecular Metabolism, 46, 101102. https://doi.org/10.1016/j.molmet.2020.101102 [accessed 13 August 2026]
  4. NHS. (2026). Tirzepatide: a medicine to manage type 2 diabetes and treat obesity. https://www.nhs.uk/medicines/tirzepatide/ Accessed 13 August 2026.
  5. NHS. (2026). Overweight and obesity in adults. https://www.nhs.uk/conditions/overweight-and-obesity/ Accessed 13 August 2026.
  6. NHS England. (2026). Weight management injections. https://www.england.nhs.uk/ourwork/prevention/obesity/medicines-for-obesity/weight-management-injections/ Accessed 13 August 2026.

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication. Side effect frequencies are based on clinical trial data and individual experiences may vary. If you experience severe or persistent side effects, contact your prescriber or seek immediate medical attention.

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Jane L.

"Brilliant. Lost 4 stone on mounjaro no side effects at all. Cured pharmacy are excellent. Always helpful pens sent out quickly always comes with needles and sterile wipes. If you want to go on GLP-1 go to cured pharmacy. So professional. Thank you cured pharmacy you changed my health and well being."

Ann-Marie

"I absolutely love this product, I have been using 2.5mg as maintenance dose and have managed to control my weight without any side effects and can still eat well balanced meals. The pharmacy is very efficient friendly and helpful I would not purchase from anywhere else."

Sacha W.

"So far I'm really impressed by my results it's crazy cause I'm not snacking like how I used to do and I see my face slimming down already and it's only been 2 and a half weeks. Can't wait to give my feedback in 5 months time thank you cured pharmacy."

Kimberly G.

"Mounjaro has corrected my hormonal weight gain during menopause. I am using it now to maintain that balance. The results for me have been exceptional!"

Jennifer

"Great really helps cure those nasty habits can't wait for my next mounjaro pen."

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Faq

Which has fewer side effects, Wegovy or Mounjaro?
Clinical trials suggest Mounjaro causes slightly less nausea (31% vs 44%), but overall side effect profiles are similar, with individual responses varying significantly.
How long do Wegovy and Mounjaro side effects last?
Most gastrointestinal side effects peak during the first 4-8 weeks and gradually improve as your body adapts to treatment. Symptoms typically reduce significantly after reaching a stable maintenance dose.
Can I switch from Wegovy to Mounjaro if I experience side effects?
Yes, many patients who struggle with one GLP-1 medication tolerate the alternative well. Your UK prescriber can assess whether switching is appropriate based on your specific side effects and medical history.
Are Wegovy vs Mounjaro side effects dangerous?
Most side effects are mild to moderate gastrointestinal symptoms that improve over time. Serious side effects like pancreatitis are rare (less than 0.2%), but require immediate medical attention if symptoms occur.
Does Mounjaro cause less nausea than Wegovy?
Clinical trial data shows 31% of Mounjaro patients experienced nausea compared to 44% on Wegovy, suggesting a modest difference, though individual tolerance varies.
What are the most common Wegovy vs Mounjaro side effects?
Both medications most commonly cause nausea, diarrhoea, constipation, vomiting, and abdominal discomfort—all related to their effect on gastric emptying and appetite regulation.
How can I reduce side effects when starting Wegovy or Mounjaro?
Start at the lowest prescribed dose, eat smaller frequent meals, avoid high-fat foods, stay well-hydrated, and follow your prescriber's gradual dose escalation schedule. Most patients adapt within 4-8 weeks.
Do I need a prescription for Wegovy or Mounjaro in the UK?
Yes, both are prescription-only medications requiring clinical assessment by a UK-registered prescriber. Cured Pharmacy offers free online consultations, with Wegovy from £135.00 and Mounjaro from £124.99 subject to prescriber approval.
Which has worse side effects, Wegovy or Mounjaro?
Both Wegovy and Mounjaro cause similar gastrointestinal side effects like nausea, vomiting and diarrhoea, though severity varies by individual. Clinical trials show Mounjaro users report slightly higher rates of nausea initially, but both medications are generally well-tolerated when doses are increased gradually under medical supervision at Cured Pharmacy.
Do Wegovy vs Mounjaro side effects improve over time?
Yes, most side effects from both Wegovy and Mounjaro typically decrease after the first few weeks as your body adjusts to the medication. Starting at lower doses and following the recommended titration schedule provided by Cured Pharmacy helps minimise side effects during the adjustment period.
Can I switch from Wegovy to Mounjaro if side effects are too severe?
Yes, you can switch between Wegovy and Mounjaro under medical guidance if you experience intolerable side effects with one medication. Cured Pharmacy's UK-registered prescribers will assess your individual response and recommend the appropriate starting dose when switching to ensure safety and minimise side effects.
Are Mounjaro side effects more dangerous than Wegovy side effects in the UK?
Both Mounjaro and Wegovy have similar safety profiles and are approved by UK regulators with comparable risk levels. Serious side effects are rare with both medications, and Cured Pharmacy ensures all patients are screened for contraindications before prescribing either treatment.
How can I reduce side effects when comparing Wegovy vs Mounjaro?
To minimise side effects with either Wegovy or Mounjaro, eat smaller meals, avoid high-fat foods, stay hydrated, and follow the gradual dose escalation schedule. Cured Pharmacy provides comprehensive guidance on managing side effects and offers ongoing prescriber support throughout your weight loss journey with either medication.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Reviewed on: June 03, 2026

Last reviewed: 13 August 2026

Last updated on 13 August 2026.

Review History

Our experts continually monitor new findings in health and medicine, and we update our articles when new information becomes available.

Why this page was updated on 13 August 2026

Content checked and updated as part of our periodic review, to ensure accuracy and currentness.

Current version (13 August 2026)

Edited by: The Editorial Team

Medically reviewed by:

Tarun Kumar, GPhC No. 2233073, Prescribing Pharmacist


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