Orlistat vs Mounjaro UK | Expert Pharmacy Comparison

Clinically Proven UK Registered Pharmacy

Cheapest Orlistat vs Mounjaro - UK Price £124.99

Compare treatments and get the cheapest UK price on Mounjaro from £124.99 plus £20 off with code Weightlossnew.

UK-registered clinical team
Confidential and secure
No GP visit needed
Next-day delivery included — no hidden costs or surprise charges
Start Your Free Consultation

Takes less than 2 minutes to complete 100% online

WEIGHTLOSSNEW £20 off for new customers

Treatment from £124.99

Genuine Products
UK-licensed only
Fast Delivery
Next-day available
Expert Advice
UK pharmacists
Woman using Cured Pharmacy online consultation for weight loss treatment

Check if you're eligible

Height 175 cm
Weight 82 kg

Your BMI

26.8
Start Free Consultation

Free · BMI thresholds shown are illustrative. Final eligibility is confirmed by a UK prescriber during your free consultation.

LIVE PRICING

Our Pricing

Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £124.99

£31.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
Start Consultation
Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £159.00

£39.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
Start Consultation
Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £200.00

£50.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
Start Consultation
Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £225.00

£56.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
Start Consultation
Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £250.00

£62.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
Start Consultation
Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £267.00

£66.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
Start Consultation
Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £69.00

£17.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
Start Consultation
Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£99 £79.00

£19.75 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £99
Start Consultation
Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £99.00

£24.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
Start Consultation
Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £149.00

£37.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
Start Consultation
Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £179.00

£44.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
Start Consultation
Wegovy Oral Pill
Weeks 1–4

1.5mg

1 pen • 4 Weeks

£83.00 £63.00

£20.75 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £83.00
Start Consultation
Wegovy Oral Pill
Weeks 5–8

4mg

1 pen • 4 Weeks

£110.00 £90.00

£27.50 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £110.00
Start Consultation
Wegovy Oral Pill
Weeks 9–12

9mg

1 pen • 4 Weeks

£140.00 £120.00

£35.00 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £140.00
Start Consultation
Wegovy Oral Pill
Weeks 13+

25mg

1 pen • 4 Weeks

£199.00 £179.00

£49.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199.00
Start Consultation

Orlistat vs Mounjaro: UK Registered Pharmacy Comparison

Published on: June 03, 2026

When comparing orlistat vs mounjaro uk pharmacy options, understanding the fundamental differences between these two MHRA-licensed weight loss treatments is essential for making an informed choice. Orlistat works by blocking fat absorption in your digestive system, while Mounjaro (tirzepatide) is a dual-action injectable that regulates appetite and blood sugar through hormone pathways. At Cured Pharmacy, our UK-registered clinical team can assess which treatment aligns with your medical history, weight loss goals, and lifestyle during a free online consultation.

How Orlistat and Mounjaro Work Differently

Orlistat is a lipase inhibitor that prevents approximately 30% of dietary fat from being absorbed in your intestines [1]. The unabsorbed fat passes through your digestive system, which means orlistat only works when you consume fat-containing meals. It's been available in the UK since 1998 and remains the only oral weight loss medication licensed for long-term use without injection.

Mounjaro contains tirzepatide, the first dual GIP/GLP-1 receptor agonist approved by the MHRA for chronic weight management [2]. Unlike orlistat's mechanical action, tirzepatide works systemically by activating two incretin hormone pathways that regulate appetite, slow gastric emptying, and improve insulin sensitivity. This dual mechanism produces significantly greater weight reduction in clinical trials compared to single-pathway treatments.

Clinical Efficacy: Orlistat vs Mounjaro Weight Loss Results

In clinical trials, orlistat combined with a reduced-calorie diet produced an average weight loss of 5-10% of initial body weight over 12 months [1]. Patients typically lose 50% more weight with orlistat than with diet and exercise alone, making it a clinically proven option for those seeking moderate weight reduction.

Mounjaro demonstrates substantially greater efficacy in head-to-head comparisons. The SURMOUNT-1 trial showed patients on the 15mg maintenance dose achieved an average 22.5% body weight reduction over 72 weeks [2]. Even at the 5mg starting dose, average weight loss exceeded 15% — triple the typical results seen with orlistat therapy.

