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SMA Althera Infant Milk 400g

SMA Althera Infant Milk 400g

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  • ✔️ Extensively hydrolysed whey protein reduces cow's milk allergy reactions
  • ✔️ Contains HMOs to support infant gut microbiome development
  • ✔️ Suitable for infants with CMPA from birth onwards
  • ✔️ Reduced lactose content aids digestion in sensitive infants
  • ✔️ Clinically indicated first-line formula for cow's milk protein intolerance

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What Is SMA Althera Infant Milk and Who Is It For?

 

If your baby has been diagnosed with cow's milk protein allergy (CMPA) or cow's milk protein intolerance, finding the right formula can feel overwhelming. SMA Althera infant milk is an extensively hydrolysed whey protein formula designed specifically for infants from birth who cannot tolerate standard cow's milk-based feeds. It is one of the most widely recommended hydrolysed formulas in the UK, and it is available here at Cured Pharmacy for £21.99 per 400g tin. You can browse our full range of baby and toddler products for additional feeding and care essentials.

Cow's milk protein allergy affects an estimated 2–3% of infants in the UK, according to NHS guidance. Symptoms can range from skin rashes and eczema to digestive discomfort, vomiting, and in some cases more serious reactions. SMA Althera infant milk is formulated to reduce the allergenic load of cow's milk proteins while still providing the complete nutrition your baby needs to grow and thrive.

 

How Does SMA Althera Infant Milk Work?

 

The key to this formula lies in its protein structure. Standard infant formulas contain intact cow's milk proteins — it is these proteins that trigger allergic responses in sensitive infants. SMA Althera uses an extensive hydrolysis process to break those proteins down into much smaller peptide fragments, making them far less likely to be recognised by the immune system as a threat.

  • Proteins are broken down through enzymatic hydrolysis into small peptide fragments
  • The formula contains human milk oligosaccharides (HMOs), specifically 2'-FL and LNnT, which support gut microbiome development
  • It provides a complete nutritional profile including vitamins, minerals, and essential fatty acids appropriate for infants from birth
  • The lactose content is reduced, which may also help infants with secondary lactose intolerance alongside CMPA

 

Who Should Use SMA Althera Infant Milk?

 

This formula is intended for infants who have a confirmed or suspected diagnosis of cow's milk protein allergy or intolerance. It is not a general-purpose formula and should be used under the guidance of a GP, paediatrician, or registered dietitian. The NHS recommends that CMPA in formula-fed infants is managed with an extensively hydrolysed formula as a first-line dietary treatment in most cases.

SMA Althera infant milk may be appropriate for infants who:

  • Have been diagnosed with IgE-mediated or non-IgE-mediated cow's milk protein allergy
  • Show persistent symptoms such as eczema, colic, reflux, or loose stools linked to standard formula feeding
  • Are being managed under a healthcare professional's supervision for CMPA
  • Have not responded adequately to dietary changes in a breastfeeding mother's diet

 

How Does SMA Althera Compare to Other Hydrolysed Formulas?

 

Feature SMA Althera Infant Milk Aptamil Pepti 1
Protein type Extensively hydrolysed whey Extensively hydrolysed whey
HMOs included Yes (2'-FL and LNnT) No
Lactose content Reduced Reduced
Suitable from birth Yes Yes

 

How Should You Store SMA Althera Infant Milk?

 

Proper storage is essential to maintain the safety and nutritional quality of this formula. Once opened, the tin should be stored in a cool, dry place below 25°C and used within three weeks. Do not store prepared feeds for longer than two hours at room temperature, or 24 hours in the refrigerator. If you are also managing your infant's skin condition alongside their feeding plan, you may find our allergy products section useful for additional support.

Never use formula that has passed its best-before date, and always check the tin for any signs of damage before use. Prepared feeds should never be reheated in a microwave, as this can create hot spots that may burn your baby's mouth.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

SMA Althera Infant Milk 400g specifications
Treatment category Cow's milk protein allergy / intolerance dietary management
Mechanism of action Extensively hydrolysed whey protein reduces allergenic load; HMOs support gut microbiome
Effective for Infants with CMPA or cow's milk protein intolerance from birth
Suitable for Infants from birth under medical supervision
Active ingredient Extensively hydrolysed whey protein with HMOs (2'-FL, LNnT)
Pack size 400g
UK classification Food for special medical purposes (FSMP)
Preparation Powder for oral solution
Route of administration Oral

Specifications of SMA Althera Infant Milk 400g

 

What Is SMA Althera Infant Milk and What Is It Used For?

