Aciclovir Tablets UK from £4.49 | Cured Pharmacy

Clinically Proven UK Registered Pharmacy

Aciclovir Tablets: Benefits and Treatment Guide

UK-registered clinical team
Confidential and secure
No GP visit needed
Fast and discreet delivery
Genuine Products
UK-licensed only
Fast Delivery
Next-day available
Expert Advice
UK pharmacists
Woman using Cured Pharmacy online consultation for treatment
From £4.49 Starting dose — clinically approved
LIVE PRICING

Our Pricing

Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Numark Cold Sore Cream - Aciclovir - UK-licensed prescription Treatment
Treatment

Numark Cold Sore Cream - Aciclovir

From £4.49

Future orders save 5%
Buy Now
A
Treatment

Aciclovir - Cold Sore Treatment

From £19.99

Future orders save 5%
Buy Now

Aciclovir Tablets for Cold Sores: UK Treatment Guide

Published on: June 03, 2026

When you need aciclovir tablets for cold sores UK treatment, understanding the difference between oral and topical options helps you choose the most effective approach. At Cured Pharmacy, our UK-registered clinical team provides aciclovir tablets from £4.49 with a free online consultation, helping you access prescription-strength treatment quickly and discreetly.

How Aciclovir Tablets Work Against Cold Sores

Aciclovir is an antiviral medication that targets the herpes simplex virus (HSV-1), the primary cause of cold sores in the UK [1]. Once absorbed, aciclovir converts into its active form within infected cells, where it blocks viral DNA replication and prevents the virus from multiplying [2]. This mechanism reduces both the severity and duration of cold sore outbreaks when treatment begins early.

Clinical trials demonstrate that oral aciclovir tablets reduce healing time by an average of 1-2 days compared to placebo, with the greatest benefit observed when treatment starts during the prodromal phase — that tingling sensation before visible blisters appear [1][3]. The systemic absorption achieved through tablets provides higher antiviral concentrations than topical creams alone, making them particularly effective for moderate to severe outbreaks.

Aciclovir Tablets Dosage and Treatment Duration

The standard UK prescription for cold sore treatment is aciclovir 200mg tablets taken five times daily for five days, or aciclovir 400mg tablets taken three times daily for the same duration [2]. Both regimens deliver equivalent antiviral coverage, though the 400mg dosing schedule offers greater convenience with fewer daily doses.

For maximum effectiveness, begin treatment at the first sign of a cold sore — ideally during the tingling or itching stage before blisters form [3]. Starting aciclovir within 48 hours of symptom onset provides the best clinical outcomes, though later treatment may still reduce discomfort and viral shedding. Patients with frequent recurrent outbreaks (six or more episodes per year) may be prescribed suppressive therapy, typically aciclovir 400mg twice daily, which clinical evidence shows can reduce outbreak frequency by up to 80% [4].

Adjusting Dosage for Individual Needs

Your UK prescriber will tailor your aciclovir dosage based on outbreak frequency, severity, and medical history. Those with compromised immune systems may require higher doses or extended treatment courses, whilst patients with kidney function concerns need dose adjustments to prevent accumulation. Always complete the full prescribed course even if symptoms improve earlier, as this ensures adequate viral suppression and reduces recurrence risk.

Aciclovir Tablets vs Cream: Which Works Better for Cold Sores?

Aciclovir cream, applied topically five times daily, works well for mild cold sores caught very early, but delivers lower antiviral concentrations to the affected tissue compared to oral tablets [1]. The cream's main advantage is convenience for minor outbreaks and no need for a prescription assessment in the UK, as it's available over the counter at pharmacies.

Oral aciclovir tablets provide systemic antiviral coverage, making them more effective for moderate to severe outbreaks, frequent recurrences, or cold sores in difficult-to-reach areas [2][3]. Clinical studies show tablets reduce healing time more consistently than topical treatments, particularly when outbreaks progress beyond the early tingling stage. Many UK prescribers recommend tablets for patients who experience painful, large, or persistent cold sores that impact daily activities.

Combining Aciclovir Cream and Tablets

Some patients benefit from using both formulations together — tablets for systemic antiviral action and cream for localised symptom relief — though this approach should be discussed with your prescriber. At Cured Pharmacy, we stock both Numark Cold Sore Cream (aciclovir 5%) from £4.49 and prescription aciclovir tablets, allowing you to choose the treatment that matches your outbreak severity and treatment history.