What the Trial Data Means for You

These percentage differences translate to meaningful real-world outcomes. A 100kg patient might expect to lose 5-10kg with orlistat over a year, compared to 15-22kg with Mounjaro at therapeutic doses [1][2]. However, individual results vary based on adherence, dietary changes, physical activity, and metabolic factors that your UK prescriber will assess during consultation.

Side Effect Profiles and Tolerability

Orlistat's side effects are directly related to its mechanism of blocking fat absorption. Common gastrointestinal effects include oily stools, increased bowel movements, flatulence with discharge, and faecal urgency [3]. These effects intensify when patients consume high-fat meals, which actually reinforces adherence to a lower-fat diet. Most patients find these effects manageable by limiting dietary fat intake to 15-20g per meal.

Mounjaro's side effects stem from its action on the gastrointestinal tract and include nausea, vomiting, diarrhoea, constipation, and decreased appetite [4]. These effects are typically most pronounced during the first few weeks and dose escalation periods. Approximately 5-10% of patients discontinue treatment due to gastrointestinal intolerance, though most find symptoms diminish with continued use.

Managing Side Effects in Clinical Practice

Our clinical team at Cured Pharmacy provides specific guidance on minimising side effects for both treatments. With orlistat, distributing fat intake evenly across meals and taking a multivitamin at bedtime helps prevent nutritional deficiencies. For Mounjaro patients, eating smaller portions, avoiding high-fat foods, and staying well-hydrated significantly reduces nausea and gastrointestinal discomfort during the initial treatment phase.

Feature Orlistat Mounjaro
Active ingredient Orlistat 120mg Tirzepatide
Administration Oral capsule Weekly injection
Mechanism Blocks fat absorption Dual GIP/GLP-1 agonist
Average weight loss 5-10% over 12 months 15-22.5% over 72 weeks
Dosing frequency Three times daily with meals Once weekly
Common side effects Oily stools, bowel urgency Nausea, vomiting, diarrhoea
Starting price at Cured From £124.99 From £124.99
Prescription required Yes Yes

Dosing, Administration and Treatment Convenience

Orlistat requires taking one 120mg capsule with each main meal containing fat, up to three times daily [3]. If you skip a meal or eat a fat-free meal, you omit that dose. This dosing flexibility appeals to patients who prefer oral medication and want treatment that adapts to their eating patterns. The lower-strength 60mg formulation is available without prescription for patients with BMI 28-30.

Mounjaro is administered as a once-weekly subcutaneous injection using a pre-filled KwikPen. Treatment begins at 2.5mg weekly for four weeks, then increases to 5mg, with potential escalation to 7.5mg, 10mg, 12.5mg, or 15mg based on response and tolerability [4]. The weekly injection schedule offers convenience compared to daily treatments, though it does require patients to be comfortable with self-injection technique.

Suitability Criteria and Prescribing Guidelines

Orlistat is licensed for adults with BMI ≥30 kg/m², or BMI ≥28 kg/m² with weight-related comorbidities such as type 2 diabetes or hypertension [3]. It's often considered first-line pharmacotherapy due to its established safety profile, oral administration, and lower cost compared to injectable alternatives. Orlistat is contraindicated in chronic malabsorption syndrome, cholestasis, and pregnancy.

Mounjaro is indicated for adults with BMI ≥30 kg/m², or BMI ≥27 kg/m² with at least one weight-related comorbidity [4]. It's particularly suitable for patients who haven't achieved adequate weight loss with lifestyle modifications alone or who have concurrent type 2 diabetes. Contraindications include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, and severe gastrointestinal disease.

Clinical Assessment at Cured Pharmacy

During your online consultation, our UK prescribers evaluate your BMI, medical history, current medications, and weight loss goals to determine which treatment is clinically appropriate. Superintendent pharmacist Tarun Kumar (GPhC 2233073) and our clinical team consider factors including your previous weight loss attempts, dietary habits, injection tolerance, and any contraindications before recommending orlistat, Mounjaro, or alternative treatments available through our weight loss programme.

Cost Comparison and Treatment Value

Orlistat represents the most affordable prescription weight loss option at Cured Pharmacy, starting from £135.00 for a month's supply. This cost-effectiveness makes it accessible for patients seeking clinically proven weight loss support without the higher investment required for injectable treatments. Generic orlistat delivers identical efficacy to branded Xenical at a lower price point.