 

SMA Althera infant milk 400g is a food for special medical purposes (FSMP) classified as an extensively hydrolysed formula (eHF). It is used for the dietary management of cow's milk protein allergy (CMPA) and cow's milk protein intolerance in infants from birth. It is not a standard infant formula and must be used under the supervision of a healthcare professional — typically a GP, paediatrician, or registered dietitian.

CMPA is one of the most common food allergies in infancy in the UK. The NHS advises that formula-fed infants with confirmed or suspected CMPA should be switched to an extensively hydrolysed formula as a first-line dietary intervention. SMA Althera infant milk meets this clinical requirement and also contains HMOs to support immune and gut health development.

 

What Do You Need to Know Before Using SMA Althera Infant Milk?

 

Before starting your infant on this formula, it is important to be aware of the following contraindications and precautions:

  • Not suitable for infants with galactosaemia
  • Not suitable for infants with a confirmed allergy to any of the formula's ingredients
  • Not suitable as a sole source of nutrition for infants over 6 months without dietetic guidance
  • Should not be used as a substitute for breast milk without medical advice
  • A small number of infants with severe CMPA may not tolerate extensively hydrolysed formulas and may require an amino acid-based formula — seek specialist advice if symptoms persist

There are no known drug interactions with SMA Althera infant milk. However, if your infant is prescribed any medication, always check with your pharmacist or GP that it is compatible with this formula. If your baby has any additional health concerns, our vitamins and supplements section may offer complementary support products recommended by your healthcare team.

 

How Should You Use SMA Althera Infant Milk?

 

Always prepare feeds freshly and follow the instructions on the tin carefully. Incorrect preparation can affect both the nutritional content and the safety of the feed.

  1. Wash your hands thoroughly with soap and water before preparing any feed
  2. Sterilise all feeding equipment — bottles, teats, and caps — before use
  3. Boil fresh tap water and allow it to cool to no less than 70°C (do not use water that has been boiled more than once)
  4. Pour the required amount of water into the sterilised bottle first
  5. Using the scoop provided, add the correct number of level scoops of powder — do not pack or heap the scoop
  6. Replace the bottle cap and shake well until the powder is fully dissolved
  7. Cool the feed to a safe feeding temperature by holding the bottle under cold running water
  8. Test the temperature on the inside of your wrist before feeding
  9. Discard any unused feed within two hours of preparation
Age Approximate feeds per day Approximate volume per feed
0–2 weeks 6–8 60–90 ml
2 weeks–2 months 5–7 90–120 ml
2–4 months 5–6 120–150 ml
4–6 months 4–5 150–210 ml

These are approximate guides only. Always follow the specific advice of your GP or dietitian regarding your baby's individual feeding requirements.

 

What Are the Possible Side Effects of SMA Althera Infant Milk?

 

As with any change in infant feeding, some babies may experience a period of adjustment when transitioning to SMA Althera. Most side effects are mild and temporary.

Common side effects:

  • Loose or more frequent stools
  • Increased wind or flatulence
  • Temporary changes in stool colour (often greener or more yellow)
  • Mild fussiness during feeds

Less common side effects:

  • Persistent vomiting or regurgitation
  • Skin rash or worsening eczema (may indicate the formula is not suitable)
  • Refusal to feed due to the formula's slightly bitter taste

If your infant continues to show signs of allergic reaction — such as hives, swelling, or breathing difficulties — stop feeding immediately and seek urgent medical attention. If symptoms of CMPA do not improve within two to four weeks of starting the formula, speak to your GP or paediatrician, as an amino acid-based formula may be required. You can also explore our allergy support range for additional guidance on managing allergic conditions in the family.

 

How Should You Store SMA Althera Infant Milk?

 

  • Store in a cool, dry place below 25°C
  • Once opened, use within three weeks
  • Always replace the lid firmly after each use
  • Do not store in the refrigerator once opened — moisture can affect the powder
  • Prepared feeds may be stored in the refrigerator (2–4°C) for up to 24 hours
  • Do not freeze prepared feeds
  • Keep out of reach of children
  • Do not use after the best-before date printed on the base of the tin

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy SMA Althera infant milk online in the UK?

You can buy SMA Althera infant milk 400g directly from Cured Pharmacy, a UK GPhC-registered online pharmacy. It is also stocked in some high street pharmacies, though availability can vary. Ordering online ensures you can check stock and have it delivered to your door without the need to travel.

How does SMA Althera infant milk work in the body?

