Tadalafil and Moclobemide: Can They Be Taken Together?
Learn about the interaction and what your prescriber checks before approving treatment.
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Tadalafil and Moclobemide: Understanding the Interaction
Published: 23 October 2026
Tadalafil and moclobemide can generally be taken together, but your prescriber will need to review your full medication history and health status before confirming suitability. Tadalafil is a PDE5 inhibitor used to treat erectile dysfunction, while moclobemide is a reversible MAO-A inhibitor antidepressant. No major direct interaction between these two medicines is commonly reported in UK prescribing guidance, but every person's situation is different and requires individual assessment by a qualified healthcare professional.
Key takeaways
- No major direct interaction between tadalafil and moclobemide is commonly reported in UK prescribing guidance
- Your prescriber will review your full medication list and health status before confirming suitability
- Never take tadalafil with nitrates, nicorandil, riociguat, or poppers—this combination is dangerous
- Declare all medicines including moclobemide during your consultation for a safe assessment
- Seek urgent help for erections lasting over 4 hours or sudden vision or hearing loss
What is tadalafil and how does it work?
Tadalafil is the generic name for Cialis, a prescription medicine licensed in the UK to treat erectile dysfunction (ED). It belongs to a group of medicines called PDE5 inhibitors, which work by relaxing blood vessels in the penis to help blood flow more easily when you are sexually aroused [4].
Tadalafil is available in two ways: on-demand tablets (10mg or 20mg) taken at least 30 minutes before sexual activity, with effects lasting up to 36 hours, or daily low-dose tablets (2.5mg or 5mg) taken every day at the same time. Both options require sexual stimulation to work—tadalafil does not cause an erection on its own [4].
At Cured Pharmacy, tadalafil is available on prescription after an online consultation reviewed by a UK-registered prescriber. The prescriber will check your medical history, current medicines, and overall health to confirm tadalafil is suitable and safe for you.
What is moclobemide and why is it prescribed?
Moclobemide is a prescription antidepressant that belongs to a class of medicines called reversible inhibitors of monoamine oxidase type A (RIMA). It is used to treat depression and social anxiety disorder by increasing levels of certain natural chemicals in the brain, including serotonin, noradrenaline, and dopamine, which help improve mood and emotional wellbeing.
Unlike older, irreversible MAO inhibitors, moclobemide is considered safer and has fewer dietary restrictions. However, it still requires careful monitoring and can interact with certain other medicines, foods, and substances. Your doctor will have prescribed moclobemide after considering your symptoms, other treatments you may have tried, and your overall health.
If you have been prescribed moclobemide and are considering treatment for erectile dysfunction, it is essential to declare this medicine during your consultation. Your prescriber needs a complete picture of all your current medicines to assess safety and suitability.
At a glance
The interaction between tadalafil and moclobemide explained
No major direct pharmacological interaction between tadalafil and moclobemide is commonly reported in UK prescribing references. Tadalafil works primarily by inhibiting the PDE5 enzyme in blood vessels, while moclobemide works on monoamine oxidase enzymes in the brain. These are different mechanisms that do not directly interfere with each other.
However, both medicines can have effects on blood pressure. Tadalafil can cause a modest drop in blood pressure, and moclobemide may occasionally affect blood pressure regulation, particularly when combined with certain other substances. Your prescriber will assess whether the combination is appropriate for you based on your cardiovascular health, blood pressure readings, and any other medicines you take.
It is also important to consider the underlying cause of erectile dysfunction. Depression and anxiety—conditions for which moclobemide is prescribed—can themselves contribute to ED. Some people find that treating the mood disorder helps improve erectile function, while others may benefit from both treatments together. Your prescriber will take a holistic view of your health when making treatment decisions.
Why individual assessment matters
Even when no major interaction is reported between two medicines, individual factors such as age, kidney or liver function, other health conditions, and additional medicines can all influence safety. This is why every prescription for tadalafil at Cured Pharmacy follows a thorough consultation with a UK-registered prescriber who reviews your complete medical profile before approving treatment.
What your prescriber will check before prescribing tadalafil and moclobemide together
During your online consultation, the prescriber will ask detailed questions about your current health and medicines. For someone taking moclobemide, they will want to know the dose, how long you have been taking it, whether it is controlling your symptoms well, and whether you have experienced any side effects.
The prescriber will also check your cardiovascular health, including any history of heart disease, stroke, high or low blood pressure, and whether you take any other medicines that affect blood pressure. They will ask about other medicines that are absolutely contraindicated with tadalafil, such as nitrates (GTN spray, isosorbide mononitrate), nicorandil, riociguat, or recreational drugs called poppers—these must never be taken with any PDE5 inhibitor because the combination can cause a dangerous drop in blood pressure [4].
If you take alpha-blockers for prostate symptoms (such as tamsulosin or doxazosin), the prescriber will ensure you are stable on that medicine and may recommend starting tadalafil at a lower dose to minimise the risk of dizziness or low blood pressure. They will also check for any potent CYP3A4 inhibitors, which can raise tadalafil levels in the blood and require dose adjustments [4].
Declaring all your medicines
It is vital to list every medicine you take during your consultation, including prescription medicines, over-the-counter products, herbal remedies (such as St John's wort), and any recreational substances. Even if you think a medicine is unrelated to ED treatment, it may still be relevant to your prescriber's safety assessment.
Always declare moclobemide
Even though no major interaction is commonly reported, your prescriber needs to know about moclobemide and every other medicine you take to assess your individual safety and choose the right dose of tadalafil for you.