Mounjaro starts from £124.99 per month at Cured Pharmacy, reflecting the advanced pharmaceutical development and superior efficacy demonstrated in clinical trials [2]. While the upfront cost is higher, many patients find the significantly greater weight loss results and once-weekly convenience justify the investment. Our transparent pricing model shows exact costs before you complete your consultation, with no hidden fees or surprise charges.

Scientific References

  1. Torgerson, J. S., Hauptman, J., Boldrin, M. N., & Sjöström, L. (2004). XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care, 27(1), 155–161. https://doi.org/10.2337/diacare.27.1.155 [accessed 13 August 2026]
  2. Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205–216. https://doi.org/10.1056/NEJMoa2206038 [accessed 13 August 2026]
  3. Electronic Medicines Compendium. (2023). Orlistat 120mg Hard Capsules - Summary of Product Characteristics. Medicines and Healthcare products Regulatory Agency. https://www.medicines.org.uk/emc/product/2592/smpc [accessed 13 August 2026]
  4. Electronic Medicines Compendium. (2023). Mounjaro 2.5 mg solution for injection in pre-filled pen - Summary of Product Characteristics. Medicines and Healthcare products Regulatory Agency. https://www.medicines.org.uk/emc/product/14881/smpc [accessed 13 August 2026]
  5. NHS. (2026). Tirzepatide: a medicine to manage type 2 diabetes and treat obesity. https://www.nhs.uk/medicines/tirzepatide/ Accessed 13 August 2026.
  6. NHS. (2026). Overweight and obesity in adults. https://www.nhs.uk/conditions/overweight-and-obesity/ Accessed 13 August 2026.
  7. NHS England. (2026). Weight management injections. https://www.england.nhs.uk/ourwork/prevention/obesity/medicines-for-obesity/weight-management-injections/ Accessed 13 August 2026.

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication. Individual results may vary, and weight loss outcomes depend on adherence to treatment, dietary modifications, and lifestyle changes. Cured Pharmacy is registered with the General Pharmaceutical Council (GPhC 9012511), with superintendent pharmacist Tarun Kumar (GPhC 2233073).

Trusted by thousands

Real people, real results

Jane L.

"Brilliant. Lost 4 stone on mounjaro no side effects at all. Cured pharmacy are excellent. Always helpful pens sent out quickly always comes with needles and sterile wipes. If you want to go on GLP-1 go to cured pharmacy. So professional. Thank you cured pharmacy you changed my health and well being."

Ann-Marie

"I absolutely love this product, I have been using 2.5mg as maintenance dose and have managed to control my weight without any side effects and can still eat well balanced meals. The pharmacy is very efficient friendly and helpful I would not purchase from anywhere else."

Sacha W.

"So far I'm really impressed by my results it's crazy cause I'm not snacking like how I used to do and I see my face slimming down already and it's only been 2 and a half weeks. Can't wait to give my feedback in 5 months time thank you cured pharmacy."

Kimberly G.

"Mounjaro has corrected my hormonal weight gain during menopause. I am using it now to maintain that balance. The results for me have been exceptional!"

Jennifer

"Great really helps cure those nasty habits can't wait for my next mounjaro pen."

How it Works?

Select from our recommended UK-licensed medications.

1

Choose your treatment

Step 1: Choose your treatment from Cured Pharmacy

Select safe UK treatments. Quick answers.

2

Answer quick questions

Step 2: Answer quick consultation questions

We will deliver direct to you as quickly as tomorrow.

3

Get it delivered fast

Step 3: Fast discreet delivery to your door

Start Your Assessment For Weight Loss

Start your journey to better health today.

  • Reviewed by UK-based prescribers
  • Takes under 3 minutes
  • Discreet Packaging

Start Your Journey To Better Health Today

Once you complete a short online assessment you will be able to choose your preferred treatment from safe medically approved options tailored to you.

Start My Assessment

Returning Customer?