SMA Althera uses extensively hydrolysed whey protein, meaning the cow's milk proteins are broken into very small peptide fragments that are far less likely to trigger an immune response in allergic infants. It also contains HMOs — human milk oligosaccharides — which help support the development of a healthy gut microbiome. Together, these features make it suitable for infants with cow's milk protein allergy who need complete nutrition without the allergenic proteins.

How do I prepare SMA Althera formula step by step?

Boil fresh tap water and allow it to cool to no less than 70°C before adding the powder — this temperature helps reduce the risk of bacterial contamination. Add the correct number of level scoops to the measured water in a sterilised bottle, shake well, then cool to feeding temperature under cold running water. Always discard any unused feed within two hours of preparation and never reheat in a microwave.

What is the correct dose of SMA Althera for my baby?

The feeding guide on the tin provides approximate volumes based on your baby's age, but individual needs vary depending on weight and growth. Your GP, health visitor, or dietitian will advise on the most appropriate feeding volumes for your infant. Always follow professional guidance rather than relying solely on the tin guide.

What are the side effects of SMA Althera formula?

Some infants experience loose stools, increased wind, or changes in stool colour when first starting SMA Althera — these effects are usually temporary as the gut adjusts. Less commonly, some babies may show persistent vomiting or skin reactions, which could indicate the formula is not suitable. If symptoms do not improve within two to four weeks, speak to your GP or paediatrician.

Who is SMA Althera infant milk suitable for?

SMA Althera is suitable for infants from birth who have a confirmed or suspected diagnosis of cow's milk protein allergy or intolerance. It should always be used under the supervision of a healthcare professional such as a GP, paediatrician, or dietitian. It is not intended for healthy infants without a clinical indication. You can find more baby and toddler products in our dedicated collection.

Is SMA Althera the same as Nestlé Althera HMO?

Yes — SMA Althera infant milk is manufactured by Nestlé Health Science and is the same product marketed under the Nestlé Althera HMO name in some markets. In the UK, it is sold under the SMA brand, which is Nestlé's infant nutrition brand. The formula contains HMOs (2'-FL and LNnT) as part of its composition.

What are the alternatives to SMA Althera for cow's milk protein allergy?

Other extensively hydrolysed formulas available in the UK include Aptamil Pepti 1 and Nutramigen with LGG, both of which are also used for CMPA management. If an infant does not tolerate any extensively hydrolysed formula, a specialist may recommend an amino acid-based formula such as Neocate or Alfamino. The choice of formula should always be guided by a healthcare professional based on your baby's specific symptoms and diagnosis.

How long should my baby stay on SMA Althera infant milk?

Most infants with CMPA are reviewed by their GP or dietitian every 6 to 12 months to assess whether a gradual reintroduction of cow's milk protein — often via the milk ladder — is appropriate. The NHS advises that many children outgrow cow's milk protein allergy by the age of three to five years. Duration of use is individual and should always be determined by your healthcare team.

Can I use SMA Althera if my baby is also breastfed?

Yes, SMA Althera can be used alongside breastfeeding if your healthcare professional has recommended it. In breastfed infants with CMPA, the first step is usually for the mother to eliminate dairy from her own diet; formula supplementation with an eHF may be advised if breastfeeding alone is insufficient or not possible. Always discuss mixed feeding plans with your GP or health visitor.

Does SMA Althera contain lactose?

SMA Althera has a reduced lactose content compared to standard infant formulas, which may benefit infants who also have secondary lactose intolerance alongside CMPA. However, it is not completely lactose-free, so it may not be appropriate for infants with primary lactose intolerance or galactosaemia. Check with your GP or dietitian if you are unsure whether reduced-lactose formula is suitable for your baby.

What happens if I miss a feed of SMA Althera?

If you miss a scheduled feed, simply prepare and offer the next feed as normal when your baby shows hunger cues — do not double up on volumes to compensate. Infants naturally regulate their intake, and missing one feed occasionally is unlikely to cause harm. If you are concerned about your baby's feeding pattern or weight gain, speak to your health visitor or GP.

How should I store SMA Althera once the tin is opened?

Once opened, store the tin in a cool, dry place below 25°C and use within three weeks. Do not refrigerate the powder tin, as moisture can affect the quality of the formula. Always replace the lid firmly after each use and check the best-before date on the base of the tin before preparing any feed.

What are the latest studies on hydrolysed formula for cow's milk protein allergy?

Current clinical evidence, including NICE guideline CG116, supports extensively hydrolysed formula as the first-line dietary treatment for most infants with CMPA. Research into HMOs — such as those included in SMA Althera — suggests they may play a role in supporting gut microbiome diversity and immune tolerance development, though studies are ongoing. Your GP or paediatrician can advise on the most up-to-date clinical recommendations for your baby's specific situation.