Practical advice for taking tadalafil while on moclobemide
If your prescriber approves tadalafil, take it exactly as directed. For on-demand tadalafil (10mg or 20mg), take one tablet at least 30 minutes before you plan to have sex; the effect can last up to 36 hours, but you should not take more than one dose in 24 hours. For daily tadalafil (2.5mg or 5mg), take one tablet at the same time every day, whether or not you plan to have sex [4].
Continue taking moclobemide as prescribed by your doctor. Do not stop or change the dose of moclobemide without medical advice, even if you start ED treatment. Stopping an antidepressant suddenly can cause withdrawal symptoms and a return of depression or anxiety.
Be mindful of alcohol. Heavy drinking can worsen erectile dysfunction and add to the blood-pressure-lowering effects of tadalafil, increasing the risk of dizziness or fainting. Grapefruit juice can raise tadalafil levels in the blood, so it is best to avoid it while taking tadalafil [4]. Monitor how you feel when you first start tadalafil, especially if you experience dizziness, light-headedness, or any unusual symptoms.
Warning signs and when to seek help with tadalafil and moclobemide
Most men tolerate tadalafil well, but you should be aware of warning signs that need urgent medical attention. If you develop an erection that lasts longer than four hours (priapism), go to A&E immediately—this is a medical emergency that requires prompt treatment to prevent permanent damage [4].
Seek urgent help if you experience sudden loss of vision in one or both eyes, or sudden decrease or loss of hearing, which may be accompanied by ringing in the ears or dizziness. If you develop chest pain during or after sexual activity, stop and seek medical advice—do not take nitrate medicines (such as GTN spray) if you have used tadalafil in the past 48 hours, as this combination is dangerous [4].
If you notice any new or worsening symptoms after starting tadalafil, or if you have concerns about how it interacts with moclobemide or any other medicine, contact your prescriber or GP. Never stop taking moclobemide suddenly without medical supervision. If you experience severe mood changes, suicidal thoughts, or any psychiatric symptoms, contact your doctor or call NHS 111 immediately.
Reporting side effects
Common side effects of tadalafil include headache, indigestion, back pain, muscle aches, flushing, and nasal congestion. These are usually mild and temporary. If side effects are troublesome or persistent, speak to your prescriber—they may be able to adjust your dose or suggest an alternative treatment. You can report side effects via the Yellow Card Scheme at yellowcard.mhra.gov.uk.
When to get urgent help
- Erection lasting longer than 4 hours (priapism)—go to A&E immediately
- Sudden loss of vision in one or both eyes—seek urgent medical help
- Sudden decrease or loss of hearing, possibly with ringing in the ears or dizziness
- Chest pain during or after sexual activity—stop and seek medical advice; do not take nitrates
- Severe mood changes or suicidal thoughts—contact your doctor or call NHS 111 immediately
Call 999 or go to A&E in an emergency, or contact NHS 111 for urgent advice.
Scientific References
- NHS. (n.d.). Erectile dysfunction (impotence). NHS website. https://www.nhs.uk/conditions/erection-problems-erectile-dysfunction/ [accessed 23 October 2026]
- National Institute for Health and Care Excellence. (n.d.). Erectile dysfunction. Clinical Knowledge Summaries. https://cks.nice.org.uk/topics/erectile-dysfunction/ [accessed 23 October 2026]
- Joint Formulary Committee. (n.d.). Tadalafil. British National Formulary. NICE. https://bnf.nice.org.uk/drugs/tadalafil/ [accessed 23 October 2026]
- Electronic Medicines Compendium. (n.d.). Summaries of Product Characteristics and Patient Information Leaflets. https://www.medicines.org.uk/emc/ [accessed 23 October 2026]
Information on this page is for educational purposes only and is not medical advice. Prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting or changing any medication.
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Common Questions
Can't find your answer? Our UK pharmacists review every consultation and can help.
Can I take tadalafil if I'm on moclobemide?
Generally yes, as no major direct interaction is commonly reported, but your prescriber must review your full medical history and current medicines to confirm it is safe for you individually.
Will moclobemide make tadalafil less effective?
Moclobemide is not known to reduce the effectiveness of tadalafil. However, depression and anxiety can contribute to erectile dysfunction, so treating your mood disorder may also help improve ED.
Do I need to tell my prescriber I'm taking moclobemide?
Yes, absolutely. You must declare all medicines, including moclobemide, during your consultation so the prescriber can assess safety and suitability.
Can I take tadalafil with other antidepressants?
Many antidepressants can be taken with tadalafil, but you must declare every medicine during your consultation. The prescriber will check for any interactions and confirm suitability.
What should I avoid while taking tadalafil and moclobemide?
Never take tadalafil with nitrates, nicorandil, riociguat, or poppers. Avoid heavy alcohol and grapefruit juice. Continue any dietary advice given with moclobemide and do not stop it suddenly.
How long after taking tadalafil can I take a nitrate medicine?
You must not take nitrates within 48 hours of taking tadalafil. If you develop chest pain and need nitrate treatment, tell the healthcare professional you have taken tadalafil.
Can depression medication cause erectile dysfunction?
Some antidepressants, particularly SSRIs, can contribute to sexual side effects including ED. Moclobemide is generally considered to have a lower risk of sexual side effects than many other antidepressants.
What if I get side effects from tadalafil while on moclobemide?
Contact your prescriber if you experience troublesome side effects. They can adjust your dose or suggest an alternative ED treatment that may suit you better.
Medically reviewed by
Tarun Kumar, Superintendent Pharmacist (GPhC 2233073)