Log in to Your Account

Faq

Can I take orlistat and Mounjaro together?
No, these treatments are not prescribed together. Your UK prescriber will recommend the single most appropriate option based on your clinical assessment, medical history, and weight loss goals.
Which is better for weight loss: orlistat or Mounjaro?
Clinical trials show Mounjaro produces significantly greater weight loss (average 15-22.5%) compared to orlistat (5-10%). However, 'better' depends on your individual circumstances, budget, injection tolerance, and medical suitability, which our prescribers assess during consultation.
How quickly do orlistat and Mounjaro work?
Orlistat begins blocking fat absorption immediately, with noticeable weight loss typically within 2-4 weeks when combined with dietary changes. Mounjaro patients often notice appetite reduction within days, with measurable weight loss accelerating after the first month as doses increase.
Do I need a prescription for orlistat vs Mounjaro in the UK?
Yes, both require a prescription from a UK-registered prescriber. Lower-strength orlistat 60mg (Alli) is available without prescription, but the more effective 120mg strength and all Mounjaro doses are prescription-only medications regulated by the MHRA.
What happens when I stop taking orlistat or Mounjaro?
Weight regain is possible with both treatments if lifestyle modifications aren't maintained. Orlistat can be stopped immediately without tapering, while Mounjaro doesn't require dose reduction before discontinuation, though your prescriber may recommend a structured transition plan.
Can I switch from orlistat to Mounjaro?
Yes, switching is possible if orlistat hasn't produced adequate results or if your clinical circumstances have changed. Your UK prescriber will assess whether Mounjaro is suitable and can initiate treatment immediately after stopping orlistat, as there's no required washout period.
Are orlistat and Mounjaro safe for long-term use?
Orlistat has been used safely for over 25 years with an established long-term safety profile. Mounjaro is approved for chronic weight management, though it's a newer medication with ongoing post-marketing surveillance by the MHRA. Both require ongoing prescriber monitoring.
Which treatment has fewer side effects: orlistat or Mounjaro?
Side effect profiles differ rather than one being definitively 'better'. Orlistat causes primarily gastrointestinal effects related to fat malabsorption, while Mounjaro causes nausea and GI symptoms from hormone pathway activation. Your prescriber will discuss which side effect profile is more acceptable for your lifestyle.
Is Mounjaro more effective than Orlistat for weight loss?
Clinical studies show Mounjaro typically produces greater weight loss than Orlistat, with patients losing an average of 15-20% body weight compared to 5-10% with Orlistat. Cured Pharmacy offers both treatments with expert guidance to help you choose the most suitable option based on your weight loss goals and medical history.
Why is Mounjaro more expensive than Orlistat at UK pharmacies?
Mounjaro is a newer injectable GLP-1 medication requiring advanced manufacturing, while Orlistat is an older oral medication available as a generic. Despite the price difference, Cured Pharmacy offers Mounjaro from £124.99 with £20 off your first order, making it more accessible for those seeking advanced weight loss treatment.
Can I switch from Orlistat to Mounjaro through Cured Pharmacy?
Yes, many patients switch from Orlistat to Mounjaro if they need more effective weight loss support. Cured Pharmacy's UK-registered prescribers will review your treatment history and assess your suitability for Mounjaro during a confidential online consultation.
Do Orlistat and Mounjaro work in the same way?
No, they work differently: Orlistat blocks fat absorption in your digestive system, while Mounjaro is a GLP-1 receptor agonist that regulates appetite and blood sugar. Cured Pharmacy can help you understand which mechanism suits your lifestyle and weight loss needs best.
How do I get the cheapest Mounjaro price at a UK pharmacy?
Cured Pharmacy offers the cheapest UK price for Mounjaro starting at £124.99, plus you can save an additional £20 on your first order with code Weightlossnew. Our transparent pricing includes prescription, medication, and delivery with no hidden fees.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Reviewed on: June 03, 2026

Last reviewed: 13 August 2026

Last updated on 13 August 2026.

Review History

Our experts continually monitor new findings in health and medicine, and we update our articles when new information becomes available.

Why this page was updated on 13 August 2026

Content checked and updated as part of our periodic review, to ensure accuracy and currentness.

Current version (13 August 2026)

Edited by: The Editorial Team

Medically reviewed by:

Tarun Kumar, GPhC No. 2233073, Prescribing Pharmacist


How we source info.

When we present you with stats, data, opinion or a consensus, we'll tell you where this came from.