Can I get SMA Althera on prescription in the UK?

Yes, SMA Althera infant milk can be prescribed on an NHS prescription for infants with a confirmed diagnosis of cow's milk protein allergy, subject to local prescribing guidelines. Some NHS clinical commissioning groups have specific formularies that determine which hydrolysed formulas are available on prescription. Speak to your GP about whether a prescription is appropriate, or you can purchase it over the counter from Cured Pharmacy's baby and toddler range.

How Should You Use SMA Althera Infant Milk?

Always prepare feeds freshly using the correct technique to ensure your baby receives safe, nutritionally complete feeds. Never add extra scoops of powder or dilute the formula with additional water, as this can affect the nutritional balance and your baby's health.

What Is the Correct Dose of SMA Althera Infant Milk?

Feeding volumes should be guided by your baby's age, weight, and individual appetite. The table below provides approximate guidance only — always follow the specific advice of your GP, health visitor, or dietitian, as individual requirements vary.

When Is the Best Time to Use SMA Althera Infant Milk?

Feed your baby on demand, responding to hunger cues such as rooting, sucking movements, or fussiness. Newborns typically feed every two to three hours, while older infants may settle into a more predictable routine. Preparing feeds just before they are needed — rather than in advance — reduces the risk of bacterial growth and ensures the best nutritional quality.

If you need to prepare a feed in advance for convenience, it can be stored in the back of the refrigerator at 2–4°C for up to 24 hours. Always shake the bottle gently before use and check the temperature carefully before feeding.

How Long Can You Use SMA Althera Infant Milk For?

SMA Althera is suitable as a sole source of nutrition from birth up to six months of age, and as part of a mixed diet from six months onwards during the weaning period. Most infants with cow's milk protein allergy are reviewed by their GP or dietitian at regular intervals — typically every 6 to 12 months — to assess whether reintroduction of cow's milk protein is appropriate via the milk ladder. Do not stop or change the formula without guidance from your healthcare team.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of SMA Althera Infant Milk?

When your baby first transitions to SMA Althera, it is not unusual for them to experience a short adjustment period. The change in protein structure and reduced lactose content can temporarily affect digestion.

  • Loose or more frequent stools
  • Increased wind or flatulence
  • Changes in stool colour — often greener or more yellow than usual
  • Mild fussiness or unsettledness during or after feeds

These effects are generally mild and tend to resolve within one to two weeks as your baby's digestive system adapts. If they persist beyond this point, speak to your GP or health visitor.

What Are the Less Common Side Effects of SMA Althera Infant Milk?

A smaller number of infants may experience more noticeable reactions, particularly if the formula is not the right fit for their specific allergy profile.

  • Persistent vomiting or regurgitation beyond normal infant reflux
  • Refusal to feed — some infants find the slightly bitter taste of hydrolysed formula less palatable than standard formula
  • Worsening eczema or new skin rash
  • Persistent colic-like symptoms despite the formula change

If your baby refuses the formula due to taste, try warming it slightly or transitioning gradually by mixing it with their previous formula over several days. Always seek advice from your healthcare team before making changes.

What Are the Serious Side Effects of SMA Althera Infant Milk?

Serious reactions to SMA Althera are rare but require immediate medical attention. If your baby shows any of the following signs after feeding, stop the formula and seek urgent help:

  • Hives, urticaria, or widespread skin rash appearing rapidly after feeding
  • Swelling of the lips, face, or throat
  • Difficulty breathing or wheezing
  • Sudden pallor, limpness, or loss of consciousness

These symptoms may indicate anaphylaxis, which is a medical emergency. Call 999 immediately if you suspect your baby is having a severe allergic reaction.

What Should You Do If Your Baby Experiences Side Effects?

For mild digestive side effects, continue the formula and monitor your baby closely over one to two weeks. Keep a feeding diary noting symptoms, volumes, and timing — this information is invaluable when speaking to your GP or dietitian. If symptoms are moderate or worsening, contact your GP promptly rather than waiting for a routine appointment.

If your baby's CMPA symptoms do not improve within two to four weeks of starting SMA Althera, your GP may refer you to a paediatric dietitian or allergist to consider an amino acid-based formula as an alternative.

Can SMA Althera Interact With Other Medicines?

There are no known clinically significant interactions between SMA Althera infant milk and prescribed medicines. However, if your baby is taking any medication — including vitamin supplements or prescribed treatments — always check with your pharmacist or GP that it is compatible with this formula. Some medications may need to be given separately from feeds to ensure correct absorption.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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