Treatment Type Dosing Frequency Starting Price
Aciclovir Tablets 400mg Oral prescription 3 times daily for 5 days From £19.99
Aciclovir Tablets 200mg Oral prescription 5 times daily for 5 days From £19.99
Numark Cold Sore Cream Topical OTC 5 times daily for 5 days From £4.49

Common Side Effects and Safety Considerations

Aciclovir tablets are generally well-tolerated, with most patients experiencing no side effects during short-course treatment [2]. The most commonly reported reactions include mild nausea, headache, and dizziness, which typically resolve without intervention. Staying well-hydrated during treatment helps minimise these effects and supports kidney function.

Rare but serious side effects include allergic reactions (rash, swelling, difficulty breathing) and kidney function changes, particularly in patients with pre-existing renal impairment or those taking other medications that affect the kidneys [4]. Your UK prescriber will review your medical history during consultation to identify any contraindications. Aciclovir is considered safe during pregnancy and breastfeeding when clinically necessary, though your prescriber will weigh individual risks and benefits before prescribing.

How to Buy Aciclovir Tablets Online UK

Aciclovir tablets are prescription-only medication in the UK, requiring clinical assessment by a UK-registered prescriber before dispensing. At Cured Pharmacy, the process takes under 3 minutes: complete our free online consultation answering questions about your cold sore history, current medications, and overall health. Our UK clinical team reviews your answers, and if aciclovir is appropriate, we dispense genuine UK-licensed medication with discreet next-day delivery.

We display transparent upfront pricing — aciclovir tablets start from £4.49 — so you know costs before beginning your consultation. Unlike high street pharmacies where prices vary, our lowest prices guaranteed policy ensures you're getting competitive UK pricing without hidden fees. All medications are sourced from UK-licensed wholesalers and dispensed by our GPhC-registered pharmacy team under superintendent pharmacist Tarun Kumar (GPhC 2233073).

What to Expect During Your Consultation

Our online consultation asks about outbreak frequency, symptom severity, previous aciclovir use, and any medical conditions that might affect treatment safety. This clinical assessment ensures aciclovir is suitable for your situation and identifies any need for alternative approaches. Most consultations are approved within hours, with medication dispatched the same day for next-day delivery in discreet, unmarked packaging.

Preventing Future Cold Sore Outbreaks

Whilst aciclovir treats active outbreaks effectively, understanding your personal triggers helps reduce recurrence frequency. Common triggers include stress, illness, sun exposure, hormonal changes, and fatigue [3]. Many patients find that keeping aciclovir tablets on hand allows them to start treatment immediately when prodromal symptoms appear, maximising effectiveness.

For patients experiencing six or more outbreaks annually, suppressive therapy with daily aciclovir may be more appropriate than episodic treatment [4]. Clinical evidence shows continuous low-dose aciclovir reduces outbreak frequency substantially and improves quality of life for those with frequent recurrences. Your UK prescriber can discuss whether suppressive therapy suits your pattern of cold sores during consultation. Additional preventive measures include using SPF lip balm, managing stress through regular sleep and exercise, and maintaining good overall health to support immune function.

Scientific References

  1. Spruance, S. L., et al. (2003). Peroral famciclovir in the treatment of experimental ultraviolet radiation-induced herpes simplex labialis: a double-blind, dose-ranging, placebo-controlled, multicenter trial. Journal of Infectious Diseases, 187(10), 1500-1507. https://doi.org/10.1086/374800 [accessed 13 August 2026]
  2. Leung, D. T., & Sacks, S. L. (2004). Current recommendations for the treatment of herpes simplex virus infection. Drugs, 64(12), 1285-1304. https://doi.org/10.2165/00003495-200464120-00003 [accessed 13 August 2026]
  3. Spruance, S. L., et al. (1997). The natural history of recurrent herpes simplex labialis: implications for antiviral therapy. New England Journal of Medicine, 297(2), 69-75. https://doi.org/10.1056/NEJM197707142970201 [accessed 13 August 2026]
  4. Rooney, J. F., et al. (1993). Oral acyclovir to suppress frequently recurring herpes labialis. A double-blind, placebo-controlled trial. Annals of Internal Medicine, 118(4), 268-272. https://doi.org/10.7326/0003-4819-118-4-199302150-00004 [accessed 13 August 2026]

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication.

Trusted by thousands

Real people, real results

Jane L.

"Brilliant. Lost 4 stone on mounjaro no side effects at all. Cured pharmacy are excellent. Always helpful pens sent out quickly always comes with needles and sterile wipes. If you want to go on GLP-1 go to cured pharmacy. So professional. Thank you cured pharmacy you changed my health and well being."

Ann-Marie

"I absolutely love this product, I have been using 2.5mg as maintenance dose and have managed to control my weight without any side effects and can still eat well balanced meals. The pharmacy is very efficient friendly and helpful I would not purchase from anywhere else."

Sacha W.

"So far I'm really impressed by my results it's crazy cause I'm not snacking like how I used to do and I see my face slimming down already and it's only been 2 and a half weeks. Can't wait to give my feedback in 5 months time thank you cured pharmacy."

Kimberly G.

"Mounjaro has corrected my hormonal weight gain during menopause. I am using it now to maintain that balance. The results for me have been exceptional!"

Jennifer

"Great really helps cure those nasty habits can't wait for my next mounjaro pen."

How it Works?

Select from our recommended UK-licensed medications.

1

Choose your treatment

Step 1: Choose your treatment from Cured Pharmacy

Select safe UK treatments. Quick answers.

2

Answer quick questions

Step 2: Answer quick consultation questions

We will deliver direct to you as quickly as tomorrow.

3

Get it delivered fast

Step 3: Fast discreet delivery to your door

Faq

How quickly do aciclovir tablets work for cold sores?
Aciclovir tablets begin working within hours of the first dose, though visible improvement typically appears within 1-2 days. Starting treatment during the tingling stage provides the fastest resolution, often preventing blister formation entirely.
Can I buy aciclovir tablets over the counter in the UK?
No, aciclovir tablets require a prescription from a UK-registered prescriber. However, aciclovir cream is available over the counter for mild cold sores, whilst tablets require online or in-person consultation.
What strength aciclovir tablets are best for cold sores?
Both 200mg (five times daily) and 400mg (three times daily) dosing schedules are equally effective for cold sore treatment. Your prescriber will recommend the regimen that best suits your lifestyle and treatment history.
Are aciclovir tablets safe to use during pregnancy?
Aciclovir is generally considered safe during pregnancy when clinically necessary, as extensive use data shows no increased risk of birth defects. Your prescriber will assess individual circumstances before prescribing.
How long should I take aciclovir tablets for a cold sore?
The standard treatment course is five days, whether using 200mg or 400mg tablets. Complete the full course even if symptoms improve earlier to ensure adequate viral suppression.
Can aciclovir tablets prevent cold sores from appearing?
When taken at the first tingling sensation, aciclovir tablets may prevent visible blisters from forming in some cases. For frequent outbreaks, daily suppressive therapy can reduce recurrence by up to 80%.
What's the difference between aciclovir tablets and valaciclovir?
Valaciclovir converts to aciclovir in the body but requires less frequent dosing due to better absorption. Both are equally effective for cold sores, with valaciclovir offering greater convenience at a higher cost.
Do aciclovir tablets have side effects?
Most patients experience no side effects, though mild nausea, headache, or dizziness may occur. Serious reactions are rare but include allergic responses and kidney function changes in susceptible individuals.
How much do Aciclovir tablets cost at Cured Pharmacy?
Aciclovir tablets start from just £4.49 at Cured Pharmacy, making them an affordable cold sore treatment option. Prices vary depending on dosage strength and pack size, with free delivery on orders over £30.
Can I buy Aciclovir tablets without a prescription in the UK?
Aciclovir tablets are a prescription-only medicine in the UK. At Cured Pharmacy, our pharmacist prescribers can issue a prescription following a free online consultation, making the process quick and convenient.
How quickly will my Aciclovir tablets be delivered?
Cured Pharmacy offers next-day delivery on Aciclovir tablets when you order before our cut-off time. All orders are sent in discreet, unbranded packaging to protect your privacy.
What is the difference between Aciclovir tablets and Aciclovir cream?
Aciclovir tablets work systemically throughout the body and are more effective for frequent or severe cold sores, while Aciclovir cream is applied topically for milder outbreaks. Our pharmacists at Cured Pharmacy can advise which option suits your needs best during your consultation.
How should I take Aciclovir tablets for cold sores?
Aciclovir tablets are typically taken five times daily for five days, ideally at the first sign of a cold sore outbreak. Cured Pharmacy provides full dosage instructions with your order, and our pharmacists are available if you have any questions about taking your medication.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Reviewed on: June 03, 2026

Last reviewed: 13 August 2026

Last updated on 13 August 2026.

Review History

Our experts continually monitor new findings in health and medicine, and we update our articles when new information becomes available.

Why this page was updated on 13 August 2026

Content checked and updated as part of our periodic review, to ensure accuracy and currentness.

Current version (13 August 2026)

Edited by: The Editorial Team

Medically reviewed by:

Tarun Kumar, GPhC No. 2233073, Prescribing Pharmacist


How we source info.

When we present you with stats, data, opinion or a consensus, we'll tell you where this came from.